The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Double–Blind, Crossover Comparison of 3 mg Apomorphine SL with Placebo and with 4 mg Apomorphine SL in Male Erectile Dysfunction
Abstract
Objective To establish the efficacy and safety of a fixed, 3-mg dose of apomorphine SL compared with placebo, and to compare 3 mg with 4 mg apomorphine SL in patients with erectile dysfunction. Methods This randomized, double-blind, crossover study included 296 heterosexual men with ED of various etiologies and severities. Two crossover groups were evaluated separately: 3 mg apomorphine SL vs. placebo (n = 194), and 3 vs. 4 mg apomorphine SL (n = 102). The primary efficacy variable was the percentage of attempts resulting in erections firm enough for intercourse; additional variables included the percentage of attempts resulting in intercourse and time to erection. Partner assessments were also analyzed. Results 3 mg apomorphine SL was significantly more effective than placebo (p Conclusions 3 mg apomorphine SL was significantly more effective than placebo and comparable to 4 mg, while offering an improved risk-benefit ratio.
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“Efficacy rates (erections hard enough for intercourse) range from 28.5% to 55% [27].”
From Erectile dysfunction and its pharmacology: An overview (2017) · cites this paper as [27]
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Cites
Rosen, R. C., Riley, A., Wagner, G., Osterloh, I. H., Kirkpatrick, J., & Mishra, A. (1997) · Urology · doi:10.1016/s0090-4295(97)00238-0 · Cited by 5,849
Impotence and Its Medical and Psychosocial Correlates: Results of the Massachusetts Male Aging Study
Feldman, H. A., Goldstein, I., Hatzichristou, D. G., Krane, R. J., & McKinlay, J. B. (1994) · Journal of Urology · doi:10.1016/s0022-5347(17)34871-1 · Cited by 5,074
THE EPIDEMIOLOGY AND PATHOPHYSIOLOGY OF ERECTILE DYSFUNCTION
MELMAN, A., & GINGELL, J. C. (1999) · The Journal of Urology · doi:10.1097/00005392-199901000-00004 · Cited by 254
Recovery of erectile function by the oral administration of apomorphine
Heaton, J. P. W., Morales, Á., ADAMS, M. A., Johnston, B., & El‐Rashidy, R. (1995) · Urology · doi:10.1016/0090-4295(95)80005-0 · Cited by 170
Use of nocturnal penile tumescence and rigidity in the evaluation of male erectile dysfunction.
Levine, L. A., & Lenting, E. L. (1995) · PubMed · Cited by 109
Hatzichristou, D. G., Konstantinos Hatzimouratidis, A., Ioannides, E., Yannakoyorgos, K., DIMITRIADIS, G., & Kalinderis, A. (1998) · The Journal of Urology · doi:10.1016/s0022-5347(01)63197-5 · Cited by 103
The assessment of nocturnal REM erection in the differential diagnosis of sexual impotence
Fisher, C. M., Schiavi, R. C., Lear, H., Edwards, A., Davis, D. M., & Witkin, A. P. (1975) · Journal of Sex & Marital Therapy · doi:10.1080/00926237508403702 · Cited by 100
Dula, E., Keating, W., Siami, P. F., Edmonds, A., O’Neil, J., & Buttler, S. M. (2000) · Urology · doi:10.1016/s0090-4295(00)00575-6 · Cited by 100
Self-citationOdds Ratio Inference With Dependent Data
Liang, K. (1985) · Biometrika · doi:10.1093/biomet/72.3.678 · Cited by 79
Mulhall, J. P., Bukofzer, S., Edmonds, A., & George, M. (2001) · Clinical Therapeutics · doi:10.1016/s0149-2918(01)80105-3 · Cited by 40
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Cited by
Morgan, P., Van Der Graaf, P. H., Arrowsmith, J., Feltner, D. E., Drummond, K. S., Wegner, C. D., & Street, S. D. A. (2012) · Drug Discovery Today · doi:10.1016/j.drudis.2011.12.020 · Cited by 692
Erectile dysfunction and its pharmacology: An overview
Patnaik, S. K., Polimati, H., & Pragada, R. R. (2017) · Asian Journal of Pharmaceutical and Clinical Research · doi:10.22159/ajpcr.2017.v10i2.15183 · Cited by 3
Metadata
- Authors
- Dula, E., Bukofzer, S., Perdok, R., & George, M.
- Affiliations
- Abbott (United States) (US)
- Takeda (United Kingdom) (GB)
- ORCID
- Bukofzer, Stan
- Venue
- European Urology
- Publisher
- Elsevier BV
- Published
- 2001
- Volume
- 39
- Issue
- 5
- Pages
- 558-564
- ISSN
- 0302-2838 (ISSN-L)
- 1421-993X
- OpenAlex
- W2036887714
- Cited by
- 131
- References
- 12
- Citations by year
- 2025: 1 · 2022: 1 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 2 · 2016: 1 · 2015: 1 · 2014: 1 · 2013: 2 · 2012: 4
- FWCI
- 14.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Urology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
- Health Sciences › Medicine › Urology › Urological Disorders and Treatments
- Health Sciences › Medicine › Urology › Urinary Bladder and Prostate Research
- Keywords
- apomorphine, erectile dysfunction, sublingual administration, dose comparison, placebo comparison, nausea, adverse events, risk-benefit ratio
- MeSH terms
- Administration, Sublingual, Adult, Aged, Apomorphine, Coitus, Double-Blind Method, Humans, Erectile Dysfunction, Male, Middle Aged, Dopamine Agonists, Cross-Over Studies
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