The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Induction of Cellular Differentiation by Retinoic Acid in vitro
Abstract
Cellular differentiation by the vitamin A derivative retinoic acid (RA) has been studied with undifferentiated pluripotent embryonic carcinoma (EC) and embryonic stem (ES) cells in vitro. Both cellular systems are suitable to study differentiation of various cell types, because they recapitulate early stages of mouse embryogenesis. In vivo, RA was identified as a morphogenic and teratogenic compound and furthermore as a signalling molecule influencing gene expression in a complex manner via a family of RA receptors. Here, we summarize in vitro studies with ES and EC cells in comparison to in vivo studies that have contributed to our understanding how RA influences differentiation and regulates gene expression. We demonstrate that modulation of ES cell differentiation in vitro by RA depends on the concentration and developmental stage of application which is comparable to its stage-dependent influence on embryonic development in vivo.
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Cites
The nuclear receptor superfamily: the second decade
Mangelsdorf, D. J., Thummel, C., Beato, M., Herrlich, P., Schütz, G., Umesono, K., Blumberg, B., Kastner, P., Mark, M., Chambon, P., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90199-x · Cited by 6,964
A decade of molecular biology of retinoic acid receptors
Chambon, P. (1996) · The FASEB Journal · doi:10.1096/fasebj.10.9.8801176 · Cited by 2,889 · cited 7×
“Thirdly, an additional level of complexity is generated by the formation of functionally active heterodimers of RXRs with other nuclear receptors and by interaction of RARs and RXRs with other factors that induce or inhibit gene expression [Chambon, 1996].”
BackgroundInfluentialLammer, E. J., Chen, D. T., Hoar, R. M., Agnish, N. D., Benke, P. J., Braun, J. T., Curry, C. J., Fernhoff, P. M., Grix, A. W., Lott, I. T., et al. (1985) · New England Journal of Medicine · doi:10.1056/nejm198510033131401 · Cited by 1,942 · cited 4×
“Application of RA during embryogenesis resulted mainly in severe defects of craniofocial structures including the central nervous system [Lammer et al., 1985; Durston et al., 1989], the limbs [Kochhar, 1973; Alles and Sulik, 1989; Eichele, 1989; Tabin, 1991] and the axial skeleton [Sive et al.”
BackgroundInfluentialEmbryonic development and pattern formation
Morriss‐Kay, G. M., & Sokolova, N. (1996) · The FASEB Journal · doi:10.1096/fasebj.10.9.8801178 · Cited by 203
Cited by
Shaw, N., Elholm, M., & Noy, N. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.c300368200 · Cited by 243
BOST, F., CARON, L., MARCHETTI, I., DANI, C., MARCHAND-BRUSTEL, Y. L., & BINÉTRUY, B. (2002) · Biochemical Journal · doi:10.1042/bj3610621 · Cited by 184
Metadata
- Authors
- Rohwedel, J., Guan, K., & Wobus, A. M.
- Venue
- Cells Tissues Organs
- Publisher
- S. Karger AG
- Published
- 1999
- Volume
- 165
- Issue
- 3-4
- Pages
- 190-202
- ISSN
- 1422-6405 (ISSN-L)
- 1422-6421
- OpenAlex
- W1999468613
- Cited by
- 211
- References
- 4
- FWCI
- 2.17
- Type
- journal article
- Language
- en
- Open access
- closed
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