Organoid Profiling Identifies Common Responders to Chemotherapy in Pancreatic Cancer
Tiriac, Hervé, Belleau, Pascal, Engle, Dannielle D., Plenker, Dennis, Deschênes, Astrid, Somerville, Tim D. D., Froeling, Fieke E. M., Burkhart, Richard A. +62 more·2018·Cancer Discovery
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- Correlation of the treatment sensitivity of patient-derived organoids with treatment outcomes in patients with head and neck cancer (SOTO): protocol for a prospective observational studyIfigenia Vasiliadou, Christiana Cattaneo, Phoebe Yuen Ka Chan, Rhonda Henley‐Smith, Harry Gregson-Williams, Lisette Collins, Gabriella Wojewodka, Teresa Guerrero Urbano, Jean‐Pierre Jeannon, Steve E. J. Connor et al. · 2024 · BMJ Open
- Establishing a cryopreserved biobank of living tumor tissues for drug sensitivity testingPing Chen, Jingbo Zhou, Xiangpeng Chu, Yangyang Feng, Qibing Zeng, Josh-Haipeng Lei, Ka-Pou Wong, Tai-Ip Chan, Chon-Wa Lam, Wenli Zhu et al. · 2024 · Bioactive Materials
- Preliminary study of utilizing a patient derived tumor spheroid model to augment precision therapy in metastatic brain tumorsChun-Jen Chang, Kai‐Wen Kan, Yu‐Yin Shih, Yu-Han Nan, Yu-Chung Juan, Chih-Hsiu Tu, Chen-Ting Yang, Wei-Lin Hsu, Der‐Yang Cho, Ming‐You Shie et al. · 2024 · Scientific Reports
- Predicting patient outcomes with gene-expression biomarkers from colorectal cancer organoids and cell linesA. V. Razumovskaya, M. O. Silkina, Andrey A. Poloznikov, Timur Kulagin, M. P. Raigorodskaya, N. A. Gorban, Anna V. Kudryavtseva, Maria Fedorova, B. Yа. Alekseev, Alexander Tonevitsky et al. · 2025 · Frontiers in Molecular Biosciences
- Multiplexed glycan immunofluorescence identification of pancreatic cancer cell subpopulations in both tumor and blood samplesBraelyn Binkowski, Zachary L. Klamer, ChongFeng Gao, Ben Staal, Anna Repesh, Hoang-Le Tran, David M. Brass, Pamela Bartlett, Steve Gallinger, Maria Blomqvist et al. · 2025 · Science Advances
- Histamine H1 Receptor: A potential therapeutic target for pancreatic ductal adenocarcinomaCristina Salmerón, Elena Tomás Bort, Krishna Sriram, Mehrak Javadi Paydar, Jane E. Smitham, Kimberly Pham, Richard Philip Grose, Peter James McCormick, Anna Di Nardo, Jonathan Weitz et al. · 2025 · Journal of Pharmacology and Experimental Therapeutics
- Accurate diagnosis of mismatch repair deficiency in colorectal cancer using high-quality DNA samples from cultured stem cellsTadayoshi Yamaura, Hiroyuki Miyoshi, Hisatsugu Maekawa, Tomonori Morimoto, Takehito Yamamoto, Fumihiko Kakizaki, Koichiro Higasa, Kenji Kawada, Fumihiko Matsuda, Yoshiharu Sakai et al. · 2018 · Oncotarget
- Pharmacodynamic modeling of synergistic birinapant/paclitaxel interactions in pancreatic cancer cellsJin Niu, Xue Wang, Jun Qu, Donald E. Mager, Robert M. Straubinger · 2020 · BMC Cancer
- In vitro Modeling of Embryonal TumorsLars Custers, Irene Paassen, Jarno Drost · 2021 · Frontiers in Cell and Developmental Biology
- Organoid models derived from patients with malignant phyllodes tumor of the breastXinyu Chu, Ming‐Tsang Wu, Jianbo Yang, Yang Fu, Xuewei Wang, Huan Wang, Xiao Yang, Dong Chen, Jinsong He · 2023 · Breast Cancer Research and Treatment
- Modeling Liver Development and Disease in a DishWaqas Iqbal, Yaru Wang, Pingnan Sun, Xiaoling Zhou · 2023 · International Journal of Molecular Sciences
