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The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.

mTOR Inhibition Improves Antitumor Effects of Vaccination with Antigen-Encoding RNA

Diken, Mustafa, Kreiter, Sebastian, Vascotto, Fulvia, Selmi, Abderraouf, Attig, Sebastian, Diekmann, Jan, Huber, Christoph, Türeci, Özlem, Sahin, Ugur·2013·Cancer Immunology Research
DOI 10.1158/2326-6066.cir-13-0046

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Abstract

Vaccination with in vitro transcribed RNA encoding tumor antigens is an emerging approach in cancer immunotherapy. Attempting to further improve RNA vaccine efficacy, we have explored combining RNA with immunomodulators such as rapamycin. Rapamycin, the inhibitor of mTOR, was used originally for immunosuppression. Recent reports in mouse systems, however, suggest that mTOR inhibition may enhance the formation and differentiation of the memory CD8+ T-cell pool. Because memory T-cell formation is critical to the outcome of vaccination aproaches, we studied the impact of rapamycin on the in vivo primed RNA vaccine-induced immune response using the chicken ovalbumin-expressing B16 melanoma model in C57BL/6 mice. Our data show that treatment with rapamycin at the effector-to-memory transition phase skews the vaccine-induced immune response toward the formation of a quantitatively and qualitatively superior memory pool and results in a better recall response. Tumor-infiltrating immune cells from these mice display a favorable ratio of effector versus suppressor cell populations. Survival of mice treated with the combined regimen of RNA vaccination with rapamycin is significantly longer (91.5 days) than that in the control groups receiving only one of these compounds (32 and 46 days, respectively). Our findings indicate that rapamycin enhances therapeutic efficacy of antigen-specific CD8+ T cells induced by RNA vaccination, and we propose further clinical exploration of rapamycin as a component of immunotherapeutic regimens. Cancer Immunol Res; 1(6); 386–92. ©2013 AACR.

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Research works printed but not linked: 17

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Metadata

Authors
Diken, M., Kreiter, S., Vascotto, F., Selmi, A., Attig, S., Diekmann, J., Huber, C., Türeci, Ö., & Sahin, U.
Affiliations
Authors' Affiliations: 1TRON-Translational Oncology and 2Department of Internal Medicine III, University Medical Center of Johannes Gutenberg University; 3Ribological, Biontech AG; and 4Ganymed Pharmaceuticals, Mainz, Germany
Venue
Cancer Immunology Research
Publisher
American Association for Cancer Research (AACR)
Published
2013-12-01
Volume
1
Issue
6
Pages
386-392
ISSN
  • 2326-6066
  • 2326-6074
DOI
10.1158/2326-6066.cir-13-0046
Cited by
45
References
8
Language
en

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CoChat. (2026). Citation check: mTOR Inhibition Improves Antitumor Effects of Vaccination with Antigen-Encoding RNA. https://app.cochat.ai/papers/10.1158/2326-6066.cir-13-0046
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Diken, M., Kreiter, S., Vascotto, F., Selmi, A., Attig, S., Diekmann, J., Huber, C., Türeci, Ö., & Sahin, U. (2013). mTOR Inhibition Improves Antitumor Effects of Vaccination with Antigen-Encoding RNA. Cancer Immunology Research. https://doi.org/10.1158/2326-6066.cir-13-0046