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Cited by 79Stress Responses and CortisolTactile and Sensory InteractionsNeuroendocrine regulation and behavior

Postnatal Touch Stimulation Acutely Alters Corticosterone Levels and Glucocorticoid Receptor Gene Expression in the Neonatal Rat

Jutapakdeegul, N., Casalotti, Stefano O., Govitrapong, P., Kotchabhakdi, N.·2003·Developmental Neuroscience
DOI 10.1159/000071465
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Abstract

Environmental manipulation early in life can alter the development of the hypothalamic-pituitary-adrenal (HPA) axis by mechanisms that are still unclear. The aim of the present work was to study the acute effects of postnatal touch stimulation, in an attempt to understand the mechanism by which touch stimulation early in life alters the HPA response to stress in adult animals. Rat pups were gently brushed for 15 min daily during the 1st postnatal week. Serum corticosterone levels were determined by radioimmunoassays, while glucocorticoid receptor (GR) gene expression was assayed by semiquantitative reverse transcriptase-polymerase chain reaction. Touch stimulation induced a significant decrease (30-36%) in serum corticosteroid secretion during the 1st and 2nd postnatal day as compared to the unstimulated group. In contrast, GR gene expression in the touch stimulation group was significantly increased in several brain areas such as the hippocampus (19-21%), frontal cortex (26-34%) and midbrain (15-24%). The results thus indicate that neonatal touch stimulation causes acute hormone- secretion and gene-expression changes within the period of stimulation. These changes may be the underlying cause for the permanent changes that have been observed in adult animals touch-stimulated as neonates.

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Crossref · 10.1159/000071465

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2 of 2 references verified0 citation errors · 0 not checkable

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  • Maternal care such as pup licking/grooming from the mother over the first week of postnatal life provides tactile stimulation for the neonate, which increases hippocampal glucocorticoid receptor gene expression through epigenetic modifications of DNA and decreases HPA responses to stress (158, 159).

    “maternal care such as pup licking/grooming from the mother over the first week of postnatal life provides tactile stimulation for the neonate, which increases hippocampal glucocorticoid receptor gene expression through epigenetic modifications of DNA and decreases HPA responses to stress (158, 159).”

    From Gene × Environment Interactions in Autism Spectrum Disorders: Role of Epigenetic Mechanisms (2014) · cites this paper as [159]

  • Animals brushed for 15 min/day exhibit increased hippocampal GR expression.

    “Finally, studies directly examining the effects of the tactile stimulation associated with pup LG show that animals “brushed” for 15 min/day exhibit increased hippocampal GR expression.77”

    From Early life adversity and the epigenetic programming of hypothalamic-pituitary-adrenal function (2014) · cites this paper as [77]

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Authors
Jutapakdeegul, N., Casalotti, S. O., Govitrapong, P., & Kotchabhakdi, N.
Affiliations
Mahidol University (TH)
ORCID
Venue
Developmental Neuroscience
Publisher
S. Karger AG
Published
2003
Volume
25
Issue
1
Pages
26-33
ISSN
  • 0378-5866 (ISSN-L)
  • 1421-9859
DOI
10.1159/000071465
OpenAlex
W2006026869
Cited by
79
References
2
Citations by year
2026: 2 · 2024: 1 · 2023: 1 · 2022: 4 · 2021: 2 · 2020: 6 · 2019: 2 · 2018: 2 · 2017: 3 · 2016: 3 · 2015: 2 · 2014: 4 · 2013: 4 · 2012: 5
FWCI
0.63
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Developmental Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • UCL Discovery (University College London) (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Tactile and Sensory Interactions
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Keywords
corticosterone, hypothalamic-pituitary-adrenal axis, neonatal rats, stress response, hippocampus, frontal cortex, midbrain, neuroendocrine development
MeSH terms
Animals, Animals, Newborn, Corticosterone, Handling, Psychological, Receptors, Glucocorticoid, RNA, Messenger, Gene Expression, Rats, Sprague-Dawley, Reverse Transcriptase Polymerase Chain Reaction, Rats

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