The DOI matches its Crossref record; 347 of the 347 references it cites were found in a registry or an index.
Fibroblasts in cancer: Unity in heterogeneity
Open accessAbstract
SUMMARY Tumor cells do not exist in isolation in vivo, and carcinogenesis depends on the surrounding tumor microenvironment (TME), composed of a myriad of cell types and biophysical and biochemical components. Fibroblasts are integral in maintaining tissue homeostasis. However, even before a tumor develops, pro-tumorigenic fibroblasts in close proximity can provide the fertile ‘soil’ to the cancer ‘seed’ and are known as cancer-associated fibroblasts (CAFs). In response to intrinsic and extrinsic stressors, CAFs reorganize the TME enabling metastasis, therapeutic resistance, dormancy and reactivation by secreting cellular and acellular factors. In this review, we summarize the recent discoveries on CAF-mediated cancer progression with a particular focus on fibroblast heterogeneity and plasticity.
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Zhang, Y., Fang, Z., Pan, D., Li, Y., Zhou, J., Chen, H., Li, Z., Zhu, M., Li, C., Qin, L., et al. (2024) · Advanced Materials · doi:10.1002/adma.202401304 · Cited by 116
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Metadata
- Authors
- Chhabra, Y., & Weeraratna, A. T.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2023-04
- Volume
- 186
- Issue
- 8
- Pages
- 1580-1609
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W4365446439
- Cited by
- 474
- References
- 347
- FWCI
- 50.42
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
