Reversion of the Malignant Phenotype of Human Breast Cells in Three-Dimensional Culture and In Vivo by Integrin Blocking Antibodies
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In a recently developed human breast cancer model, treatment of tumor cells in a 3-dimensional culture with inhibitory β1-integrin antibody or its Fab fragments led to a striking morphological and functional reversion to a normal phenotype. A stimulatory β1-integrin antibody proved to be ineffective. The newly formed reverted acini re-assembled a basement membrane and re-established E-cadherin–catenin complexes, and re-organized their cytoskeletons. At the same time they downregulated cyclin D1, upregulated p21cip,waf-1, and stopped growing. Tumor cells treated with the same antibody and injected into nude mice had significantly reduced number and size of tumors in nude mice. The tissue distribution of other integrins was also normalized, suggesting the existence of intimate interactions between the different integrin pathways as well as adherens junctions. On the other hand, nonmalignant cells when treated with either α6 or β4 function altering antibodies continued to grow, and had disorganized colony morphologies resembling the untreated tumor colonies. This shows a significant role of the α6/β4 heterodimer in directing polarity and tissue structure. The observed phenotypes were reversible when the cells were disassociated and the antibodies removed. Our results illustrate that the extracellular matrix and its receptors dictate the phenotype of mammary epithelial cells, and thus in this model system the tissue phenotype is dominant over the cellular genotype.
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2D cell culture tests sometimes provide misleading and nonpredictive data for in vivo responses.
“As a result, 2D cell culture tests sometimes provide misleading and nonpredictive data for in vivo responses. 1-3”
From Three-dimensional cell culture systems and their applications in drug discovery and cell-based biosensors (2014) · cites this paper as [2]
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The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases.
Wade Harper, J. (1993) · Cell · doi:10.1016/0092-8674(93)90499-g · Cited by 5,651 · see citing works
Cell Adhesion: The Molecular Basis of Tissue Architecture and Morphogenesis
Gumbiner, B. M. (1996) · Cell · doi:10.1016/s0092-8674(00)81279-9 · Cited by 3,471 · see citing works
E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells.
Frixen, U. H., Behrens, J., Sachs, M., Eberle, G., Voß, B., Warda, A., Löchner, D., & Birchmeier, W. (1991) · The Journal of Cell Biology · doi:10.1083/jcb.113.1.173 · Cited by 1,550 · see citing works
How does the extracellular matrix direct gene expression?
Bissell, M. J., Hall, H. G., & Parry, G. (1982) · Journal of Theoretical Biology · doi:10.1016/0022-5193(82)90388-5 · Cited by 1,522 · see citing works
Self-citationIntegrin function: molecular hierarchies of cytoskeletal and signaling molecules.
Miyamoto, S., Teramoto, H., Coso, O. A., Gutkind, J. S., Burbelo, P. D., Akiyama, S. K., & Yamada, K. M. (1995) · The Journal of Cell Biology · doi:10.1083/jcb.131.3.791 · Cited by 1,202 · see citing works
Regulation of development and differentiation by the extracellular matrix
Adams, J. C., & Watt, F. M. (1993) · Development · doi:10.1242/dev.117.4.1183 · Cited by 1,197 · see citing works
Normal genetically mosaic mice produced from malignant teratocarcinoma cells.
Mintz, B., & Illmensee, K. (1975) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.72.9.3585 · Cited by 1,179 · see citing works
Suppression of ICE and Apoptosis in Mammary Epithelial Cells by Extracellular Matrix
Boudreau, N. J., Sympson, C. J., Werb, Z., & Bissell, M. J. (1995) · Science · doi:10.1126/science.7531366 · Cited by 1,174 · see citing works
Self-citationControl of adhesion-dependent cell survival by focal adhesion kinase.
Frisch, S. M., Vuori, K., Ruoslahti, E. I., & Chan-Hui, P.-Y. (1996) · The Journal of Cell Biology · doi:10.1083/jcb.134.3.793 · Cited by 1,111 · see citing works
PETERSEN, O. W., Rønnov‐Jessen, L., Howlett, A. R., & Bissell, M. J. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.19.9064 · Cited by 1,096 · see citing works
Self-citationWerb, Z., Tremble, P., Behrendtsen, O., Crowley, E., & Damsky, C. H. (1989) · The Journal of Cell Biology · doi:10.1083/jcb.109.2.877 · Cited by 1,057 · see citing works
Self-citationDrubin, D. G., & Nelson, W. J. (1996) · Cell · doi:10.1016/s0092-8674(00)81278-7 · Cited by 1,030 · see citing works
Birchmeier, W., & Behrens, J. (1994) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/0304-419x(94)90003-5 · Cited by 1,006 · see citing works
Cadherins in cancer: implications for invasion and metastasis
Takeichi, M. (1993) · Current Opinion in Cell Biology · doi:10.1016/0955-0674(93)90029-p · Cited by 927 · see citing works
Synergistic Roles for Receptor Occupancy and Aggregation in Integrin Transmembrane Function
Miyamoto, S., Akiyama, S. K., & Yamada, K. M. (1995) · Science · doi:10.1126/science.7846531 · Cited by 897 · see citing works
Stem cell patterning and fate in human epidermis
Jones, P. H., Harper, S. J., & Watt, F. M. (1995) · Cell · doi:10.1016/0092-8674(95)90453-0 · Cited by 783 · see citing works
Barcellos‐Hoff, M. H., Aggeler, J., Ram, T. G., & Bissell, M. J. (1989) · Development · doi:10.1242/dev.105.2.223 · Cited by 713 · see citing works
Self-citationHoschuetzky, H., Aberle, H., & Kemler, R. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.127.5.1375 · Cited by 712 · see citing works
Laminin receptor on platelets is the integrin VLA-6
Sonnenberg, A., Modderman, P. W., & Hogervorst, F. B. L. (1988) · Nature · doi:10.1038/336487a0 · Cited by 678 · see citing works
Streuli, C. H., Bailey, N., & Bissell, M. J. (1991) · The Journal of Cell Biology · doi:10.1083/jcb.115.5.1383 · Cited by 678 · see citing works
Self-citationApoptotic cell death and tissue remodelling during mouse mammary gland involution
Strange, R., Li, F., Saurer, S., Burkhardt, A., & Friis, R. R. (1992) · Development · doi:10.1242/dev.115.1.49 · Cited by 533 · see citing works
Damsky, C. H., & Werb, Z. (1992) · Current Opinion in Cell Biology · doi:10.1016/0955-0674(92)90100-q · Cited by 524 · see citing works
Self-citationMatsuyoshi, N., Hamaguchi, M., Taniguchi, S., Nagafuchi, A., Tsukita, S., & Takeichi, M. (1992) · The Journal of Cell Biology · doi:10.1083/jcb.118.3.703 · Cited by 510 · see citing works
Beta4 integrin is required for hemidesmosome formation, cell adhesion and cell survival.
