Mesenchymal lineage heterogeneity underlies nonredundant functions of pancreatic cancer-associated fibroblasts

A framework for advancing our understanding of cancer-associated fibroblasts

Sahai, E., Astsaturov, I., Cukierman, E., DeNardo, D. G., Egeblad, M., Evans, R. M., Fearon, D., Greten, F. R., Hingorani, S. R., Hunter, T., et al. (2020) · Nature Reviews Cancer · doi:10.1038/s41568-019-0238-1 · Cited by 3,863

A global double-fluorescent Cre reporter mouse

Muzumdar, M. D., Tasic, B., Miyamichi, K., Li, L., & Luo, L. (2007) · genesis · doi:10.1002/dvg.20335 · Cited by 3,491

Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer

Olive, K. P., Jacobetz, M. A., Davidson, C. J., Gopinathan, A., McIntyre, D., Honess, D., Madhu, B., Goldgraben, M. A., Caldwell, M. E., Allard, D., et al. (2009) · Science · doi:10.1126/science.1171362 · Cited by 3,170

Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival

Özdemir, B. C., Pentcheva-Hoang, T., Carstens, J. L., Zheng, X., Wu, C.-C., Simpson, T. R., Laklai, H., Sugimoto, H., Kahlert, C., Novitskiy, S. V., et al. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.04.005 · Cited by 2,681

Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice

Hingorani, S. R., Wang, L., Multani, A. S., Combs, C., Deramaudt, T. B., Hruban, R. H., Rustgi, A. K., Chang, S., & Tuveson, D. A. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.04.023 · Cited by 2,609

Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer

Öhlund, D., Handly-Santana, A., Biffi, G., Elyada, E., Almeida, A. S., Ponz-Sarvise, M., Corbo, V., Oni, T. E., Hearn, S. A., Lee, E. J., et al. (2017) · Journal of Experimental Medicine · doi:10.1084/jem.20162024 · Cited by 2,590

Cross-species single-cell analysis of pancreatic ductal adenocarcinoma reveals antigen-presenting cancer-associated fibroblasts

Elyada, E., Bolisetty, M., Laise, P., Flynn, W. F., Courtois, E. T., Burkhart, R. A., Teinor, J. A., Belleau, P., Biffi, G., Lucito, M. S., et al. (2019) · Cancer Discovery · doi:10.1158/2159-8290.cd-19-0094 · Cited by 2,241

Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma

Provenzano, P. P., Cuevas, C., Chang, A. E., Goel, V. K., Von Hoff, D. D., & Hingorani, S. R. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.01.007 · Cited by 2,195

Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer

Feig, C., Jones, J. O., Kraman, M., Wells, R. J. B., Deonarine, A., Chan, D. S., Connell, C. M., Roberts, E. W., Zhao, Q., Caballero, O. L., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1320318110 · Cited by 2,100

Stromal Elements Act to Restrain, Rather Than Support, Pancreatic Ductal Adenocarcinoma

Rhim, A. D., Oberstein, P. E., Thomas, D. H., Mirek, E. T., Palermo, C. F., Sastra, S. A., Dekleva, E. N., Saunders, T., Becerra, C. P., Tattersall, I. W., et al. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.04.021 · Cited by 2,085

Acid-base homeostasis orchestrated by NHE1 defines the pancreatic stellate cell phenotype in pancreatic cancer

Pethő, Z., Najder, K., Beel, S., Fels, B., Neumann, I., Schimmelpfennig, S., Sargin, S., Wolters, M., Grantins, K., Wardelmann, E., et al. (2023) · JCI Insight · doi:10.1172/jci.insight.170928 · Cited by 18

The immune microenvironment in endometrial carcinoma: mechanisms and therapeutic targeting

Wang, Y., Liu, N., Guo, X., Han, R., Bai, J., Zhong, J., & Wang, Q. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1586315 · Cited by 15

Tumor Stroma as a Therapeutic Target for Pancreatic Ductal Adenocarcinoma

Lee, D. U., Han, B. S., Jung, K. H., & Hong, S. (2024) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2024.029 · Cited by 16

Tumor-Stroma Interaction in PDAC as a New Approach for Liquid Biopsy and its Potential Clinical Implications

Götze, J., Nitschke, C., Uzunoglu, F. G., Pantel, K., Sinn, M., & Wikman, H. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.918795 · Cited by 15

From precursor to cancer: decoding the intrinsic and extrinsic pathways of pancreatic intraepithelial neoplasia progression

Graham, S., Dmitrieva, M., Costa, D. B. V., Francescone, R., Trujillo, M. A. M., Cukierman, E., & Wood, L. D. (2024) · Carcinogenesis · doi:10.1093/carcin/bgae064 · Cited by 15

Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases: Workshop Proceedings

Mastracci, T. L., Apte, M. V., Amundadottir, L. T., Alvarsson, A., Artandi, S. E., Bellin, M. D., Bernal‐Mizrachi, E., Caicedo, A., Campbell‐Thompson, M., Cruz‐Monserrate, Z., et al. (2023) · Diabetes · doi:10.2337/db22-0942 · Cited by 15

Differential Effects of Pancreatic Cancer-Derived Extracellular Vesicles Driving a Suppressive Environment

Purushothaman, A., Oliva, J., Treekitkarnmongkol, W., Sankaran, D., Hurd, M. W., Putluri, N., Maitra, A., Haymaker, C., & Sen, S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241914652 · Cited by 13

Drug Delivery System Targeting Cancer-Associated Fibroblast for Improving Immunotherapy

Zhang, Z., Wang, R., & Chen, L. (2025) · International Journal of Nanomedicine · doi:10.2147/ijn.s500591 · Cited by 16

Depletion of tumor-derived CXCL5 improves T cell infiltration and anti-PD-1 therapy response in an obese model of pancreatic cancer

Walsh, R. M., Ambrose, J., Jack, J. L., Eades, A. E., Bye, B. A., Ruckert, M. T., Messaggio, F., Olou, A. A., Chalise, P., Pei, D., et al. (2025) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2024-010057 · Cited by 14

Meflin is a marker of pancreatic stellate cells involved in fibrosis and epithelial regeneration in the pancreas

Ando, R., Shiraki, Y., Miyai, Y., Shimizu, H., Furuhashi, K., Minatoguchi, S., Kato, K., Kato, A., Iida, T., Mizutani, Y., et al. (2023) · The Journal of Pathology · doi:10.1002/path.6211 · Cited by 13

Opposing roles for ADAMTS2 and ADAMTS14 in myofibroblast differentiation and function

Carter, E. P., Yoneten, K. K., Gavara, N., Tyler, E. J., Gauthier, V., Murray, E. R., ten Dijke, P., Cameron, A. J. M., Pearce, O. M. T., & Grose, R. P. (2023) · The Journal of Pathology · doi:10.1002/path.6214 · Cited by 15

Cancer-Associated Fibroblasts: From Spectators to Protagonists in Pancreatic Cancer Progression

Mucciolo, G., Li, W., & Biffi, G. (2024) · Cancer Research · doi:10.1158/0008-5472.can-24-2448 · Cited by 13

Heterocellular crosstalk and architecture of the pancreatic tumour microenvironment

Arnold, F., Vecchio, A. D., Hussain, Z., & Sherman, M. H. (2026) · Nature reviews. Cancer · doi:10.1038/s41568-025-00905-9 · Cited by 15

Heterogeneity and plasticity of cancer-associated fibroblasts

Pramod, S., Lavon, H., Scherz‐Shouval, R., & Sherman, M. H. (2026) · Nature Cancer · doi:10.1038/s43018-026-01146-x · Cited by 14

Regulation of ROS signaling by TIGAR induces cancer-modulating responses in the tumor microenvironment

Cheung, E. C., Strathdee, D., Stevenson, D., Coomes, J., Blyth, K., & Vousden, K. H. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2416076121 · Cited by 12

Nanomaterials in cancer immunotherapy: targeting cancer-associated fibroblasts

Zhang, Z., & Chen, L. (2025) · Cancer Nanotechnology · doi:10.1186/s12645-024-00302-1 · Cited by 13

What is the Potential Interplay between Microbiome and Tumor Microenvironment in Oral Squamous Cell Carcinomas?

Li, C., Liu, H., & Gong, Z. (2022) · Asian Pacific Journal of Cancer Prevention · doi:10.31557/apjcp.2022.23.7.2199 · Cited by 11

Molecular, metabolic, and histological subtypes of pancreatic ductal adenocarcinoma and its tumor microenvironment: Insights into tumor heterogeneity and clinical implications

Ohara, Y., Liu, H., Moreno, P., Suzuki, S., & Hussain, S. P. (2025) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2025.108946 · Cited by 11

Bronchial epithelial cell transcriptional responses to inhaled corticosteroids dictate severe asthmatic outcomes

Ginebaugh, S. P., Hagner, M., Ray, A., ERZURUM, S. C., COMHAIR, S. A. A., Denlinger, L. C., Jarjour, N. N., Castro, M., Woodruff, P. G., Christenson, S. A., et al. (2023) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2023.01.028 · Cited by 11

Hydrogel-Based Therapeutics for Pancreatic Ductal Adenocarcinoma Treatment

Liu, J., Wu, W., Zhu, Q., & Zhu, H. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15102421 · Cited by 12

Depletion of Adipose Stroma-Like Cancer-Associated Fibroblasts Potentiates Pancreatic Cancer Immunotherapy

