The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
Fibroblast Heterogeneity in the Pancreatic Tumor Microenvironment
Open accessAbstract
The poor prognosis for patients with pancreatic ductal adenocarcinoma (PDAC) impels an improved understanding of disease biology to facilitate the development of better therapies. PDAC typically features a remarkably dense stromal reaction, featuring and established by a prominent population of cancer-associated fibroblasts (CAF). Genetically engineered mouse models and increasingly sophisticated cell culture techniques have demonstrated important roles for fibroblasts in PDAC progression and therapy response, but these roles are complex, with strong evidence for both tumor-supportive and tumor-suppressive or homeostatic functions. Here, we review the recent literature that has improved our understanding of heterogeneity in fibroblast fate and function in this disease including the existence of distinct fibroblast populations, and highlight important avenues for future study. Significance: Although the abundant stromal reaction associated with pancreatic cancer has long been appreciated, the functions of the CAF cells that establish this stromal reaction remain unclear. An improved understanding of the transcriptional and functional heterogeneity of pancreatic CAFs, as well as their tumor-supportive versus tumor-suppressive capacity, may facilitate the development of effective therapies for this disease.
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Cites
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Cited by
Clinical and therapeutic relevance of cancer-associated fibroblasts
Chen, Y., McAndrews, K. M., & Kalluri, R. (2021) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-021-00546-5 · Cited by 1,230
Rational combinations of targeted cancer therapies: background, advances and challenges
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Fibroblasts in cancer: Unity in heterogeneity
Chhabra, Y., & Weeraratna, A. T. (2023) · Cell · doi:10.1016/j.cell.2023.03.016 · Cited by 474
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Cancer-associated fibroblasts and their influence on tumor immunity and immunotherapy
Barrett, R. L., & Puré, E. (2020) · eLife · doi:10.7554/elife.57243 · Cited by 346
Metadata
- Authors
- Helms, E., Onate, M. K., & Sherman, M. H.
- Venue
- Cancer Discovery
- Published
- 2020-05-01
- Volume
- 10
- Issue
- 5
- Pages
- 648-656
- ISSN
- 2159-8274 (ISSN-L)
- 2159-8290
- OpenAlex
- W3005107936
- Cited by
- 283
- References
- 56
- FWCI
- 15.32
- Type
- journal article
- Language
- en
- Open access
- green
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