The Role of Bile and Bile Acids in Bacterial Translocation in Obstructive Jaundice in Rats
Abstract
Male Sprague-Dawley rats were randomly divided into five groups in which group 1 received a sham operation (controls), groups 2-5 underwent common bile duct ligation and transection 14 days before the experiments. Two days prior to the studies, animals in groups 1 and 2 received saline orally, while groups 3–5 received an oral administration of either cholic acid, deoxycholic acid or whole bile. Specimens were taken for bacterial culture, and blood was collected for endotoxin assay. The rate of positive bacterial cultures from mesenteric lymph nodes in jaundiced salinetreated animals was significantly higher (p < 0.05) as compared with both controls and the other jaundiced animals treated with either bile or bile acids. Assays were positive for endotoxin in the jaundiced salinetreated group, whereas they were negative in both controls and bile- or bile-acid-treated animals. We conclude that oral administration of cholic acid, deoxycholic acid or whole bile inhibited bacterial translocation and endotoxin absorption in obstructive jaundice in the rat.
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- Authors
- Ding, J. W., Andersson, R., Soltesz, V., Willén, R., & Bengmark, S.
- Affiliations
- Lund University (SE)
- Venue
- European Surgical Research
- Publisher
- S. Karger AG
- Published
- 2008-04-23
- Volume
- 25
- Issue
- 1
- Pages
- 11-19
- ISSN
- 0014-312X (ISSN-L)
- 1421-9921
- OpenAlex
- W2061558768
- Cited by
- 133
- References
- 0
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 3 · 2023: 4 · 2022: 6 · 2021: 5 · 2020: 2 · 2019: 6 · 2018: 6 · 2017: 5 · 2016: 7 · 2015: 3 · 2014: 2 · 2013: 2 · 2012: 2
- FWCI
- 4.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Surgical Research (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Gallbladder and Bile Duct Disorders
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Health Sciences › Medicine › Epidemiology › Sepsis Diagnosis and Treatment
- Keywords
- bile acids, bacterial translocation, obstructive jaundice, cholic acid, deoxycholic acid, endotoxin absorption, common bile duct ligation, mesenteric lymph nodes, bacterial culture
- MeSH terms
- Animals, Bile, Bile Acids and Salts, Cell Movement, Cholestasis, Endotoxins, Ileum, Male, Rats, Sprague-Dawley, Bacterial Physiological Phenomena, Rats
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