Rupert, J. E., Daquinag, A. C., Yu, Y., Dai, Y., Zhao, Z., & Kolonin, M. G. (2024) · Cancer Research Communications · doi:10.1158/2767-9764.crc-24-0298 · Cited by 11

Impacts of ageing on the efficacy of CAR-T cell therapy

Qi, S., Li, J., Gu, X., Zhang, Y., Zhou, W., Wang, F., & Wang, W. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102715 · Cited by 11

Photodynamic Stromal Depletion in Pancreatic Ductal Adenocarcinoma

Lintern, N., Smith, A. M., Jayne, D. G., & Khaled, Y. S. (2023) · Cancers · doi:10.3390/cancers15164135 · Cited by 10

Heterogeneity of primary and metastatic CAFs: From differential treatment outcomes to treatment opportunities (Review)

Kou, Z., Liu, C., Zhang, W., Sun, C., Liu, L., & Zhang, Q. (2024) · International Journal of Oncology · doi:10.3892/ijo.2024.5642 · Cited by 11

Correlation of antigen expression with epigenetic modifications after rAAV delivery of a human factor IX variant in mice and rhesus macaques

Pekrun, K., Stephens, C. J., Gonzalez‐Sandoval, A., Goswami, A., Zhang, F., Tarantal, A. F., Blouse, G. E., & Kay, M. A. (2024) · Molecular Therapy · doi:10.1016/j.ymthe.2024.05.005 · Cited by 10

Regulation of metaplasia and dysplasia in the stomach by the stromal microenvironment

Rhodes, J., Goldenring, J. R., & Lee, S. (2024) · Experimental & Molecular Medicine · doi:10.1038/s12276-024-01240-z · Cited by 12

Effect of Bioactive Black Phosphorus Nanomaterials on Cancer-Associated Fibroblast Heterogeneity in Pancreatic Cancer

Qu, J., Yan, Z., Lei, D., Zhong, T., Fang, C., Wen, Z., Liu, J., Lai, Z., Yu, X., Zheng, B., et al. (2024) · ACS Nano · doi:10.1021/acsnano.4c06147 · Cited by 10

Different subpopulations of macrophages, neutrophils, mast cells, and fibroblasts are involved in the control of tumor angiogenesis

Ribatti, D. (2024) · Frontiers in Medicine · doi:10.3389/fmed.2024.1481609 · Cited by 10

Targeting a chemo-induced adaptive signaling circuit confers therapeutic vulnerabilities in pancreatic cancer

Saito, Y., Xiao, Y. Q., Yao, J., Li, Y., Liu, W., Yuzhalin, A. E., Shyu, Y.-M., Li, H., Yuan, X., Li, P., et al. (2024) · Cell Discovery · doi:10.1038/s41421-024-00720-w · Cited by 13

Statins as Secondary Preventive Agent to Limit Breast Cancer Metastatic Outgrowth

Atale, N., & Wells, A. H. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26031300 · Cited by 10

Emerging Therapeutic Approaches to Pancreatic Adenocarcinoma: Advances and Future Directions

Peng, C., & Oberstein, P. E. (2025) · Current Treatment Options in Oncology · doi:10.1007/s11864-025-01352-2 · Cited by 14

Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases

Mastracci, T. L., Apte, M. V., Amundadottir, L. T., Alvarsson, A., Artandi, S. E., Bellin, M. D., Bernal‐Mizrachi, E., Caicedo, A., Campbell‐Thompson, M., Cruz‐Monserrate, Z., et al. (2022) · Pancreas · doi:10.1097/mpa.0000000000002170 · Cited by 10

Engineered cyclic peptide targeting ITGA5 disrupts tumor–stroma interaction to overcome desmoplasia and resistance in pancreatic ductal adenocarcinoma

Mardhian, D. F., Pednekar, K. P., Hemdan, A. G., Kuninty, P. R., Karim, S. A., de Winter, S., Metselaar, J. M., Morton, J. P., & Prakash, J. (2025) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2025.10.022 · Cited by 11

Pancreatic Cancer Organoids: Modeling Disease and Guiding Therapy

Morceau, F., El‐Khoury, V., Lee, K., Berna, M. J., & Kwon, Y. (2025) · Cancers · doi:10.3390/cancers17233850 · Cited by 10

Single Cell Analysis of Cultivated Fibroblasts from Chronic Pancreatitis and Pancreatic Cancer Patients

Sunami, Y., Chen, Y., Trojanowicz, B., Sommerer, M., Hämmerle, M., Eils, R., & Kleeff, J. H. (2022) · Cells · doi:10.3390/cells11162583 · Cited by 9

Cellular collusion: cracking the code of immunosuppression and chemo resistance in PDAC