Dowling, J. J., Yu, Q. C., & Fuchs, E. V. (1996) · The Journal of Cell Biology · doi:10.1083/jcb.134.2.559 · Cited by 508 · see citing works
Roskelley, C. D., Desprez, P. Y., & Bissell, M. J. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.26.12378 · Cited by 473 · see citing works
Self-citationDifferential loss of E-cadherin expression in infiltrating ductal and lobular breast carcinomas.
Moll, R., Mitze, M., Frixen, U. H., & Birchmeier, W. (1993) · PubMed Central · Cited by 458 · see citing works
Guo, L., Degenstein, L., Dowling, J. J., Yu, Q., Wollmann, R. L., Perman, B., & Fuchs, E. V. (1995) · Cell · doi:10.1016/0092-8674(95)90333-x · Cited by 440 · see citing works
Sympson, C. J. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.125.3.681 · Cited by 400 · see citing works
A hierarchy of ECM-mediated signalling regulates tissue-specific gene expression
Roskelley, C. D. (1995) · Current Opinion in Cell Biology · doi:10.1016/0955-0674(95)80117-0 · Cited by 385 · see citing works
Boudreau, N. J., Werb, Z., & Bissell, M. J. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.8.3509 · Cited by 340 · see citing works
Self-citationCell shape, cytoskeletal mechanics, and cell cycle control in angiogenesis
Ingber, D. E., Prusty, D., Sun, Z., Betensky, H., & Wang, N. (1995) · Journal of Biomechanics · doi:10.1016/0021-9290(95)00095-x · Cited by 335 · see citing works
Näthke, I. S., Hinck, L., Swedlow, J. R., Papkoff, J. S., & Nelson, W. J. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.125.6.1341 · Cited by 321 · see citing works
An Essential Cytoskeletal Linker Protein Connecting Actin Microfilaments to Intermediate Filaments
Yang, Y., Dowling, J. J., Yu, Q., Kouklis, P. D., Cleveland, D. W., & Fuchs, E. V. (1996) · Cell · doi:10.1016/s0092-8674(00)80138-5 · Cited by 305 · see citing works
Tyrosine phosphorylation regulates the adhesions of ras-transformed breast epithelia.
Kinch, M. S., Clark, G. J., Der, C. J., & Burridge, K. (1995) · The Journal of Cell Biology · doi:10.1083/jcb.130.2.461 · Cited by 299 · see citing works
Sorokin, L. M., Sonnenberg, A., Aumailley, M., Timpl, R., & Ekblom, P. (1990) · The Journal of Cell Biology · doi:10.1083/jcb.111.3.1265 · Cited by 245 · see citing works
Briand, P., PETERSEN, O. W., & van Deurs, B. (1987) · In Vitro Cellular & Developmental Biology - Plant · doi:10.1007/bf02623578 · Cited by 241 · see citing works
Self-citationZutter, M. M., Santoro, S. A., Staatz, W. D., & Tsung, Y. L. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.16.7411 · Cited by 232 · see citing works
Hodivala‐Dilke, K., & Watt, F. M. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.124.4.589 · Cited by 218 · see citing works
Hemidesmosomes: roles in adhesion, signaling and human diseases
Borradori, L., & Sonnenberg, A. (1996) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(96)80106-2 · Cited by 212 · see citing works
Symington, B. E., Takada, Y., & Carter, W. G. (1993) · The Journal of Cell Biology · doi:10.1083/jcb.120.2.523 · Cited by 210 · see citing works
Takada, Y., & Puzon, W. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)85374-7 · Cited by 207 · see citing works
Howlett, A. R., Bailey, N., Damsky, C. H., PETERSEN, O. W., & Bissell, M. J. (1995) · Journal of Cell Science · doi:10.1242/jcs.108.5.1945 · Cited by 204 · see citing works
Self-citationIntegrin-mediated adhesion and signaling in tumorigenesis
Giancotti, F. G., & Mainiero, F. (1994) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/0304-419x(94)90005-1 · Cited by 199 · see citing works
Friedrichs, K., Ruiz, P., Franke, F. A., Gille, I., Terpe, H.-J., & Imhof, B. A. (1995) · PubMed · Cited by 195 · see citing works
Sastry, S. K., Lakonishok, M., Thomas, D. A., Muschler, J. L., & Horwitz, A. F. (1996) · The Journal of Cell Biology · doi:10.1083/jcb.133.1.169 · Cited by 192 · see citing works
The ?6?1 and ?6?4 integrins in human prostate cancer progression
Cress, A. E., Rabinovitz, I., Zhu, W., & Nagle, R. B. (1995) · Cancer and Metastasis Reviews · doi:10.1007/bf00690293 · Cited by 185 · see citing works
Suppression of Mammary Epithelial Cell Differentiation by the Helix-Loop-Helix Protein Id-1
Desprez, P., Hara, E., Bissell, M. J., & Campisi, J. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.6.3398 · Cited by 183 · see citing works
Self-citationbeta-Catenin associates with the actin-bundling protein fascin in a noncadherin complex.
