Survival in Familial Pancreatic Cancer
Abstract
Background Family history has been reported to be associated with an increased risk of pancreatic cancer. However, its possible influence on pancreatic cancer survival has rarely been studied, probably because of the rareness of cases in the same family.Methods We used the nationwide Swedish Family-Cancer Database to examine the survival differences between familial and sporadic pancreatic cancers. Hazard ratios (HRs) for cause-specific and overall survival in pancreatic cancer were examined. HRs show the probability of death in the study group compared to the reference group.Results A total of 75 familial pancreatic cancers were noted. HRs were significantly higher among offspring with an affected parent compared to those without an affected parent; for cause-specific and overall survival, the HRs were 1.44 and 1.37, respectively. Reversing the analysis and deriving HRs for parents (offspring as probands) showed that familial pancreatic cancer had a worse prognosis than sporadic cases (HR 1.37 for cause-specific and 1.28 for overall survival). The HRs were close to unity among spouses with concordant pancreatic cancer.Conclusion The data show that survival in familial pancreatic cancer is worse than that in sporadic disease, which could be explained by genetic factors, if other confounding factors can be excluded. and IAP.
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The comparison of outcomes between screen-detected PDAC and PDAC diagnosed after dropping out of surveillance is worthwhile because these groups have similar demographic/risk characteristics, but the number of such cases was small.
“Comparing outcomes of those diagnosed with a screen-detected PDAC to those whose PDAC was diagnosed after dropping out of surveillance is worthwhile because these groups have similar demographic/risk characteristics, and for whom data on pancreatic cancer outcomes is limited,41-43 but the number of such cases was small.”
From The Multicenter Cancer of Pancreas Screening Study: Impact on Stage and Survival (2022) · cites this paper as [42]
Cites
Globocan 2000 : cancer incidence, mortality and prevalence worldwide
Ferlay, J., Pisani, P., & Parkin, D. M. (2001) · Medical Entomology and Zoology · Cited by 1,587 · see citing works
Systematic Population-Based Assessment of Cancer Risk in First-Degree Relatives of Cancer Probands
Goldgar, D. E., Easton, D. F., Cannon‐Albright, L., & Skolnick, M. H. (1994) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/86.21.1600 · Cited by 1,030 · see citing works
Integrative molecular concept modeling of prostate cancer progression
Tomlins, S. A., Mehra, R., Rhodes, D. R., Cao, X., Wang, L., Dhanasekaran, S. M., Sundaram, S. K., Wei, J. T., Rubin, M. A., Pienta, K. J., et al. (2006) · Nature Genetics · doi:10.1038/ng1935 · Cited by 909 · see citing works
Genetic determinants of cancer metastasis
Nguyen, D. X., & Massagué, J. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2101 · Cited by 796 · see citing works
The Nation-wide Swedish Family-Cancer Database&Updated Structure and Familial Rates
Hemminki, K. (2001) · Acta Oncologica · doi:10.1080/02841860152619214 · Cited by 231 · see citing works
Self-citationFamily history and the risk of liver, gallbladder, and pancreatic cancer.
Fernández, E., Vecchia, C. L., D’Avanzo, B., Negri, E., & Franceschi, S. (1994) · PubMed · Cited by 200 · see citing works
Brune, K. A., & Klein, A. P. (2008) · Springer eBooks · doi:10.1007/978-0-387-69252-4_5 · Cited by 149 · see citing works
Precursor Lesions of Pancreatic Cancer: Molecular Pathology and Clinical Implications
Singh, M., & Maitra, A. (2007) · Pancreatology · doi:10.1159/000101873 · Cited by 148 · see citing works
Familial and second primary pancreatic cancers: A nationwide epidemiologic study from Sweden
Hemminki, K., & Li, X. (2002) · International Journal of Cancer · doi:10.1002/ijc.10863 · Cited by 128 · see citing works
Self-citationSmoking history and cancer patient survival: a hospital cancer registry study.