- Modeling Epithelial Homeostasis and Perturbation in Three-Dimensional Human Esophageal OrganoidsMasataka Shimonosono, Masaki Morimoto, Wataru Hirose, Yasuto Tomita, Norihiro Matsuura, Samuel P. Flashner, Mesra S. Ebadi, Emilea H. Okayasu, Christian Y. Lee, William R. Britton et al. · 2024 · Biomolecules
- Xenografts Derived From Patients' Ascites Recapitulate the Gemcitabine Resistance Observed in Pancreatic Cancer PatientsAkihito Machinaga, Yuichi Hori, Kazuya Shimizu, K Okahara, Emmy Yanagita, Makoto Miyoshi, Tomoo Itoh, Ken Sasai · 2019 · Pancreas
- Isolation and Characterization of Patient-derived Pancreatic Ductal Adenocarcinoma Organoid ModelsHervé Tiriac, Randall P. French, Andrew M. Lowy · 2020 · Journal of Visualized Experiments
- Occult polyclonality of preclinical pancreatic cancer models drives in vitro evolutionMaria E. Monberg, Heather M. Geiger, Jaewon James Lee, Roshan Sharma, Alexander Semaan, Vincent Bernard, Justin Wong, Fang Wang, Shaoheng Liang, Daniel B. Swartzlander et al. · 2022 · RePEc: Research Papers in Economics
- Evolution of oncosurgical management of pancreatic cancerUlla Klaiber, Susanne Roth, Thilo Hackert, John P. Neoptolemos · 2019 · European surgery. Supplement/European surgery
- Organoidomics — falling star or new galaxy in pancreatic cancer?Thomas Theodor Werner Seufferlein, Alexander Kleger · 2018 · Nature Reviews Gastroenterology & Hepatology
- Pancreatic tumor organoids for modeling in vivo drug response and discovering clinically-actionable biomarkersLing Huang, Bruno Bockorny, Indranil Paul, Dipikaa Akshinthala, Omar Gandarilla, Arindam Bose, Veronica Sanchez‐Gonzalez, Emily E. Rouse, Sylvain D. Lehoux, Nicole Pandell et al. · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
- Phenotypic, Genomic, and Transcriptomic Heterogeneity in a Pancreatic Cancer Cell LineGengqiang Xie, Liting Zhang, Olalekan H. Usman, Sampath Kumar, Chaity Modak, Dhenu Patel, Megan Kavanaugh, Xian Mallory, Yue Julia Wang, Jerome Irianto · 2024 · Pancreas
- A Two-Step Protocol for Isolation and Maintenance of Lung Cancer Primary 3D CulturesSilvia Strocchi, Giacomo Santandrea, Eleonora Zanetti, Giulio Verna, Vincenza Ylenia Cusenza, Davide Nicoli, Valentina Fantini, A Grieco, Massimiliano Paci, Alessia Ciarrocchi et al. · 2024 · Cancers
- Bench to Bedside Modeling of mRNA Encoding IgG Using a Multiscale Mechanistic Pharmacokinetic‐Toxicokinetic ( PK ‐ TK ) Model: A Case Study With Anti‐Claudin 18.2Devam A Desai, Rodrigo Cristofoletti · 2025 · Clinical and Translational Science
- Toward Precision Chemotherapy for Pancreatic Cancer Guided by Transcriptomic SignaturesBrice Chanez, Matthieu Delaye, Nicolas Alejandro Fraunhoffer, Juan Iovanna, Cindy Neuzillet, Nelson Dusetti · 2025 · United European Gastroenterology Journal
- Pancreatic Cancer Organoids Recapitulate Chemotherapy Response and Identify a Potent Cytotoxic T-Cell PopulationRenee R. Anderko, Alexandra E Bowman, Praneel Murthy, Pranav Murthy, Asmita Chopra, Nikhil V. Tirukkovalur, Sebastiaan Ceuppens, Alessandro Paniccia, Kenneth K.W. Lee, Robbie B. Mailliard et al. · 2025 · Clinical Cancer Research
- Longitudinal, label-free, high-resolution imaging of glioblastoma spheroid response to therapy: a translational tool for preclinical evaluation of chemotherapy, radiation, and immunotherapyCaroline E. Serafini, Amin Davarzani, Dan Cappabianca, Zhenmin Li, Daniela Baez Collazos, Deniz Mamaghani, Leidong Mao, Krishanu Saha, Lohitash Karumbaiah, Francisco E. Robles · 2025 · Optica
