Anti-acne effects of Oriental herb extracts: A novel screening method to select anti-acne agents
Abstract
The acne-therapeutic effects of Oriental herb extracts were investigated in terms of antichemotactic effect on polymorphonuclear leucocytes, antilipogenic actions, antibacterial activity against Propionibacterium acnes and resistance induction potency in the bacteria. The ethanol extract (0.01%) of Angelica dahurica markedly suppressed neutrophil chemotaxis, comparable to the effect of erythromycin (0.01%), whereas a strong antilipogenic effect was obtained with rhizoma coptidis (Coptis chinensis) extract (0.01%), leading to a higher efficacy than that of retinoic acid (0.01%). Interestingly, only Glycyrrhiza glabra showed a remarkable antibacterial activity against P. acnes, resulting in negligible induction of resistance, in comparison with a marked development of resistance in the bacteria treated with erythromycin. We suggest that an appropriate formulation containing A. dahurica, rhizoma coptidis and G. glabra could be helpful for the prevention and treatment of acne lesions.
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G. glabra showed remarkable antibacterial activity against P. acnes with a negligible induction of resistance compared to marked development of resistance in bacteria treated with erythromycin.
“G. glabra showed remarkable antibacterial activity against P. acnes with a negligible induction of resistance compared to marked development of resistance in bacteria treated with erythromycin [93].”
From Licorice (Glycyrrhiza glabra, G. uralensis, and G. inflata) and Their Constituents as Active Cosmeceutical Ingredients (2022) · cites this paper as [93]
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Cerulli, A., Masullo, M., Montoro, P., & Piacente, S. (2022) · Cosmetics · doi:10.3390/cosmetics9010007 · Cited by 83 · see citing works
- Authors
- Nam, C., Kim, S., Sim, Y., & Chang, I.
- ORCID
- Nam, C.
- Venue
- Skin Pharmacology and Physiology
- Publisher
- S. Karger AG
- Published
- 2003
- Volume
- 16
- Issue
- 2
- Pages
- 84-90
- ISSN
- 1422-2868 (ISSN-L)
- 1660-5527
- 1660-5535
- OpenAlex
- W2040869197
- Cited by
- 65
- References
- 0
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 6 · 2022: 6 · 2021: 6 · 2020: 4 · 2019: 1 · 2018: 1 · 2017: 5 · 2016: 3 · 2015: 3 · 2014: 4 · 2013: 1 · 2012: 4
- FWCI
- 2.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Skin Pharmacology and Physiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Acne and Rosacea Treatments and Effects
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Keywords
- acne, anti-acne agents, Angelica dahurica, Coptidis Rhizoma, Coptis chinensis, licorice, neutrophil chemotaxis, Propionibacterium acnes, antibacterial activity, antibiotic resistance induction, screening method
- MeSH terms
- Acne Vulgaris, Animals, Anti-Bacterial Agents, Cells, Cultured, Chemotaxis, Drug Resistance, Microbial, Drugs, Chinese Herbal, Erythromycin, Glycyrrhiza, Humans, Phytotherapy, Microbial Sensitivity Tests, Neutrophils, Angelica, Arctium, Rats
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