Obesity and the metabolic syndrome in the elderly–a mini-review
Abstract
The metabolic syndrome is defined as a cluster of cardiometabolic risk factors which are related to insulin resistance. Beyond the importance of each separate risk factor, the aggregation of abdominal obesity, impaired glucose metabolism, dyslipidemia and hypertension, summarized as the metabolic syndrome, characterizes individuals with a significant increase in the risk for type 2 diabetes and cardiovascular disease. In the prosperous countries of the world, the prevalence of the metabolic syndrome is about 20% in the adult population, and increases with increasing age, which is mainly attributed to the significant increase in overweight and obesity, also in elderly. Current data indicate that weight-loss therapy improves physical function, quality of life and the medical complications associated with obesity. This review summarizes epidemiologic data, diagnostic criteria and the clinical importance of the metabolic syndrome, the complex pathophysiologic mechanisms involved in the development of insulin resistance in elderly, and the various therapeutic options. According to these data the identification and treatment of patients with a metabolic syndrome would be an important approach to reduce morbidity and impairments in the elderly.
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When obesity was defined by BMI, it was a protective factor of sarcopenia.
“When obesity was defined by BMI, we found that it was a protective factor of sarcopenia despite the various metabolic problems that can occur (34).”
From The role of obesity in sarcopenia and the optimal body composition to prevent against sarcopenia and obesity (2023) · cites this paper as [34]
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- Grundy SM: Metabolic syndrome pandemia. Arterioscler Thromb Vasc Biol 2008; 28: 629- 632.
- Willett WC, Dietz WH, Colditz GA: Guide- lines for healthy weight. N Engl J Med 1999; 341: 427-439.
- Matsuzawa Y, Funahashi T, Kimara S, Shi- momura I: Adiponectin and metabolic syn- drome. Arterioscler Thromb Vasc Biol 2004; 24: 29-33.
- Ridker PM: Inflammatory biomarkers and risk for myocardial infarction, stroke, diabe- tes and total mortality: implications for lon- gevity. Nutr Rev 2007; 65:S253-S259.
- Petersen KF, Befroy D, Dufour S, Dziura J, Ariyan C, Rothman DL, DiPietro L, Cline GW, Shulman GI: Mitochondrial dysfunc- tion in the elderly: possible role in insulin re- sistance. Science 2003; 300: 1140-1142.
- Rissanen A, Knekt P, Heliövaara M, Aromaa A, Reunanen A, Maatela J: Weight and mor- tality in Finnish women. J Clin Epidemiol 1991; 44: 787-795.
- Goodpaster BH, Krishnaswami S, Harris TB, Katsiaras A, Kritchevsky SB, Smansick EM, Nevitt M, Holvoet P, Newman AB: Obe- sity, regional fat distribution, and the meta- bolic syndrome in older men and women. Arch Intern Med 2005; 165: 777-783.
- Wadden TA, Berkowitz RI, Woble LG, Sar- wer TB, Phelan S, Cato RK, Hesson LA, Osei SY, Kaplan R, Stunkard AJ: Randomised tri- al of lifestyle modification and pharmaco- therapy for obesity. N Engl J Med 2005; 353: 2111-2120.
- Lakka TA, Laaksonen DE, Lakka HM, Männikkö N, Niskanen LK, Rauramaa R, Salonen JT: Sedentary lifestyle, poor cardio- respiratory fitness, and the metabolic syn- drome. Med Sci Sports Exerc 2003; 35: 1279- 1286.
- Authors
- Lechleitner, M.
- Affiliations
- Tirol Kliniken (AT)
- Corresponding author
- Lechleitner, Monika
- Venue
- Gerontology
- Publisher
- S. Karger AG
- Published
- 2008
- Volume
- 54
- Issue
- 5
- Pages
- 253-259
- ISSN
- 0304-324X (ISSN-L)
- 1423-0003
- OpenAlex
- W2116138977
- Cited by
- 100
- References
- 70
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 4 · 2023: 3 · 2022: 4 · 2021: 6 · 2020: 3 · 2019: 5 · 2018: 10 · 2017: 1 · 2016: 10 · 2015: 2 · 2014: 9 · 2013: 10 · 2012: 6
- FWCI
- 1.01
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Gerontology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Keywords
- metabolic syndrome, obesity, older adults, insulin resistance, abdominal obesity, impaired glucose metabolism, dyslipidemia, hypertension, type 2 diabetes, cardiovascular disease, weight loss treatment, pathophysiology, diagnostic criteria, prevalence, physical function, quality of life
- MeSH terms
- Aged, Aged, 80 and over, Cardiovascular Diseases, Diabetes Mellitus, Type 2, Humans, Obesity, Risk Factors, Prevalence, Metabolic Syndrome
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