Cited by 200Iron Metabolism and DisordersNeurogenesis and neuroplasticity mechanismsTrace Elements in Health

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Pre- and Postweaning Iron Deficiency Alters Myelination in Sprague-Dawley Rats

Beard, John L., Wiesinger, Jason A., Connor, James R.·2003·Developmental Neuroscience

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Abstract

Iron deficiency in early life is associated with hypomyelination; however, the role which iron plays in myelinogenesis is not clearly established. In this study, we examined the effect of preweaning [postnatal days (PND) 4–14 and PND 4–21] and postweaning (PND 21–63) iron deficiency on hindbrain 2′,3′-cyclic nucleotide 3′-phosphohydrolase (CNPase) activity (marker of oligodendrocyte metabolic activity) and myelin basic protein (MBP) concentrations. Both CNPase activity and concentrations in the cerebrum and hindbrain were significantly lower in pre- and postweaning iron-deficient rats. Similarly, MBP concentrations were also reduced (25–35%) in all three groups of iron-deficient animals. Iron-deficient animals also had significant alterations in the fatty acid composition of individual phospholipids within the hindbrain as well as changes in cytochrome oxidase activities. These studies show that postnatal iron deficiency, for as little as 10 days, can significantly alter the production of myelin and oligodendrocyte functioning. Importantly, postweaning iron deficiency was still associated with a decrease in CNPase activity and MBP concentrations despite occurring well past a likely key sensitive period of peak myelinogenesis at PND 8–12. This suggests that iron deficiency in later life, as well as during early postnatal growth, can effect the production and maintenance of myelin.

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Additional file 1 of Chromatin accessibility and H3K9me3 landscapes reveal long-term epigenetic effects of fetal-neonatal iron deficiency in rat hippocampus
Liu, S. X., Ramakrishnan, A., Shen, L., Gewirtz, J. C., Georgieff, M. K., & Tran, P. V. (2024) · Figshare · doi:10.6084/m9.figshare.25459510
Additional file 4 of Chromatin accessibility and H3K9me3 landscapes reveal long-term epigenetic effects of fetal-neonatal iron deficiency in rat hippocampus
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Additional file 3 of Chromatin accessibility and H3K9me3 landscapes reveal long-term epigenetic effects of fetal-neonatal iron deficiency in rat hippocampus
Liu, S. X., Ramakrishnan, A., Shen, L., Gewirtz, J. C., Georgieff, M. K., & Tran, P. V. (2024) · Figshare · doi:10.6084/m9.figshare.26696274
Additional file 2 of Chromatin accessibility and H3K9me3 landscapes reveal long-term epigenetic effects of fetal-neonatal iron deficiency in rat hippocampus
Liu, S. X., Ramakrishnan, A., Shen, L., Gewirtz, J. C., Georgieff, M. K., & Tran, P. V. (2024) · Figshare · doi:10.6084/m9.figshare.25459657
Additional file 5 of Chromatin accessibility and H3K9me3 landscapes reveal long-term epigenetic effects of fetal-neonatal iron deficiency in rat hippocampus
Liu, S. X., Ramakrishnan, A., Shen, L., Gewirtz, J. C., Georgieff, M. K., & Tran, P. V. (2024) · Figshare · doi:10.6084/m9.figshare.26696280
Additional file 6 of Chromatin accessibility and H3K9me3 landscapes reveal long-term epigenetic effects of fetal-neonatal iron deficiency in rat hippocampus
Liu, S. X., Ramakrishnan, A., Shen, L., Gewirtz, J. C., Georgieff, M. K., & Tran, P. V. (2024) · Figshare · doi:10.6084/m9.figshare.26696286
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Iron Deficiency and Human Brain Electrophysiology Across the Lifespan: A Systematic and Mechanistic Review of Resting EEG, Event-Related Potentials, and Treatment Responsiveness
Chmiel, J., Góral-Półrola, J., Leśnicka, P., & Kopańska, M. (2026) · Nutrients · doi:10.3390/nu18182955

Authors: Beard, J. L., Wiesinger, J. A., & Connor, J. R.
Affiliations: Pennsylvania State University (US)
ORCID: Wiesinger, Jason A.
Connor, James R.
Venue: Developmental Neuroscience
Publisher: S. Karger AG
Published: 2003
Volume: 25
Issue: 5
Pages: 308-315
ISSN: 0378-5866 (ISSN-L)
1421-9859
DOI: 10.1159/000073507
OpenAlex: W1970461946
Cited by: 200
References: 31
Citations by year: 2026: 4 · 2025: 6 · 2024: 13 · 2023: 6 · 2022: 6 · 2021: 5 · 2020: 4 · 2019: 12 · 2018: 11 · 2017: 5 · 2016: 6 · 2015: 11 · 2014: 9 · 2013: 11 · 2012: 10
FWCI: 3.41
Type: journal article
Language: en
Open access: closed
Licence: www.karger.com/Services/SiteLicenses (vor)
www.karger.com/Services/SiteLicenses (tdm)
Locations: Developmental Neuroscience (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01ns034280-04)
National Institute of Neurological Disorders and Stroke (NS34280)
Topics: Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
Keywords: iron deficiency, myelination, myelin basic protein, CNPase, oligodendrocytes, postnatal development, phospholipid fatty acid composition, cytochrome c oxidase, hindbrain, cerebrum
MeSH terms: Iron Deficiencies, Age Factors, Animals, Animals, Suckling, Brain, Brain Chemistry, Electron Transport Complex IV, Diet, Myelin Basic Protein, Enzyme-Linked Immunosorbent Assay, Female, Immunohistochemistry, Male, Myelin Sheath, Phospholipids, Tyrosine 3-Monooxygenase, Weaning, 2',3'-Cyclic-Nucleotide Phosphodiesterases, Rats, Sprague-Dawley, Rats

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Pre- and Postweaning Iron Deficiency Alters Myelination in Sprague-Dawley Rats

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