The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
A 52-Week Study of the Efficacy of Rivastigmine in Patients with Mild to Moderately Severe Alzheimer’s Disease
Abstract
The efficacy of a centrally active cholinesterase inhibitor, rivastigmine tartrate (ENA 713; Exelon®), in patients with mild to moderately severe Alzheimer’s disease was evaluated in a 26-week open-label extension of a 26-week, double-blind, placebo-controlled study. By 52 weeks, patients originally treated with 6–12 mg/day rivastigmine had significantly better cognitive function than patients originally treated with placebo.
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“Initiation of AChEI treatment as soon as possible after the diagnosis is preferred as patients who started the AChEI 6 months later showed more rapid cognitive decline than those who started the drug immediately.17”
From Current and Future Treatments in Alzheimer Disease: An Update (2020) · cites this paper as [17]
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Metadata
- Authors
- Farlow, M., Anand, R., Messina Jr, J., Hartman, R., & Veach, J.
- Affiliations
- Indiana University Indianapolis (US)
- Venue
- European Neurology
- Publisher
- S. Karger AG
- Published
- 2000
- Volume
- 44
- Issue
- 4
- Pages
- 236-241
- ISSN
- 0014-3022 (ISSN-L)
- 1421-9913
- OpenAlex
- W2076676029
- Cited by
- 332
- References
- 10
- Citations by year
- 2026: 6 · 2025: 6 · 2024: 7 · 2023: 9 · 2022: 10 · 2021: 8 · 2020: 6 · 2019: 7 · 2018: 5 · 2017: 5 · 2016: 8 · 2015: 4 · 2014: 3 · 2013: 9 · 2012: 7
- FWCI
- 15.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Cholinesterase and Neurodegenerative Diseases
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Keywords
- rivastigmine, Alzheimer's disease, cholinesterase inhibitors, cognitive function, open-label extension, long-term efficacy
- MeSH terms
- Rivastigmine, Age Factors, Aged, Alzheimer Disease, Carbamates, Cholinesterase Inhibitors, Cognition, Dose-Response Relationship, Drug, Double-Blind Method, Humans, Time Factors, Treatment Outcome, Disease Progression, Phenylcarbamates
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