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(±)3,4-Methylenedioxymethamphetamine (‘Ecstasy’)-Induced Serotonin Neurotoxicity: Clinical Studies
Abstract
(±)3,4-Methylenedioxymethamphetamine (MDMA, ‘Ecstasy’) is a brain serotonergic neurotoxin in experimental animals, including nonhuman primates. It is also an increasingly popular recreational drug of abuse, and doses of MDMA that are used recreationally overlap with those that produce serotonin (5-HT) neurotoxicity in animals. Studies in human MDMA users probing for evidence of brain serotonergic neurotoxicity indicate that some MDMA users may incur MDMA-related 5-HT neural injury and, possibly, functional sequelae. In particular, MDMA users have selective decrements in cerebrospinal fluid 5-hydroxyindoleacetic acid and brain 5-HT transporters, similar to nonhuman primates with documented MDMA-induced neurotoxicity. Functional abnormalities seen in MDMA users that may be related to 5- HT injury include cognitive deficits, altered sleep architecture, altered neuroendocrine function, altered behavioral responses to 5-HT selective drugs, and increased impulsivity. Additional studies in animals, as well as longitudinal and epidemiological studies in MDMA users, are required to confirm and extend the present data, and to determine whether MDMA users are at increased risk for developing neuropsychiatric illness as they age.
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“This may have affected results, as it is possible that heavy ecstasy use causes long-term alterations to serotonergic neurotransmission (McCann et al. 2000; see also Bedi et al., 2008 for discussion of methodological issues).”
From Effects of MDMA on sociability and neural response to social threat and social reward (2009) · cites this paper as McCann et al. 2000
Citations
Cites
An inventory for assessing different kinds of hostility.
Buss, A. H., & Durkee, A. (1957) · Journal of Consulting Psychology · doi:10.1037/h0046900 · Cited by 2,614
McCann, U., Szabò, Z., Scheffel, U., Dannals, R. F., & Ricaurte, G. A. (1998) · The Lancet · doi:10.1016/s0140-6736(98)04329-3 · Cited by 658
Self-citationCharney, D. S., Woods, S. W., Goodman, W. K., & Heninger, G. R. (1987) · Psychopharmacology · doi:10.1007/bf00215473 · Cited by 462
Central Serotonin and Impulsive Aggression
Coccaro, E. F. (1989) · The British Journal of Psychiatry · doi:10.1192/s0007125000291769 · Cited by 451
Memory impairment in abstinent MDMA ("Ecstasy") users
Bolla, K. I., McCann, U. D., & Ricaurte, G. A. (1998) · Neurology · doi:10.1212/wnl.51.6.1532 · Cited by 374
Self-citationSerotonergic Responsivity in Obsessive-Compulsive Disorder
Zohar, J. (1987) · Archives of General Psychiatry · doi:10.1001/archpsyc.1987.01800230026006 · Cited by 370
Ecstasy use in Australia: patterns of use and associated harm
Topp, L., Hando, J., Dillon, P., ROCHE, A. M., & Solowij, N. (1999) · Drug and Alcohol Dependence · doi:10.1016/s0376-8716(99)00002-2 · Cited by 353
Ecstasy (MDMA) effects upon mood and cognition: before, during and after a Saturday night dance
Parrott, A. C., & Lasky, J. (1998) · Psychopharmacology · doi:10.1007/s002130050714 · Cited by 338
McCann, U. D., Ridenour, A., Shaham, Y., & Ricaurte, G. A. (1994) · Neuropsychopharmacology · doi:10.1038/npp.1994.15 · Cited by 333
Self-citationMcCann, U., Mertl, M., Eligulashvili, V., & Ricaurte, G. A. (1999) · Psychopharmacology · doi:10.1007/s002130050967 · Cited by 300
Self-citation(±)3,4-Methylenedioxymethamphetamine (‘Ecstasy’)-Induced Serotonin Neurotoxicity: Studies in Animals
Ricaurte, G. A., Yuan, J., & McCann, U. D. (2000) · Neuropsychobiology · doi:10.1159/000026664 · Cited by 292
Self-citationRecreational Use of “Ecstasy” (MDMA) Is Associated with Elevated Impulsivity
Morgan, M. J. (1998) · Neuropsychopharmacology · doi:10.1016/s0893-133x(98)00012-8 · Cited by 291
Memory deficits associated with recreational use of "ecstasy" (MDMA)
Morgan, M. J. (1999) · Psychopharmacology · doi:10.1007/s002130050803 · Cited by 284
Ricaurte, G. A., Martello, A. L., Katz, J. L., & Martello, M. (1992) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)11083-5 · Cited by 268
Self-citationFischer, C., Hatzidimitriou, G., Wlos, J., Katz, J. L., & Ricaurte, G. A. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-08-05476.1995 · Cited by 267
Self-citationCognitive performance in recreational users of MDMA or 'ecstasy': evidence for memory deficits
Parrott, A. C., Lees, A., Garnham, N. J., Jones, M., & Wesnes, K. A. (1998) · Journal of Psychopharmacology · doi:10.1177/026988119801200110 · Cited by 219
Murphy, D. L., Lesch, K., Aulakh, C. S., & Pigott, T. A. (1991) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06674-8 · Cited by 216
Lucki, I., Ward, H. R., & Frazer, A. (1989) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)23232-3 · Cited by 189
Krystal, J. H., Price, L. H., Opsahl, C. A., Ricaurte, G. A., & Heninger, G. R. (1992) · The American Journal of Drug and Alcohol Abuse · doi:10.3109/00952999209026070 · Cited by 168