Tao, Y., Edwards, R. A., Tubb, B. E., Wang, S., Bryan, J., & McCrea, P. D. (1996) · The Journal of Cell Biology · doi:10.1083/jcb.134.5.1271 · Cited by 175 · see citing works
c-erbB-2 Gene Product Associates with Catenins in Human Cancer Cells
Ochiai, A., Akimoto, S., Kanai, Y., Shibata, T., Oyama, T., & Hirohashi, S. (1994) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1994.2631 · Cited by 162 · see citing works
Howlett, A. R., PETERSEN, O. W., Bissell, M. J., & Steeg, P. S. (1994) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/86.24.1838 · Cited by 154 · see citing works
Self-citationD’Souza, B., & Taylor‐Papadimitriou, J. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.15.7202 · Cited by 148 · see citing works
Regulation of keratinocyte terminal differentiation by integrin-extracellular matrix interactions
Watt, F. M., Kubler, M.-D., Hotchin, N. A., Nicholson, L. J., & Adams, J. C. (1993) · Journal of Cell Science · doi:10.1242/jcs.106.1.175 · Cited by 144 · see citing works
Activation of the p21 Pathway of Growth Arrest and Apoptosis by the β4 Integrin Cytoplasmic Domain
Clarke, A. S., Lotz, M. M., Chao, C., & Mercurio, A. M. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.39.22673 · Cited by 134 · see citing works
The development of a functionally relevant cell culture model of progressive human breast cancer
Weaver, V. M., Howlett, A. R., Langton-Webster, B. C., PETERSEN, O. W., & Bissell, M. J. (1995) · Seminars in Cancer Biology · doi:10.1006/scbi.1995.0021 · Cited by 132 · see citing works
Self-citationRegulation of cell surface beta 1 integrin levels during keratinocyte terminal differentiation.
Hotchin, N. A., Gandarillas, A., & Watt, F. M. (1995) · The Journal of Cell Biology · doi:10.1083/jcb.128.6.1209 · Cited by 130 · see citing works
Schoenenberger, C., Żuk, A., Zinkl, G. M., Kendall, D., & Matlin, K. S. (1994) · Journal of Cell Science · doi:10.1242/jcs.107.2.527 · Cited by 125 · see citing works
Spinardi, L., Ren, Y. L., Sanders, R., & Giancotti, F. G. (1993) · Molecular Biology of the Cell · doi:10.1091/mbc.4.9.871 · Cited by 124 · see citing works
The Extracellular Matrix in Epithelial Biology: Shared Molecules and Common Themes in Distant Phyla
Ashkenas, J., Muschler, J. L., & Bissell, M. J. (1996) · Developmental Biology · doi:10.1006/dbio.1996.0317 · Cited by 122 · see citing works
Self-citationRegulation of epithelial cell surface polarity reversal by β1 integrins
Ojakian, G. K., & Schwimmer, R. (1994) · Journal of Cell Science · doi:10.1242/jcs.107.3.561 · Cited by 119 · see citing works
Briand, P., Nielsen, K. V., Madsen, M. W., & PETERSEN, O. W. (1996) · PubMed · Cited by 118 · see citing works
Self-citationBasement membrane diversity detected by monoclonal antibodies
Hessle, H., Sakai, L. Y., Hollister, D. W., Burgeson, R. E., & Engvall, E. (1984) · Differentiation · doi:10.1111/j.1432-0436.1984.tb01372.x · Cited by 117 · see citing works
Changes in expression of α6/β 4 integrin heterodimer in primary and metastatic breast cancer
Natali, P., Nicotra, M., Botti, C., Mottolese, M., Bigotti, A., & Segatto, O. (1992) · British Journal of Cancer · doi:10.1038/bjc.1992.263 · Cited by 113 · see citing works
Teratocarcinomas and Other Neoplasms as Developmental Defects in Gene Expression
Mintz, B., & Fleischman, R. A. (1981) · Advances in cancer research · doi:10.1016/s0065-230x(08)60243-2 · Cited by 107 · see citing works
Nonmitogenic Morphoregulatory Action of pp6Ov-src on Multicellular Epithelial Structures
Warren, S. L., & Nelson, W. J. (1987) · Molecular and Cellular Biology · doi:10.1128/mcb.7.4.1326-1337.1987 · Cited by 107 · see citing works
Developmental expression of the syndecans: possible function and regulation
Bernfield, M. R., Hinkes, M. T., & Gallo, R. L. (1993) · Development · doi:10.1242/dev.119.supplement.205 · Cited by 105 · see citing works
Giancotti, F. G. (1996) · Journal of Cell Science · doi:10.1242/jcs.109.6.1165 · Cited by 100 · see citing works
Altered integrin expression in adenocarcinoma of the breast. Analysis by in situ hybridization.
Zutter, M. M., Krigman, H. R., & Santoro, S. A. (1993) · PubMed · Cited by 98 · see citing works
Fujita, S., Suzuki, H., Kinoshita, M., & Hirohashi, S. (1992) · Japanese Journal of Cancer Research · doi:10.1111/j.1349-7006.1992.tb02764.x · Cited by 93 · see citing works
Distribution of the alpha 1-alpha 6 integrin subunits in human developing and term placenta.
