The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Pre- and Postweaning Iron Deficiency Alters Myelination in Sprague-Dawley Rats
Abstract
Iron deficiency in early life is associated with hypomyelination; however, the role which iron plays in myelinogenesis is not clearly established. In this study, we examined the effect of preweaning [postnatal days (PND) 4–14 and PND 4–21] and postweaning (PND 21–63) iron deficiency on hindbrain 2′,3′-cyclic nucleotide 3′-phosphohydrolase (CNPase) activity (marker of oligodendrocyte metabolic activity) and myelin basic protein (MBP) concentrations. Both CNPase activity and concentrations in the cerebrum and hindbrain were significantly lower in pre- and postweaning iron-deficient rats. Similarly, MBP concentrations were also reduced (25–35%) in all three groups of iron-deficient animals. Iron-deficient animals also had significant alterations in the fatty acid composition of individual phospholipids within the hindbrain as well as changes in cytochrome oxidase activities. These studies show that postnatal iron deficiency, for as little as 10 days, can significantly alter the production of myelin and oligodendrocyte functioning. Importantly, postweaning iron deficiency was still associated with a decrease in CNPase activity and MBP concentrations despite occurring well past a likely key sensitive period of peak myelinogenesis at PND 8–12. This suggests that iron deficiency in later life, as well as during early postnatal growth, can effect the production and maintenance of myelin.
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“Long-term effects are observed in adulthood, long after iron repletion, in hippocampal structure and function, monoamine metabolism, and myelination (55 -60), indicating that early developmental periods are critical and that prevention of iron de fi ciency might be key for protecting against adverse neurodevelopmental outcomes.”
From Maternal Intake of Supplemental Iron and Risk of Autism Spectrum Disorder (2014) · cites this paper as [56]
In the citing paper
“Long-term effects are observed in adulthood, long after iron repletion, in hippocampal structure and function, monoamine metabolism, and myelination (55 -60), indicating that early developmental periods are critical and that prevention of iron de fi ciency might be key for protecting against adverse neurodevelopmental outcomes.”
From Maternal Intake of Supplemental Iron and Risk of Autism Spectrum Disorder (2014) · cites this paper as [56]
In the citing paper
“Prenatal in fl ammation can produce a cytokine-mediated reduction of circulating nonheme iron, or hypoferremia (48), that can disrupt fetal brain development and lead to persistent structural and functional brain defects (55 -60).”
From Maternal Intake of Supplemental Iron and Risk of Autism Spectrum Disorder (2014) · cites this paper as [56]
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Metadata
- Authors
- Beard, J. L., Wiesinger, J. A., & Connor, J. R.
- Affiliations
- Pennsylvania State University (US)
- Venue
- Developmental Neuroscience
- Publisher
- S. Karger AG
- Published
- 2003
- Volume
- 25
- Issue
- 5
- Pages
- 308-315
- ISSN
- 0378-5866 (ISSN-L)
- 1421-9859
- OpenAlex
- W1970461946
- Cited by
- 200
- References
- 31
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 13 · 2023: 6 · 2022: 6 · 2021: 5 · 2020: 4 · 2019: 12 · 2018: 11 · 2017: 5 · 2016: 6 · 2015: 11 · 2014: 9 · 2013: 11 · 2012: 10
- FWCI
- 3.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Developmental Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01ns034280-04)
- National Institute of Neurological Disorders and Stroke (NS34280)
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Keywords
- iron deficiency, myelination, myelin basic protein, CNPase, oligodendrocytes, postnatal development, phospholipid fatty acid composition, cytochrome c oxidase, hindbrain, cerebrum
- MeSH terms
- Iron Deficiencies, Age Factors, Animals, Animals, Suckling, Brain, Brain Chemistry, Electron Transport Complex IV, Diet, Myelin Basic Protein, Enzyme-Linked Immunosorbent Assay, Female, Immunohistochemistry, Male, Myelin Sheath, Phospholipids, Tyrosine 3-Monooxygenase, Weaning, 2',3'-Cyclic-Nucleotide Phosphodiesterases, Rats, Sprague-Dawley, Rats
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