The Bone Marrow-Derived Stromal Cells: Commitment and Regulation of Adipogenesis

Human Adipose Tissue Is a Source of Multipotent Stem Cells

Zuk, P. A., Zhu, M., Ashjian, P. H., Ugarte, D. A. D., Huang, J. I., Mizuno, H., Alfonso, Z. C., Fraser, J. K., Benhaim, P., & Hedrick, M. H. (2002) · Molecular Biology of the Cell · doi:10.1091/mbc.e02-02-0105 · Cited by 6,669 · see citing works

The Wnt Signaling Pathway in Development and Disease

Logan, C. Y., & Nusse, R. (2004) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.20.010403.113126 · Cited by 5,325 · see citing works

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

Boström, P., Wu, J., Jedrychowski, M. P., Korde, A., Ye, L., Lo, J. C., Rasbach, K. A., Boström, E. A., Choi, J. H., Long, J. Z., et al. (2012) · Nature · doi:10.1038/nature10777 · Cited by 4,810 · see citing works

Sox9 Modulates Proliferation and Expression of Osteogenic Markers of Adipose-Derived Stem Cells (ASC)

Stöckl, S., Göttl, C., Grifka, J. K., & Grässel, S. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350089 · Cited by 4,670 · see citing works

Mechanisms of fatty acid-induced inhibition of glucose uptake.

Boden, G., Chen, X., Ruiz, J., White, J. V., & Rossetti, L. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117252 · Cited by 3,702 · see citing works

Mesenchymal and haematopoietic stem cells form a unique bone marrow niche

Méndez‐Ferrer, S., Michurina, T. V., Ferraro, F., Mazloom, A. R., MacArthur, B. D., Lira, S. A., Scadden, D. T., Ma’ayan, A., Enikolopov, G., & Frenette, P. S. (2010) · Nature · doi:10.1038/nature09262 · Cited by 3,381 · see citing works

Adipocyte differentiation from the inside out

Rosen, E. D., & MacDougald, O. A. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2066 · Cited by 2,607 · see citing works

Adipose-derived stem cells for regenerative medicine

Gimble, J. M., Katz, A. J., & Bunnell, B. A. (2007) · Circulation Research · doi:10.1161/01.res.0000265074.83288.09 · Cited by 2,332 · see citing works

Leptin Inhibits Bone Formation through a Hypothalamic Relay

Ducy, P., Amling, M., Takeda, S., Priemel, M., Schilling, A. F., Beil, F. T., Shen, J., Vinson, C., Rueger, J. M., & Karsenty, G. (2000) · Cell · doi:10.1016/s0092-8674(00)81558-5 · Cited by 2,077 · see citing works

C/EBPα induces adipogenesis through PPARγ: a unified pathwayPreprint

Rosen, E. D., Hsu, C.-H., Wang, X., Sakai, S., Freeman, M. W., Gonzalez, F. J., & Spiegelman, B. M. (2002) · Genes & Development · doi:10.1101/gad.948702 · Cited by 1,497 · see citing works

The epidemiology of corticosteroid-induced osteoporosis: a meta-analysis

Staa, T. P. V., Staa, T. P. V., Staa, T. P. V., Leufkens, H. G. M., & Cooper, C. (2002) · Osteoporosis International · doi:10.1007/s001980200108 · Cited by 1,294 · see citing works

Romosozumab in Postmenopausal Women with Low Bone Mineral Density

McClung, M. R., Grauer, A., Boonen, S., Bolognese, M. A., Brown, J. P., Diez-Perez, A., Langdahl, B. L., Reginster, J.-Y., Zanchetta, J. R., Wasserman, S. M., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1305224 · Cited by 1,258 · see citing works

Comparison of Multi-Lineage Cells from Human Adipose Tissue and Bone Marrow

De Ugarte, D. A., Morizono, K., Elbarbary, A., Alfonso, Z., Zuk, P. A., Zhu, M., Dragoo, J. L., Ashjian, P., Thomas, B., Benhaim, P., et al. (2003) · Cells Tissues Organs · doi:10.1159/000071150 · Cited by 1,173 · see citing works

New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure

Tseng, Y.-H., Kokkotou, E., Schulz, T. J., Huang, T. L., Winnay, J. N., Taniguchi, C. M., Tran, T. T., Suzuki, R., Espinoza, D. O., Yamamoto, Y., et al. (2008) · Nature · doi:10.1038/nature07221 · Cited by 1,099 · see citing works

TRANSCRIPTIONAL REGULATION OF GENE EXPRESSION DURING ADIPOCYTE DIFFERENTIATION

MacDougald, O. A., & Lane, M. D. (1995) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.64.070195.002021 · Cited by 1,064 · see citing works

Sclerostin Is an Osteocyte-expressed Negative Regulator of Bone Formation, But Not a Classical BMP Antagonist

van Bezooijen, R. L., Roelen, B. A. J., Visser, A., van der Wee-Pals, L. J. A., de Wilt, E., Karperien, M., Hamersma, H. A., Papapoulos, S. E., ten Dijke, P., & Löwik, C. W. G. M. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20031454 · Cited by 893 · see citing works

PPAR γ insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors

Akune, T., Ohba, S., Kamekura, S., Yamaguchi, M., Chung, U., Kubota, N., Terauchi, Y., Harada, Y., Azuma, Y., Nakamura, K., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci19900 · Cited by 871 · see citing works

Adipocyte tissue volume in bone marrow is increased with aging and in patients with osteoporosis

Justesen, J., Stenderup, K., Ebbesen, E., Mosekilde, L., Steiniche, T., & Kassem, M. (2004) · Biogerontology (Dordrecht) · doi:10.1023/a:1011513223894 · Cited by 847 · see citing works

Aging activates adipogenic and suppresses osteogenic programs in mesenchymal marrow stroma/stem cells: the role of PPAR‐γ2 transcription factor and TGF‐β/BMP signaling pathways

Moerman, E., Teng, K., Lipschitz, D., & Lecka-Czernik, B. (2004) · Aging Cell · doi:10.1111/j.1474-9728.2004.00127.x · Cited by 840 · see citing works

Defective adipocyte differentiation in mice lacking the C/EBPβ and/or C/EBPδ gene

Tanaka, T., Yoshida, N., Kishimoto, T., & Akira, S. (1997) · The EMBO Journal · doi:10.1093/emboj/16.24.7432 · Cited by 804 · see citing works

Identification and Specification of the Mouse Skeletal Stem Cell

Chan, C. K. F., Seo, E. Y., Chen, J. Y., Lo, D. D., McArdle, A., Sinha, R., Tevlin, R., Seita, J., Vincent-Tompkins, J., Wearda, T. L., et al. (2015) · Cell · doi:10.1016/j.cell.2014.12.002 · Cited by 763 · see citing works

Interleukin‐6 deficient mice are protected from bone loss caused by estrogen depletion.

Poli, V., Balena, R. F., Fattori, E., Markatos, A., Yamamoto, M., Tanaka, H., Ciliberto, G., Rodan, G. A., & Costantini, F. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06368.x · Cited by 745 · see citing works

Regulation of Wnt Signaling during Adipogenesis

Bennett, C. N., Ross, S. E., Longo, K. A., Bajnok, L., Hemati, N., Johnson, K. W., Harrison, S. D., & MacDougald, O. A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204527200 · Cited by 743 · see citing works

Irisin Stimulates Browning of White Adipocytes Through Mitogen-Activated Protein Kinase p38 MAP Kinase and ERK MAP Kinase Signaling

Zhang, Y., Li, R., Meng, Y., Li, S., Donelan, W., Zhao, Y., Qi, L., Zhang, M., Wang, X., Cui, T., et al. (2014) · Diabetes · doi:10.2337/db13-1106 · Cited by 733 · cited 2× · see citing works

PPAR γ insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors

Akune, T., Ohba, S., Kamekura, S., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200419900 · Cited by 730 · see citing works

Leptin Acts on Human Marrow Stromal Cells to Enhance Differentiation to Osteoblasts and to Inhibit Differentiation to Adipocytes1

Thomas, T., Gori, F., Khosla, S., Jensen, M. D., Burguera, B. G., & Riggs, B. L. (1999) · Endocrinology · doi:10.1210/endo.140.4.6637 · Cited by 725 · see citing works

The bone morphogenetic protein family and osteogenesis

Wozney, J. M. (1992) · Molecular Reproduction and Development · doi:10.1002/mrd.1080320212 · Cited by 684 · see citing works

Gremlin 1 Identifies a Skeletal Stem Cell with Bone, Cartilage, and Reticular Stromal Potential

Worthley, D. L., Churchill, M., Compton, J. T., Tailor, Y. H., Rao, M., Si, Y., Levin, D. E., Schwartz, M. G., Uygur, A., Hayakawa, Y., et al. (2015) · Cell · doi:10.1016/j.cell.2014.11.042 · Cited by 635 · see citing works

Matrix IGF-1 maintains bone mass by activation of mTOR in mesenchymal stem cells

Xian, L., Wu, X., Pang, L., Lou, M., Rosen, C. J., Qiu, T., Crane, J., Frassica, F., Zhang, L., Rodriguez, J. P., et al. (2012) · Nature Medicine · doi:10.1038/nm.2793 · Cited by 631 · see citing works

Osteo-chondroprogenitor cells are derived from Sox9 expressing precursors

Akiyama, H., Kim, J., Nakashima, K., Balmes, G. C., Iwai, N., Deng, J. M., Zhang, Z., Martin, J. F., Behringer, R. R., Nakamura, T., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504750102 · Cited by 607 · see citing works

Fibroblast Growth Factor-21 Regulates PPARγ Activity and the Antidiabetic Actions of Thiazolidinediones

Dutchak, P. A., Katafuchi, T., Bookout, A. L., Choi, J. H., Yu, R. T., Mangelsdorf, D. J., & Kliewer, S. A. (2012) · Cell · doi:10.1016/j.cell.2011.11.062 · Cited by 537 · see citing works

The myokine irisin increases cortical bone mass

Colaianni, G., Cuscito, C., Mongelli, T., Pignataro, P., Buccoliero, C., Liu, P., Lü, P., Sartini, L., Comite, M. D., Mori, G., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1516622112 · Cited by 513 · see citing works

Insulin-like growth factor-I is an essential regulator of the differentiation of 3T3-L1 adipocytes.

