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Arginine Vasopressin Is a Much More Potent Stimulus to ACTH Release from Ovine Anterior Pituitary Cells than Ovine Corticotropin-Releasing Factor
Abstract
Cultured rat and ovine anterior pituitary cells were treated with a range of doses (0.01-1,000 nM) of arginine vasopressin (AVP) and ovine corticotropin-releasing factor (CRF), alone or in combination, and medium and cell content of immunoreactive (ir-)ACTH determined. In rat cells, a dose-response curve to CRF was obtained, with a threshold dose of 0.1 nM; AVP was much less effective alone, but augmented CRF responses when administered with CRF. In ovine pituitary cells AVP markedly stimulated ACTH release in a dose-dependent fashion, and with a threshold of 0.1 nM; in contrast, CRF increased ACTH release over basal only at doses greater than 100 nM. In combination, subthreshold doses of AVP potentiated rat pituitary cell responses to CRF; addition of 1 nM of AVP to varying doses of CRF was more effective in terms of ACTH release than addition of 1 nM of CRF to increasing doses of AVP. In contrast, in ovine cells the addition of 1 nM CRF to increasing doses of AVP elicited a larger ACTH response than the addition of 1 nM AVP to increasing doses of CRF. Dexamethasone pretreatment (5 nM) for 48 h significantly decreased CRF potentiation of AVP-stimulated ACTH release in ovine cells. These studies confirm that CRF is a more potent stimulus of ACTH release than AVP in the rat, and establish that in contrast AVP is a much more potent stimulus of ACTH secretion than CRF in isolated ovine pituitary cells.
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In the citing paper
“Moreover, CRH and AVP are also capable of potentiating each other’s activity (37, 38).”
From Influence of arginine vasopressin on the ultradian dynamics of Hypothalamic-Pituitary-Adrenal axis (2022) · cites this paper as [37]
In the citing paper
“Their synergistic stimulation of ACTH production and secretion by corticotrope cells could yield a several-fold higher output than due to the action of either one individually (26, 34–41, 43–47).”
From Influence of arginine vasopressin on the ultradian dynamics of Hypothalamic-Pituitary-Adrenal axis (2022) · cites this paper as [37]
In the citing paper
“Namely, both in human (39, 43–47, 55) and in rat (26, 36–38, 40, 41), CRH reaction pathway is considered to be dominant in pituitary-adrenal regulation.”
From Influence of arginine vasopressin on the ultradian dynamics of Hypothalamic-Pituitary-Adrenal axis (2022) · cites this paper as [37]
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Regulation of the Hypothalamic‐Pituitary‐Adrenocortical Stress Response
Herman, J. P., McKlveen, J. M., Ghosal, S., Kopp, B., Wulsin, A., Makinson, R., Scheimann, J., & Myers, B. (2016) · Comprehensive Physiology · doi:10.1002/cphy.c150015 · Cited by 1,819
“, in vitro study suggest that AVP acts as a stronger stimulus for pituitary ACTH secretion in sheep corticotropes (43).”
Regulation of the hypothalamic corticotropin-releasing hormone neurosecretory system
Whitnall, M. H. (1993) · Progress in Neurobiology · doi:10.1016/0301-0082(93)90035-q · Cited by 582
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Engler, D., Pham, T., Fullerton, M. J., Ooi, G., Funder, J. W., & Clarke, I. J. (2008) · Neuroendocrinology · doi:10.1159/000125141 · Cited by 235
Hypothalamic-pituitary-adrenal axis changes allow seasonal modulation of corticosterone in a bird
Romero, L. M., Soma, K. K., & Wingfield, J. C. (1998) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1998.274.5.r1338 · Cited by 184
Metadata
- Authors
- Familari, M., Smith, I., Smith, R., & Funder, J. W.
- Venue
- Neuroendocrinology
- Publisher
- S. Karger AG
- Published
- 2008-04-02
- Volume
- 50
- Issue
- 2
- Pages
- 152-157
- ISSN
- 0028-3835 (ISSN-L)
- 1423-0194
- OpenAlex
- W2042841775
- Cited by
- 116
- References
- 0
- Citations by year
- 2025: 2 · 2024: 1 · 2022: 1 · 2020: 1 · 2019: 2 · 2018: 1 · 2017: 1 · 2016: 3 · 2015: 2 · 2014: 4 · 2013: 3
- FWCI
- 0.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- vasopressin, corticotropin-releasing factor, ACTH secretion, anterior pituitary cells, ovine pituitary, rat pituitary, hormone potentiation, dexamethasone
- MeSH terms
- Adrenocorticotropic Hormone, Animals, Arginine Vasopressin, Cells, Cultured, Corticotropin-Releasing Hormone, Dexamethasone, Dose-Response Relationship, Drug, Drug Synergism, Female, Male, Pituitary Gland, Anterior, Rats, Inbred Strains, Sheep, Stress, Physiological, Rats
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