Oxidative Targets in the Stratum corneum
Abstract
As the outermost layer of skin, the stratum corneum (SC) is continuously exposed to an oxidative environment, including air pollutants, ultraviolet radiation, chemical oxidants, and aerobic microorganisms. Human SC reveals characteristic antioxidant and protein oxidation gradients with increasing antioxidant depletion and protein oxidation towards the outer layers. SC antioxidants, lipids, and proteins are oxidatively modified upon treatments with ultraviolet A/ultraviolet B, ozone, and benzoyl peroxide. α-Tocopherol represents the predominating SC antioxidant with respect to its concentration and its unique susceptibility to the various oxidative challenges tested. In sites rich in sebaceous glands, α-tocopherol is physiologically delivered to the surface via secretion of sebum. Oxidative damage in the human SC represents an early pathophysiological event preceding barrier disruption and inflammation in environmentally challenged skin. Furthermore, oxidative gradients in SC proteins may have implications for the process of desquamation in human skin.
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Vitamin E is delivered to the surface of skin through sebum to protect the stratum corneum.
“Vitamin E is delivered to the surface of skin through sebum to protect the stratum corneum from this oxidative insult (Thiele, 2001).”
From Ferulic Acid Stabilizes a Solution of Vitamins C and E and Doubles its Photoprotection of Skin (2005) · cites this paper as Thiele, 2001
Cites
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Pillai, S., Oresajo, C., & Hayward, J. (2005) · International Journal of Cosmetic Science · doi:10.1111/j.1467-2494.2004.00241.x · Cited by 706 · see citing works
Cutaneous photodamage, oxidative stress, and topical antioxidant protection
Pinnell, S. R. (2003) · Journal of the American Academy of Dermatology · doi:10.1067/mjd.2003.16 · Cited by 544 · see citing works
Ferulic Acid Stabilizes a Solution of Vitamins C and E and Doubles its Photoprotection of Skin
Lin, F.-H., Lin, J.-Y., Gupta, R. D., Tournas, J. A., Burch, J. A., Angelica Selim, M., Monteiro-Riviere, N. A., Grichnik, J. M., Zielinski, J., & Pinnell, S. R. (2005) · Journal of Investigative Dermatology · doi:10.1111/j.0022-202x.2005.23768.x · Cited by 365 · see citing works
UV photoprotection by combination topical antioxidants vitamin C and vitamin E
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Stem cells and aberrant signaling of molecular systems in skin aging
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- Authors
- Thiele, J. J.
- Affiliations
- Friedrich Schiller University Jena (DE)
- Corresponding author
- Thiele, J.J.
- ORCID
- Thiele, J.J.
- Venue
- Skin Pharmacology and Physiology
- Publisher
- S. Karger AG
- Published
- 2001
- Volume
- 14
- Issue
- Suppl. 1
- Pages
- 87-91
- ISSN
- 1422-2868 (ISSN-L)
- 1660-5527
- 1660-5535
- OpenAlex
- W2089405377
- Cited by
- 117
- References
- 1
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 2 · 2023: 4 · 2022: 2 · 2021: 6 · 2020: 4 · 2019: 6 · 2018: 2 · 2017: 3 · 2016: 3 · 2015: 3 · 2014: 8 · 2013: 1 · 2012: 5
- FWCI
- 3.99
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Skin Pharmacology and Physiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Topics
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Keywords
- stratum corneum, oxidative stress, protein oxidation, alpha-tocopherol, ultraviolet radiation, ozone, benzoyl peroxide, sebum, sebaceous glands, skin barrier, desquamation, skin inflammation
- MeSH terms
- Administration, Topical, Animals, Antioxidants, Humans, Oxidation-Reduction, Skin, Oxidants
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