Smith, P. J., Wise, L. S., Berkowitz, R., Wan, C. F., & Rubin, C. S. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)76555-7 · Cited by 511 · see citing works

Bone marrow adipose tissue is an endocrine organ that contributes to increased circulating adiponectin during caloric restriction

Cawthorn, W., Scheller, E., Learman, B. S., Parlee, S., Simon, B., Mori, H., Ning, X.-M., Bree, A. J., Schell, B. A., Broome, D. T., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.06.003 · Cited by 506 · see citing works

Playing with bone and fat

Gimble, J. M., Zvonic, S., Floyd, Z. E., Kassem, M. S., & NUTTALL, M. E. (2006) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20777 · Cited by 505 · see citing works

Bone Morphogenetic Protein-2 Causes Commitment and Differentiation in C3Hl0T1/2 and 3T3 Cells

Wang, E. A., Israel, D. I., Kelly, S. J., & Luxenberg, D. P. (1993) · Growth Factors · doi:10.3109/08977199308991582 · Cited by 490 · see citing works

Deletion of PPARγ in adipose tissues of mice protects against high fat diet-induced obesity and insulin resistance

Jones, J. R., Barrick, C. J., Kim, K., Lindner, J., Blondeau, B., Fujimoto, Y., Shiota, M., Kesterson, R. A., Kahn, B. B., & Magnuson, M. A. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0306743102 · Cited by 487 · see citing works

Leptin Receptor Promotes Adipogenesis and Reduces Osteogenesis by Regulating Mesenchymal Stromal Cells in Adult Bone Marrow

Yue, R., Zhou, B. O., Shimada, I. S., Zhao, Z., & Morrison, S. J. (2016) · Cell stem cell · doi:10.1016/j.stem.2016.02.015 · Cited by 485 · see citing works

Bone Is a Target for the Antidiabetic Compound Rosiglitazone

Rzońca, S., Suva, L. J., Gaddy, D., Montague, D. C., & Lecka‐Czernik, B. (2003) · Endocrinology · doi:10.1210/en.2003-0746 · Cited by 455 · see citing works

Cartilage‐like gene expression in differentiated human stem cell spheroids: A comparison of bone marrow–derived and adipose tissue–derived stromal cells

Winter, A., Breit, S., Parsch, D., Benz, K., Steck, E., Hauner, H., Weber, R. M., Ewerbeck, V., & Richter, W. (2003) · Arthritis & Rheumatism · doi:10.1002/art.10767 · Cited by 454 · see citing works

Lrp5 functions in bone to regulate bone mass

Cui, Y., Niziolek, P., MacDonald, B. T., Diegel, C. R., Alenina, N. V., Robinson, D. R., Zhong, Z. A., Matthes, S., Jacobsen, C. M., Conlon, R. A., et al. (2011) · Nature Medicine · doi:10.1038/nm.2388 · Cited by 454 · see citing works

MicroRNAs as Regulators of Differentiation and Cell Fate Decisions

Ivey, K. N., & Srivastava, D. (2010) · Cell Stem Cell · doi:10.1016/j.stem.2010.06.012 · Cited by 449 · see citing works

The function of adipocytes in the bone marrow stroma: an update

Gimble, J. M., Robinson, C. E., Wu, X., & Kelly, K. A. (1996) · Bone · doi:10.1016/s8756-3282(96)00258-x · Cited by 446 · see citing works

Identification of Common Pathways Mediating Differentiation of Bone Marrow- and Adipose Tissue-Derived Human Mesenchymal Stem Cells into Three Mesenchymal Lineages

Liu, T. M., Martina, M., Hutmacher, D. W., Hui, J. H. P., Lee, E. H., & Lim, B. (2006) · Stem Cells · doi:10.1634/stemcells.2006-0394 · Cited by 430 · see citing works

Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor γ

Wei, W., Dutchak, P. A., Wang, X., Ding, X., Wang, X., Bookout, A. L., Goetz, R., Mohammadi, M., Gerard, R. D., Dechow, P. C., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1200797109 · Cited by 426 · see citing works

Adiponectin increases bone mass by suppressing osteoclast and activating osteoblast

Oshima, K., Nampei, A., Matsuda, M., Iwaki, M., Fukuhara, A., Hashi­moto, J., Yoshikawa, H., & Shimomura, I. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.03.210 · Cited by 399 · see citing works

Transdifferentiation potential of human mesenchymal stem cells derived from bone marrow

Song, L., & Tuan, R. S. (2004) · The FASEB Journal · doi:10.1096/fj.03-1100fje · Cited by 395 · see citing works

Increased Bone Marrow Fat in Anorexia Nervosa

Bredella, M. A., Fazeli, P. K., Miller, K. K., Misra, M., Torriani, M., Thomas, B. J., Ghomi, R. H., Rosen, C. J., & Klibanski, A. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-2532 · Cited by 387 · see citing works

Differential Roles for Bone Morphogenetic Protein (BMP) Receptor Type IB and IA in Differentiation and Specification of Mesenchymal Precursor Cells to Osteoblast and Adipocyte Lineages

Chen, D., Ji, X., Harris, M. A., Feng, J. Q., Karsenty, G., Celeste, A. J., Rosen, V., Mundy, G. R., & Harris, S. E. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.142.1.295 · Cited by 382 · see citing works

Adipocytic cells cultured from marrow have osteogenic potential

Bennett, J. H., Joyner, C. J., Triffitt, J. T., & Owen, M. E. (1991) · Journal of Cell Science · doi:10.1242/jcs.99.1.131 · Cited by 361 · see citing works

Macrophages block insulin action in adipocytes by altering expression of signaling and glucose transport proteins

Lumeng, C. N., Deyoung, S. M., & Saltiel, A. R. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00284.2006 · Cited by 359 · see citing works

Marrow Fat and the Bone Microenvironment: Developmental, Functional, and Pathological Implications

Rosen, C. J., Ackert‐Bicknell, C. L., Rodriguez, J. P., & Pino, A. M. (2009) · Critical Reviews in Eukaryotic Gene Expression · doi:10.1615/critreveukargeneexpr.v19.i2.20 · Cited by 353 · see citing works

Vertebral Bone Marrow Fat Is Positively Associated With Visceral Fat and Inversely Associated With IGF‐1 in Obese Women

Bredella, M. A., Torriani, M., Ghomi, R. H., Thomas, B. J., Brick, D. J., Gerweck, A. V., Rosen, C. J., Klibanski, A., & Miller, K. K. (2010) · Obesity · doi:10.1038/oby.2010.106 · Cited by 346 · see citing works

Transforming Growth Factor-β Inhibits Adipocyte Differentiation by Smad3 Interacting with CCAAT/Enhancer-binding Protein (C/EBP) and Repressing C/EBP Transactivation Function

Choy, L., & Derynck, R. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212259200 · Cited by 343 · see citing works

C/EBPα is required for differentiation of white, but not brown, adipose tissue

Linhart, H., Ishimura‐Oka, K., DeMayo, F. J., Kibe, T., Repka, D., Poindexter, B. J., Bick, R. J., & Darlington, G. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.211416898 · Cited by 333 · see citing works

Direct and indirect effects of leptin on adipocyte metabolism

Harris, R. B. S. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.05.009 · Cited by 316 · see citing works

Treatment of Obese Diabetic Mice With a Heme Oxygenase Inducer Reduces Visceral and Subcutaneous Adiposity, Increases Adiponectin Levels, and Improves Insulin Sensitivity and Glucose Tolerance

Li, M., Kim, D. H., Tsenovoy, P. L., Peterson, S. J., Rezzani, R., Rodella, L. F., Aronow, W. S., Ikehara, S., & Abraham, N. G. (2008) · Diabetes · doi:10.2337/db07-1764 · Cited by 311 · see citing works

Peroxisome proliferator-activated receptor-gamma activation by thiazolidinediones induces adipogenesis in bone marrow stromal cells.

Gimble, J. M., Robinson, C. E., Wu, X., Kelly, K. A., Rodriguez, B., Kliewer, S. A., Lehmann, J. M., & Morris, D. C. (1996) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)09536-7 · Cited by 295 · see citing works

Cellular signaling by neural cell adhesion molecules of the immunoglobulin superfamily

Crossin, K. L., & Krushel, L. A. (2000) · Developmental Dynamics · doi:10.1002/(sici)1097-0177(200006)218:2 · Cited by 283 · see citing works

Interleukin‐6 maintains bone marrow‐derived mesenchymal stem cell stemness by an ERK1/2‐dependent mechanism

Pricola, K. L., Zahir, N., Haleem‐Smith, H., Song, Y., & Tuan, R. S. (2009) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22289 · Cited by 281 · see citing works

Transcriptional networks and chromatin remodeling controlling adipogenesis

Siersbæk, R., Nielsen, R., & Mandrup, S. (2011) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2011.10.001 · Cited by 278 · see citing works

Insulin signalling mechanisms for triacylglycerol storage

Czech, M., Tencerová, M., Pedersen, D. J., & Aouadi, M. (2013) · Diabetologia · doi:10.1007/s00125-013-2869-1 · Cited by 272 · see citing works

Bone Loss and Increased Bone Adiposity in Spontaneous and Pharmacologically Induced Diabetic Mice

Boțolin, S., & McCabe, L. R. (2006) · Endocrinology · doi:10.1210/en.2006-1006 · Cited by 267 · see citing works

Peripheral leptin regulates bone formation

Turner, R. T., Kalra, S. P., Wong, C. P., Philbrick, K. A., Lindenmaier, L. B., Boghossian, S., & Iwaniec, U. T. (2013) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.1734 · Cited by 264 · cited 2× · see citing works

Native human adipose stromal cells: localization, morphology and phenotype

Maumus, M., Peyrafitte, J.-A., D’Angelo, R., Fournier‐Wirth, C., Bouloumié, A., Casteilla, L., Sengenès, C., & Bourin, P. (2011) · International Journal of Obesity · doi:10.1038/ijo.2010.269 · Cited by 263 · see citing works

Cytokines Promote Wnt Signaling and Inflammation and Impair the Normal Differentiation and Lipid Accumulation in 3T3-L1 Preadipocytes

Gustafson, B., & Smith, U. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m512077200 · Cited by 261 · see citing works

Bone marrow fat has brown adipose tissue characteristics, which are attenuated with aging and diabetes

Krings, A., Rahman, S., Huang, S., Lu, Y., Czernik, P. J., & Lecka‐Czernik, B. (2011) · Bone · doi:10.1016/j.bone.2011.06.016 · Cited by 258 · see citing works

A bispecific antibody targeting sclerostin and DKK-1 promotes bone mass accrual and fracture repair

Florio, M., Gunasekaran, K., Stolina, M., Li, X., Liu, L., Tipton, B., Salimi-Moosavi, H., Asuncion, F., Li, C., Sun, B., et al. (2016) · Nature Communications · doi:10.1038/ncomms11505 · Cited by 258 · see citing works

Control of adipocyte differentiation

Smas, C. M., & Sul, H. S. (1995) · Biochemical Journal · doi:10.1042/bj3090697 · Cited by 255 · see citing works

Bone-specific insulin resistance disrupts whole-body glucose homeostasis via decreased osteocalcin activation

Wei, J., Ferron, M., Clarke, C. J., Hannun, Y. A., Jiang, H., Blaner, W. S., & Karsenty, G. (2014) · Journal of Clinical Investigation · doi:10.1172/jci72323 · Cited by 246 · see citing works

Adiponectin Regulates Bone Mass via Opposite Central and Peripheral Mechanisms through FoxO1