Musiu, C., Lupo, F., Agostini, A., Lionetto, G., Bevere, M., Paiella, S., Carbone, C., Corbo, V., Ugel, S., & Sanctis, F. D. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1341079 · Cited by 9

BNIP3+ fibroblasts associated with hypoxia and inflammation predict prognosis and immunotherapy response in pancreatic ductal adenocarcinoma

Gao, B., Hu, G., Sun, B., Li, W., & Yang, H. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05674-x · Cited by 8

Ferroptosis in cancer toward molecular insights and clinical translation in pancreatic cancer

Chen, Q., Liu, F., Zhang, Y., Yan, L., Wu, Y., Xu, D., Wu, P., Yuan, H., & Jiang, K. (2026) · Molecular Cancer · doi:10.1186/s12943-025-02567-5 · Cited by 10

Association between high expression of intratumoral fibroblast activation protein and survival in patients with intrahepatic cholangiocarcinoma

Waki, Y., Morine, Y., Noma, T., Takasu, C., Teraoku, H., Yamada, S., Saito, Y., Ikemoto, T., & Shimada, M. (2023) · BMC Gastroenterology · doi:10.1186/s12876-023-03012-x · Cited by 8

Evolving Tumor Characteristics and Smart Nanodrugs for Tumor Immunotherapy

Sun, W., Xie, S., Liu, S., Hu, X., & Xing, D. (2024) · International Journal of Nanomedicine · doi:10.2147/ijn.s453265 · Cited by 8

Mouse Models to Evaluate the Functional Role of the Tumor Microenvironment in Cancer Progression and Therapy ResponsesPreprint

McAndrews, K. M., Mahadevan, K. K., & Kalluri, R. (2024) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a041411 · Cited by 8

Tumor microenvironment subtyping in pancreatic ductal adenocarcinoma: New avenues for personalized therapeutic strategies

Srinivasan, D., Gout, J., Kleger, A., & Roger, É. (2025) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2025.115697 · Cited by 7

Adipose Stromal Cell-Derived Cancer-Associated Fibroblasts Promote Pancreatic Adenocarcinoma Progression Through SFRP4 Signaling

Rupert, J. E., Cai, L., Daquinag, A. C., Anastassiou, D., & Kolonin, M. G. (2026) · Cancers · doi:10.3390/cancers18020233 · Cited by 7

Fibroblast subtypes in pancreatic cancer and pancreatitis: from mechanisms to therapeutic strategies

Huang, H., Lu, W., Zhang, X., Pan, J., Cao, F., & Li, W. (2023) · Cellular Oncology · doi:10.1007/s13402-023-00874-x · Cited by 7

Top advances of the year: Pancreatic cancer

Warren, E. A. K., Lesinski, G. B., & Maithel, S. K. (2023) · Cancer · doi:10.1002/cncr.35031 · Cited by 7

CAFomics: convergence to translation for precision stroma approaches

McCabe, I. C., Peng, X. L., Kearney, J. F., & Yeh, J. J. (2024) · Carcinogenesis · doi:10.1093/carcin/bgae063 · Cited by 6

Stromal Cells in Early Inflammation-Related Pancreatic Carcinogenesis—Biology and Its Potential Role in Therapeutic Targeting

Seidel, T., Ohri, N., Glaß, M., Sunami, Y., Müller, L. P., & Kleeff, J. H. (2025) · Cancers · doi:10.3390/cancers17091541 · Cited by 7

Domestication and feedback: bidirectional hijacking in pancreatic ductal adenocarcinoma microenvironment

Qiao, Y., Yin, H., Zhang, Y., Zhang, J., & Dong, Q. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1585858 · Cited by 8

CCR-CCL axes as key upstream influencers of pancreatic ductal adenocarcinoma: CCR2–CCL2, CCR5–CCL5, CCR4–CCL17/22, CCR6–CCL20, CCR7–CCL19/21

Bahng, I. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1713123 · Cited by 6

The Poorly Immunogenic Tumor Microenvironment of Pancreatic Cancer: The Impact of Radiation Therapy, and Strategies Targeting Resistance

Hughes, R., Snook, A. E., & Mueller, A. C. (2022) · Immunotherapy · doi:10.2217/imt-2022-0046 · Cited by 6

Multiphasic Heterogeneity of Fibroblasts in the Microenvironment of Pancreatic Ductal Adenocarcinoma: Dissection and the Sum of the Dynamics

Ijichi, H. (2022) · Cancers · doi:10.3390/cancers14194880 · Cited by 6

Type 2 diabetes alters quiescent pancreatic stellate cells to tumor-prone state

Hara, Y., Mizukami, H., Yamada, T., Shimoyama, S., Yamazaki, K., Sasaki, T., Wang, Z., Kushibiki, H., Ryuzaki, M., Ogasawara, S., et al. (2025) · JCI Insight · doi:10.1172/jci.insight.187424 · Cited by 6

