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Cited by 90Helicobacter pylori-related gastroenterology studiesColorectal Cancer Screening and DetectionGenetic factors in colorectal cancer

Hypergastrinemia Is Associated with Increased Risk of Distal Colon Adenomas

Georgopoulos, Sotirios D., Polymeros, Dimitrios, Triantafyllou, Konstantinos, Spiliadi, Charis, Mentis, Andreas, Karamanolis, Dimitrios G., Ladas, Spiros D.·2006·Digestion
DOI 10.1159/000096593
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Abstract

Background/Aims:Helicobacter pylori infection is a recognized cause of hypergastrinemia, but the association of blood gastrin levels with colonic adenomas (CAs) is controversial. The aim of this study is to investigate if hypergastrinemia, H. pylori infection and/or cagA protein are risk factors for CAs. Methods: In this prospective case-control study, fasting serum samples from 78 consecutive patients with CAs and 78 demographically matched colonoscopy-negative controls were assayed for anti-H. pylori immunoglobulin G, cagA protein and serum gastrin levels. Multivariate analysis was performed to identify risk factors for colon adenomas. Results: Though prevalence of H. pylori antibodies was not significantly different, the prevalence of cagA protein was significantly higher in patients with adenomas (42.3%) as compared with controls (25.6%, p < 0.03). Mediangastrin levels were significantly higher in patients with CAs (55, 20–975 pg/ml) than in controls (45.2, 23–529 pg/ml) (p < 0.001). Hypergastrinemia (>110 pg/ml) was commoner in patients with CAs than in controls (29.5 vs. 11.5%, p = 0.006) and was the only independent risk factor for adenomas (odds ratio 3.2, 95% CI 1.4–7.5) by multivariate analysis, but not H. pylori infection or cagA positivity. There was a significant association of hypergastrinemia and distal distribution of adenomas (p < 0.002). Conclusions: Our study shows that hypergastrinemia is a risk factor for CAs, especially of the distal colon.

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  • Chronic hypergastrinemia, typically present during PPI use, can promote the growth of malignant colonic epithelial cells, facilitating the deleterious sequencing adenoma-carcinoma.

    “Last, chronic hypergastrinemia, typically present during PPI use, can promote the growth of malignant colonic epithelial cells, facilitating the deleterious sequencing adenoma-carcinoma[151-153].”

    From Proton pump inhibitors and dysbiosis: current knowledge and aspects to be clarified (2019) · cites this paper as [153]

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Authors
Georgopoulos, S. D., Polymeros, D., Triantafyllou, K., Spiliadi, C., Mentis, A., Karamanolis, D. G., & Ladas, S. D.
Affiliations
  • National and Kapodistrian University of Athens (GR)
  • Evangelismos Hospital (GR)
  • Tzaneion General Hospital (GR)
ORCID
Ladas, Spiros D.
Venue
Digestion
Publisher
S. Karger AG
Published
2006
Volume
74
Issue
1
Pages
42-46
ISSN
  • 0012-2823 (ISSN-L)
  • 1421-9867
DOI
10.1159/000096593
OpenAlex
W2082000793
Cited by
90
References
42
Citations by year
2026: 1 · 2025: 3 · 2024: 1 · 2023: 5 · 2022: 4 · 2021: 5 · 2020: 9 · 2019: 11 · 2018: 3 · 2017: 3 · 2016: 6 · 2015: 2 · 2014: 6 · 2013: 9 · 2012: 7
FWCI
3.03
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Digestion (publishedVersion)
  • PubMed (publishedVersion)
Funders
Hellenic Society of Gastroenterology
Topics
  • Health Sciences › Medicine › Surgery › Helicobacter pylori-related gastroenterology studies
  • Health Sciences › Medicine › Oncology › Colorectal Cancer Screening and Detection
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
Keywords
hypergastrinemia, colonic adenoma, Helicobacter pylori infection, CagA protein, serum gastrin, colorectal cancer risk factors, anti-H. pylori antibodies
MeSH terms
Adenoma, Adult, Aged, Aged, 80 and over, Antigens, Bacterial, Bacterial Proteins, Colonic Neoplasms, Female, Gastrins, Humans, Male, Middle Aged, Prospective Studies, Risk Factors, Multivariate Analysis, Case-Control Studies, Helicobacter pylori, Helicobacter Infections

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