Korhonen, M. O., Ylänne, J., Laitinen, L. A., Cooper, H. M., Quaranta, & Virtanen, I. (1991) · PubMed · Cited by 93 · see citing works
Shaw, L. M., Chao, C., Wewer, U. M., & Mercurio, A. M. (1996) · PubMed · Cited by 90 · see citing works
Stoker, A. W., Hatier, C., & Bissell, M. J. (1990) · The Journal of Cell Biology · doi:10.1083/jcb.111.1.217 · Cited by 88 · see citing works
Self-citationSonnenberg, A., Hogervorst, F. B. L., Osterop, A., & Veltman, F. E. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)68180-3 · Cited by 87 · see citing works
Integrin expression in primary breast cancer and its relation to axillary nodal status
Gui, G. P. H., Wells, C. A., Browne, P., Yeomans, P., Jordan, S., Puddefoot, J. R., Vinson, G. P., & Carpenter, R. (1995) · Surgery · doi:10.1016/s0039-6060(05)80236-3 · Cited by 82 · see citing works
A novel laminin E8 cell adhesion site required for lung alveolar formation in vitro
Matter, M. L., & Laurie, G. W. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.124.6.1083 · Cited by 82 · see citing works
[25] Cell differentiation by extracellular matrix components
Blaschke, R., Howlett, A. R., Desprez, P. Y., PETERSEN, O. W., & Bissell, M. J. (1994) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(94)45027-7 · Cited by 81 · see citing works
Self-citationd'Ardenne, A. J., Richman, P. I., Horton, M. A., McAulay, A., & Jordan, S. (1991) · The Journal of Pathology · doi:10.1002/path.1711650304 · Cited by 71 · see citing works
Braga, V. M. M., Hodivala‐Dilke, K., & Watt, F. M. (1995) · Cell Communication & Adhesion · doi:10.3109/15419069509081287 · Cited by 65 · see citing works
Integrin mediated signal transduction in oncogenesis: An overview
Dedhar, S. (1995) · Cancer and Metastasis Reviews · doi:10.1007/bf00690289 · Cited by 61 · see citing works
Cell adhesion molecules in the normal and cancerous mammary gland
Alford, D., & Taylor‐Papadimitriou, J. (1996) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1007/bf02013644 · Cited by 61 · see citing works
Fujita, S., Watanabe, M., Kubota, T., Teramoto, T., & Kitajima, M. (1995) · Cancer Letters · doi:10.1016/0304-3835(95)03735-f · Cited by 60 · see citing works
Role of Integrins in Cell Adhesion and Polarity in Normal Keratinocytes and Human Skin Pathologies
Luca, M. D., Pellegrini, G., Zambruno, G., & Marchisio, P. C. (1994) · The Journal of Dermatology · doi:10.1111/j.1346-8138.1994.tb03296.x · Cited by 58 · see citing works
Madsen, M. W., Lykkesfeldt, A. E., Laursen, I., Nielsen, K. V., & Briand, P. (1992) · PubMed · Cited by 55 · see citing works
Self-citationDoyle, J., Stempak, J. G., Cowin, P., Colman, D., & D’Urso, D. (1995) · The Journal of Cell Biology · doi:10.1083/jcb.131.2.465 · Cited by 55 · see citing works
Schmidt, J. W., Piepenhagen, P. A., & Nelson, W. J. (1993) · Seminars in Cell Biology · doi:10.1006/scel.1993.1020 · Cited by 52 · see citing works
Saiki, I., Murata, J., Matsuno, K., Ogawa, R., Nishi, N., Tokura, S., & Azuma, I. (1990) · Japanese Journal of Cancer Research · doi:10.1111/j.1349-7006.1990.tb02624.x · Cited by 49 · see citing works
Investigation of the role of β1 integrins in cell-cell adhesion
Weitzman, J. B., Chen, S. A., & Hemler, M. E. (1995) · Journal of Cell Science · doi:10.1242/jcs.108.11.3635 · Cited by 47 · see citing works
Jewell, K., Kapron‐Brás, C. M., Jeevaratnam, P., & Dedhar, S. (1995) · Journal of Cell Science · doi:10.1242/jcs.108.3.1165 · Cited by 46 · see citing works
Rossen, K., Dahlstrøm, K. K., Mercurio, A. M., & Wewer, U. M. (1994) · Acta Dermato Venereologica · doi:10.2340/0001555574106109 · Cited by 45 · see citing works
B Lymphocyte Fibronectin Receptors: Expression and Utilization
Stupack, D. G., STEWART, S., CARTER, W. G., Wayner, E. A., & Wilkins, J. A. (1991) · Scandinavian Journal of Immunology · doi:10.1111/j.1365-3083.1991.tb01601.x · Cited by 39 · see citing works
Moyret‐Lalle, C., Madsen, M. W., Cooke, J., Briand, P., & Theillet, C. G. (1994) · Experimental Cell Research · doi:10.1006/excr.1994.1355 · Cited by 36 · see citing works
Self-citationMortarini, R., Gismondi, A., Maggioni, A., Santoni, A., Herlyn, M., & Anichini, A. (1995) · PubMed · Cited by 34 · see citing works
The role of cadherin-mediated adhesion in breast cancer
Sommers, C. L. (1996) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1007/bf02013645 · Cited by 32 · see citing works
Leppä, S., Heino, J., & Jalkanen, M. (1995) · PubMed · Cited by 31 · see citing works
Nielsen, K. V., Madsen, M. W., & Briand, P. (1994) · Cancer Genetics and Cytogenetics · doi:10.1016/0165-4608(94)90089-2 · Cited by 29 · see citing works
Self-citationNielsen, K. V., & Briand, P. (1989) · Cancer Genetics and Cytogenetics · doi:10.1016/0165-4608(89)90236-7 · Cited by 27 · see citing works
Self-citationDhawan, J., & Farmer, S. R. (1994) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-2578-3_15 · Cited by 6 · see citing works
ALTERATIONS IN INTEGRIN AND BASEMENT-MEMBRANE PROTEIN EXPRESSION BY MALIGNANT BREAST CELLS
Bergstraesser, L. M., & Weitzman, S. (1994) · International Journal of Oncology · doi:10.3892/ijo.4.4.915 · Cited by 4 · see citing works
Flagged first, then by citations
1 of the 98 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- Rossen K Dahlstrom KK Mercurio AM Wewer UM Expression of the α6β4 integrin by squamous cell carcinomas and basal cell carcinomas: possible relation to invasive potential? Acta Dermato-Venereologica 1994 74 101 105 7911612
- Streuli CH Bailey N Bissell MJ Control of mammary epithelial differentiation: the separate roles of cell-substratum and cell–cell interaction J Cell Biol 1991 115 1383 1395 1955479 PMC2289247