Kajimura, D., Lee, H. W., Riley, K. J., Arteaga‐Solis, E., Ferron, M., Zhou, B., Clarke, C. J., Hannun, Y. A., DePinho, R. A., Guo, X.-D. E., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.04.009 · Cited by 238 · see citing works

Osteocalcin Promotes β-Cell Proliferation During Development and Adulthood Through Gprc6a

Wei, J., Hanna, T., Suda, N., Karsenty, G., & Ducy, P. F. (2013) · Diabetes · doi:10.2337/db13-0887 · Cited by 237 · see citing works

Human Osteogenic Protein-1 Induces Chondroblastic, Osteoblastic, and/or Adipocytic Differentiation of Clonal Murine Target Cells

Asahina, I., Sampath, T. K., & Hauschka, P. V. (1996) · Experimental Cell Research · doi:10.1006/excr.1996.0005 · Cited by 236 · see citing works

Stable stem cell commitment to the adipocyte lineage by inhibition of DNA methylation: Role of the BMP-4 gene

Bowers, R. R., Kim, J. W., Otto, T. C., & Lane, M. D. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605789103 · Cited by 228 · see citing works

Regulation of Human Skeletal Stem Cells Differentiation by Dlk1/Pref-1

Abdallah, B. M., Jensen, C. H., Gutierrez, G. E., Leslie, R. G. Q., Jensen, T. G., & Kassem, M. S. (2004) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.040118 · Cited by 228 · see citing works

Irisin Enhances Osteoblast DifferentiationIn Vitro

Colaianni, G., Cuscito, C., Mongelli, T., Oranger, A., Mori, G., Brunetti, G., Colucci, S. C., Cinti, S., & Grano, M. (2014) · International Journal of Endocrinology · doi:10.1155/2014/902186 · Cited by 225 · see citing works

BMP4 and BMP Antagonists Regulate Human White and Beige Adipogenesis

Gustafson, B., Hammarstedt, A., Hedjazifar, S., Hoffmann, J. M., Svensson, P., Grimsby, J. S., Rondinone, C. M., & Smith, U. (2015) · Diabetes · doi:10.2337/db14-1127 · Cited by 211 · see citing works

Bone Morphogenetic Protein-2-induced Alkaline Phosphatase Expression Is Stimulated by Dlx5 and Repressed by Msx2

Kim, Y. J., Lee, M., Wozney, J. M., Cho, J., & Ryoo, H. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m404145200 · Cited by 202 · see citing works

Activation of CCAAT/Enhancer-binding Protein (C/EBP) α Expression by C/EBPβ during Adipogenesis Requires a Peroxisome Proliferator-activated Receptor-γ-associated Repression of HDAC1 at the C/ebpα Gene Promoter

Zuo, Y., Qiang, L., & Farmer, S. R. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m510682200 · Cited by 201 · see citing works

FGF21 as a Hepatokine, Adipokine, and Myokine in Metabolism and Diseases

Itoh, N. (2014) · Frontiers in Endocrinology · doi:10.3389/fendo.2014.00107 · Cited by 198 · see citing works

Leptin Acts on Human Marrow Stromal Cells to Enhance Differentiation to Osteoblasts and to Inhibit Differentiation to Adipocytes

Thomas, T. (1999) · Endocrinology · doi:10.1210/en.140.4.1630 · Cited by 192 · see citing works

Regulating the Balance between Peroxisome Proliferator-activated Receptor γ and β-Catenin Signaling during Adipogenesis

Liu, J., & Farmer, S. R. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m407050200 · Cited by 187 · see citing works

IGF-1 regulation of key signaling pathways in bone

Guntur, A. R., & Rosen, C. J. (2013) · BoneKEy Reports · doi:10.1038/bonekey.2013.171 · Cited by 184 · see citing works

Bone Geometry, Volumetric Density, Microarchitecture, and Estimated Bone Strength Assessed by HR-pQCT in Adult Patients With Type 1 Diabetes Mellitus

Shanbhogue, V. V., Hansen, S., Frost, M., Jørgensen, N. R., Hermann, A. P., Henriksen, J. E., & Brixen, K. (2015) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2573 · Cited by 183 · see citing works

Bone Loss in Diabetes: Use of Antidiabetic Thiazolidinediones and Secondary Osteoporosis

Lecka‐Czernik, B. (2010) · Current Osteoporosis Reports · doi:10.1007/s11914-010-0027-y · Cited by 182 · see citing works

Comparative investigation of the differentiation capability of bone-marrow- and adipose-derived mesenchymal stem cells by qualitative and quantitative analysis

Vishnubalaji, R., Al-Nbaheen, M. S., Kadalmani, B., Aldahmash, A. M., & Ramesh, T. (2012) · Cell and Tissue Research · doi:10.1007/s00441-011-1306-3 · Cited by 180 · see citing works

Patients With High Bone Mass Phenotype Exhibit Enhanced Osteoblast Differentiation and Inhibition of Adipogenesis of Human Mesenchymal Stem Cells

Qiu, W., Andersen, T. E., Bollerslev, J., Mandrup, S., Abdallah, B. M., & Kassem, M. S. (2007) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.070721 · Cited by 177 · see citing works

Krüppel-like Factor-6 Promotes Preadipocyte Differentiation through Histone Deacetylase 3-dependent Repression of DLK1

Li, D., Yea, S., Li, S., Zhu, C. X., Narla, G., Banck, M. S., Laborda, J., Tan, S., Friedman, J. M., Friedman, S. L., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m500463200 · Cited by 177 · see citing works

Effects of diabetes drugs on the skeleton

Meier, C., Schwartz, A. V., Egger, A., & Lecka‐Czernik, B. (2015) · Bone · doi:10.1016/j.bone.2015.04.026 · Cited by 173 · see citing works

Compromised cortical bone compartment in type 2 diabetes mellitus patients with microvascular disease

Shanbhogue, V. V., Hansen, S. G., Frost, M., Jørgensen, N. R., Hermann, A. P., Henriksen, J. E., & Brixen, K. (2015) · European Journal of Endocrinology · doi:10.1530/eje-15-0860 · Cited by 172 · see citing works

Dkk1-induced inhibition of Wnt signaling in osteoblast differentiation is an underlying mechanism of bone loss in multiple myeloma

Qiang, Y., Barlogie, B., Rudikoff, S., & Shaughnessy, J. D. (2007) · Bone · doi:10.1016/j.bone.2007.12.006 · Cited by 168 · see citing works

Marrow fat metabolism is linked to the systemic energy metabolism

Lecka‐Czernik, B. (2011) · Bone · doi:10.1016/j.bone.2011.06.032 · Cited by 168 · see citing works

A comparison between osteogenic differentiation of human unrestricted somatic stem cells and mesenchymal stem cells from bone marrow and adipose tissue

Shafiee, A., Seyedjafari, E., Soleimani, M., Ahmadbeigi, N., Dinarvand, P., & Ghaemi, N. (2011) · Biotechnology Letters · doi:10.1007/s10529-011-0541-8 · Cited by 163 · see citing works

The role of the epidermal growth factor-like protein dlk in cell differentiation.

Laborda, J. (2000) · PubMed · doi:10.14670/hh-15.119 · Cited by 158 · see citing works

A Role for Bone Morphogenetic Protein-4 in Adipocyte Development

Bowers, R. R., & Lane, M. D. (2007) · Cell Cycle · doi:10.4161/cc.6.4.3804 · Cited by 153 · see citing works

Age-related Marrow Adipogenesis Is Linked to Increased Expression of RANKL

Takeshita, S., Fumoto, T., Naoe, Y., & Ikeda, K. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.547919 · Cited by 146 · see citing works

microRNA-320/RUNX2 axis regulates adipocytic differentiation of human mesenchymal (skeletal) stem cells

Hamam, D., Ali, D., Vishnubalaji, R., Hamam, R., Al-Nbaheen, M. S., Chen, L., Kassem, M. S., Aldahmash, A. M., & Alajez, N. M. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.462 · Cited by 144 · see citing works

Transforming Growth Factor β2 Inhibits Adipocyte Differentiation Induced by Skeletal Unloading in Rat Bone Marrow Stroma

Ahdjoudj, S., Lasmoles, F., Holy, X., Zérath, E., & Marie, P. J. (2002) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2002.17.4.668 · Cited by 144 · see citing works

Overexpression of Adiponectin Targeted to Adipose Tissue in Transgenic Mice: Impaired Adipocyte Differentiation

Bauche, I. B., Ait-El-Mkadem, S., Pottier, A.-M., Sènou, M., Many, M., Rezsöhazy, R., Pénicaud, L., Maeda, N., Funahashi, T., & Brichard, S. M. (2007) · Endocrinology · doi:10.1210/en.2006-0838 · Cited by 143 · see citing works

Concise Review: MicroRNA Function in Multipotent Mesenchymal Stromal Cells

Clark, E. A., Kalomoiris, S., Nolta, J. A., & Fierro, F. A. (2013) · Stem Cells · doi:10.1002/stem.1623 · Cited by 142 · see citing works

Paracrine regulation of fat cell formation in bone marrow cultures via adiponectin and prostaglandins

Yokota, T., Meka, C. S. R., Medina, K. L., Igarashi, H., Comp, P. C., Takahashi, M., Nishida, M., Oritani, K., Miyagawa, J.-I., Funahashi, T., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci14506 · Cited by 141 · see citing works

Ectodomain Shedding of Preadipocyte Factor 1 (Pref-1) by Tumor Necrosis Factor Alpha Converting Enzyme (TACE) and Inhibition of Adipocyte Differentiation

Wang, Y., & Sul, H. S. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.02437-05 · Cited by 140 · see citing works

Role of Foxa-2 in adipocyte metabolism and differentiation

Wolfrum, C., Shih, D. Q., Kuwajima, S., Norris, A. W., Kahn, C. R., & Stoffel, M. (2003) · Journal of Clinical Investigation · doi:10.1172/jci18698 · Cited by 139 · see citing works

Demonstration of the presence of independent pre-osteoblastic and pre-adipocytic cell populations in bone marrow-derived mesenchymal stem cells

Post, S., Abdallah, B. M., Bentzon, J. F., & Kassem, M. S. (2008) · Bone · doi:10.1016/j.bone.2008.03.011 · Cited by 139 · see citing works

Dissociation of the neuronal regulation of bone mass and energy metabolism by leptin in vivo

Shi, Y., Yadav, V. K., Suda, N., Liu, X. S., Guo, X.-D. E., Myers, M. G., & Karsenty, G. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808701106 · Cited by 136 · see citing works

Diet‐induced obesity alters bone remodeling leading to decreased femoral trabecular bone mass in mice

Cao, J., Sun, L., & Gao, H. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.05252.x · Cited by 136 · see citing works

The WNT Inhibitor Dickkopf 1 and Bone Morphogenetic Protein 4 Rescue Adipogenesis in Hypertrophic Obesity in Humans

