Assignment of the human gene for pregnancy-associated plasma protein A (PAPPA) to 9q33.1 by fluorescence in situ hybridization to mitotic and meiotic chromosomes
Abstract
Low levels of pregnancy-associated plasma protein A (PAPPA) during the first trimester has been suggested as a biochemical indicator of pregnancies with aneuploid fetuses. Furthermore, the complete absence of PAPPA in pregnancies associated with Cornelia de Lange syndrome (CL) has suggested a causal connection between PAPPA and the development of CL. We have assigned the locus for PAPPA to chromosome region 9q33.1 on mitotic and meiotic chromosomes by fluorescence in situ hybridization, using a 3.7-kb partial PAPPA cDNA probe.
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A high concentration of PAPPA is found in the serum of pregnant women.
“A high concentration of this protein is found in the serum of pregnant women (Silahtaroglu et al. 1993; Conover et al. 1999; Lawrence et al. 1999).”
From Limb-Girdle Muscular Dystrophy Type 2H Associated with Mutation in TRIM32, a Putative E3-Ubiquitin–Ligase Gene (2002) · cites this paper as Silahtaroglu et al. 1993
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“1 by fluorescence in situ hybridization (54), and these two chromosomal regions have been shown to correspond to each other (55).”
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“1, possibly close to FRA9E (9q32) (Silahtaroglu et al., 1993).”
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La pregnancy-associated plasma protein A (PAPP-A)
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Vigo, P. D., Silvares, E. Á., Pérez, M. T. A., et al. (2015) · Clínica e Investigación en Ginecología y Obstetricia · doi:10.1016/j.gine.2015.05.004
- Authors
- Silahtaroglu, A. N., Tümer, Z., Kristensen, T., Sottrup-Jensen, L., & Tommerup, N.
- Affiliations
- Kennedy Center (DK)
- Venue
- Cytogenetics and Cell Genetics
- Publisher
- S. Karger AG
- Published
- 2008-05-14
- Volume
- 62
- Issue
- 4
- Pages
- 214-216
- ISSN
- 0301-0171 (ISSN-L)
- 1421-9816
- OpenAlex
- W2001365926
- Cited by
- 28
- References
- 0
- Citations by year
- 2024: 1 · 2020: 1 · 2019: 1 · 2018: 3 · 2015: 1 · 2014: 1 · 2013: 2 · 2012: 2
- FWCI
- 1.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cytogenetics and Cell Genetics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Screening and Diagnostics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genomic variations and chromosomal abnormalities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- PAPP-A, gene mapping, Cornelia de Lange syndrome, aneuploidy, meiotic chromosomes, metaphase chromosomes
- MeSH terms
- Chromosome Mapping, Chromosomes, Human, Pair 9, Female, Humans, Male, Meiosis, Mitosis, Molecular Sequence Data, Pregnancy-Associated Plasma Protein-A, DNA Probes, In Situ Hybridization, Fluorescence
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