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Damm, T. B., & Egli, M. (2014) · Cellular Physiology and Biochemistry · doi:10.1159/000356667 · Cited by 14,548 · see citing works
Tumour exosome integrins determine organotropic metastasis
Hoshino, A., Costa-Silva, B., Shen, T.-L., Rodrigues, G., Hashimoto, A., Tesic Mark, M., Molina, H., Kohsaka, S., Di Giannatale, A., Ceder, S., et al. (2015) · Nature · doi:10.1038/nature15756 · Cited by 5,101 · see citing works
Self-citationMatrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling
Levental, K. R., Yu, H., Kass, L., Lakins, J. N., Egeblad, M., Erler, J. T., Fong, S. F. T., Csiszar, K., Giaccia, A., Weninger, W., et al. (2009) · Cell · doi:10.1016/j.cell.2009.10.027 · Cited by 4,101 · see citing works
Self-citationMicroenvironmental regulation of metastasis
Joyce, J. A., & Pollard, J. W. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2618 · Cited by 3,684 · see citing works
The third dimension bridges the gap between cell culture and live tissue
Pampaloni, F., Reynaud, E. G., & Stelzer, E. H. K. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2236 · Cited by 2,817 · see citing works
Edmondson, R., Broglie, J. J., Adcock, A. F., & Yang, L. (2014) · ASSAY and Drug Development Technologies · doi:10.1089/adt.2014.573 · Cited by 2,515 · see citing works
Stromal fibroblasts in cancer initiation and progression
Bhowmick, N. A., Neilson, E. G., & Moses, H. L. (2004) · Nature · doi:10.1038/nature03096 · Cited by 2,291 · see citing works
Bissell, M. J., & Radisky, D. (2001) · Nature Reviews Cancer · doi:10.1038/35094059 · Cited by 2,180 · see citing works
Self-citationDebnath, J., Muthuswamy, S. K., & Brugge, J. S. (2003) · Methods · doi:10.1016/s1046-2023(03)00032-x · Cited by 2,001 · see citing works
A tense situation: forcing tumour progression
Butcher, D. T., Alliston, T. N., & Weaver, V. M. (2009) · Nature reviews. Cancer · doi:10.1038/nrc2544 · Cited by 1,922 · see citing works
Self-citationFriends or foes — bipolar effects of the tumour stroma in cancer
Mueller, M. M., & Fusenig, N. E. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1477 · Cited by 1,757 · see citing works
Deconstructing the third dimension – how 3D culture microenvironments alter cellular cues
Baker, B. M., & Chen, C. S. (2012) · Journal of Cell Science · doi:10.1242/jcs.079509 · Cited by 1,760 · see citing works
Models, mechanisms and clinical evidence for cancer dormancy
Aguirre‐Ghiso, J. A. (2007) · Nature reviews. Cancer · doi:10.1038/nrc2256 · Cited by 1,673 · see citing works
Cox, T. R., & Erler, J. T. (2011) · Disease Models & Mechanisms · doi:10.1242/dmm.004077 · Cited by 1,569 · see citing works
Choosing the right cell line for breast cancer research
Holliday, D. L., & Speirs, V. (2011) · Breast Cancer Research · doi:10.1186/bcr2889 · Cited by 1,548 · see citing works
Bissell, M. J., & Hines, W. C. (2011) · Nature Medicine · doi:10.1038/nm.2328 · Cited by 1,516 · see citing works
Self-citationIntegrin signalling during tumour progression
Guo, W., & Giancotti, F. G. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1490 · Cited by 1,473 · see citing works
Three-dimensional culture models of normal and malignant breast epithelial cells
Lee, G. Y., Kenny, P. A., Lee, E. H., & Bissell, M. J. (2007) · Nature Methods · doi:10.1038/nmeth1015 · Cited by 1,336 · see citing works
Self-citationThree-dimensional cell culture: the missing link in drug discovery
Breslin, S., & O’Driscoll, L. (2013) · Drug Discovery Today · doi:10.1016/j.drudis.2012.10.003 · Cited by 1,332 · see citing works
Integrins as biomechanical sensors of the microenvironment
Kechagia, J. Z., Ivaska, J., & Roca-Cusachs, P. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0134-2 · Cited by 1,311 · see citing works
Tumors as Organs: Complex Tissues that Interface with the Entire Organism
Egeblad, M., Nakasone, E. S., & Werb, Z. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.05.012 · Cited by 1,230 · see citing works
Abbott, A. (2003) · Nature · doi:10.1038/424870a · Cited by 1,237 · see citing works
3D Cell Culture Systems: Advantages and Applications
Ravi, M., Paramesh, V., Kaviya, S. R., Anuradha, E., & Solomon, F. D. P. (2015) · Journal of Cellular Physiology · doi:10.1002/jcp.24683 · Cited by 1,206 · see citing works
Kim, S., Turnbull, J. E., & Guimond, S. E. (2011) · Journal of Endocrinology · doi:10.1530/joe-10-0377 · Cited by 1,166 · see citing works
The perivascular niche regulates breast tumour dormancy
Ghajar, C. M., Peinado, H., Mori, H., Matei, I. R., Evason, K. J., Brazier, H., Almeida, D., Koller, A., Hajjar, K. A., Stainier, D. Y. R., et al. (2013) · Nature Cell Biology · doi:10.1038/ncb2767 · Cited by 1,148 · see citing works
Self-citationNelson, C. M., & Bissell, M. J. (2006) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.22.010305.104315 · Cited by 1,121 · see citing works
Self-citationCancer-Associated Stromal Fibroblasts Promote Pancreatic Tumor Progression
Hwang, R. F., Moore, T. T., Arumugam, T., Ramachandran, V., Amos, K. D., Rivera, A. M., Ji, B., Evans, D. B., & Logsdon, C. D. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-5714 · Cited by 1,093 · see citing works
Role of Extracellular Matrix in Development and Cancer Progression
Walker, C., Mojares, E., & Hernández, A. E. D. R. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19103028 · Cited by 1,103 · see citing works
Three-Dimensional Cell Culture Matrices: State of the Art
Lee, J., Cuddihy, M. J., & Kotov, N. A. (2008) · Tissue Engineering Part B: Reviews · doi:10.1089/teb.2007.0150 · Cited by 1,047 · see citing works
Kenny, P. A., Lee, G. Y., Myers, C. A., Neve, R. M., Semeiks, J. R., Spellman, P. T., Lorenz, K., Lee, E. H., Barcellos‐Hoff, M. H., PETERSEN, O. W., et al. (2008) · eScholarship (California Digital Library) · Cited by 1,039 · see citing works
