A pilot study on the percutaneous absorption of microfine titanium dioxide from sunscreens
Abstract
SUMMARY: Many Australians are being advised to apply microfine titanium dioxide sunscreen daily from the cradle to the grave. However, there is a surprising lack of data on the percutaneous absorption of microfine titanium dioxide. A prospective pilot study was conducted to analyse the percutaneous absorption of microfine titanium dioxide from sunscreens. Selected patients scheduled to have skin surgery, applied titanium dioxide sunscreen to the skin daily for 2–6 weeks prior to their operation. After excision, the stratum corneum of the sample was stripped and the titanium concentration of the remaining epidermis and dermis was measured by inductively coupled plasma‐mass spectrometry. The results from this pilot study showed that levels of titanium in the epidermis and dermis of subjects who applied microfine titanium dioxide to their skin were higher than the levels of titanium found in controls. Studies with larger cohorts are necessary to establish if this absorption is statistically significant.
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There is no increased level of penetration of nano-sized TiO2 and ZnO when compared to macro-sized counterparts.
“There is no increased level of penetration when compared to the macro-sized counterparts.”
From Photoprotection: a Review of the Current and Future Technologies (2010) · cites this paper as [56]
A large number of in vitro and in vivo studies using murine, porcine, or human skin have shown that nano-sized TiO2 and ZnO remain at the stratum corneum level.
“However, a large number of in vitro and in vivo studies using murine, porcine, or human skin have shown that the nano-sized TiO2 and ZnO remain at the stratum corneum level (56)(57)(58)(59)(60)(61)(62)(63)(64)(65).”
From Photoprotection: a Review of the Current and Future Technologies (2010) · cites this paper as [56]
Cites
Effects of petrolatum on stratum corneum structure and function
Ghadially, R., Halkier-Sorensen, L., & Elias, P. M. (1992) · Journal of the American Academy of Dermatology · doi:10.1016/0190-9622(92)70060-s · Cited by 332 · see citing works
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Donaldson, K., Aitken, R., Tran, L., Stone, V., Duffin, R., Forrest, G., & Alexander, A. (2006) · Toxicological Sciences · doi:10.1093/toxsci/kfj130 · Cited by 1,167 · see citing works
Inorganic and organic UV filters: Their role and efficacy in sunscreens and suncare products
Serpone, N., Dondi, D., & Albini, A. (2007) · Inorganica Chimica Acta · doi:10.1016/j.ica.2005.12.057 · Cited by 711 · see citing works
Chemical oxidation and DNA damage catalysed by inorganic sunscreen ingredients
Dunford, R., Salinaro, A., Cai, L., Serpone, N., Horikoshi, S., Hidaka, H., & Knowland, J. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)01356-2 · Cited by 540 · see citing works
Nanoparticles skin absorption: New aspects for a safety profile evaluation
Larese Filon, F., Mauro, M., Adami, G., Bovenzi, M., & Crosera, M. (2015) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2015.05.005 · Cited by 390 · see citing works
Nanoparticle dermal absorption and toxicity: a review of the literature
Crosera, M., Bovenzi, M., Maina, G., Adami, G., Zanette, C., Florio, C., & Filon Larese, F. (2009) · International Archives of Occupational and Environmental Health · doi:10.1007/s00420-009-0458-x · Cited by 297 · see citing works
Photoprotection: a Review of the Current and Future Technologies
Wang, S. Q., Balagula, Y., & Osterwalder, U. (2010) · Dermatologic Therapy · doi:10.1111/j.1529-8019.2009.01289.x · Cited by 294 · see citing works
Han, H., Roan, F., & Ziegler, S. F. (2017) · Immunological Reviews · doi:10.1111/imr.12546 · Cited by 285 · see citing works
Biological interactions of quantum dot nanoparticles in skin and in human epidermal keratinocytes
ZHANG, L., YU, W., COLVIN, V, & MONTEIRORIVIERE, N. (2008) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2007.12.022 · Cited by 247 · see citing works
Human safety and efficacy of ultraviolet filters and sunscreen products
Nash, J. (2006) · Dermatologic Clinics · doi:10.1016/j.det.2005.09.006 · Cited by 126 · see citing works
Melanoma Chemoprevention: Current Status and Future Prospects
Chhabra, G., Ndiaye, M. A., Garcia‐Peterson, L. M., & Ahmad, N. (2017) · Photochemistry and Photobiology · doi:10.1111/php.12749 · Cited by 51 · see citing works
- Authors
- Tan, M., Commens, C. A., Burnett, L., & Snitch, P. J.
- Affiliations
- Westmead Hospital (AU)
- Royal Prince Alfred Hospital (AU)
- Corresponding author
- Commens, Chris A
- ORCID
- Burnett, Leslie
- Venue
- Australasian Journal of Dermatology
- Publisher
- Wiley
- Published
- 1996-11
- Volume
- 37
- Issue
- 4
- Pages
- 185-187
- ISSN
- 0004-8380 (ISSN-L)
- 1440-0960
- OpenAlex
- W2029664240
- Cited by
- 197
- References
- 1
- Citations by year
- 2025: 4 · 2024: 4 · 2023: 4 · 2022: 4 · 2021: 3 · 2020: 5 · 2019: 9 · 2018: 7 · 2017: 10 · 2016: 12 · 2015: 12 · 2014: 7 · 2013: 11 · 2012: 15
- FWCI
- 3.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Australasian Journal of Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Health Sciences › Medicine › Dermatology › Contact Dermatitis and Allergies
- Physical Sciences › Materials Science › Materials Chemistry › Nanoparticles: synthesis and applications
- Keywords
- sunscreen, percutaneous absorption, stratum corneum, epidermis, dermis, skin surgery
- MeSH terms
- Absorption, Administration, Topical, Aged, Aged, 80 and over, Cadaver, Female, Humans, Male, Middle Aged, Pilot Projects, Reference Values, Skin, Sunscreening Agents, Titanium
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