Gustafson, B., & Smith, U. (2012) · Diabetes · doi:10.2337/db11-1419 · Cited by 136 · see citing works

Adiponectin Stimulates Osteoblast Differentiation Through Induction of COX2 in Mesenchymal Progenitor Cells

Lee, H. W., Kim, S., Kim, A., Lee, E. J., Choi, J., & Kim, J. B. (2009) · Stem Cells · doi:10.1002/stem.144 · Cited by 135 · see citing works

MECHANISMS IN ENDOCRINOLOGY: Micro-RNAs: targets for enhancing osteoblast differentiation and bone formation

Taipaleenmäki, H., Hokland, L. B., Chen, L., Kauppinen, S., & Kassem, M. S. (2011) · European Journal of Endocrinology · doi:10.1530/eje-11-0646 · Cited by 131 · see citing works

A comparison of adipose and bone marrow-derived mesenchymal stromal cell secreted factors in the treatment of systemic inflammation

Elman, J. S., Li, M., Wang, F., Gimble, J. M., & Parekkadan, B. (2014) · Journal of Inflammation · doi:10.1186/1476-9255-11-1 · Cited by 126 · see citing works

Paracrine regulation of fat cell formation in bone marrow cultures via adiponectin and prostaglandins

Yokota, T., Meka, C. S. R., Medina, K. L., Igarashi, H., Comp, P. C., Takahashi, M., Nishida, M., Oritani, K., Miyagawa, J., Funahashi, T., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0214506 · Cited by 125 · see citing works

New factors controlling the balance between osteoblastogenesis and adipogenesis

Abdallah, B. M., & Kassem, M. S. (2011) · Bone · doi:10.1016/j.bone.2011.06.030 · Cited by 124 · see citing works

The omega-6 arachidonic fatty acid, but not the omega-3 fatty acids, inhibits osteoblastogenesis and induces adipogenesis of human mesenchymal stem cells: potential implication in osteoporosis

Casado‐Díaz, A., Santiago‐Mora, R., Dorado, G., & Quesada‐Gómez, J. M. (2012) · Osteoporosis International · doi:10.1007/s00198-012-2138-z · Cited by 122 · see citing works

A conversation with Marc Feldmann

Neill, U. S. (2014) · Journal of Clinical Investigation · doi:10.1172/jci71860 · Cited by 120 · see citing works

Troglitazone Treatment Increases Bone Marrow Adipose Tissue Volume but Does not Affect Trabecular Bone Volume in Mice

Tornvig, L., Mosekilde, L., Justesen, J., Falk, E., & Kassem, M. S. (2001) · Calcified Tissue International · doi:10.1007/s002230020018 · Cited by 118 · see citing works

The KLF2 Transcription Factor Does Not Affect the Formation of Preadipocytes but Inhibits Their Differentiation into Adipocytes

Wu, J., Srinivasan, S. V., Neumann, J. C., & Lingrel, J. B. (2005) · Biochemistry · doi:10.1021/bi050166i · Cited by 117 · see citing works

Wnt signalling mediates the cross-talk between bone marrow derived pre-adipocytic and pre-osteoblastic cell populations

Taipaleenmäki, H., Abdallah, B. M., Aldahmash, A. M., Säämänen, A., & Kassem, M. S. (2011) · Experimental Cell Research · doi:10.1016/j.yexcr.2010.12.015 · Cited by 117 · see citing works

Characterization of adipocyte differentiation from human mesenchymal stem cells in bone marrow

Qian, S.-W., Li, X., Zhang, Y.-Y., Huang, H.-Y., Liu, Y., Sun, X., & Tang, Q.-Q. (2010) · BMC Developmental Biology · doi:10.1186/1471-213x-10-47 · Cited by 114 · see citing works

CCAAT/Enhancer-binding Protein β Promotes Osteoblast Differentiation by Enhancing Runx2 Activity with ATF4

Tominaga, H., Maeda, S., Hayashi, M., Takeda, S., Akira, S., Komiya, S., Nakamura, T., Akiyama, H., & Imamura, T. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-03-0329 · Cited by 114 · see citing works

Disruption of the insulin-like growth factor-1 gene in osteocytes impairs developmental bone growth in mice

Sheng, M. H. ‐., Zhou, X.-D., Bonewald, L. F., Baylink, D. J., & Lau, K. ‐. W. (2012) · Bone · doi:10.1016/j.bone.2012.09.027 · Cited by 111 · see citing works

Conditional Deletion of Insulin-Like Growth Factor-I in Collagen Type 1α2-Expressing Cells Results in Postnatal Lethality and a Dramatic Reduction in Bone Accretion

Govoni, K. E., Wergedal, J. E., Florin, L., Angel, P. E., Baylink, D. J., & Mohan, S. (2007) · Endocrinology · doi:10.1210/en.2007-0608 · Cited by 109 · see citing works

Circulating levels of fibroblast growth factor-21 increase with age independently of body composition indices among healthy individuals

Hanks, L. J., Gutiérrez, O. M., Bamman, M. M., Ashraf, A., McCormick, K. L., & Casazza, K. (2015) · Journal of Clinical & Translational Endocrinology · doi:10.1016/j.jcte.2015.02.001 · Cited by 104 · see citing works

Secreted frizzled-related protein 1 regulates adipose tissue expansion and is dysregulated in severe obesity

Lagathu, C., Christodoulides, C., Tan, C. Y., Virtue, S., Laudes, M., Campbell, M., Ishikawa, K., Ortega, F. J., Tinahones, F. J., Fernández‐Real, J. M., et al. (2010) · International Journal of Obesity · doi:10.1038/ijo.2010.107 · Cited by 103 · see citing works

LRP5 Regulates Human Body Fat Distribution by Modulating Adipose Progenitor Biology in a Dose- and Depot-Specific Fashion

Loh, N. Y., Neville, M. J., Marinou, K., Hardcastle, S., Fielding, B. A., Duncan, E. L., McCarthy, M. I., Tobias, J. H., Gregson, C. L., Karpe, F., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.01.009 · Cited by 102 · see citing works

CD146/MCAM defines functionality of human bone marrow stromal stem cell populations

Harkness, L., Zaher, W. A., Ditzel, N., Isa, A., & Kassem, M. S. (2016) · Stem Cell Research & Therapy · doi:10.1186/s13287-015-0266-z · Cited by 100 · see citing works

A study of bone marrow and subcutaneous fatty acid composition in subjects of varying bone mineral density

Griffith, J. F., Yeung, D. K. W., Ahuja, A. T., Choy, C. W. Y., Mei, W. Y., Lam, S. S. L., Lam, T. P., Chen, Z., & Leung, P. (2009) · Bone · doi:10.1016/j.bone.2009.02.022 · Cited by 98 · see citing works

Macrophage-conditioned medium inhibits the differentiation of 3T3-L1 and human abdominal preadipocytes

Constant, V. A., Gagnon, A., Landry, A., & Sorisky, A. (2006) · Diabetologia · doi:10.1007/s00125-006-0253-0 · Cited by 98 · see citing works

Cross-talk between Insulin and Wnt Signaling in Preadipocytes

Palsgaard, J., Emanuelli, B., Winnay, J. N., Sumara, G., Karsenty, G., & Kahn, C. R. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.337048 · Cited by 98 · see citing works

Increased heme-oxygenase 1 expression in mesenchymal stem cell-derived adipocytes decreases differentiation and lipid accumulation via upregulation of the canonical Wnt signaling cascade

Vanella, L., Sodhi, K., Kim, D. H., Puri, N., Maheshwari, M., Hinds, T. D., Bellner, L., Goldstein, D. B., Peterson, S. J., Shapiro, J. I., et al. (2013) · Stem Cell Research & Therapy · doi:10.1186/scrt176 · Cited by 96 · see citing works

Molecular and functional characterization of human bone marrow adipocytes

Poloni, A., Maurizi, G., Serrani, F., Mancini, S., Zingaretti, M. C., Frontini, A., Cinti, S., Olivieri, A., & Leoni, P. (2013) · Experimental Hematology · doi:10.1016/j.exphem.2013.02.005 · Cited by 88 · see citing works

A CCAAT/Enhancer Binding Protein β Isoform, Liver-Enriched Inhibitory Protein, Regulates Commitment of Osteoblasts and Adipocytes

Hata, K., Nishimura, R., Ueda, M., Ikeda, F., Matsubara, T., Ichida, F., Hisada, K., Nokubi, T., Yamaguchi, A., & Yoneda, T. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.5.1971-1979.2005 · Cited by 87 · see citing works

Adiponectin Regulates Bone Marrow Mesenchymal Stem Cell Niche Through a Unique Signal Transduction Pathway: An Approach for Treating Bone Disease in Diabetes

Yu, L., Tu, Q., Han, Q., Zhang, L., Sui, L., Zheng, L., Meng, S., Tang, Y., Xuan, D., Zhang, J., et al. (2014) · Stem Cells · doi:10.1002/stem.1844 · Cited by 81 · see citing works

Treatment needs and current options for postmenopausal osteoporosis

Gennari, L., Rotatori, S., Bianciardi, S., Nuti, R., & Merlotti, D. (2016) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2016.1176147 · Cited by 78 · see citing works

Effect of Fatty Acids on Human Bone Marrow Mesenchymal Stem Cell Energy Metabolism and Survival

Fillmore, N., Huqi, A., Jaswal, J. S., Mori, J., Paulin, R., Haromy, A., Onay-Beşi̇kçi̇, A., Ionescu, L., Thébaud, B., Michelakis, E. D., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0120257 · Cited by 75 · see citing works

Romosozumab in Postmenopausal Women with Osteopenia

Evenepoel, P., D'Haese, P., & Brandenburg, V. (2014) · New England Journal of Medicine · doi:10.1056/nejmc1402396 · Cited by 71 · see citing works

Dlk1/FA1 Is a Novel Endocrine Regulator of Bone and Fat Mass and Its Serum Level Is Modulated by Growth Hormone

Abdallah, B. M., Ding, M. L., Jensen, C. H., Ditzel, N., Flyvbjerg, A., Jensen, T. G., Dagnæs‐Hansen, F., Gasser, J. A., & Kassem, M. S. (2007) · Endocrinology · doi:10.1210/en.2007-0171 · Cited by 69 · see citing works

microRNAs as Regulators of Adipogenic Differentiation of Mesenchymal Stem Cells

Hamam, D., Ali, D., Kassem, M., Aldahmash, A., & Alajez, N. (2015) · Stem Cells and Development · doi:10.1089/scd.2014.0331 · Cited by 67 · see citing works

Human Stromal (Mesenchymal) Stem Cells: Basic Biology and Current Clinical Use for Tissue Regeneration

Aldahmash, A. M., Zaher, W. A., Al-Nbaheen, M. S., & Kassem, M. S. (2012) · Annals of Saudi Medicine · doi:10.5144/0256-4947.2012.68 · Cited by 67 · see citing works

