The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Penetration of Titanium Dioxide Microparticles in a Sunscreen Formulation into the Horny Layer and the Follicular Orifice
Abstract
Coated titanium dioxide (TiO 2) microparticles are commonly used as UV filter substances in commercial sunscreen products. The penetration of these microparticles into the horny layer and the orifice of the hair follicle was investigated. The distribution of the microparticles in the horny layer was analyzed using the method of tape stripping in combination with spectroscopic measurements. Deeper layers of the stratum corneum were devoid of TiO 2 even after repetitive application of sunscreen preparation when analyzing interfollicular areas. Only in the areas of the pilosebaceous orifices could microparticles be identified. The penetration of TiO 2 was investigated in histological skin sections. A biopsy was taken from a skin area from which the horny layer had been removed by tape stripping. In isolated areas, a penetration of coated TiO 2 into the open part of the follicle was observed. The amount of TiO 2 found in a given follicle was less than 1% of the applied total amount of sunscreens. A penetration of microparticles into viable skin tissue could not be detected.
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Cites
A pilot study on the percutaneous absorption of microfine titanium dioxide from sunscreens
Tan, M., Commens, C. A., Burnett, L., & Snitch, P. J. (1996) · Australasian Journal of Dermatology · doi:10.1111/j.1440-0960.1996.tb01050.x · Cited by 197
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Xu, L., Wang, Y.-Y., Huang, J., Chen, C.-Y., Wang, Z.-X., & Xie, H. (2020) · Theranostics · doi:10.7150/thno.45413 · Cited by 1,315
Nanoparticles and microparticles for skin drug delivery
Prow, T. W., Grice, J. E., Lin, L. L., Faye, R., Butler, M., Becker, W., Wurm, E. M. T., Yoong, C., Robertson, T. A., Soyer, H. P., et al. (2011) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2011.01.012 · Cited by 873
Inorganic and organic UV filters: Their role and efficacy in sunscreens and suncare products
Serpone, N., Dondi, D., & Albini, A. (2007) · Inorganica Chimica Acta · doi:10.1016/j.ica.2005.12.057 · Cited by 711
Grey Goo on the Skin? Nanotechnology, Cosmetic and Sunscreen Safety
Nohynek, G. J., Lademann, J., Ribaud, C., & Roberts, M. S. (2007) · Critical Reviews in Toxicology · doi:10.1080/10408440601177780 · Cited by 644
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Metadata
- Authors
- Lademann, J., Weigmann, H.-J., Rickmeyer, C., Barthelmes, H., Schaefer, H., Mueller, G., & Sterry, W.
- Venue
- Skin Pharmacology and Physiology
- Publisher
- S. Karger AG
- Published
- 1999
- Volume
- 12
- Issue
- 5
- Pages
- 247-256
- ISSN
- 1422-2868 (ISSN-L)
- 1660-5527
- 1660-5535
- OpenAlex
- W2010063869
- Cited by
- 527
- References
- 1
- FWCI
- 3.48
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Lademann, J., Weigmann, H.-J., Rickmeyer, C., Barthelmes, H., Schaefer, H., Mueller, G., & Sterry, W. (1999). Penetration of Titanium Dioxide Microparticles in a Sunscreen Formulation into the Horny Layer and the Follicular Orifice. Skin Pharmacology and Physiology. https://doi.org/10.1159/000066249
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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