Self-citationSerotonergic function after (±)3,4-methylene-dioxymethamphetarnine (‘Ecstasy’) in humans
Gerra, G., Zaimovic, A., Giucastro, G., Maestri, D., Monica, C., Sartori, R., Caccavari, R., & Delsignore, R. (1998) · International Clinical Psychopharmacology · doi:10.1097/00004850-199801000-00001 · Cited by 145
Brewerton, T. D., Berrettini, W. H., Nürnberger, J. I., & Linnoila, M. (1988) · Psychiatry Research · doi:10.1016/0165-1781(88)90016-9 · Cited by 140
Ricaurte, G. A., Finnegan, K. T., Irwin, I., & Langston, J. W. (1990) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1990.tb16919.x · Cited by 102
Self-citationBjork, J. M., Moeller, F. G., Kramer, G. L., Kram, M., Surís, A., Rush, A. J., & Petty, F. (2001) · Psychiatry Research · doi:10.1016/s0165-1781(01)00220-7 · Cited by 92
Price, L. H. (1989) · Archives of General Psychiatry · doi:10.1001/archpsyc.1989.01810010022003 · Cited by 92
Cerebrospinal Fluid Studies of Neurotransmitter Function in Manic and Depressive Illness
Post, R. M., Ballenger, J. C., & Goodwin, F. K. (1980) · Springer eBooks · doi:10.1007/978-1-4684-1039-6_47 · Cited by 88
Ricaurte, G. A., DeLanney, L. E., Wiener, S. G., Irwin, I., & Langston, J. W. (1988) · Brain Research · doi:10.1016/0006-8993(88)90451-9 · Cited by 87
Self-citationHypnotic Effects of L-Tryptophan
Hartmann, E. L. (1974) · Archives of General Psychiatry · doi:10.1001/archpsyc.1974.01760150098014 · Cited by 74
Effects of mCPP on the Extracellular Concentrations of Serotonin and Dopamine in Rat Brain
Eriksson, E. (1999) · Neuropsychopharmacology · doi:10.1016/s0893-133x(98)00070-0 · Cited by 72
Tryptophan and Sleep in Young Adults
Griffiths, W. J., Lester, B. K., Coulter, J. D., & Williams, H. L. (1972) · Psychophysiology · doi:10.1111/j.1469-8986.1972.tb03218.x · Cited by 59
Quattrone, A., Schettini, G., Annunziato, L., & Renzo, G. D. (1981) · European Journal of Pharmacology · doi:10.1016/0014-2999(81)90003-0 · Cited by 59
Bertilsson, L., Åsberg, M., Lantto, O., Scalia‐Tomba, G., Träskman‐Bendz, L., & Tybring, G. (1982) · Psychiatry Research · doi:10.1016/0165-1781(82)90040-3 · Cited by 53
Kuhn, C. M., Vogel, R. A., Mailman, R. B., Mueller, R. A., Schanberg, S. M., & Breese, G. R. (1981) · Psychopharmacology · doi:10.1007/bf00429216 · Cited by 38
Madras, B. K., Meltzer, P. C., Liang, A. Y., Elmaleh, D. R., Babich, J. W., & Fischman, A. J. (1998) · Synapse · doi:10.1002/(sici)1098-2396(199806)29:2 · Cited by 37
Self-citationClinical studies of 5-HT function using I.V. l-Tryptophan
Price, L. H., Charney, D. S., Delgado, P. L., Goodman, W. K., Krystal, J. H., Woods, S. W., & Heninger, G. R. (1990) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/0278-5846(90)90002-x · Cited by 36
Effects of L-tryptophan on sleep onset insomniacs.
Brown, C. C., Horrom, N. J., & Wagman, A. M. I. (1979) · PubMed · Cited by 23
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The pharmacology and toxicology of "ecstasy" (MDMA) and related drugs.
Kalant, H. (2001) · Europe PMC (PubMed Central) · Cited by 604
de la Torre, R., Farré, M., Roset, P. N., Pizarro, N., Abanades, S., Segura, M., Segura, J., & Camí, J. (2004) · Therapeutic Drug Monitoring · doi:10.1097/00007691-200404000-00009 · Cited by 459
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Liechti, M. E., Gamma, A., & Vollenweider, F. X. (2001) · Psychopharmacology · doi:10.1007/s002130000648 · Cited by 360
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Parrott, A. C. (2001) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.351 · Cited by 337
Metadata
- Authors
- McCann, U. D., Eligulashvili, V., & Ricaurte, G. A.
- Affiliations
- Johns Hopkins University (US)
- Venue
- Neuropsychobiology
- Publisher
- S. Karger AG
- Published
- 2000
- Volume
- 42
- Issue
- 1
- Pages
- 11-16
- ISSN
- 0302-282X (ISSN-L)
- 1423-0224
- OpenAlex
- W2056429846
- Cited by
- 190
- References
- 36
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 4 · 2022: 2 · 2021: 2 · 2020: 7 · 2019: 1 · 2018: 1 · 2017: 7 · 2016: 1 · 2015: 2 · 2014: 9 · 2013: 2 · 2012: 4
- FWCI
- 20.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuropsychobiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Johns Hopkins University
- Deutsches Krebsforschungszentrum
- National Institute on Drug Abuse (DA05938, DA05707, DA 00206, R01DA005938)
- NIH Clinical Center
- Topics
- Social Sciences › Psychology › Clinical Psychology › Psychedelics and Drug Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Forensic Toxicology and Drug Analysis
- Keywords
- MDMA, ecstasy, serotonin neurotoxicity, recreational drug use, 5-hydroxyindoleacetic acid, serotonin transporter, cognitive impairment, sleep architecture, impulsivity, neuropsychiatric disorders
- MeSH terms
- Animals, Hallucinogens, Humans, Serotonin, Serotonin Agents, N-Methyl-3,4-methylenedioxyamphetamine, Neurotoxicity Syndromes
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