Circulating Sclerostin Associated With Vertebral Bone Marrow Fat in Older Men But Not Women

Ma, Y.-H. V., Schwartz, A. V., Sigurdsson, S. O., Hue, T. F., Lang, T., Harris, T. B., Rosen, C. J., Vittinghoff, E., Eiríksdóttir, G., Hauksdóttir, A. M., et al. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-4493 · Cited by 66 · see citing works

Adiponectin receptor 1 regulates bone formation and osteoblast differentiation by GSK-3β/β-Catenin signaling in mice

Lin, Y., Chen, C., Chuang, T. Y., Lin, Y., Liu, H. Y., Mersmann, H. J., Wu, S., & Ding, S. (2014) · Bone · doi:10.1016/j.bone.2014.03.051 · Cited by 65 · see citing works

DLK1 Regulates Whole-Body Glucose Metabolism: A Negative Feedback Regulation of the Osteocalcin-Insulin Loop

Abdallah, B. M., Ditzel, N., Laborda, J., Karsenty, G., & Kassem, M. S. (2015) · Diabetes · doi:10.2337/db14-1642 · Cited by 63 · see citing works

Skeletal Stem Cells in Space and Time

Kassem, M. S., & Bianco, P. (2015) · Cell · doi:10.1016/j.cell.2014.12.034 · Cited by 62 · see citing works

The effects of thiazolidinediones on human bone marrow stromal cell differentiation in vitro and in thiazolidinedione-treated patients with type 2 diabetes

Beck, G. R., Khazai, N. B., Bouloux, G. F., Camalier, C. E., Lin, Y., Garneys, L. M., Siqueira, J., Peng, L., Pasquel, F. J., Umpierrez, D., et al. (2012) · Translational research · doi:10.1016/j.trsl.2012.08.006 · Cited by 61 · see citing works

Molecular Mechanisms of Adipocyte Differentiation and Inhibitory Action of Pref-1

Smas, C. M., & Sul, H. S. (1997) · Critical Reviews in Eukaryotic Gene Expression · doi:10.1615/critreveukargeneexpr.v7.i4.10 · Cited by 61 · see citing works

Sera of overweight people promote in vitro adipocyte differentiation of bone marrow stromal cells

Bernardo, G. D., Messina, G., Capasso, S., Gaudio, S. D., Cipollaro, M., Peluso, G., Casale, F., Monda, M., & Galderisi, U. (2014) · Stem Cell Research & Therapy · doi:10.1186/scrt393 · Cited by 57 · see citing works

Patients with high-bone-mass phenotype owing to Lrp5-T253I mutation have low plasma levels of serotonin

Frost, M., Andersen, T. E., Yadav, V. K., Brixen, K., Karsenty, G., & Kassem, M. S. (2010) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.44 · Cited by 55 · see citing works

A New Selective Estrogen Receptor Modulator with Potent Uterine Antagonist Activity, Agonist Activity in Bone, and Minimal Ovarian Stimulation

Geiser, A. G., Hummel, C. W., Draper, M. W., Henck, J. W., COHEN, I. R., Rudmann, D. G., Donnelly, K. B., Adrian, M. D., Shepherd, T. A., Wallace, O. B., et al. (2005) · Endocrinology · doi:10.1210/en.2005-0024 · Cited by 53 · see citing works

Microarray analyses of transdifferentiated mesenchymal stem cells

Schilling, T., Küffner, R., Klein‐Hitpaß, L., Zimmer, R., Jakob, F. J., & Schütze, N. (2007) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21415 · Cited by 53 · see citing works

Lipid Profiling of In Vitro Cell Models of Adipogenic Differentiation: Relationships With Mouse Adipose Tissues

Liaw, L., Prudovsky, I. A., Koza, R. A., Anunciado-Koza, R. V. P., Siviski, M. E., Lindner, V., Friesel, R. E., Rosen, C. J., Baker, P. R. S., Simons, B. L., et al. (2016) · Journal of Cellular Biochemistry · doi:10.1002/jcb.25522 · Cited by 51 · see citing works

Pioglitazone increases bone marrow fat in type 2 diabetes: results from a randomized controlled trial

Grey, A. B., Beckley, V., Doyle, A., Fenwick, S., Horne, A. M., Gamble, G. D., & Bolland, M. J. (2012) · European Journal of Endocrinology · doi:10.1530/eje-11-1075 · Cited by 50 · see citing works

Energy Excess, Glucose Utilization, and Skeletal Remodeling: New Insights

Lecka‐Czernik, B., & Rosen, C. J. (2015) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2574 · Cited by 48 · see citing works

Morphologic and transcriptomic comparison of adipose- and bone-marrow-derived porcine stem cells cultured in alginate hydrogels

Kim, D., Monaco, E. L., Maki, A. J., de Lima, A. S., Kong, H. J., Hurley, W. L., & Wheeler, M. B. (2010) · Cell and Tissue Research · doi:10.1007/s00441-010-1015-3 · Cited by 45 · see citing works

Effects of leptin on the differentiation and metabolism of human adipocytes

Aprath-Husmann, I., Röhrig, K., Gottschling-Zeller, H., Skurk, T., Scriba, D., Birgel, M., & Hauner, H. (2001) · International Journal of Obesity · doi:10.1038/sj.ijo.0801737 · Cited by 44 · see citing works

C/EBP regulates body composition, energy balance-related hormones and tumor growth

Staiger, J., Lueben, M. J., Berrigan, D. A., Malı́k, R., Perkins, S. N., Hursting, S. D., & Johnson, P. F. (2008) · Carcinogenesis · doi:10.1093/carcin/bgn273 · Cited by 42 · see citing works

Interleukin‐6 induces the lineage commitment of bone marrow‐derived mesenchymal multipotent cells through down‐regulation of Sox2 by osteogenic transcription factors

Yoon, D. S., Kim, Y. H., Lee, S., Lee, K., Park, K. H., Jang, Y., & Lee, J. W. (2014) · The FASEB Journal · doi:10.1096/fj.13-248567 · Cited by 41 · see citing works

Misexpression of CCAAT/enhancer binding protein beta causes osteopenia

Zanotti, S., Stadmeyer, L., Smerdel‐Ramoya, A., Durant, D., & CANALIS, E. M. (2009) · Journal of Endocrinology · doi:10.1677/joe-08-0514 · Cited by 38 · see citing works

CD34 defines an osteoprogenitor cell population in mouse bone marrow stromal cells

Abdallah, B. M., AL-Shammary, A. A., Skagen, P., Dawud, R. A., Adjaye, J., Aldahmash, A. M., & Kassem, M. S. (2015) · Stem Cell Research · doi:10.1016/j.scr.2015.09.005 · Cited by 37 · see citing works

Fetal antigen 1 (FA1), a circulating member of the epidermal growth factor (EGF) superfamily: ELISA development, physiology and metabolism in relation to renal function

Jensen, C. H., Krogh, T. N., Støving, R. K., Holmskov, U., & Teisner, B. (1997) · Clinica Chimica Acta · doi:10.1016/s0009-8981(97)00152-6 · Cited by 35 · see citing works

Identification of a Subpopulation of Marrow MSC-Derived Medullary Adipocytes That Express Osteoclast-Regulating Molecules: Marrow Adipocytes Express Osteoclast Mediators

Holt, V., Caplan, A. I., & Haynesworth, S. E. (2014) · PLoS ONE · doi:10.1371/journal.pone.0108920 · Cited by 34 · see citing works

Cell size and plamitate-1-14c turnover of rabbit marrow fat

Trubowitz, S., & Bathija, A. (1977) · Blood · doi:10.1182/blood.v49.4.599.599 · Cited by 29 · see citing works

Fatty Involution of Marrow and the Role of Adipose Tissue in Hemopoiesis

Tavassoli, M. (1989) · Humana Press eBooks · doi:10.1007/978-1-4612-4494-3_4 · Cited by 22 · see citing works

Diabetes and bone fracture: risk factors for old and young

Vestergaard, P. (2014) · Diabetologia · doi:10.1007/s00125-014-3338-1 · Cited by 20 · see citing works

Adipogenesis of the mesenchymal stromal cells and bone oedema in rheumatoid arthritis.

Okada, A., Yamasaki, S., Koga, T., Kawashiri, S., Tamai, M., Origuchi, T., Nakamura, H., Eguchi, K., & Kawakami, A. (2012) · PubMed · Cited by 18 · see citing works

Bone Loss and Inhaled Glucocorticoids

van Staa, T. P., Leufkens, B., & Cooper, C. C. (2002) · New England Journal of Medicine · doi:10.1056/nejm200202143460716 · Cited by 17 · see citing works

Impaired mitochondrial function and reduced viability in bone marrow cells of obese mice

de Oliveira, G. P., Cortez, E. A. C., Araujo, G. J., Sabino, K. C. C., Neves, F. A., Bernardo, A. F., de Carvalho, S. N., Moura, A. S., de Carvalho, L., & Thole, A. A. (2014) · Cell and Tissue Research · doi:10.1007/s00441-014-1857-1 · Cited by 16 · see citing works

Adipocytes Differentiated In Vitro from Rat Mesenchymal Stem Cells Lack Essential Free Fatty Acids Compared to Adult Adipocytes

Bojin, F. M., Lukinich-Gruia, A. T., Cristea, M. I., Ordodi, V. L., Păunescu, V., & Mic, F. A. (2011) · Stem Cells and Development · doi:10.1089/scd.2011.0491 · Cited by 14 · see citing works

The effect of cytokines on osteoblasts and osteoclasts in bone remodeling in osteoporosis: a review

Xu, J., Yu, L., Liu, F., Wan, L., & Deng, Z. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1222129 · Cited by 283 · see citing works

High‐Fat Diet–Induced Obesity Promotes Expansion of Bone Marrow Adipose Tissue and Impairs Skeletal Stem Cell Functions in Mice

Tencerova, M., Figeac, F., Ditzel, N., Taipaleenmäki, H., Nielsen, T., & Kassem, M. (2018) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3408 · Cited by 218 · see citing works

Obesity-Associated Hypermetabolism and Accelerated Senescence of Bone Marrow Stromal Stem Cells Suggest a Potential Mechanism for Bone Fragility.

