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Arginine Vasopressin Is a Much More Potent Stimulus to ACTH Release from Ovine Anterior Pituitary Cells than Ovine Corticotropin-Releasing Factor
Abstract
Cultured rat and ovine anterior pituitary cells were treated with a range of doses (0.01-1,000 nM) of arginine vasopressin (AVP) and ovine corticotropin-releasing factor (CRF), alone or in combination, and medium and cell content of immunoreactive (ir-)ACTH determined. In rat cells, a dose-response curve to CRF was obtained, with a threshold dose of 0.1 nM; AVP was much less effective alone, but augmented CRF responses when administered with CRF. In ovine pituitary cells AVP markedly stimulated ACTH release in a dose-dependent fashion, and with a threshold of 0.1 nM; in contrast, CRF increased ACTH release over basal only at doses greater than 100 nM. In combination, subthreshold doses of AVP potentiated rat pituitary cell responses to CRF; addition of 1 nM of AVP to varying doses of CRF was more effective in terms of ACTH release than addition of 1 nM of CRF to increasing doses of AVP. In contrast, in ovine cells the addition of 1 nM CRF to increasing doses of AVP elicited a larger ACTH response than the addition of 1 nM AVP to increasing doses of CRF. Dexamethasone pretreatment (5 nM) for 48 h significantly decreased CRF potentiation of AVP-stimulated ACTH release in ovine cells. These studies confirm that CRF is a more potent stimulus of ACTH release than AVP in the rat, and establish that in contrast AVP is a much more potent stimulus of ACTH secretion than CRF in isolated ovine pituitary cells.
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In the citing paper
“Moreover, CRH and AVP are also capable of potentiating each other’s activity (37, 38).”
From Influence of arginine vasopressin on the ultradian dynamics of Hypothalamic-Pituitary-Adrenal axis (2022) · cites this paper as [37]
In the citing paper
“Their synergistic stimulation of ACTH production and secretion by corticotrope cells could yield a several-fold higher output than due to the action of either one individually (26, 34–41, 43–47).”
From Influence of arginine vasopressin on the ultradian dynamics of Hypothalamic-Pituitary-Adrenal axis (2022) · cites this paper as [37]
In the citing paper
“Namely, both in human (39, 43–47, 55) and in rat (26, 36–38, 40, 41), CRH reaction pathway is considered to be dominant in pituitary-adrenal regulation.”
From Influence of arginine vasopressin on the ultradian dynamics of Hypothalamic-Pituitary-Adrenal axis (2022) · cites this paper as [37]
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Items 101–115 of 115
The role of vasopressin on ACTH secretion and biosynthesis in the ovine pituitary gland
Smith, A. I., Levin, N. W., Wallace, C. A., et al. (1993) · Regulatory Peptides · doi:10.1016/0167-0115(93)90212-q · Cited by 4
Self-citationChronic stress and pituitary-adrenal function in female pigs
Janssens, C. J. J. G. (1994) · doi:10.18174/207067 · Cited by 3
Leff, P., Pellón-Díaz, G., Camacho‐Arroyo, I., Palomera-Garfias, N., & Flores‐Ramos, M. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26189007 · Cited by 5
“However, several studies have provided evidence that AVP acts as a stronger stimulus on ACTH secretion from pituitary corticotropes [130] and that splanchnic nerves mediate the sympathetic potentiation of ACTH-induced CORT release following acute and chronic stress [129,131,132].”
Nishihara, K., Kobayashi, R., Suzuki, Y., Sato, K., Katoh, K., & Roh, S. (2017) · Asian-Australasian Journal of Animal Sciences · doi:10.5713/ajas.16.0965 · Cited by 2
Kemppainen, R. J., & Clark, T. P. (1995) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1995.268.1.e85 · Cited by 2
Hasegawa, N., SUGIWAKA, T., KAWAMURA, T., et al. (1996) · Nihon Chikusan Gakkaiho · doi:10.2508/chikusan.67.591 · Cited by 1
ACTH and cortisol responses to hypotension in fetal sheep after a prior CRF injection
Kerr, D. R., Castro, M. I., Valego, N. K., Rawashdeh, N. M., & Rose, J. C. (1992) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1992.262.3.e325 · Cited by 1
Characterization of immunoreactive AVP in the ovine hypothalamo-pituitary axis
Shen, P.-J., Clarke, I. J., Funder, J. W., & Smith, A. I. (1993) · Peptides · doi:10.1016/0196-9781(93)90119-2 · Cited by 1
Self-citationStructure-function studies of vasopressin analogues with d-3 pyridyl-alanine in position 2
Sobocińska, M. K., Derdowska, I., Schwartz, J., et al. (1995) · Peptides · doi:10.1016/0196-9781(94)00209-o · Cited by 1
Gao, L. ‐., & Ju, G. (2004) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2004.01120.x · Cited by 1
Fan, S. (2006) · UC Research Repository (University of Canterbury) · doi:10.26021/7257
Desensitization of the adrenocorticotropin response to arginine vasopressin
Hassan, A. H. (2001) · UC Research Repository (University of Canterbury) · doi:10.26021/6914
Arginine-vasopressin analogues containing D-3-(3′-pyridyl)-alanine residue in position 2
Kupryszewski, G., Sobocińska, M., Derdowska, I., et al. (1993) · Springer eBooks · doi:10.1007/978-94-011-1470-7_325
Stojiljković, A., Čupić, Ž., Maćešić, S. R., Ivanović-Šašić, A., & Mojović, M. (2025) · Royal Society Open Science · doi:10.1098/rsos.251323
Perani, C. V. (2014) · University of Regensburg Publication Server (University of Regensburg) · doi:10.5283/epub.30044
Metadata
- Authors
- Familari, M., Smith, I., Smith, R., & Funder, J. W.
- Venue
- Neuroendocrinology
- Publisher
- S. Karger AG
- Published
- 2008-04-02
- Volume
- 50
- Issue
- 2
- Pages
- 152-157
- ISSN
- 0028-3835 (ISSN-L)
- 1423-0194
- OpenAlex
- W2042841775
- Cited by
- 116
- References
- 0
- Citations by year
- 2025: 2 · 2024: 1 · 2022: 1 · 2020: 1 · 2019: 2 · 2018: 1 · 2017: 1 · 2016: 3 · 2015: 2 · 2014: 4 · 2013: 3
- FWCI
- 0.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- vasopressin, corticotropin-releasing factor, ACTH secretion, anterior pituitary cells, ovine pituitary, rat pituitary, hormone potentiation, dexamethasone
- MeSH terms
- Adrenocorticotropic Hormone, Animals, Arginine Vasopressin, Cells, Cultured, Corticotropin-Releasing Hormone, Dexamethasone, Dose-Response Relationship, Drug, Drug Synergism, Female, Male, Pituitary Gland, Anterior, Rats, Inbred Strains, Sheep, Stress, Physiological, Rats
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