Cancer-associated fibroblasts-derived exosomes in colorectal cancer progression: Mechanism and therapeutic opportunities

Yang, L., Akbarabadi, P., & Babashah, S. (2026) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2026.189545 · Cited by 6

The function of microRNA related to cancer-associated fibroblasts in pancreatic ductal adenocarcinoma

Fang, Y., Tan, C., Zheng, Z., Yang, J., Tang, J., Guo, R., Silli, E. K., Chen, Z., Chen, J., Ge, R., et al. (2025) · Biochemical Pharmacology · doi:10.1016/j.bcp.2025.116849 · Cited by 6

Unraveling the Connection Between Ion Channels and Pancreatic Stellate Cell Activation

Auwercx, J., Fourgeaud, M., Lalot, A., & Gautier, M. (2025) · Cellular Physiology and Biochemistry · doi:10.33594/000000754 · Cited by 5

Macropinocytosis controls metabolic stress-driven CAF subtype identity in pancreatic cancerPreprint

Zhang, Y., Li, L., Maganti, S., Hope, J. L., Galapate, C. M., Carrette, F., Duong‐Polk, K., Bagchi, A., Scott, D. A., Lowy, A. M., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.11.29.625709 · Cited by 5

IGF2BP2 stabilized by USP7 promotes cancer-associated fibroblast activation and attenuates gemcitabine sensitivity in PDAC

Ge, F., Zhu, H., Liu, X., Li, Y., Guo, R., Zeng, C., Yuan, T., Yang, L., Dong, X., Wu, Y., et al. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.116476 · Cited by 4

Stromal cells contribute to progression, recurrence, and metastasis in oral squamous cell carcinoma: a call for therapy

Hao, J., Zakershahrak, M., Ly, P., Le, A. D., Yu, W., Gates, J. C., & Chen, C. (2026) · Journal of Translational Medicine · doi:10.1186/s12967-026-07786-y · Cited by 5

The Significance of the Heterogeneity of Cancer-Associated Fibroblasts in Tumor Microenvironments

Imanishi, D., Nishikubo, H., Ma, D., Gao, H., Sano, T., Fan, C., Sakuma, T., Yamamoto, Y., & Yashiro, M. (2026) · Metabolites · doi:10.3390/metabo16020120 · Cited by 4

Cancer-associated fibroblasts promote immune evasion in pancreatic cancer via miR-181b-5p/STING/LGALS1 pathway

Zhang, S., Guo, Y., Qi, H., Wu, M., Hu, Y., Lv, G., Ye, Y., Han, J., Zeng, Q., Du, Y., et al. (2026) · Cancer Letters · doi:10.1016/j.canlet.2026.218331 · Cited by 4

Extracellular Vesicle‐Packaged Linc‐ZNF25‐1 from Pancreatic Cancer Cell Promotes Pancreatic Stellate Cell Uptake of Asparagine to Advance Chemoresistance

Yu, M., Su, M., Tian, Z., Pan, L., Li, Z., Huang, E., & Chen, Y. (2025) · Advanced Science · doi:10.1002/advs.202413439 · Cited by 4

Modelling the micro- and macro- environment of pancreatic cancer: from patients to pre-clinical models and back

Lloyd, E. G., Henríquez, J. A., & Biffi, G. (2024) · Disease Models & Mechanisms · doi:10.1242/dmm.050624 · Cited by 4

Stromal KITL/SCF Maintains Pancreas Tissue Homeostasis and Restrains Tumor Progression

Oñate, M. K., Oon, C. H., Bhattacharyya, S., Low, V., Chen, C., Zhao, X., Arnold, F., Yan, Z., Pramod, S., Hang, Y., et al. (2025) · Cancer Discovery · doi:10.1158/2159-8290.cd-24-1079 · Cited by 4

Tie2 activity in cancer associated myofibroblasts serves as novel target against reprogramming of cancer cells to embryonic-like cell state and associated poor prognosis in oral carcinoma patients

Mitra, P., Saha, U., Kingsly, J. S., Prasad, P., Jena, S., Patel, A. K., Harshavardhan, B. V., Mondal, S. K., Kurkalang, S., Roy, S., et al. (2025) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-025-03405-8 · Cited by 5

The Prolyl Isomerase PIN1 Affects Fibroblast Differentiation States and Cross-talk in Pancreatic Cancer

Bowman, C. L., Daniel, C. J., Carlson, E. J., Shah, V. M., Farrell, A. S., Kresse, K. M., Wang, X., Lindley, K. A., Kuhn, M. R., Hawthorne, K., et al. (2025) · Cancer Research · doi:10.1158/0008-5472.can-24-3437 · Cited by 6