Tencerova, M., Frost, M., Figeac, F., Nielsen, T., Ali, D., Lauterlein, J., Andersen, T. L., Haakonsson, A., Rauch, A., Madsen, J. S., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.04.066 · Cited by 125 · see citing works

Bone Marrow Mesenchymal Stromal Cells: Identification, Classification, and Differentiation

Gao, Q., Wang, L., Wang, S., Huang, B., Jing, Y., & Su, J. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.787118 · Cited by 140 · see citing works

Defining osteoblast and adipocyte lineages in the bone marrow

Pierce, J. L., Begun, D. L., Westendorf, J. J., & McGee‐Lawrence, M. E. (2018) · Bone · doi:10.1016/j.bone.2018.05.019 · Cited by 134 · see citing works

Bone marrow‐derived mesenchymal stem cell‐derived exosomal microRNA‐208a promotes osteosarcoma cell proliferation, migration, and invasion

Qin, F., Tang, H., Zhang, Y., Zhang, Z., Huang, P., & Zhu, J. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.29351 · Cited by 121 · see citing works

Regional specialization and fate specification of bone stromal cells in skeletal development

Sivaraj, K. K., Jeong, H., Dharmalingam, B., Zeuschner, D., Adams, S., Potente, M., & Adams, R. H. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109352 · Cited by 104 · see citing works

Skeletal disorders associated with the growth hormone–insulin-like growth factor 1 axis

Mazziotti, G., Lania, A. G., & CANALIS, E. M. (2022) · Nature Reviews Endocrinology · doi:10.1038/s41574-022-00649-8 · Cited by 108 · see citing works

Obesity-Induced Changes in Bone Marrow Homeostasis

Beňová, A., & Tencerová, M. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00294 · Cited by 95 · see citing works

Interleukin-6 Knockout Inhibits Senescence of Bone Mesenchymal Stem Cells in High-Fat Diet-Induced Bone Loss

Li, Y.-J., Lu, L., Xie, Y., Chen, X., Tian, L., Liang, Y., Li, H.-F., Zhang, J., Liu, Y., & Yu, X.-J. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.622950 · Cited by 76 · see citing works

Role of Tumor-Derived Chemokines in Osteolytic Bone Metastasis

Coniglio, S. J. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00313 · Cited by 82 · see citing works

The Analysis of In Vivo Aging in Human Bone Marrow Mesenchymal Stromal Cells Using Colony-Forming Unit-Fibroblast Assay and the CD45 low CD271 + Phenotype

Ganguly, P., El‐Jawhari, J. J., Burska, A. N., Ponchel, F., Giannoudis, P. V., & Jones, E. (2019) · Stem Cells International · doi:10.1155/2019/5197983 · Cited by 76 · see citing works

The implications of bone marrow adipose tissue on inflammaging

Aaron, N., Costa, S., Rosen, C. J., & Qiang, L. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.853765 · Cited by 74 · see citing works

Resveratrol inhibits adipocyte differentiation and cellular senescence of human bone marrow stromal stem cells.

Ali, D., Chen, L., Kowal, J., Okla, M., Manikandan, M., Alshehri, M., Almana, Y., AlObaidan, R. H., Alotaibi, N., Hamam, R., et al. (2020) · Bone · doi:10.1016/j.bone.2020.115252 · Cited by 69 · see citing works

Hypertrophic chondrocytes serve as a reservoir for marrow-associated skeletal stem and progenitor cells, osteoblasts, and adipocytes during skeletal development

Long, J. T., Leinroth, A. P., Liao, Y., Ren, Y., Mirando, A. J., Nguyen, T., Guo, W., Sharma, D., Rouse, D., Wu, C., et al. (2022) · eLife · doi:10.7554/elife.76932 · Cited by 67 · see citing works

High‐fat diet‐induced obesity augments the deleterious effects of estrogen deficiency on bone: Evidence from ovariectomized mice

Ali, D., Figeac, F., Caci, A., Ditzel, N., Schmal, C., Kerckhofs, G., Havelund, J. F., Færgeman, N. J., Rauch, A., Tencerová, M., et al. (2022) · Aging Cell · doi:10.1111/acel.13726 · Cited by 65 · see citing works

Metabolic programming determines the lineage-differentiation fate of murine bone marrow stromal progenitor cells

Tencerová, M., Rendina-Ruedy, E., Neess, D., Færgeman, N. J., Figeac, F., Ali, D., Danielsen, M., Haakonsson, A. K., Rosen, C. J., & Kassem, M. S. (2019) · Bone Research · doi:10.1038/s41413-019-0076-5 · Cited by 55 · see citing works

Bone marrow adipose tissue: Role in bone remodeling and energy metabolism

Tencerová, M., Ferenčáková, M., & Kassem, M. S. (2021) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2021.101545 · Cited by 53 · see citing works

Molecular differences between subtypes of bone marrow adipocytes

Craft, C. S., Li, Z.-R., MacDougald, O., & Scheller, E. (2018) · Current Molecular Biology Reports · doi:10.1007/s40610-018-0087-9 · Cited by 52 · see citing works

A Review of Potential Beneficial Effects of Honey on Bone Health

Kamaruzzaman, M. A., Chin, K., & Ramli, E. S. M. (2019) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2019/8543618 · Cited by 50 · see citing works

Do polyunsaturated fatty acids protect against bone loss in our aging and osteoporotic population?

Martyniak, K., Wei, F., Ballesteros, A., Meckmongkol, T. T., Calder, A. N., Gilbertson, T. A., Orlovskaya, N. A., & Coathup, M. J. (2020) · Bone · doi:10.1016/j.bone.2020.115736 · Cited by 49 · see citing works

Insulin Signaling in Bone Marrow Adipocytes

Tencerová, M., Okla, M., & Kassem, M. S. (2019) · Current Osteoporosis Reports · doi:10.1007/s11914-019-00552-8 · Cited by 48 · see citing works

Melatonin suppresses bone marrow adiposity in ovariectomized rats by rescuing the imbalance between osteogenesis and adipogenesis through SIRT1 activation

Huang, X., Chen, W., Gu, C., Liu, H., Hou, M., Qin, W., Zhu, X., Chen, X., Liu, T., Yang, H., et al. (2022) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2022.10.002 · Cited by 47 · see citing works

The emerging role of bone marrow adipose tissue in bone health and dysfunction

Ambrosi, T. H., & Schulz, T. J. (2017) · Journal of Molecular Medicine · doi:10.1007/s00109-017-1604-7 · Cited by 47 · see citing works

Fgf9 regulates bone marrow mesenchymal stem cell fate and bone-fat balance in osteoporosis by PI3K/AKT/Hippo and MEK/ERK signaling

Chen, M., Liang, H., Wu, M., Ge, H., Ma, Y., Shen, Y., Lu, S., Shen, C., Zhang, H., Wang, Z., et al. (2024) · International Journal of Biological Sciences · doi:10.7150/ijbs.94863 · Cited by 45 · see citing works

Bone circuitry and interorgan skeletal crosstalk

Zaidi, M., Kim, S.-M., Mathew, M., Korkmaz, F., Sultana, F., Miyashita, S., Gumerova, A. A., Frolinger, T., Moldavski, O., Barak, O., et al. (2023) · eLife · doi:10.7554/elife.83142 · Cited by 45 · see citing works

BMP-2 Long-Term Stimulation of Human Pre-Osteoblasts Induces Osteogenic Differentiation and Promotes Transdifferentiation and Bone Remodeling Processes

Ingwersen, L.-C., Frank, M., Naujokat, H., Loger, K., Bader, R., & Jonitz‐Heincke, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23063077 · Cited by 43 · see citing works

Irisin alleviates obesity-induced bone loss by inhibiting interleukin 6 expression via TLR4/MyD88/NF-κB axis in adipocytes

Zhang, Y.-S., He, X., Wang, K., Xue, Y., Hu, S.-H., Jin, Y.-S., Zhu, G., Rui, Y.-J., & Shi, Q. (2024) · Journal of Advanced Research · doi:10.1016/j.jare.2024.04.013 · Cited by 49 · see citing works

Exploring the Role of Hormones and Cytokines in Osteoporosis Development

Umur, E., Bulut, S. B., Yiğit, P., Bayrak, E., Arkan, Y., Arslan, F., Baysoy, E., Kaleli‐Can, G., & Ayan, B. (2024) · Biomedicines · doi:10.3390/biomedicines12081830 · Cited by 41 · see citing works

Immunomodulation of Skin Repair: Cell-Based Therapeutic Strategies for Skin Replacement (A Comprehensive Review)

Tavakoli, S., Kisiel, M., Biedermann, T., & Klar, A. S. (2022) · Biomedicines · doi:10.3390/biomedicines10010118 · Cited by 35 · see citing works

Influence of age on stem cells depends on the sex of the bone marrow donor

Selle, M., Koch, J. D., Ongsiek, A., Ulbrich, L., Ye, W., Jiang, Z., Krettek, C., Neunaber, C., & Noack, S. (2022) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17201 · Cited by 37 · see citing works

MicroRNA-141-3p Negatively Modulates SDF-1 Expression in Age-Dependent Pathophysiology of Human and Murine Bone Marrow Stromal Cells

Periyasamy‐Thandavan, S., Burke, J., Mendhe, B., Kondrikova, G., Kolhe, R. B., Hunter, M., Isales, C. M., Hamrick, M. W., Hill, W., & Fulzele, S. (2018) · The Journals of Gerontology Series A · doi:10.1093/gerona/gly186 · Cited by 36 · see citing works

Single-cell high-content imaging parameters predict functional phenotype of cultured human bone marrow stromal stem cells

Kowal, J. M., Schmal, H., Halekoh, U., Hjelmborg, J., & Kassem, M. S. (2019) · Stem Cells Translational Medicine · doi:10.1002/sctm.19-0171 · Cited by 36 · see citing works

Chronic Kidney Disease Is Associated With Greater Bone Marrow Adiposity

Woods, G. N., Ewing, S. K., Sigurdsson, S. O., Kado, D. M., Ix, J. H., Hue, T. F., Eiríksdóttir, G., Xu, K., Gudnason, V. G., Lang, T., et al. (2018) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3562 · Cited by 35 · see citing works

Interaction between diabetes and osteoporosis: imbalance between inflammation and bone remodeling

Zhang, X. L., Xu, D., Zhang, R., Wang, H., & Yang, G. (2025) · Osteoporosis International · doi:10.1007/s00198-025-07636-5 · Cited by 39 · see citing works

LncRNA XIST from the bone marrow mesenchymal stem cell derived exosome promotes osteosarcoma growth and metastasis through miR-655/ACLY signal

Zhu, G., Xia, Y., Zhao, Z., Li, A., Li, H., & Xiao, T. (2022) · Cancer Cell International · doi:10.1186/s12935-022-02746-0 · Cited by 34 · see citing works

Scara3 regulates bone marrow mesenchymal stem cell fate switch between osteoblasts and adipocytes by promoting Foxo1

Chen, P., Hu, B., Xie, L., Jiang, T., Xia, Z., & Peng, H. (2021) · Cell Proliferation · doi:10.1111/cpr.13095 · Cited by 32 · see citing works

Immunomodulation of Skin Repair: Cell-Based Therapeutic Strategies for Skin Replacement (A Comprehensive Review)

Tavakoli, S., Kisiel, M. A., Biedermann, T., & Klar, A. S. (2022) · Zurich Open Repository and Archive (University of Zurich) · doi:10.5167/uzh-213624 · Cited by 31 · see citing works

Reciprocal Effect of Environmental Stimuli to Regulate the Adipogenesis and Osteogenesis Fate Decision in Bone Marrow-Derived Mesenchymal Stem Cells (BM-MSCs)

