Desmoplasia: A Response or a Niche?
Abstract
Summary: Desmoplasia—the presence of a rich stroma around a tumor—has long been associated with a poor clinical outcome in patients with cancer. It is considered to be a response to the presence of invasive tumor cells. There is now evidence that desmoplasia is the result of coordinated changes in several stromal cells under the control of a single gene product, CD36, whose repression leads to a decrease in fat accumulation and an increase in matrix deposition. The presence of these changes in tumor-free human breast tissue strongly suggests that desmoplasia may precede and not always follow the presence of malignant cells. This concept has an important clinical implication for women at high risk of developing breast carcinoma, considering that the presence of desmoplasia in normal breast tissue detected in the form of mammographic density is one of the strongest risk factors. Cancer Discov; 2(9); 772–4. ©2012 AACR. Commentary on DeFilippis et al., p. 826.
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The non-proliferative nature of senescent cells makes it unlikely that they are a major contributor to the abundant stromal fibroblasts observed in desmoplastic tumours.
“The non-proliferative nature of senescent cells makes it unlikely that they are a major contributor to the abundant stromal fibroblasts observed in desmoplastic tumours73.”
From A framework for advancing our understanding of cancer-associated fibroblasts (2020) · cites this paper as [73]
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Weaver, V. M., Petersen, O. W., Wang, F., Larabell, C. A., Briand, P., Damsky, C., & Bissell, M. J. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.137.1.231 · Cited by 1,483 · see citing works
DeFilippis, R. A., Chang, H., Dumont, N., Rabban, J. T., Chen, Y.-Y., Fontenay, G. V., Berman, H. K., Gauthier, M. L., Zhao, J., Hu, D., et al. (2012) · Cancer Discovery · doi:10.1158/2159-8290.cd-12-0107 · Cited by 212 · see citing works
Proangiogenic Contribution of Adiponectin toward Mammary Tumor Growth <i>In vivo</i>
Landskroner-Eiger, S., Qian, B., Muise, E. S., Nawrocki, A. R., Berger, J. P., Fine, E. J., Koba, W., Deng, Y., Pollard, J. W., & Scherer, P. E. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-2649 · Cited by 145 · see citing works
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A framework for advancing our understanding of cancer-associated fibroblasts
Sahai, E., Astsaturov, I., Cukierman, E., DeNardo, D. G., Egeblad, M., Evans, R. M., Fearon, D., Greten, F. R., Hingorani, S. R., Hunter, T., et al. (2020) · Nature Reviews Cancer · doi:10.1038/s41568-019-0238-1 · Cited by 3,863 · see citing works
- Authors
- DeClerck, Y. A.
- Affiliations
- University of Southern California (US)
- Corresponding author
- DeClerck, Yves A.
- ORCID
- DeClerck, Yves A.
- Venue
- Cancer Discovery
- Published
- 2012-09-01
- Volume
- 2
- Issue
- 9
- Pages
- 772-774
- ISSN
- 2159-8274 (ISSN-L)
- 2159-8290
- OpenAlex
- W2121262075
- Cited by
- 94
- References
- 3
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 13 · 2023: 13 · 2022: 9 · 2021: 11 · 2020: 12 · 2019: 10 · 2018: 5 · 2017: 4 · 2016: 2 · 2014: 2 · 2013: 2
- FWCI
- 0.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cancer Discovery (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Health Sciences › Medicine › Pathology and Forensic Medicine › Breast Lesions and Carcinomas
- Keywords
- desmoplasia, tumor stroma, CD36, breast cancer, breast density, mammography, breast cancer risk, tumor microenvironment, stromal cells, matrix deposition, fat deposition
- MeSH terms
- Animals, Breast Neoplasms, Female, Humans, Radiography, Stromal Cells, CD36 Antigens
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