Radioimmunoassay of Gastrin in Human Saliva
Abstract
We have developed a personal procedure for the radioimmunoassay of gastrin (lower detection limit 3 pg/ml). Using 5-fold concentrated lyophilized salivary samples, we are able to detect the basal content of gastrin immunoreactivity in saliva of normal fasting people (mean ± SD: 1.38 ± 0.61 pg/ml) compared to plasma gastrin (mean ± SD: 28.88 ± 11.00 pg/ml). We found that after meal stimulus, the value of salivary as well as plasma gastrin concentration increased (the correlation coefficient r among salivary and plasma gastrin being 0.899; p < 0.001). We believe that gastrin appears in a very low concentration in saliva and that it is not produced by the gland, but derives probably from the serum clearance.
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Gastrin is secreted in response to a meal and can be measured in saliva.
“Gastrin, which is secreted in response to a meal [12] and can be measured in saliva [13], thus allowing it to be evaluated in non-stressful conditions, is one of the hormones regulating the rhythm of gastric acid secretion [14].”
From Acute Effects of Coffee Consumption on Self-Reported Gastrointestinal Symptoms, Blood Pressure and Stress Indices in Healthy Individuals (2015) · cites this paper as [13]
There is only one study in the literature showing a positive correlation between gastrin measured in plasma and saliva (rho = 0.899, P < 0.001).
“Concerning salivary gastrin measurements, there is only one study in the literature showing a positive correlation between the gastrin measured in plasma and saliva (rho = 0.899, P < 0.001) [13]”
From Acute Effects of Coffee Consumption on Self-Reported Gastrointestinal Symptoms, Blood Pressure and Stress Indices in Healthy Individuals (2015) · cites this paper as [13]
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“001) [13] and further studies are needed to confirm these findings.”
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- Authors
- Ingenito, A., Catelani, C., Mercaldo, A., d’Agata, A., Cappelli, G., & Andreoli, F.
- Affiliations
- University of Florence (IT)
- ORCID
- Cappelli, G.
- Venue
- European Surgical Research
- Publisher
- S. Karger AG
- Published
- 2008-04-18
- Volume
- 18
- Issue
- 2
- Pages
- 129-132
- ISSN
- 0014-312X (ISSN-L)
- 1421-9921
- OpenAlex
- W2087332824
- Cited by
- 5
- References
- 0
- Citations by year
- 2015: 1
- FWCI
- 0.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Surgical Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Health Sciences › Medicine › Physiology › Salivary Gland Disorders and Functions
- Health Sciences › Medicine › Surgery › Helicobacter pylori-related gastroenterology studies
- Keywords
- gastrin, plasma gastrin, radioimmunoassay, meal stimulation, serum clearance, salivary glands
- MeSH terms
- Gastrins, Humans, Radioimmunoassay, Saliva
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