Loss of TRPV4 reduces pancreatic cancer growth and metastasis

Romac, J. M.-J., Swain, S. M., Mullappilly, N., Bindhani, B., & Liddle, R. A. (2025) · JCI Insight · doi:10.1172/jci.insight.196280 · Cited by 7

SDC1 + CAFs secreting CTGF drive tumour metastasis via FGFR3 signalling in cancers

Gao, G., Ruan, Z.-H., Zhang, S.-B., He, S., Li, Y., Lyu, J., Liu, Y., Tan, X.-L., Wang, Y.-J., Liu, Z., et al. (2026) · Gut · doi:10.1136/gutjnl-2025-337606 · Cited by 3

Reprogramming the pancreatic tumor microenvironment using smart stem cells: A new frontier in cancer therapy

Khan, T. B., Choudhary, N., Sharma, S., Kumar, D., Kaushik, U., Gupta, V., Gowri, S., Faiyazuddin, M., & Webster, T. J. (2026) · Advances in Cancer Biology - Metastasis · doi:10.1016/j.adcanc.2026.100188 · Cited by 4

ATM Deficiency Induces TGFβ-Mediated Stromal Programming in Pancreatic Cancer

Roger, É., Mummey, H. M., Zimmer, E., Srinivasan, D., Härle, A., Moubri, L., Michels, A. K., Singh, R., Ekizce, M., Melzer, M. K., et al. (2026) · Cancer Research · doi:10.1158/0008-5472.can-26-0138 · Cited by 4

The Few yet Fabp4ulous Pancreatic Stellate Cells Give Rise to Protumoral CAFs

Cukierman, E. (2022) · Cancer Discovery · doi:10.1158/2159-8290.cd-21-1501 · Cited by 3

The relationship between cadmium exposure and hepatitis B susceptibility and the establishment of its prediction model

Lu, J., Shi, Z., Hu, H., Shen, D., Zhou, Y., Feng, Y., Tang, D., Qin, H., & Wang, J. (2023) · Environmental Science and Pollution Research · doi:10.1007/s11356-023-29267-1 · Cited by 3

The molecular classification of cancer-associated fibroblasts on a pan-cancer single-cell transcriptional profilingPreprint

Chen, B., Chan, W. N., Xie, F., Mui, C. W., Cheung, A. H. K., liu, X., Lung, R. W. M., Chow, C., Zhang, Z., Shi, S., et al. (2023) · Research Square · doi:10.21203/rs.3.rs-2412848/v1 · Cited by 3

Analysis of donor pancreata defines the transcriptomic signature and microenvironment of early pre-neoplastic pancreatic lesionsPreprint

Carpenter, E. S., Elhossiny, A. M., Kadiyala, P., Li, J., McGue, J. J., Griffith, B. D., Zhang, Y., Edwards, J., Nelson, S., Lima, F., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.01.13.523300 · Cited by 3

Netrin G1 Ligand is a new stromal immunomodulator that promotes pancreatic cancerPreprint

Costa, D. B. V., Francescone, R., Franco‐Barraza, J., Luong, T., Graves, M., de Aquino, A. M., Steele, N. G., Gardiner, J. C., dos Santos, S. A. A., Ogier, C., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.05.15.594354 · Cited by 3

Stromal KITL/SCF promotes pancreas tissue homeostasis and restrains tumor progressionPreprint

Oñate, M. K., Oon, C. H., Bhattacharyya, S., Low, V., Chen, C., Zhao, X., Yan, Z., Hang, Y., Kim, S. K., Xia, Z., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.07.29.605485 · Cited by 3

Hypoxia-induced histone methylation and NF-κB activation in pancreas cancer fibroblasts promote EMT-supportive growth factor secretionPreprint

Kowalewski, K. M., Adair, S. J., Talkington, A., Wieder, J. J., Pitarresi, J. R., Perez-Vale, K. Z., Chu, B., Dolatshahi, S., Sears, R. C., Stanger, B. Z., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.01.30.635486 · Cited by 3

Cancer‑associated fibroblasts in human malignancies, with a particular emphasis on sarcomas (Review)

Benešová, I., Kalkusova, K., Kwon, Y., Táborská, P., Stakheev, D., Krausová, K., Smetanová, J., Ozaniak, A., Bartůňková, J., Smrž, D., et al. (2025) · International Journal of Oncology · doi:10.3892/ijo.2025.5785 · Cited by 3

Wilms Tumor 1–Expressing Stromal Cells Promote Pancreatic Cancer Progression

Bischoff, A. C., Brown, K. L., Lasse-Opsahl, E., Watkoske, H. R., Espinoza, C. E., Okoye, J., Olivei, A., Green, L. M., Rai, R., The, S., et al. (2025) · Cancer Research · doi:10.1158/0008-5472.can-25-1014

