The DOI matches its Crossref record; 35 of the 36 references it cites were found in a registry or an index.
(±)3,4-Methylenedioxymethamphetamine (‘Ecstasy’)-Induced Serotonin Neurotoxicity: Clinical Studies
Abstract
(±)3,4-Methylenedioxymethamphetamine (MDMA, ‘Ecstasy’) is a brain serotonergic neurotoxin in experimental animals, including nonhuman primates. It is also an increasingly popular recreational drug of abuse, and doses of MDMA that are used recreationally overlap with those that produce serotonin (5-HT) neurotoxicity in animals. Studies in human MDMA users probing for evidence of brain serotonergic neurotoxicity indicate that some MDMA users may incur MDMA-related 5-HT neural injury and, possibly, functional sequelae. In particular, MDMA users have selective decrements in cerebrospinal fluid 5-hydroxyindoleacetic acid and brain 5-HT transporters, similar to nonhuman primates with documented MDMA-induced neurotoxicity. Functional abnormalities seen in MDMA users that may be related to 5- HT injury include cognitive deficits, altered sleep architecture, altered neuroendocrine function, altered behavioral responses to 5-HT selective drugs, and increased impulsivity. Additional studies in animals, as well as longitudinal and epidemiological studies in MDMA users, are required to confirm and extend the present data, and to determine whether MDMA users are at increased risk for developing neuropsychiatric illness as they age.
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“This may have affected results, as it is possible that heavy ecstasy use causes long-term alterations to serotonergic neurotransmission (McCann et al. 2000; see also Bedi et al., 2008 for discussion of methodological issues).”
From Effects of MDMA on sociability and neural response to social threat and social reward (2009) · cites this paper as McCann et al. 2000
Citations
Cites
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Memory impairment in abstinent MDMA ("Ecstasy") users
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Self-citationSerotonergic Responsivity in Obsessive-Compulsive Disorder
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Ecstasy (MDMA) effects upon mood and cognition: before, during and after a Saturday night dance
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Cognitive Inflexibility After Prefrontal Serotonin Depletion
Clarke, H. F., Dalley, J. W., Crofts, H. S., Robbins, T. W., & Roberts, A. C. (2004) · Science · doi:10.1126/science.1094987 · Cited by 632
The pharmacology and toxicology of "ecstasy" (MDMA) and related drugs.
Kalant, H. (2001) · Europe PMC (PubMed Central) · Cited by 604
de la Torre, R., Farré, M., Roset, P. N., Pizarro, N., Abanades, S., Segura, M., Segura, J., & Camí, J. (2004) · Therapeutic Drug Monitoring · doi:10.1097/00007691-200404000-00009 · Cited by 459
Gender differences in the subjective effects of MDMA
Liechti, M. E., Gamma, A., & Vollenweider, F. X. (2001) · Psychopharmacology · doi:10.1007/s002130000648 · Cited by 360
Human psychopharmacology of Ecstasy (MDMA): a review of 15 years of empirical research
Parrott, A. C. (2001) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.351 · Cited by 337
Metadata
- Authors
- McCann, U. D., Eligulashvili, V., & Ricaurte, G. A.
- Affiliations
- Johns Hopkins University (US)
- Venue
- Neuropsychobiology
- Publisher
- S. Karger AG
- Published
- 2000
- Volume
- 42
- Issue
- 1
- Pages
- 11-16
- ISSN
- 0302-282X (ISSN-L)
- 1423-0224
- OpenAlex
- W2056429846
- Cited by
- 190
- References
- 36
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 4 · 2022: 2 · 2021: 2 · 2020: 7 · 2019: 1 · 2018: 1 · 2017: 7 · 2016: 1 · 2015: 2 · 2014: 9 · 2013: 2 · 2012: 4
- FWCI
- 20.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuropsychobiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Johns Hopkins University
- Deutsches Krebsforschungszentrum
- National Institute on Drug Abuse (DA05938, DA05707, DA 00206, R01DA005938)
- NIH Clinical Center
- Topics
- Social Sciences › Psychology › Clinical Psychology › Psychedelics and Drug Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Forensic Toxicology and Drug Analysis
- Keywords
- MDMA, ecstasy, serotonin neurotoxicity, recreational drug use, 5-hydroxyindoleacetic acid, serotonin transporter, cognitive impairment, sleep architecture, impulsivity, neuropsychiatric disorders
- MeSH terms
- Animals, Hallucinogens, Humans, Serotonin, Serotonin Agents, N-Methyl-3,4-methylenedioxyamphetamine, Neurotoxicity Syndromes
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