- Immune and Immune‐Integrated Organoids as NextGeneration Platforms for Disease ModelingKimiya Rashidan, Malaksima Ayadilord, Ali Hazrati, Amirhossein Nazerian, Abbas Shafiee, Seyed Mahmoud Hashemi · 2025 · MedComm
- Organoids in translation: a bench-to-bedside framework for pancreatic cancer precision medicineDanial A. Malik, E. Schmieder, Gina Genova, Jeremey Gaskins, Robert C.G. Martin · 2026 · Journal of Translational Medicine
- Patient-derived osteosarcoma tumoroid model reveals functional phenotypic diversity with implications for drug responsesSugandha Bhatia, Briony Claxton, Erik W. Thompson, Martin Lowe, Michael Wagels, Wayne Nicholls, Philip D. Rowell, Dietmar Werner Hutmacher, Jacqui McGovern · 2026 · Biofabrication
- Harnessing human tumor organoids for cancer modeling and precision therapyTonghai Zhou, Qianyi Wang, Zhang Mei-li, Yue Huang · 2026 · Protein & Cell
- Increased copy number of imprinted genes in the chromosomal region 20q11-q13.32 is associated with resistance to antitumor agents in cancer cell linesJulia Krushkal, Suleyman Vural, Travis Lee Jensen, George W. Wright, Yingdong Zhao · 2022 · Clinical Epigenetics
- Progress in patient-derived liver cancer cell models: a step forward for precision medicineZhengtao Zhang, Lijian Hui · 2023 · Acta Biochimica et Biophysica Sinica
- Establishment of matched bladder cancer PDX and PDX-derived organoid model and evaluation of anti-tumor efficacy of abemaciclibXiongbing Lu, Chao Hu, Lingxing Duan, Ke Chen, Hua Hao, Yuanqiao He · 2024 · Clinical & Translational Oncology
- Quantitative Live Imaging Reveals Phase Dependency of PDAC Patient‐Derived Organoids on ERK and AMPK ActivityShoko Tsukamoto, Ye Huaze, Zhang Weisheng, Akihito Machinaga, Nobuyuki Kakiuchi, Seishi Ogawa, Hiroshi Seno, Shigeki Higashiyama, Michiyuki Matsuda, Toru Hiratsuka · 2024 · Cancer Science
- MicroRNAs in pancreatic cancer drug resistance: mechanisms and therapeutic potentialFangying Dong, Jing Zhou, Yijie Wu, Zhaofeng Gao, Weiwei Li, Zhengwei Song · 2025 · Frontiers in Cell and Developmental Biology
- Combination of tumor organoids with advanced technologies: A powerful platform for tumor evolution and treatment response (Review)Ying Hua Wu, Fan Zhang, Furong Du, Juan Huang, Shuqing Wei · 2025 · Molecular Medicine Reports
- Using organoid models to predict chemotherapy efficacy: the future of precision oncology?Steven Donald Forsythe, Tracey Pu, Aleksander Skardal · 2019 · Expert Review of Precision Medicine and Drug Development
- Diagnosing pancreatic ductal adenocarcinoma using plasma extracellular vesicle RNA profilesAdam Enver Frampton, Elisa Giovannetti · 2019 · Gut
- Nucleolin Aptamer N6L Reprograms the Translational Machinery and Acts Synergistically with mTORi to Inhibit Pancreatic Cancer ProliferationMounira Chalabi‐Dchar, Elisabeth Cruz, Hichem C. Mertani, Jean‐Jacques Diaz, José Courty, Ilaria Cascone, Philippe Bouvet · 2021 · Cancers
- OrganoidsBernat Navarro-Serer, Laura DeLong Wood · 2022 · Pancreas
- Revolutionizing digestive system tumor organoids research: Exploring the potential of tumor organoidsZhian Xiu, Qian Yang, Fusheng Xie, Feng Han, Weiwei He, Weifang Liao · 2024 · Journal of Tissue Engineering
- Castrate-resistant prostate cancer response to taxane is determined by an HNF1-dependent apoptosis resistance circuitIlya S. Senatorov, Joel Bowman, Keith H. Jansson, Aian Neil Alilin, Brian J. Capaldo, Ross G. Lake, Morgan Riba, Yasmine C. Abbey, Crystal G. McKnight, Xiaohu Zhang et al. · 2024 · Cell Reports Medicine
