The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
X-Chromosome inactivation: a repeat hypothesis
Abstract
Recent work has shown that X-chromosome inactivation is brought about by Xist mRNA, which coats the inactive X-chromosome. This paper presents a hypothesis on the function of this RNA. It is suggested that interspersed repetitive elements of the LINE type, in which the X-chromosome is particularly rich, act as booster elements to promote the spread of Xist mRNA. Contact with this RNA causes the LINE elements to be sensed as repeated elements by the cell’s system for repeat-induced gene silencing. This leads to the silencing of these elements and the intervening unique sequences by their conversion to heterochromatin.
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Citations
Cites
Gene Action in the X-chromosome of the Mouse (Mus musculus L.)
LYON, M. F. (1961) · Nature · doi:10.1038/190372a0 · Cited by 3,978
Self-citationCytosine methylation and the ecology of intragenomic parasites
Yoder, J. A., Walsh, C. P., & Bestor, T. H. (1997) · Trends in Genetics · doi:10.1016/s0168-9525(97)01181-5 · Cited by 1,562
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Brown, C. J., Hendrich, B. D., Rupert, J. L., Lafrenière, R. G., Xing, Y., Lawrence, J., & Willard, H. F. (1992) · Cell · doi:10.1016/0092-8674(92)90520-m · Cited by 1,310
Requirement for Xist in X chromosome inactivation
Penny, G. D., Kay, G. F., Sheardown, S. A., Rastan, S., & Brockdorff, N. (1996) · Nature · doi:10.1038/379131a0 · Cited by 1,205
Brockdorff, N., Ashworth, A., Kay, G. F., McCabe, V. M., Norris, D. P., Cooper, P. J., Swift, S., & Rastan, S. (1992) · Cell · doi:10.1016/0092-8674(92)90519-i · Cited by 1,026
Requirement for Xist in X chromosome inactivation
(1996) · Trends in Genetics · doi:10.1016/0168-9525(96)81414-4 · Cited by 970
Clemson, C. M., McNeil, J. A., Willard, H. F., & Lawrence, J. B. (1996) · The Journal of cell biology · doi:10.1083/jcb.132.3.259 · Cited by 805
Xist-deficient mice are defective in dosage compensation but not spermatogenesis.
Marahrens, Y., Panning, B., Dausman, J., Strauss, W., & Jaenisch, R. (1997) · Genes & Development · doi:10.1101/gad.11.2.156 · Cited by 734
Conservation of position and exclusive expression of mouse Xist from the inactive X chromosome
Brockdorff, N., Ashworth, A., Kay, G. F., Cooper, P., Smith, S., McCabe, V. M., Norris, D. P., Penny, G. D., Patel, D., & Rastan, S. (1991) · Nature · doi:10.1038/351329a0 · Cited by 643
Cited by
Initial sequencing and comparative analysis of the mouse genome
Mouse Genome Sequencing Consortium (2002) · Nature · doi:10.1038/nature01262 · Cited by 7,187
X-inactivation profile reveals extensive variability in X-linked gene expression in females
Carrel, L., & Willard, H. F. (2005) · Nature · doi:10.1038/nature03479 · Cited by 2,097
Mobile Elements: Drivers of Genome Evolution
Kazazian, H. H. (2004) · Science · doi:10.1126/science.1089670 · Cited by 1,922
Regulatory activities of transposable elements: from conflicts to benefits
Chuong, E. B., Elde, N. C., & Feschotte, C. (2017) · Nature Reviews Genetics · doi:10.1038/nrg.2016.139 · Cited by 1,489
The DNA sequence of the human X chromosome
Ross, M. T., Grafham, D. V., Coffey, A. J., Scherer, S., McLay, K., Muzny, D., Platzer, M., Howell, G. R., Burrows, C., Bird, C. P., et al. (2005) · Nature · doi:10.1038/nature03440 · Cited by 1,129
Metadata
- Authors
- Lyon, M. F.
- Venue
- Cytogenetic and Genome Research
- Publisher
- S. Karger AG
- Published
- 1998
- Volume
- 80
- Issue
- 1-4
- Pages
- 133-137
- ISSN
- 1424-859X (ISSN-L)
- 1424-8581
- OpenAlex
- W2033285403
- Cited by
- 462
- References
- 30
- FWCI
- 9.10
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lyon, M. F. (1998). X-Chromosome inactivation: a repeat hypothesis. Cytogenetic and Genome Research. https://doi.org/10.1159/000014969
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
