The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Three-Dimensional Spheroid Model in Tumor Biology
Abstract
It is becoming more and more apparent that monolayer cultures of tumor cells cannot completely represent the characteristics of three-dimensional solid tumors. Consequently, the multicellular tumor spheroid model, which is of intermediate complexity between in vivo tumors and monolayer cultures, was developed. In this review, the major similarities between spheroids and solid tumors are discussed. After a brief survey of the different spheroid culturing techniques, the general morphological and growth characteristics of these systems are examined and compared to solid tumors. Finally, selected studies regarding the use of tumor spheroids to examine cell response to antineoplastic agents and radiation, cell death including both necrosis and apoptosis and cell adhesion in spheroids are reviewed.
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Citations
Cites
Cell and environment interactions in tumor microregions: the multicell spheroid model.
Sutherland, R. M. (1988) · Science · doi:10.1126/science.2451290 · Cited by 1,803
Cited by
Spheroid-based drug screen: Considerations and practical approach
Friedrich, J., Seidel, C., Ebner, R., & Kunz-Schughart, L. A. (2009) · Nature Protocols · doi:10.1038/nprot.2008.226 · Cited by 1,742
Opportunities and challenges for use of tumor spheroids as models to test drug delivery and efficacy
Mehta, G., Hsiao, A. Y., Ingram, M., Luker, G. D., & Takayama, S. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2012.04.045 · Cited by 1,172
The use of 3-d cultures for high-throughput screening: the multicellular spheroid model.
Kunz-Schughart, L. A., Freyer, J. P., Hofstaedter, F., & Ebner, R. (2004) · SLAS DISCOVERY · doi:10.1177/1087057104265040 · Cited by 797
Pasquier, J., Guerrouahen, B. S., Al Thawadi, H., Ghiabi, P., Maleki, M., Abu-Kaoud, N., Jacob, A., Mirshahi, M., Galas, L., Rafii, S., et al. (2013) · Journal of Translational Medicine · doi:10.1186/1479-5876-11-94 · Cited by 502
A single-cell-based model of tumor growth in vitro: monolayers and spheroids
Drasdo, D., & Höhme, S. (2005) · Physical Biology · doi:10.1088/1478-3975/2/3/001 · Cited by 421
Metadata
- Authors
- Santini, M. T., & Rainaldi, G.
- Venue
- Pathobiology
- Publisher
- S. Karger AG
- Published
- 1999
- Volume
- 67
- Issue
- 3
- Pages
- 148-157
- ISSN
- 1015-2008 (ISSN-L)
- 1423-0291
- OpenAlex
- W2007466881
- Cited by
- 265
- References
- 1
- FWCI
- 2.83
- Type
- journal article
- Language
- en
- Open access
- closed
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- Santini, M. T., & Rainaldi, G. (1999). Three-Dimensional Spheroid Model in Tumor Biology. Pathobiology. https://doi.org/10.1159/000028065
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
