IL-9 in Allergic Inflammation
Abstract
Th2 type cytokines such as interleukin (IL)-4, IL-5, IL-9, and IL-13 are important mediators in allergic inflammation. The present review will focus on the role of IL-9 in allergic inflammation. The structure and genomic architecture of IL-9 and its receptor, the source of IL-9 and its regulation as well as its effects on different cell types will be reviewed. Furthermore, the specific role of IL-9 in allergic diseases and the potential therapeutic approach of blocking IL-9 will be discussed.
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IL-9 promotes allergic inflammation and is associated with various TH2 responses.
“has long been thought to be a TH2 cytokine as it promotes allergic inflammation and is associated with various TH2 responses10.”
From The transcription factor PU.1 is required for the development of IL-9-producing T cells and allergic inflammation (2010) · cites this paper as [10]
Cites
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Huss, K., Adkinson, N. F., Eggleston, P. A., Dawson, C., Van Natta, M. L., & Hamilton, R. G. (2001) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2001.111146 · Cited by 315 · see citing works
Schmitt, E., Germann, T., Goedert, S., Hoehn, P., Huels, C., Koelsch, S., Kühn, R., Müller, W., Palm, N., & Rüde, E. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.153.9.3989 · Cited by 299 · see citing works
IL-9 and its receptor in allergic and nonallergic lung disease: Increased expression in asthma
Shimbara, A., Christodoulopoulos, P., Soussi-Gounni, A., Olivenstein, R., Nakamura, Y., Levitt, R. C., Nicolaides, N. C., Holroyd, K. J., Tsicopoulos, A., Lafitte, J.-J., et al. (2000) · Journal of Allergy and Clinical Immunology · doi:10.1016/s0091-6749(00)90185-4 · Cited by 281 · see citing works
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Chang, H.-C., Sehra, S., Goswami, R., Yao, W., Yu, Q., Stritesky, G. L., Jabeen, R., McKinley, C., Ahyi, A.-N., Han, L., et al. (2010) · Nature Immunology · doi:10.1038/ni.1867 · Cited by 577 · see citing works
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- Authors
- Hauber, H.-P., Bergeron, C., & Hamid, Q.
- Affiliations
- McGill University (CA)
- ORCID
- Hamid, Qutayba
- Venue
- International Archives of Allergy and Immunology
- Publisher
- S. Karger AG
- Published
- 2004
- Volume
- 134
- Issue
- 1
- Pages
- 79-87
- ISSN
- 1018-2438 (ISSN-L)
- 1423-0097
- OpenAlex
- W2058237319
- Cited by
- 90
- References
- 4
- Citations by year
- 2025: 5 · 2024: 2 · 2023: 3 · 2022: 3 · 2021: 3 · 2020: 2 · 2019: 3 · 2018: 4 · 2017: 2 · 2016: 6 · 2015: 4 · 2014: 2 · 2013: 2 · 2012: 8
- FWCI
- 2.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Archives of Allergy and Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
- Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
- Keywords
- IL-9, allergic inflammation, Th2 cytokines, IL-9 receptor, allergic diseases, IL-4, IL-5, IL-13
- MeSH terms
- Animals, Humans, Hypersensitivity, Inflammation, Signal Transduction, Interleukin-9, Receptors, Interleukin, Inflammation Mediators
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