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Evidence for a Virus in Non-A, Non-B Hepatitis Transmitted via the Fecal-Oral Route
Abstract
Typical acute hepatitis was reproduced in a human volunteer immune to hepatitis A virus (HAV) after oral administration of pooled stool extracts from presumed cases of epidemic non-A, non-B hepatitis. Markers of hepatitis B infection, anti-HAV IgM, and increase in total anti-HAV level were not detectable in the volunteer's sera during the course of infection. Spherical 27- to 30-nm virus-like particles were visualized by immune electron microscopy (IEM) in stool samples collected during preclinical and early postclinical phases. These particles banded in CsCl at a buoyant density of 1.35 g/cm3. They reacted in the IEM test with sera from individuals who had experienced two non-B hepatitis episodes but did not react with sera from routine anti-HAV IgM-positive hepatitis patients. Intravenous inoculation of cynomolgus monkeys with the virus-containing stool extract resulted in histopathologically and enzymatically confirmed hepatitis, excretion of virus-like particles, and antibody response to them.
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Citations
Cited by
Isolation of a cDNA from the Virus Responsible for Enterically Transmitted Non-A, Non-B Hepatitis
Reyes, G. R., Purdy, M. A., Kim, J., Luk, K.-C., Young, L. M., Fry, K. E., & Bradley, D. W. (1990) · Science · doi:10.1126/science.2107574 · Cited by 867
Emerson, S. U., & Purcell, R. H. (2003) · Reviews in Medical Virology · doi:10.1002/rmv.384 · Cited by 785
Kamar, N., Dalton, H. R., Abravanel, F., & Izopet, J. (2014) · Clinical Microbiology Reviews · doi:10.1128/cmr.00057-13 · Cited by 675
EASL Clinical Practice Guidelines on hepatitis E virus infection
Dalton, H. R., Kamar, N., Baylis, S. A., Moradpour, D., Wedemeyer, H., & Negro, F. (2018) · Journal of Hepatology · doi:10.1016/j.jhep.2018.03.005 · Cited by 665
Hepatitis E Virus: Animal Reservoirs and Zoonotic Risk
Meng, X. J. (2010) · Veterinary Microbiology · doi:10.1016/j.vetmic.2009.03.017 · Cited by 491
Metadata
- Authors
- Balayart, M. S., Andjaparidze, A. G., Savinskaya, S. S., Ketiladze, E. S., Braginsky, D. M., Savinov, A. P., & Poleschuk, V. F.
- Venue
- Intervirology
- Publisher
- S. Karger AG
- Published
- 1983
- Volume
- 20
- Issue
- 1
- Pages
- 23-31
- ISSN
- 0300-5526 (ISSN-L)
- 1423-0100
- OpenAlex
- W1999639656
- Cited by
- 897
- References
- 0
- FWCI
- 3.28
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Evidence for a Virus in Non-A, Non-B Hepatitis Transmitted via the Fecal-Oral Route. https://app.cochat.ai/papers/10.1159/000149370
- The paper
- Balayart, M. S., Andjaparidze, A. G., Savinskaya, S. S., Ketiladze, E. S., Braginsky, D. M., Savinov, A. P., & Poleschuk, V. F. (1983). Evidence for a Virus in Non-A, Non-B Hepatitis Transmitted via the Fecal-Oral Route. Intervirology. https://doi.org/10.1159/000149370
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
