Postnatal Development of Dopamine D1-Like Receptors in Rat Cortical and Striatolimbic Brain Regions: An Autoradiographic Study
Abstract
Postnatal development of dopamine D1-like (D1/D5) receptors in rat caudate-putamen (CPu), nucleus accumbens (NAc), hippocampus, frontal and entorhinal cerebral cortex was assessed between postnatal days (PD) 7-60 by in vitro receptor autoradiography. Density of [3H]SCH-23390 binding to D1-like receptors increased from PD-7 to a peak at PD-28 in CPu (11-fold) and NAc (23-fold), then declined by 20-40% in both regions over PD-35-60, to adult levels. In hippocampus, frontal and entorhinal cortex, D1-like receptors increased by lesser amounts (3- to 4-fold) from PD-7 to stable, maximal adult levels at PD-60. Evidently, excess D1-like receptors were eliminated during maturation of CPu and NAc, but not in the other forebrain regions. Postnatal D1-like receptor development in rat forebrain paralleled that of D2- and D4-like receptors in the same regions.
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Animal models show that pruning of dopamine receptors is protracted in the prefrontal cortex compared with the striatum and accumbens.
“animal models show protracted pruning of dopamine receptors in the PFC compared to the striatum and accumbens (Andersen et al., 2000; Tarazi et al., 1999).”
From The effects of early life stress on reward processing (2018) · cites this paper as Tarazi et al., 1999
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References 43 · Cited by 169
- Authors
- Tarazi, F. I., Tomasini, E. C., & Baldessarini, R.
- Affiliations
- Harvard University (US)
- ORCID
- Tarazi, Frank I.
- Venue
- Developmental Neuroscience
- Publisher
- S. Karger AG
- Published
- 1999
- Volume
- 21
- Issue
- 1
- Pages
- 43-49
- ISSN
- 0378-5866 (ISSN-L)
- 1421-9859
- OpenAlex
- W2041691811
- Cited by
- 169
- References
- 43
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 6 · 2023: 5 · 2022: 4 · 2021: 5 · 2020: 3 · 2019: 4 · 2018: 5 · 2017: 6 · 2016: 11 · 2015: 4 · 2014: 2 · 2013: 7 · 2012: 5
- FWCI
- 1.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Developmental Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5k05mh047370-25, 5t32mh019905-05, 5r01mh034006-18)
- National Institute of Mental Health (MH-34006, MH47370, MH-19905)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Keywords
- D1-like receptors, dopamine D1 receptor, dopamine D5 receptor, postnatal development, receptor density, caudate-putamen, nucleus accumbens, hippocampus, frontal cortex, entorhinal cortex, rats
- MeSH terms
- Aging, Animals, Autoradiography, Cerebral Cortex, Corpus Striatum, Hippocampus, Limbic System, Male, Nucleus Accumbens, Rats, Sprague-Dawley, Receptors, Dopamine D1, Entorhinal Cortex, Rats
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