Xu, X., Zhao, L., Terry, P., & Chen, J. (2023) · Cells · doi:10.3390/cells12101400 · Cited by 29 · see citing works

Pubertal induction in adolescents with DMD is associated with high satisfaction, gonadotropin release and increased muscle contractile surface area

Wood, C. L., Hollingsworth, K. G., Hughes, E., Punniyakodi, S., Muni‐Lofra, R., Mayhew, A. G., Mitchell, R. T., Guglieri, M., Cheetham, T. D., & Straub, V. W. (2020) · European Journal of Endocrinology · doi:10.1530/eje-20-0709 · Cited by 29 · see citing works

Adipocytes spectrum — From homeostasia to obesity and its associated pathology

Grigoraş, A., Amălinei, C., Balan, R. A., Giuşcă, S. E., Avădănei, E. R., Lozneanu, L., & Căruntu, I.-D. (2018) · Annals of Anatomy - Anatomischer Anzeiger · doi:10.1016/j.aanat.2018.06.004 · Cited by 29 · see citing works

N-Acetylcysteine (NAC) Ameliorates Lipid-Related Metabolic Dysfunction in Bone Marrow Stromal Cells-Derived Adipocytes

Raffaele, M., Barbagallo, I., Licari, M., Carota, G., Sferrazzo, G., Spampinato, M., Sorrenti, V., & Vanella, L. (2018) · Evidence-Based Complementary and Alternative Medicine · doi:10.1155/2018/5310961 · Cited by 28 · see citing works

Statins reduce castration-induced bone marrow adiposity and prostate cancer progression in bone

Pan, T., Lin, S.-C., Lee, Y., Yu, G., Song, J. H., Pan, J., Titus, M. A., Satcher, R. L., Panaretakis, T., Logothetis, C. J., et al. (2021) · Oncogene · doi:10.1038/s41388-021-01874-7 · Cited by 28 · see citing works

Calcium Phosphates: A Key to Next‐Generation In Vitro Bone Modeling

Pandit, A., Indurkar, A. R., Ločs, J., Haugen, H. J., & Loča, D. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202401307 · Cited by 27 · see citing works

Bone marrow adipocytes: key players in vascular niches, aging, and disease

Fan, Y., El-Khalek, M. K. A., Zhang, Y., Liu, L., Tian, Q., Chueakula, N., Ramasamy, S. K., Dalan, R., Habib, S. J., & Kusumbe, A. P. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1633801 · Cited by 26 · see citing works

Caveolin-1 mediates soft scaffold-enhanced adipogenesis of human mesenchymal stem cells

Xiang, S., Li, Z. A., Fritch, M. R., La, L., Velankar, S., Liu, Y., Sohn, J., Baker, N., Lin, H., & Tuan, R. S. (2021) · Stem Cell Research & Therapy · doi:10.1186/s13287-021-02356-z · Cited by 26 · see citing works

Small non-coding RNAs-based bone regulation and targeting therapeutic strategies

Yang, Y., & Fang, S. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.11.018 · Cited by 26 · see citing works

SERPINB2 is a novel TGFβ-responsive lineage fate determinant of human bone marrow stromal cells

Elsafadi, M. A., Manikandan, M., Atteya, M., Dawud, R. A., Almalki, S. G., Kaimkhani, Z. A., Aldahmash, A. M., Alajez, N. M., Alfayez, M. A., Kassem, M. S., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-10983-x · Cited by 26 · see citing works

Uptake and distribution of carboxylated quantum dots in human mesenchymal stem cells: cell growing density matters

Kundrotas, G., Karabanovas, V., Plečkaitis, M., Juraleviciute, M., Steponkienė, S., Gudlevičienė, Ž., & Rotomskis, R. (2019) · Journal of Nanobiotechnology · doi:10.1186/s12951-019-0470-6 · Cited by 26 · see citing works

Honey: A Promising Therapeutic Supplement for the Prevention and Management of Osteoporosis and Breast Cancer

Martiniaková, M., Kováčová, V., Mondočková, V., Zemanová, N., Babikova, M., Bíro, R., Čierniková, S., & Omelka, R. (2023) · Antioxidants · doi:10.3390/antiox12030567 · Cited by 25 · see citing works

New Insights into Calorie Restriction Induced Bone Loss

Liu, L., & Rosen, C. J. (2023) · Endocrinology and Metabolism · doi:10.3803/enm.2023.1673 · Cited by 25 · see citing works

CT and MR for bone mineral density and trabecular bone score assessment in osteoporosis evaluation

Lee, H., Park, S., Kwack, K., & Yun, J. S. (2023) · Scientific Reports · doi:10.1038/s41598-023-43850-z · Cited by 25 · see citing works

Molecular insights into the interplay between adiposity, breast cancer and bone metastasis

Soni, S., Torvund, M., & Mandal, C. C. (2021) · Clinical & Experimental Metastasis · doi:10.1007/s10585-021-10076-0 · Cited by 25 · see citing works

Investigation for GSK3β expression in diabetic osteoporosis and negative osteogenic effects of GSK3β on bone marrow mesenchymal stem cells under a high glucose microenvironment

Chen, Y., Chen, L., Huang, R., Yang, W., Chen, S., Lin, K., & Liu, J. (2020) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2020.11.010 · Cited by 22 · see citing works

The role of the androgen receptor in the pathogenesis of obesity and its utility as a target for obesity treatments

Venkatesh, V. S., Grossmann, M., Zajac, J. D., & Davey, R. A. (2022) · Obesity Reviews · doi:10.1111/obr.13429 · Cited by 22 · see citing works

Circadian Clock Deregulation and Metabolic Reprogramming: A System Biology Approach to Tissue-Specific Redox Signaling and Disease Development

Konakchieva, R., Mladenov, M. I., Konaktchieva, M. N., Sazdova, I., Gagov, H., & Nikolaev, G. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26136267 · Cited by 28 · see citing works

Bone Marrow Adipose Tissue Composition Following High-Caloric Feeding and Fasting

Bredella, M., Buckless, C. G., Fazeli, P. K., Rosen, C., Torriani, M., Klibanski, A., & Miller, K. (2021) · Bone · doi:10.1016/j.bone.2021.116093 · Cited by 21 · see citing works

Multiple intracellular signaling pathways orchestrate adipocytic differentiation of human bone marrow stromal stem cells

Ali, D., Abuelreich, S., Alkeraishan, N., Shwish, N. B., Hamam, R., Kassem, M. S., Alfayez, M. A., Aldahmash, A. M., & Alajez, N. M. (2018) · Bioscience Reports · doi:10.1042/bsr20171252 · Cited by 21 · see citing works

A double‐virally‐inactivated (Intercept–solvent/detergent) human platelet lysate for in vitro expansion of human mesenchymal stromal cells

Barro, L., Su, Y., Nebie, O., Wu, Y., Huang, Y., Koh, M., Knutson, F., & Burnouf, T. P. R. (2019) · Transfusion · doi:10.1111/trf.15251 · Cited by 21 · see citing works

Exosomes in bone remodeling and breast cancer bone metastasis

Murari, L. S. S., Krishnan, R., Akshaya, R. L., Das, U. R., Satishkumar, S., & Selvamurugan, N. (2022) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2022.09.008 · Cited by 21 · see citing works

Brain-Derived Neurotrophic Factor (BDNF) Enhances Osteogenesis and May Improve Bone Microarchitecture in an Ovariectomized Rat Model

Park, E. J.-J., Truong, V., Jeong, W., & Min, W. (2024) · Cells · doi:10.3390/cells13060518 · Cited by 20 · see citing works

NOX4-reactive oxygen species axis: critical regulators of bone health and metabolism

Dzubanova, M., Bond, J. M., Craige, S. M., & Tencerová, M. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1432668 · Cited by 18 · see citing works

Integrating Micro- and Nanostructured Platforms and Biological Drugs to Enhance Biomaterial-Based Bone Regeneration Strategies

Shah, S. A., Sohail, M. F., Nakielski, P., Rinoldi, C., Zargarian, S. S., Kosik‐Kozioł, A., Ziai, Y., Bayan, M. A. H., Zakrzewska, A., Rybak, D., et al. (2024) · Biomacromolecules · doi:10.1021/acs.biomac.4c01133 · Cited by 18 · see citing works

The effect of PPARγ inhibition on bone marrow adipose tissue and bone in C3H/HeJ mice.

Beekman, K. M., Veldhuis-Vlug, A., van der Veen, A. J., den Heijer, M., Maas, M., Kerckhofs, G., Parac-Vogt, T., Bisschop, P., & Bravenboer, N. (2019) · American Journal of Physiology. Endocrinology and Metabolism · doi:10.1152/ajpendo.00265.2018 · Cited by 15 · see citing works

Exploring the Interplay between Bone Marrow Stem Cells and Obesity

Moscatelli, F., Monda, A., Messina, G., Picciocchi, E., Monda, M., di Padova, M., Monda, V., Mezzogiorno, A., Dipace, A., Limone, P., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25052715 · Cited by 16 · see citing works

Bone mesenchymal stem cells attenuate radicular pain by inhibiting microglial activation in a rat noncompressive disk herniation model

Huang, X., Wang, W., Liu, X., Xi, Y., Yu, J., Yang, X., & Ye, X. (2018) · Cell and Tissue Research · doi:10.1007/s00441-018-2855-5 · Cited by 17 · see citing works

Age-related trabecular bone loss is associated with a decline in serum Galectin-1 level

Xu, W., Ni, C., Wang, Y., Zheng, G., Zhang, J., & Xu, Y. (2021) · BMC Musculoskeletal Disorders · doi:10.1186/s12891-021-04272-y · Cited by 17 · see citing works

Bone marrow fat: friend or foe in people with diabetes mellitus?