Modeling CAF-tumor interactions to overcome therapy resistance

Gubała, J., Benamran, D. A., Tsantoulis, P. K., Mieville, V., Valério, M., & Nowak-Sliwinska, P. M. (2026) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-025-03633-y · Cited by 2

Pulsed Low-Dose-Rate Chemoradiation Induces Stromal Reprogramming in Pancreatic CAF-Generated ECM: Quantification by the HOST-Factor

Franco‐Barraza, J., Dmitrieva, M., Luong, T., Egleston, B. L., Raghavan, K. S., Wong, J. K., Costa, D. B. V., Francescone, R. A., III, Gardiner, J. C., Handorf, E. A., et al. (2026) · Gastro Hep Advances · doi:10.1016/j.gastha.2026.100902 · Cited by 3

Local gene editing of fibroblasts in tumors reveals a new cancer-associated fibroblast state

Kuhn, N. F., Zaleta-Linares, I., Hu, K. H., Courau, T., Davidson, B. R., Tam, T., Chu, C.-W., Kinet, M., Rosenblum, M. D., Combes, A. J., et al. (2026) · The Journal of Experimental Medicine · doi:10.1084/jem.20251228 · Cited by 5

Neutrophil extracellular traps induced by tumour-derived NGAL reprogram CAF subtypes via ITGA5 to promote tumour progression in pancreatic cancer

Liu, W. T., Wang, X., Chen, R., Wen, L., Xiao, A., Wang, W., Zhang, J. I.-X., Liu, M. J., Zhang, X., Liu, X., et al. (2026) · Gut · doi:10.1136/gutjnl-2025-337720 · Cited by 2

Differential Effects of Confinement on the Dynamics of Normal and Tumor-Derived Pancreatic Ductal Organoids

Rosas, J. M., Campanale, J. P., Harwood, J., Li, L., Bae, R., Cheng, S., Tsou, J. M., Kaiser, K. M., Engle, D. D., Montell, D. J., et al. (2024) · ACS Applied Bio Materials · doi:10.1021/acsabm.4c01301 · Cited by 3

Integrins in Cancer: Refocusing on the Tumor Microenvironment

Zeltz, C., Lü, N., Heljäsvaara, R., & Gullberg, D. (2022) · Biology of extracellular matrix · doi:10.1007/978-3-030-99708-3_11 · Cited by 3

Editorial: Mechanisms of Inflammation and Fibrosis Interplays in the Digestive Diseases

Masamune, A., & Hamada, S. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.906742 · Cited by 2

FABP4-tastic Pancreatic Stellate Cells Coddle KITL to Uphold Inherent Microenvironmental Tumor Suppression

Dolskiy, A. A., & Cukierman, E. (2025) · Cancer Discovery · doi:10.1158/2159-8290.cd-25-0212 · Cited by 1

Comparative Analysis of Primary and Liver Fibroblasts Reveals MET as a Potent Target in Pancreatic Cancer Metastasis

Singh, R., Yousefian, N., Allen, W. M., Silva, A. D., Anaraki, C., Michels, A. K., Calderon, S. E., Loveless, I. M., Rastelli, D., George, A., et al. (2026) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2026.101872 · Cited by 1

Integrated bulk and single-cell RNA profiling implicates MFAP5+ CAFs in potential role in peritoneal metastasis of gastric cancer

Ruan, R., Dai, X., Zhang, L., Xiong, J., Yao, Y., & Deng, J. (2025) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2025.152841 · Cited by 1

Mucin 5ac modulates cancer-associated fibroblast heterogeneity through epigenetic reprogramming of precursor cells

Kehrberg, R. J., Bhyravbhatla, N., Alsafwani, Z. W., Li, X., Natarajan, G., Khan, I. K., Brand, R. E., Jain, M., Batra, S. K., & Sushil Kumar, K. (2025) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00926.2024 · Cited by 1

Breaking barriers: nano-boosted drug delivery systems in overcoming the defenses of pancreatic cancer

Wang, Y., Zhang, Y., Wang, X., Zhao, W., Li, Q., Zhou, M., Liu, Y., Yi, X., He, J. I., Li, Y. P., et al. (2026) · Molecular Cancer · doi:10.1186/s12943-026-02712-8 · Cited by 1

Biofabrication and artificial intelligence strategies for investigating solid- and fluid-pressure mechanobiology in pancreatic ductal adenocarcinoma

Ding, Y., Zhao, P., Yan, J., Li, Y., Wang, Z., Lu, Y., Zhang, Y., Chen, H., Zhang, W., Luan, X., et al. (2026) · Cancer and Metastasis Reviews · doi:10.1007/s10555-026-10366-7 · Cited by 1

