Comparison of Multi-Lineage Cells from Human Adipose Tissue and Bone Marrow
Abstract
Our laboratory has recently characterized a population of cells from adipose tissue, termed processed lipoaspirate (PLA) cells, which have multi-lineage potential similar to bone-marrow-derived mesenchymal stem cells (MSCs). This study is the first comparison of PLA cells and MSCs isolated from the same patient. No significant differences were observed for yield of adherent stromal cells, growth kinetics, cell senescence, multi-lineage differentiation capacity, and gene transduction efficiency. Adipose tissue is an abundant and easily procured source of PLA cells, which have a potential like MSCs for use in tissue-engineering applications and as gene delivery vehicles.
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Studies comparing the osteogenic potential of human BM-MSCs and ASCs have yielded mixed results.
“Regarding bone tissue engineering, studies comparing the osteogenic potential of human BM-MSCs and ASCs have yielded mixed results.”
From Mesenchymal Stem/Stromal Cells: Immunomodulatory and Bone Regeneration Potential after Tumor Excision in Osteosarcoma Patients (2023) · cites this paper as [63]
Other studies propose that ASCs have equal or superior osteogenic potential compared to BM-MSCs.
“Some suggest that BM-MSCs exhibit greater osteogenic capacity [58,59,60,61,62], while others propose that ASCs have equal or superior potential [58,63,64,65,66].”
From Mesenchymal Stem/Stromal Cells: Immunomodulatory and Bone Regeneration Potential after Tumor Excision in Osteosarcoma Patients (2023) · cites this paper as [63]
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- Authors
- De Ugarte, D. A., Morizono, K., Elbarbary, A., Alfonso, Z., Zuk, P. A., Zhu, M., Dragoo, J. L., Ashjian, P., Thomas, B., Benhaim, P., Chen, I., Fraser, J., & Hedrick, M. H.
- Affiliations
- University of California, Los Angeles (US)
- Venue
- Cells Tissues Organs
- Publisher
- S. Karger AG
- Published
- 2003
- Volume
- 174
- Issue
- 3
- Pages
- 101-109
- ISSN
- 1422-6405 (ISSN-L)
- 1422-6421
- OpenAlex
- W2038467210
- Cited by
- 1,173
- References
- 1
- Citations by year
- 2026: 5 · 2025: 9 · 2024: 26 · 2023: 32 · 2022: 29 · 2021: 56 · 2020: 40 · 2019: 47 · 2018: 52 · 2017: 68 · 2016: 67 · 2015: 73 · 2014: 84 · 2013: 99 · 2012: 77
- FWCI
- 12.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cells Tissues Organs (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01dk054912-07)
- National Institute of Allergy and Infectious Diseases (AI39975, R01AI039975)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK54912)
- Topics
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- adipose tissue, bone marrow, mesenchymal stem cells, multilineage differentiation, cellular senescence, gene transduction efficiency, growth kinetics, tissue engineering, gene carriers, cell source comparison
- MeSH terms
- Adipose Tissue, Adolescent, Adult, Aged, Bone Marrow Cells, Cell Division, Cells, Cultured, Child, Female, Humans, Male, Middle Aged, Cellular Senescence, Gene Transfer Techniques, Cell Lineage, Tissue Engineering, Mesenchymal Stem Cells
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