Self-citationVinci, M., Gowan, S., Boxall, F., Patterson, L., Zimmermann, M., Court, W., Lomas, C., Mendiola, M., Hardisson, D., & Eccles, S. A. (2012) · BMC Biology · doi:10.1186/1741-7007-10-29 · Cited by 1,024 · see citing works
Modelling glandular epithelial cancers in three-dimensional cultures
Debnath, J., & Brugge, J. S. (2005) · Nature reviews. Cancer · doi:10.1038/nrc1695 · Cited by 1,014 · see citing works
Transduction of mechanical and cytoskeletal cues by YAP and TAZ
Halder, G., Dupont, S., & Piccolo, S. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3416 · Cited by 985 · see citing works
Environment-mediated drug resistance: A major contributor to minimal residual disease
Meads, M. B., Gatenby, R. A., & Dalton, W. S. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2714 · Cited by 892 · see citing works
Sensing the environment: a historical perspective on integrin signal transduction
Miranti, C. K., & Brugge, J. S. (2002) · Nature Cell Biology · doi:10.1038/ncb0402-e83 · Cited by 851 · see citing works
Chaudhuri, O., Koshy, S. T., Branco da Cunha, C., Shin, J.-W., Verbeke, C. S., Allison, K. H., & Mooney, D. J. (2014) · Nature Materials · doi:10.1038/nmat4009 · Cited by 820 · see citing works
Weaver, V. M., Lelièvre, S. A., Lakins, J. N., Chrenek, M. A., Jones, J., Giancotti, F. G., Werb, Z., & Bissell, M. J. (2002) · Cancer Cell · doi:10.1016/s1535-6108(02)00125-3 · Cited by 794 · see citing works
Self-citationXiong, G., Deng, L., Zhu, J., Rychahou, P. G., & Xu, R. (2014) · BMC Cancer · doi:10.1186/1471-2407-14-1 · Cited by 756 · see citing works
Three-dimensional organotypic culture: experimental models of mammalian biology and disease
Shamir, E. R., & Ewald, A. J. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3873 · Cited by 719 · see citing works
Cellular signaling by neural cell adhesion molecules of the immunoglobulin superfamily
Crossin, K. L., & Krushel, L. A. (2000) · Developmental Dynamics · doi:10.1002/(sici)1097-0177(200006)218:2 · Cited by 283 · see citing works
Provenzano, P. P., Inman, D. R., Eliceiri, K. W., & Keely, P. J. (2009) · Oncogene · doi:10.1038/onc.2009.299 · Cited by 679 · see citing works
The metalloproteinase matrilysin is a target of β-catenin transactivation in intestinal tumors
Crawford, H. C., Fingleton, B., Rudolph‐Owen, L. A., Goss, K. H., Rubinfeld, B., Polakis, P. G., & Matrisian, L. M. (1999) · Oncogene · doi:10.1038/sj.onc.1202627 · Cited by 674 · see citing works
Mechanisms and insights into drug resistance in cancer
Zahreddine, H. A., & Borden, K. L. B. (2013) · Frontiers in Pharmacology · doi:10.3389/fphar.2013.00028 · Cited by 660 · see citing works
Lochter, A., Galosy, S., Muschler, J. L., Freedman, N. D., Werb, Z., & Bissell, M. J. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.139.7.1861 · Cited by 657 · see citing works
Self-citationWang, F., Weaver, V. M., Petersen, O. W., Larabell, C. A., Dedhar, S., Briand, P., Lupu, R., & Bissell, M. J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.25.14821 · Cited by 653 · see citing works
Self-citationMechanical compression drives cancer cells toward invasive phenotype
Tse, J. M., Cheng, G., Tyrrell, J. A., Wilcox-Adelman, S. A., Boucher, Y., Jain, R. K., & Munn, L. L. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1118910109 · Cited by 631 · see citing works
Organoids: A historical perspective of thinking in three dimensions
Simian, M., & Bissell, M. J. (2017) · Journal of Cell Biology · doi:10.1083/jcb.201610056 · Cited by 620 · see citing works
Self-citationThe organizing principle: microenvironmental influences in the normal and malignant breast
Bissell, M. J., Radisky, D. C., Rizki, A., Weaver, V. M., & PETERSEN, O. W. (2002) · Differentiation · doi:10.1046/j.1432-0436.2002.700907.x · Cited by 602 · see citing works
Self-citationLoessner, D., Stok, K. S., Lutolf, M. P., Hutmacher, D. W., Clements, J. A., & Rizzi, S. C. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.07.064 · Cited by 602 · see citing works
Building epithelial architecture: insights from three-dimensional culture models
O'Brien, L. E., Zegers, M. M. P., & Mostov, K. E. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm859 · Cited by 596 · see citing works
The rationale for targeting the LOX family in cancer
Barker, H. E., Cox, T. R., & Erler, J. T. (2012) · Nature reviews. Cancer · doi:10.1038/nrc3319 · Cited by 592 · see citing works
Gene expression perturbation in vitro—A growing case for three-dimensional (3D) culture systems
Birgersdotter, A., Sandberg, R., & Ernberg, I. (2005) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2005.06.009 · Cited by 591 · see citing works
Modeling tissue-specific signaling and organ function in three dimensions
Schmeichel, K. L., & Bissell, M. J. (2003) · Journal of Cell Science · doi:10.1242/jcs.00503 · Cited by 583 · see citing works
Self-citationCell line-based platforms to evaluate the therapeutic efficacy of candidate anticancer agents
Sharma, S. V., Haber, D. A., & Settleman, J. (2010) · Nature reviews. Cancer · doi:10.1038/nrc2820 · Cited by 585 · see citing works
Therapeutic targeting of the tumor microenvironment
Joyce, J. A. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.05.024 · Cited by 580 · see citing works
The dormant cancer cell life cycle
Phan, T. G., & Croucher, P. I. (2020) · Nature reviews. Cancer · doi:10.1038/s41568-020-0263-0 · Cited by 581 · see citing works
Engineered In Vitro Disease Models
Benam, K. H., Dauth, S., Hassell, B., Herland, A., Jain, A., Jang, K.-J., Karalis, K., Kim, H. J., MacQueen, L., Mahmoodian, R., et al. (2015) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-012414-040418 · Cited by 554 · see citing works