Santopaolo, M., Gu, Y., Spinetti, G., & Madeddu, P. R. (2020) · Clinical Science · doi:10.1042/cs20200220 · Cited by 16 · see citing works

Nanofiltration of growth media supplemented with human platelet lysates for pathogen-safe xeno-free expansion of mesenchymal stromal cells

Barro, L., Nebie, O., Chen, M. S., Wu, Y., Koh, M., Knutson, F., Watanabe, N., Takahara, M., & Burnouf, T. P. R. (2020) · Cytotherapy · doi:10.1016/j.jcyt.2020.04.099 · Cited by 16 · see citing works

Obesity: Effects on bone marrow homeostasis and platelet activation

Vauclard, A., Bellio, M., Valet, C., Borret, M., Payrastre, B., & Severin, S. (2022) · Thrombosis Research · doi:10.1016/j.thromres.2022.10.008 · Cited by 19 · see citing works

Peiminine regulates bone‐fat balance by canonical Wnt/β‐catenin pathway in an ovariectomized rat model

Gu, H., & Wei, J. (2023) · Phytotherapy Research · doi:10.1002/ptr.7780 · Cited by 15 · see citing works

Novel Nanohydroxyapatite (nHAp)-Based Scaffold Doped with Iron Oxide Nanoparticles (IO), Functionalized with Small Non-Coding RNA (miR-21/124) Modulates Expression of Runt-Related Transcriptional Factor 2 and Osteopontin, Promoting Regeneration of Osteoporotic Bone in Bilateral Cranial Defects in a Senescence-Accelerated Mouse Model (SAM/P6). PART 2

Marycz, K., Śmieszek, A., Kornicka‐Garbowska, K., Pielok, A., Janeczek, M., Lipińska, A., Nikodem, A., Filipiak, J., Sobierajska, P., Nédélec, J., et al. (2021) · International Journal of Nanomedicine · doi:10.2147/ijn.s316240 · Cited by 15 · see citing works

Assessment of protein adhesion behaviour and biocompatibility of magnesium/Co-substituted HA-based composites for orthopaedic application

Dubey, A., Ghosh, S., Jaiswal, S., Roy, P., & Debrupa Lahiri, A. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.03.166 · Cited by 12 · see citing works

The Effect of Early Rounds of ex vivo Expansion and Cryopreservation on the Adipogenic Differentiation Capacity of Adipose-Derived Stromal/Stem Cells

Durandt, C., Dessels, C., da Silva, C., Murdoch, C., & Pepper, M. S. (2019) · Scientific Reports · doi:10.1038/s41598-019-52086-9 · Cited by 12 · see citing works

IRX5 promotes adipogenesis of hMSCs by repressing glycolysis

Jiang, B.-L., Huang, L.-Y., Tian, T., Wu, H.-L., Yao, H.-T., Marmo, T., Song, F., & Huang, C. (2022) · Cell Death Discovery · doi:10.1038/s41420-022-00986-7

Bone Metastasis in Bladder Cancer

Lei, Y., Ai, K., Li, X., Li, Z., & Li, Y. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm13010054 · Cited by 11 · see citing works

β-catenin inhibition disrupts the homeostasis of osteogenic/adipogenic differentiation leading to the development of glucocorticoid-induced osteonecrosis of the femoral head

Xia, C., Xu, H., Fang, L., Chen, J., Yuan, W., Fu, D., Wang, X., He, B., Xiao, L., Wu, C., et al. (2024) · eLife · doi:10.7554/elife.92469.3 · Cited by 11 · see citing works

The Effect of Roux‐en‐Y Gastric Bypass on Bone Marrow Adipose Tissue and Bone Mineral Density in Postmenopausal, Nondiabetic Women

Beekman, K. M., Akkerman, E., Streekstra, G., Veldhuis-Vlug, A., Acherman, Y., Gerdes, V., den Heijer, M., Maas, M., Bravenboer, N., & Bisschop, P. (2021) · Obesity · doi:10.1002/oby.23171 · Cited by 9 · see citing works

Assessment of trabecular bone Hounsfield units in the lumbar spine for osteoporosis evaluation in individuals aged 65 and above: a review

Alharthy, A. (2024) · Osteoporosis International · doi:10.1007/s00198-024-07340-w · Cited by 10 · see citing works

Microfluidic Co-culture Platforms for Studying Osteocyte Regulation of Other Cell Types under Dynamic Mechanical Stimulation

Lin, C.-Y., Song, X., Seaman, K., & You, L. (2022) · Current Osteoporosis Reports · doi:10.1007/s11914-022-00748-5 · Cited by 10 · see citing works

Bone Marrow Adiposity Assessed by HRpQCT Is Related to Fracture Risk and Bone Mineral Density in Older Swedish Women

Zoulakis, M., Axelsson, K. F., Litsne, H., Johansson, L., & Lorentzon, M. (2025) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaf216 · Cited by 9 · see citing works

PTH counteracts Hippo signaling via Src-dependent YAP stabilization to enhance bone marrow stromal cell differentiation

Monaci, S., Wu, M., Okada, H., Mesil, K., Keum, B., da Silva, M. M. R., Rosen, C. J., Gori, F., & Baron, R. (2025) · JCI Insight · doi:10.1172/jci.insight.191245 · Cited by 9 · see citing works

Romidepsin Promotes Osteogenic and Adipocytic Differentiation of Human Mesenchymal Stem Cells through Inhibition of Histondeacetylase Activity

Ali, D., Chalisserry, E. P., Manikandan, M., Hamam, R., Alfayez, M. A., Kassem, M. S., Aldahmash, A. M., & Alajez, N. M. (2018) · Stem Cells International · doi:10.1155/2018/2379546 · Cited by 9 · see citing works

Vertebrae but not femur marrow fat transiently decreases in response to body weight loss in an 18-month randomized control trial

Ofir, N., Mizrakli, Y., Greenshpan, Y., Gepner, Y., Sharabi, O., Tsaban, G., Zelicha, H., Meir, A. Y., Ceglarek, U., Stümvoll, M., et al. (2023) · Bone · doi:10.1016/j.bone.2023.116727 · Cited by 9 · see citing works

Bone Marrow Adipose Tissue

Cawthorn, W. P. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.11207-3 · Cited by 10 · see citing works

Obesity, bone marrow adiposity, and leukemia: Time to act

Kumar, V., & Stewart, J. H. (2023) · Obesity Reviews · doi:10.1111/obr.13674 · Cited by 8 · see citing works

Limited Adipogenic Differentiation Potential of Human Dental Pulp Stem Cells Compared to Human Bone Marrow Stem Cells

Bugueno, I. M., Alastra, G., Balic, A., Stadlinger, B., & Mitsiadis, T. A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252011105 · Cited by 8 · see citing works

KIAA1199 (CEMIP) regulates adipogenesis and whole-body energy metabolism

Chen, L., Shi, K., Ditzel, N., Qiu, W., Tencerová, M., Nielsen, L. H. D., Figeac, F., Rauch, A., Liu, Y., Tao, J., et al. (2025) · Bone Research · doi:10.1038/s41413-025-00415-2 · Cited by 9 · see citing works

Thermogenic Potentials of Bone Marrow Adipocytes.

Okla, M., & Kassem, M. (2020) · Bone · doi:10.1016/j.bone.2020.115658 · Cited by 7 · see citing works

AN698/40746067 suppresses bone marrow adiposity to ameliorate hyperlipidemia-induced osteoporosis through targeted inhibition of ENTR1

Ren, H., Mao, K., Yuan, X., Mu, Y., Zhao, S., Fan, X., Zhu, L., Zhou, Y., & Lan, J. Q. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116843 · Cited by 7 · see citing works

Exercise alleviates osteoporosis by regulating the secretion of the Senescent Associated Secretory Phenotype

Weng, K., He, Y., Weng, X., & Yuan, Y. J. (2025) · Bone · doi:10.1016/j.bone.2025.117485 · Cited by 7 · see citing works

Tax1 binding protein 3 regulates osteogenic and adipogenic differentiation through inactivating Wnt/β‐catenin signalling

Wang, Y., Gan, Y., Dong, Y., Zhou, J., Zhu, E., Yuan, H., Li, X., & Wang, B. (2023) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17702 · Cited by 7 · see citing works

Runx2 silencing promotes adipogenesis via down‐regulation of DLK1 in chondrogenic differentiating MSCs

Rahim, F., Pashaki, P. A., Jafarisani, M., Ghorbani, F., & Ebrahimi, A. (2020) · The Journal of Gene Medicine · doi:10.1002/jgm.3244 · Cited by 7 · see citing works

β-catenin inhibition disrupts the homeostasis of osteogenic/adipogenic differentiation leading to the development of glucocorticoid-induced osteonecrosis of the femoral head

Xia, C., Xu, H., Fang, L., Chen, J., Yuan, W., Fu, D., Wang, X., He, B., Xiao, L., Wu, C., et al. (2023) · eLife · doi:10.7554/elife.92469 · Cited by 6 · see citing works

The Combination of Chitosan-Based Biomaterial and Cellular Therapy for Successful Treatment of Diabetic Foot—Pilot Study

Humeník, F., Vdoviaková, K., Krešáková, L., Danko, J., Giretová, M., Medvecký, Ľ., Lengyel, P., & Babík, J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25158388 · Cited by 6 · see citing works

The Regulation of Marrow Fat by Vitamin D: Molecular Mechanisms and Clinical Implications

Gijsen, H. S. (2019) · Current Osteoporosis Reports · doi:10.1007/s11914-019-00546-6 · Cited by 6 · see citing works

ERα Signaling in a Subset of CXCL12 ‐Abundant Reticular Cells Regulates Trabecular Bone in Mice

Scheffler, J. M., Gustafsson, K. L., Barrett, A., Corciulo, C., Drevinge, C., Pons, A., Humeniuk, P., Engdahl, C., Gustafsson, J.-Α., Ohlsson, C., et al. (2022) · JBMR Plus · doi:10.1002/jbm4.10657 · Cited by 7 · see citing works

Hydroxyl safflower yellow A regulates bone-fat balance in osteoporosis by SphK1/S1P/S1PR signaling pathway

Xu, X., Hu, X., Zhou, S., Liu, J., Su, Z., Zheng, Z., & Luo, D. (2025) · Biochemical Pharmacology · doi:10.1016/j.bcp.2025.117258 · Cited by 5 · see citing works

Nutrition and Bone Marrow Adiposity in Relation to Bone Health.

Džubanová, M., Benova, A., Ferenčáková, M., Coupeau, R., & Tencerová, M. (2024) · Physiological Research · doi:10.33549/physiolres.935293 · Cited by 6 · see citing works

GLP-1 and GIP: Magic bullet for musculoskeletal diseases?

Fang, Q., Gan, L., Liu, P., Ding, P., & Gao, Y. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2025.08.046 · Cited by 5 · see citing works

Toward Marrow Adipocytes: Adipogenic Trajectory of the Bone Marrow Stromal Cell Lineage

Matsushita, Y., Ono, W., & Ono, N. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.882297 · Cited by 19 · see citing works

The relationship between adipose tissue and bone metabolism

Gimble, J. M., & NUTTALL, M. E. (2012) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2012.03.006 · Cited by 88 · see citing works

Bone Marrow Adiposity: Basic and Clinical Implications.

Sebo, Z. L., Rendina-Ruedy, E., Ables, G., Lindskog, D., Rodeheffer, M. S., Fazeli, P. K., & Horowitz, M. (2019) · Endocrine reviews · doi:10.1210/er.2018-00138 · Cited by 114 · see citing works

Adipocytes and the Regulation of Bone Remodeling: A Balancing Act

NUTTALL, M. E., Shah, F. S., Singh, V., Thomas‐Porch, C., Frazier, T. P., & Gimble, J. M. (2013) · Calcified Tissue International · doi:10.1007/s00223-013-9807-6 · Cited by 61 · see citing works

Defining osteoblast and adipocyte lineages in the bone marrow

Pierce, J. L., Begun, D. L., Westendorf, J. J., & McGee‐Lawrence, M. E. (2018) · Bone · doi:10.1016/j.bone.2018.05.019 · Cited by 134 · see citing works