Yu, G. P., Ostroff, J. S., Zhang, Z., Tang, J., & Schantz, S. P. (1997) · PubMed · Cited by 120 · see citing works
Cancer Survival in Sweden 1960–1998 Developments Across Four Decades
Talbäck, M., Stenbeck, M., Rosén, M., Barlow, L., & Glimelius, B. L. G. (2003) · Acta Oncologica · doi:10.1080/02841860310013391 · Cited by 112 · see citing works
Occurrence, trends and environmental etiology of pancreatic cancer
Weiderpass, E., Partanen, T. J., Kaaks, R., Vainio, H., Porta, M. S., Kauppinen, T. P., Ojajärvi, A., Boffetta, P., & Malats, N. (1998) · Scandinavian Journal of Work Environment & Health · doi:10.5271/sjweh.295 · Cited by 107 · see citing works
Pancreatitis and the Risk of Pancreatic Cancer
Fernández, E., Vecchia, C. L., Porta, M. S., et al. (1995) · Pancreas · doi:10.1097/00006676-199508000-00012 · Cited by 105 · see citing works
Rieder, H., & Bartsch, D. K. (2004) · Familial Cancer · doi:10.1023/b:fame.0000026822.67291.a1 · Cited by 96 · see citing works
Cooperman, A. M. (2001) · Surgical Clinics of North America · doi:10.1016/s0039-6109(05)70143-2 · Cited by 76 · see citing works
Risk factors associated with earlier age of onset in familial pancreatic carcinoma
James, T. A., Sheldon, D. G., Rajput, A., et al. (2004) · Cancer · doi:10.1002/cncr.20700 · Cited by 65 · see citing works
Cancer risks among long-standing spouses
Hemminki, K., & Jiang, Y. (2002) · British Journal of Cancer · doi:10.1038/sj.bjc.6600302 · Cited by 60 · see citing works
Self-citationPancreatic Cancer: Factors Regulating Tumor Development, Maintenance and Metastasis
Shi, X., Friess, H., Kleeff, J. H., Ozawa, F., & Büchler, M. W. (2001) · Pancreatology · doi:10.1159/000055854 · Cited by 46 · see citing works
Familial pancreatic carcinoma in Jews
Lynch, H. T., Deters, C. A., Lynch, J. F., & Brand, R. E. (2004) · Familial Cancer · doi:10.1007/s10689-004-9549-8 · Cited by 40 · see citing works
Hemminki, K., Granström, C., Sundquist, J., et al. (2006) · Hereditary Cancer in Clinical Practice · doi:10.1186/1897-4287-4-4-186 · Cited by 33 · see citing works
Self-citationTsuchiya, R., Tajima, Y., Matsuzaki, S., et al. (2001) · Pancreatology · doi:10.1159/000055869 · Cited by 21 · see citing works
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The Multicenter Cancer of Pancreas Screening Study: Impact on Stage and Survival
Dbouk, M., Katona, B. W., Brand, R. E., Chak, A., Syngal, S., Farrell, J. J., Kastrinos, F., Stoffel, E. M., Blackford, A. L., Rustgi, A. K., et al. (2022) · Journal of Clinical Oncology · doi:10.1200/jco.22.00298 · Cited by 247 · see citing works
- Authors
- Ji, J., Försti, A., Sundquist, J., Lenner, P., & Hemminki, K.
- Affiliations
- Karolinska Institutet (SE)
- German Cancer Research Center (DE)
- University Hospital of Umeå (SE)
- Corresponding author
- Ji, Jianguang
- Venue
- Pancreatology
- Publisher
- Elsevier BV
- Published
- 2008-06
- Volume
- 8
- Issue
- 3
- Pages
- 252-256
- ISSN
- 1424-3903 (ISSN-L)
- OpenAlex
- W2034350466
- Cited by
- 12
- References
- 21
- Citations by year
- 2026: 1 · 2022: 2 · 2021: 1 · 2020: 1 · 2018: 1 · 2017: 1 · 2016: 1 · 2014: 1 · 2013: 1 · 2012: 2
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pancreatology (publishedVersion)
- PubMed (publishedVersion)
- Lund University Publications (Lund University) (submittedVersion)
- Funders
- Forskningsrådet för Arbetsliv och Socialvetenskap
- Deutsche Krebshilfe
- Topics
- Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
- Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
- Health Sciences › Medicine › Oncology › Global Cancer Incidence and Screening
- Keywords
- familial pancreatic cancer, family history (medicine), sporadic pancreatic cancer, cause-specific survival, overall survival, hereditary cancer, genetic susceptibility, Swedish Family-Cancer Database
- MeSH terms
- Adult, Aged, Family Health, Humans, Middle Aged, Pancreatic Neoplasms, Sweden, Proportional Hazards Models, Survival Analysis
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