Multi-stromal organoid co-culture modelling reveals epithelial–fibroblast heterogeneity in pancreatic cancer and pancreatitis

Li, W., Jihad, M., Lloyd, E. G., Zaccaria, M., Mucciolo, G., Nsubuga, G., Koonan-Lonappan, A., Henríquez, J. A., Cheng, P. S. W., Harish, S., et al. (2026) · Nature Cell Biology · doi:10.1038/s41556-026-02057-w · Cited by 1

Origin, activation and heterogeneity of fibroblasts associated with pancreas and breast cancers

Han, L., Seward, C., Leone, G. W., & Ostrowski, M. C. (2022) · Advances in cancer research · doi:10.1016/bs.acr.2022.03.003 · Cited by 1

The Effect of Intratumor Heterogeneity in Pancreatic Ductal Adenocarcinoma Progression and Treatment

Saleh, O. M., Shihadeh, H., Yousef, A. A., Erekat, H., Abdallh, F., Al-leimon, A., Elsalhy, R., Altiti, A., Dajani, M., & AlBarakat, M. M. (2024) · Pancreas · doi:10.1097/mpa.0000000000002342 · Cited by 1

Exploring the potential role of palladin in modulating human CAF / ECM functional units

Dolskiy, A. A., dos Santos, S. A. A., Andrake, M., Franco‐Barraza, J., Dunbrack, R. L., & Cukierman, E. (2024) · Cytoskeleton · doi:10.1002/cm.21926 · Cited by 1

BRCA mutational status shapes the stromal microenvironment of pancreatic cancer linking CLU + CAF expression with HSF1 signalingPreprint

Shaashua, L., Pevsner‐Fischer, M., Friedman, G., Levi-Galibov, O., Nandakumar, S., Nevo, R., Brown, L. E., Zhang, W., Stein, Y., Kim, H. S., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.08.18.456576 · Cited by 1

Discovery of a Linked Constellation of Gene Expression Revealed by Local Editing of Fibroblasts in TumorsPreprint

Kuhn, N. F., Zaleta-Linares, I., Hu, K. H., Courau, T., Davidson, B., Tam, T., Combes, A. J., Nyberg, W. A., Eyquem, J., & Krummel, M. F. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.07.11.603114 · Cited by 1

Blocking Osteoprotegerin Reprograms Cancer Associated Fibroblast to Promotes Immune Infiltration into the Tumor MicroenvironmentPreprint

Wang, Y., Apostolopoulou, H., Sun, I., Bains, A., Gibbs, D. L., Huang, S., Alliston, T. N., Maker, A. V., Tlsty, T. D., Ntranos, V., et al. (2025) · eLife · doi:10.7554/elife.107984.1 · Cited by 1

Morphospatial profiling of cancer-associated fibroblasts reveals architectural subtypes of pancreatic ductal adenocarcinomaPreprint

Bryce, A. S., Martinelli, S., Santana, L. S., Officer-Jones, L., Baird, R. L., Ballantyne, F., Rakovic, K., Powley, I. R., Tataran, D., Meltzer, D. J., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.02.06.704414 · Cited by 1

Commentary on “Intercellular TIMP-1-CD63 signaling directs the evolution of immune escape and metastasis in KRAS-mutated pancreatic cancer cells”

Zhang, B., & Shang, D. (2026) · Molecular Cancer · doi:10.1186/s12943-026-02656-z · Cited by 2

Abstract SY23-03: Mesenchymal lineage heterogeneity as a determinant of matrix composition and tumor progression

Sherman, M. H. (2022) · Cancer Research · doi:10.1158/1538-7445.am2022-sy23-03

Abstract IA008: Mechanisms and consequences of pancreatic cancer stromal evolution

Sherman, M. H. (2023) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.targ-23-ia008

Abstract I01: Mechanisms and consequences of pancreatic cancer stromal evolution

Sherman, M. H. (2019) · Cancer Research · doi:10.1158/1538-7445.panca19-i01

Inter‐ and intra‐tumoural heterogeneity in cancer‐associated fibroblasts of human pancreatic ductal adenocarcinoma

Neuzillet, C., Tijeras‐Raballand, A., Ragulan, C., Cros, J. F., Patil, Y., Martinet, M., Erkan, M., Kleeff, J. H., Wilson, J. S., Apte, M. V., et al. (2018) · The Journal of Pathology · doi:10.1002/path.5224 · Cited by 310

Fibroblast Heterogeneity in the Pancreatic Tumor Microenvironment

Helms, E. J., Oñate, M. K., & Sherman, M. H. (2020) · Cancer Discovery · doi:10.1158/2159-8290.cd-19-1353 · Cited by 288