ErbB2, but not ErbB1, reinitiates proliferation and induces luminal repopulation in epithelial acini
Muthuswamy, S. K., Li, D., Lelièvre, S. A., Bissell, M. J., & Brugge, J. S. (2001) · Nature Cell Biology · doi:10.1038/ncb0901-785 · Cited by 554 · see citing works
Self-citationBilder, D. H. (2004) · Genes & Development · doi:10.1101/gad.1211604 · Cited by 552 · see citing works
ECM signalling: orchestrating cell behaviour and misbehaviour
Lukashev, M. (1998) · Trends in Cell Biology · doi:10.1016/s0962-8924(98)01362-2 · Cited by 551 · see citing works
Barcellos‐Hoff, M. H., & Ravani, S. A. (2000) · PubMed · Cited by 536 · see citing works
Three-dimensional printing of Hela cells for cervical tumor model in vitro
Zhao, Y., Yao, R., Ouyang, L., Ding, H., Zhang, T., Zhang, K., Cheng, S., & Sun, W. (2014) · Biofabrication · doi:10.1088/1758-5082/6/3/035001 · Cited by 537 · see citing works
Cellular control lies in the balance of forces
Chicurel, M., Chen, C. S., & Ingber, D. E. (1998) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(98)80145-2 · Cited by 529 · see citing works
Schedin, P. S., & Keely, P. J. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a003228 · Cited by 523 · see citing works
Gibbons, D. L., Lin, W., Creighton, C. J., Rizvi, Z. H., Gregory, P. A., Goodall, G. J., Thilaganathan, N., Du, L., Zhang, Y., Pertsemlidis, A., et al. (2009) · Genes & Development · doi:10.1101/gad.1820209 · Cited by 516 · see citing works
Oncogenes and Tumor Suppressor GenesPreprint
Lee, E. Y., & Muller, W. J. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a003236 · Cited by 515 · see citing works
A Simple Hanging Drop Cell Culture Protocol for Generation of 3D Spheroids
Foty, R. (2011) · Journal of Visualized Experiments · doi:10.3791/2720 · Cited by 263 · see citing works
Microfluidic 3D cell culture: from tools to tissue models
van Duinen, V., Trietsch, S. J., Joore, J., Vulto, P., & Hankemeier, T. (2015) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2015.05.002 · Cited by 500 · see citing works
Engineered Microenvironments for Controlled Stem Cell Differentiation
Burdick, J. A., & Vunjak-Novakovic, G. (2009) · Tissue Engineering Part A · doi:10.1089/ten.tea.2008.0131 · Cited by 485 · see citing works
The Tension Mounts: Mechanics Meets Morphogenesis and Malignancy
Paszek, M. J., & Weaver, V. M. (2004) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1007/s10911-004-1404-x · Cited by 468 · see citing works
Self-citationTissue architecture: the ultimate regulator of breast epithelial function
Bissell, M. J., Rizki, A., & Mian, S. I. (2003) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2003.10.016 · Cited by 465 · see citing works
Self-citationSmalley, K. S. M., Haass, N. K., Brafford, P. A., Lioni, M., Flaherty, K. T., & Herlyn, M. (2006) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-06-0084 · Cited by 464 · see citing works
Perspectives on biological growth and remodeling
Ambrosi, D., Ateshian, G. A., Arruda, E. M., Cowin, S. C., Dumais, J., Goriely, A., Holzapfel, G. A., Humphrey, J. D., Kemkemer, R., Ellen Kuhl, A., et al. (2010) · Journal of the Mechanics and Physics of Solids · doi:10.1016/j.jmps.2010.12.011 · Cited by 456 · see citing works
Three-dimensional in vitro tumor models for cancer research and drug evaluation
Xu, X., Farach‐Carson, M. C., & Jia, X. (2014) · Biotechnology Advances · doi:10.1016/j.biotechadv.2014.07.009 · Cited by 462 · see citing works
Context, tissue plasticity, and cancer
Bissell, M. J., & LaBarge, M. A. (2005) · Cancer Cell · doi:10.1016/j.ccr.2004.12.013 · Cited by 507 · see citing works
Self-citationMammary adipocytes stimulate breast cancer invasion through metabolic remodeling of tumor cells
Wang, Y. Y., Attané, C., Milhas, D., Dirat, B., Dauvillier, S., Guérard, A., Gilhodes, J., Lazar, I., Alet, N., Laurent, V., et al. (2017) · JCI Insight · doi:10.1172/jci.insight.87489 · Cited by 458 · see citing works
β4 Integrin Amplifies ErbB2 Signaling to Promote Mammary Tumorigenesis
Guo, W., Pylayeva, Y., Pepe, A., Yoshioka, T., Muller, W. J., Inghirami, G., & Giancotti, F. G. (2006) · Cell · doi:10.1016/j.cell.2006.05.047 · Cited by 455 · see citing works
Role of Integrins in Cancer: Survey of Expression Patterns
Mizejewski, G. J. (1999) · Proceedings of The Society for Experimental Biology and Medicine · doi:10.1046/j.1525-1373.1999.d01-122.x · Cited by 449 · see citing works
A Review of Three-Dimensional In Vitro Tissue Models for Drug Discovery and Transport Studies
Elliott, N. T., & Yuan, F. (2011) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.22257 · Cited by 449 · see citing works
Nguyen-Ngoc, K.-V., Cheung, K. J., Brenot, A., Shamir, E. R., Gray, R. S., Hines, W. C., Yaswen, P., Werb, Z., & Ewald, A. J. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1212834109 · Cited by 449 · see citing works
The tumor microenvironment is a dominant force in multidrug resistance
Correia, A. L., & Bissell, M. J. (2012) · Drug Resistance Updates · doi:10.1016/j.drup.2012.01.006 · Cited by 443 · see citing works
Self-citationSpatiotemporal hydrogel biomaterials for regenerative medicine
Brown, T. E., & Anseth, K. S. (2017) · Chemical Society Reviews · doi:10.1039/c7cs00445a · Cited by 428 · see citing works
Bioengineering strategies to accelerate stem cell therapeutics
Madl, C. M., Heilshorn, S. C., & Blau, H. M. (2018) · Nature · doi:10.1038/s41586-018-0089-z · Cited by 431 · see citing works
Inhibition of Metastatic Outgrowth from Single Dormant Tumor Cells by Targeting the Cytoskeleton
Barkan, D., Kleinman, H. K., Simmons, J. L., Asmussen, H., Kamaraju, A. K., Hoenorhoff, M. J., Liu, Z.-Y., Costes, S. V., Cho, E. H., Lockett, S., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-6849 · Cited by 426 · see citing works