- Patient-Derived Organoids: Promises, Hurdles and Potential Clinical ApplicationsSomaieh Hedayat, Nicola Valeri · 2020 · Clinical Oncology
- A Tumor‐Organoid‐Based Precision Medicine Platform for the Prediction of Drug Sensitivity of Colorectal CancerXingyue Wang, Xiaohuan Lu, Bo Cai, Xiaoqiong Li, Danyi Zou, Shijun Lei, Luming Xu, Guobin Wang, Lin Wang, Zheng Wang · 2022 · Advanced Therapeutics
- Establishment of Pancreatic Cancer-Derived Tumor Organoids and Fibroblasts From Fresh TissueJesús Frutos Dıáz-Alejo, Simon April-Monn, Marina Cihova, Verona Buociková, Jorge Villalón López, Maria Urbanova, Carmen G. Lechuga, Miroslav Tomáš, Peter Dubovan, Bárbara Luna Sánchez et al. · 2023 · Journal of Visualized Experiments
- Establishment of a novel human cell line retaining the characteristics of the original pancreatic adenocarcinoma, and evaluation of MEK as a therapeutic targetXiaoxiao Du, Kuifeng He, Yingying Huang, Zhenzhen Xu, Mei Kong, Jing Zhang, Jiang Cao, Lisong Teng · 2020 · International Journal of Oncology
- Novel co-culture strategies of tumor organoids with autologous T-cells reveal clinically relevant combinations of immune-checkpoint and targeted therapiesEnrique Podaza, Jared A. Capuano, Majd Al Assaad, Hui–Hsuan Kuo, Geoffrey J. Markowitz, Adriana Irizarry, Hiranmayi Ravichandran, Sarah E. Ackermann, Troy Kane, Jyothi Manohar et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
- Organoids in Cancer Research and Regenerative Medicine: Current Status, Challenges, and Future ProspectsRuiyang Li, Yuezhou Wu, Zhu'anzhen Zheng, Fengjin Zhou, Ke Xu, Jiacan Su · 2026 · MedComm
- Familial Pancreatic Cancer Research: Bridging Gaps in Basic Research and Clinical ApplicationSuyakarn Archasappawat, Fatimah Al-Musawi, Peinan Liu, Eunjung Lee, Chang‐Il Hwang · 2024 · Biomolecules
- Pancreatic 3D Organoids and Microfluidic Systems—Applicability and Utilization in Surgery: A Literature ReviewVidas Petrauskas, Ryte Damaseviciute, Aistė Gulla · 2025 · Medicina
- Analysis of an engineered organoid model of pancreatic cancer identifies hypoxia as a contributing factor in determining transcriptional subtypesNatalie Landon‐Brace, Simon Latour, Brendan T. Innes, Michelle Nurse, Jose L. Cadavid, Ileana L. Co, Cassidy M Tan, Ferris Nowlan, Sibyl Drissler, Faiyaz Notta et al. · 2025 · Scientific Reports
- Head and neck tumor organoid grown under simplified media conditions model tumor biology and chemoradiation responsesWeilin Li, Michiya Nishino, Eric R. Reed, Dipikaa Akshinthala, Hamdan Ahmed Pasha, Erik S. Anderson, Ling Huang, Hannah Hebestreit, Stefano Monti, Ernest Gomez et al. · 2025 · Scientific Reports
- Homologous Repair‐Deficient Pancreatic Cancer: Refined Targeting of DNA Damage Response is an Effective Therapeutic StrategyAlica K. Beutel, Christopher J. Halbrook, Menar Ekizce, Jessica Lindenmayer, Élodie Roger, Sabrina E. Calderon, Thomas Theodor Werner Seufferlein, Alexander Kleger, Johann Gout, Lukas Perkhofer · 2025 · United European Gastroenterology Journal
- Functional Precision in Pancreatic Cancer: Redefining Biomarkers with Patient-Derived OrganoidsClaire Alexandra Zhen Chew, Cheng Mun Wun, Y.F. Lee, Cheng Ean Chee, Khek Yu Ho, Glenn Kunnath Bonney · 2025 · International Journal of Molecular Sciences
