The DOI matches its Crossref record; 112 of the 112 references it cites were found in a registry or an index.
Cellular Plasticity in Cancer
Open accessAbstract
During cancer progression, tumor cells undergo molecular and phenotypic changes collectively referred to as cellular plasticity. Such changes result from microenvironmental cues, stochastic genetic and epigenetic alterations, and/or treatment-imposed selective pressures, thereby contributing to tumor heterogeneity and therapy resistance. Epithelial–mesenchymal plasticity is the best-known case of tumor cell plasticity, but recent work has uncovered other examples, often with functional consequences. In this review, we explore the nature and role(s) of these diverse cellular plasticity programs in premalignant progression, tumor evolution, and adaptation to therapy and consider ways in which targeting plasticity could lead to novel anticancer treatments. Significance: Changes in cell identity, or cellular plasticity, are common at different stages of tumor progression, and it has become clear that cellular plasticity can be a potent mediator of tumor progression and chemoresistance. Understanding the mechanisms underlying the various forms of cell plasticity may deliver new strategies for targeting the most lethal aspects of cancer: metastasis and resistance to therapy.
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Cites
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Ganesh, K., & Massagué, J. (2021) · Nature Medicine · doi:10.1038/s41591-020-01195-4 · Cited by 1,051
Cancer stem cells—Origins and biomarkers: Perspectives for targeted personalized therapies
Walcher, L., Kistenmacher, A.-K., Suo, H., Kitte, R., Dluczek, S., Strauß, A., Blaudszun, A.-R., Yevsa, T., Fricke, S., & Kossatz-Boehlert, U. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01280 · Cited by 1,007
Drug repurposing for cancer therapy
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“186 There are three manifestations of phenotypic plasticity: dedifferentiation, blocked differentiation, and transdifferentiation, each representing a distinct disruption to cellular differentiation.”
BackgroundMetastasis-Initiating Cells and Ecosystems
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Metadata
- Authors
- Yuan, S., Norgard, R. J., & Stanger, B. Z.
- Venue
- Cancer Discovery
- Published
- 2019-07-01
- Volume
- 9
- Issue
- 7
- Pages
- 837-851
- ISSN
- 2159-8274 (ISSN-L)
- 2159-8290
- OpenAlex
- W2935942593
- Cited by
- 455
- References
- 112
- FWCI
- 17.41
- Type
- journal article
- Language
- en
- Open access
- green
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