Know thy neighbor: stromal cells can contribute oncogenic signals
Tlsty, T. D., & Hein, P. W. (2001) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(00)00156-8 · Cited by 425 · see citing works
White, D. E., Kurpios, N. A., Zuo, D., Hassell, J. A., Blaess, S., Mueller, U., & Muller, W. J. (2004) · Cancer Cell · doi:10.1016/j.ccr.2004.06.025 · Cited by 413 · see citing works
Extracellular matrix, integrins, and growth factors as tailors of the stem cell niche
Brizzi, M. F., Tarone, G., & Defilippi, P. (2012) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2012.07.001 · Cited by 412 · see citing works
The effects of surgery on tumor growth: a century of investigations
Demicheli, R., Retsky, M. W., Hrushesky, W. J. M., Baum, M., & Gukas, I. D. (2008) · Annals of Oncology · doi:10.1093/annonc/mdn386 · Cited by 400 · see citing works
The influence of the microenvironment on the malignant phenotype
Park, C. C., Bissell, M. J., & Barcellos-Hoff, M. H. (2000) · Molecular Medicine Today · doi:10.1016/s1357-4310(00)01756-1 · Cited by 398 · see citing works
Self-citationTissue mechanics modulate microRNA-dependent PTEN expression to regulate malignant progression
Mouw, J. K., Yui, Y., Damiano, L., Bainer, R. O., Lakins, J. N., Acerbi, I., Ou, G., Wijekoon, A. C., Levental, K. R., Gilbert, P. M., et al. (2014) · Nature Medicine · doi:10.1038/nm.3497 · Cited by 396 · see citing works
Self-citationSimian, M., Hirai, Y., Navre, M., Werb, Z., Lochter, A., & Bissell, M. J. (2001) · Development · doi:10.1242/dev.128.16.3117 · Cited by 392 · see citing works
Self-citationBhowmick, N. A., Zent, R., Ghiassi, M., McDonnell, M. A., & Moses, H. L. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m106176200 · Cited by 388 · see citing works
Fata, J. E., Werb, Z., & Bissell, M. J. (2003) · Breast Cancer Research · doi:10.1186/bcr634 · Cited by 387 · see citing works
Self-citationSleeboom, J. J. F., van Tienderen, G. S., Schenke‐Layland, K., van der Laan, L. J. W., Khalil, A. A., & Verstegen, M. M. A. (2024) · Science Translational Medicine · doi:10.1126/scitranslmed.adg3840 · Cited by 391 · see citing works
McGowan, K. A., & Marinkovich, M. P. (2000) · Microscopy Research and Technique · doi:10.1002/1097-0029(20001101)51:3 · Cited by 75 · see citing works
Extracellular matrix: A gatekeeper in the transition from dormancy to metastatic growth
Barkan, D., Green, J. E., & Chambers, A. F. (2010) · European Journal of Cancer · doi:10.1016/j.ejca.2010.02.027 · Cited by 378 · see citing works
Signalling via integrins: Implications for cell survival and anticancer strategies
Hehlgans, S., Haase, M., & Cordes, N. (2006) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2006.09.001 · Cited by 374 · see citing works
Biological applications of microfluidic gradient devices
Kim, S., Kim, H. J., & Jeon, N. L. (2010) · Integrative Biology · doi:10.1039/c0ib00055h · Cited by 366 · see citing works
Extracellular matrix signaling: integration of form and function in normal and malignant cells
Boudreau, N. J., & Bissell, M. J. (1998) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(98)80040-9 · Cited by 363 · see citing works
Self-citationβ1-Integrin Orients Epithelial Polarity via Rac1 and Laminin
Yu, W., Datta, A., Leroy, P., O’Brien, L. E., Mak, G. Z., Jou, T., Matlin, K. S., Mostov, K. E., & Zegers, M. M. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-05-0435 · Cited by 361 · see citing works
- Authors
- Weaver, V. M., Petersen, O. W., Wang, F., Larabell, C. A., Briand, P., Damsky, C., & Bissell, M. J.
- Affiliations
- Lawrence Berkeley National Laboratory (US)
- Corresponding author
- Weaver, V.M.
- ORCID
- Weaver, V.M.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 1997-04-07
- Volume
- 137
- Issue
- 1
- Pages
- 231-245
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- PMC
- PMC2139858
- OpenAlex
- W1541555963
- Cited by
- 1,483
- References
- 98
- Citations by year
- 2026: 19 · 2025: 27 · 2024: 19 · 2023: 51 · 2022: 38 · 2021: 49 · 2020: 50 · 2019: 51 · 2018: 62 · 2017: 63 · 2016: 63 · 2015: 58 · 2014: 64 · 2013: 63 · 2012: 89
- FWCI
- 13.87
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Cell Biology (publishedVersion)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- University of North Texas Digital Library (University of North Texas) (submittedVersion)
- OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Lawrence Berkeley National Laboratory
- Funders
- U.S. Department of Defense (DE-AC02-05CH11231)
- U.S. Department of Energy (-AC02-05CH11231, DE-AC03-?, 05CH11231, DE AC02 05CH11231, DE-AC03-SF00098, DE-AC02-)
- Sundhed og Sygdom, Det Frie Forskningsråd
- National Institutes of Health (DE-AC02–05CH11231)
- Medical Research Council (DE-AC02-05CH11231)
- National Cancer Institute (CA-64786, R37CA064786, R01CA064786)
- Lawrence Berkeley National Laboratory (AC02‐05CH11231, DE-AC02-05CH11231, 05CH11231)
- Topics
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Keywords
- beta1 integrin, integrin blocking antibodies, breast cancer, 3D cell culture, E-cadherin-catenin complex, adherens junctions, extracellular matrix, mammary epithelial cells, cyclin D1, p21, tumor growth inhibition, cell polarity, tissue structure
- MeSH terms
- Animals, Antibodies, Monoclonal, Basement Membrane, Binding, Competitive, Breast Neoplasms, Cell Division, Extracellular Matrix, Female, Fluorescent Antibody Technique, Genotype, Humans, Immunoglobulin Fab Fragments, Phenotype, Transformation, Genetic, Tumor Cells, Cultured, Signal Transduction, Antigens, CD, Integrin beta1, Integrin beta4, Mice, Rats
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