- Emerging Diagnostic Indications for Endoscopic UltrasoundMichael B. Wallace, Shounak Majumder, Peter Störz, Jeanin Elise van Hooft · 2026 · Gastroenterology
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- Preclinical models derived from endoscopic ultrasound-guided tissue acquisition for individualized treatment of pancreatic ductal adenocarcinomaTing Tong, Chao Zhang, Jingbo Li, Minzi Deng, Xiaoyan Wang · 2023 · Frontiers in Medicine
- Spatial Alignment of Organoids Tracking Subclonal Chemotherapy Resistance in Pancreatic and Ampullary CancerMd Shahadat Hossan, Ethan Samuel Lin, Eleanor Riedl, Austin Stram, Eric Mehlhaff, Luke Koeppel, Jamie Warner, Inem Uko, Lori Mankowski Gettle, Sam Joseph Lubner et al. · 2023 · Bioengineering
- Advances in Systemic Therapy in Pancreatic CancerKenneth H. Yu · 2024 · Hematology/Oncology Clinics of North America
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- Metavert synergises with standard cytotoxics in human PDAC organoids and is associated with transcriptomic signatures of therapeutic responseJingyu An, Roma Kurilov, Teresa Peccerella, Frank Bergmann, Mouad Edderkaoui, Adrian Lim, Xu Zhou, Katrin Pfütze, Angela Schulz, Stephan Wolf et al. · 2024 · Translational Oncology
- Quercetin Promote the Chemosensitivity in Organoids Derived from Patients with Breast CancerShengwen Meng, Yifan Cao, Lei Lu, Xuanhe Li, Siyu Sun, Fangqian Jiang, Jianfei Lu, Dongwei Fan, Xinxin Han, Tingjing Yao · 2024 · Breast Cancer Targets and Therapy
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- Current Status and Perspectives of Patient-Derived Models for Ewing’s SarcomaTadashi Kondo · 2020 · Cancers
- Organoids and epithelial ovarian cancer ‑ a future tool for personalized treatment decisions?Yagmur Sisman, Tine Henrichsen Schnack, Estrid Vilma Solyom Høgdall, Claus Kim Høgdall · 2021 · Molecular and Clinical Oncology
- Creation and Development of Patient-Derived Organoids for Therapeutic Screening in Solid CancerWilliam Harrison Hicks, Cylaina E. Bird, Lauren C. Gattie, Mohamad El Shami, Jeffrey Isaac Traylor, Diana D. Shi, Samuel K. McBrayer, Kalil G. Abdullah · 2022 · Current Stem Cell Reports
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- Targeting homologous recombination addicted tumors: challenges and opportunitiesTalia Golan, Jonathan Robert Brody · 2020 · Annals of Pancreatic Cancer
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- A high-throughput 3D culture microfluidic platform for multi-parameter phenotypic and omics profiling of patient-derived organoidsOronza Antonietta Botrugno, Elena Bianchi, Jolanda M. Bruno, Giovanni F.M. Gallo, Claudia Felici, Eduardo Sommella, Paola De Stefano, Valentina Giansanti, Valeria Rossella, Fabrizio Merciai et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
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- Generation of Human Kidney Tubuloids from Tissue and UrineCamilla Calandrini, Jarno Drost · 2021 · Journal of Visualized Experiments
- Patient-derived organoids: Are PDOs the new PDX?Tríona Ní Chonghaile · 2018 · Science Translational Medicine
- Cancer modeling in colorectal organoids reveals intrinsic differences between oncogenic RAS and BRAF variantsJasmin B. Post, Nizar Hami, Jeroen O. Lohuis, Marieke van de Ven, Renske de Korte‐Grimmerink, Christina Stangl, Ellen Stelloo, Ingrid Verlaan-Klink, Jacco van Rheenen, Hugo J.G. Snippert · 2019 · bioRxiv (Cold Spring Harbor Laboratory)