Physiological Roles for G Protein-Regulated Adenylyl Cyclase Isoforms: Insights from Knockout and Overexpression Studies

The molecular biology of memory storage: a dialogue between genes and synapses

Kandel, E. R. (2001) · Science · doi:10.1126/science.1067020 · Cited by 3,917

Molecular and Cellular Basis of Addiction

Nestler, E. J., & Aghajanian, G. K. (1997) · Science · doi:10.1126/science.278.5335.58 · Cited by 1,295

Type-Specific Regulation of Adenylyl Cyclase by G Protein βγ Subunits

Tang, W.-J., & Gilman, A. G. (1991) · Science · doi:10.1126/science.1962211 · Cited by 1,091

AKAP signalling complexes: focal points in space and time

Wong, W., & Scott, J. D. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1527 · Cited by 1,073

Structure and Mechanism of the Glycerol-3-Phosphate Transporter from Escherichia coli

Huang, Y., Lemieux, M. J., Song, J., Auer, M., & Wang, D. (2003) · Science · doi:10.1126/science.1087619 · Cited by 1,015

G olf : an Olfactory Neuron Specific-G Protein Involved in Odorant Signal Transduction

Jones, D. T., & Reed, R. R. (1989) · Science · doi:10.1126/science.2499043 · Cited by 888

Genome-wide RNAi screen of Ca 2+ influx identifies genes that regulate Ca 2+ release-activated Ca 2+ channel activity

Zhang, S. L., Yeromin, A. V., Zhang, X. H.-F., Yu, Y., Safrina, O., Penna, A., Roos, J., Stauderman, K. A., & Cahalan, M. D. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603161103 · Cited by 879

Mu, delta, and kappa opioid receptor mRNA expression in the rat CNS: An in situ hybridization study

Mansour, A., Fox, C. A., Burke, S., Meng, F., Thompson, R. C., Akil, H., & Watson, S. J. (1994) · The Journal of Comparative Neurology · doi:10.1002/cne.903500307 · Cited by 872

Soluble Adenylyl Cyclase as an Evolutionarily Conserved Bicarbonate Sensor

Chen, Y., Cann, M. J., Litvin, T. N., Iourgenko, V., Sinclair, M. L., Levin, L. R., & Buck, J. (2000) · Science · doi:10.1126/science.289.5479.625 · Cited by 846

Crystal Structure of the Catalytic Domains of Adenylyl Cyclase in a Complex with G sα ·GTPγS

Tesmer, J. J. G., Sunahara, R. K., Gilman, A. G., & Sprang, S. R. (1997) · Science · doi:10.1126/science.278.5345.1907 · Cited by 792

β-Adrenergic Receptors/Epac Signaling Increases the Size of the Readily Releasable Pool of Synaptic Vesicles Required for Parallel Fiber LTP

Martín, R., García-Font, N., Suárez-Pinilla, A. S., Bartolomé‐Martín, D., Ferrero, J. J., Luján, R., Torres, M., & Sánchez‐Prieto, J. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.0716-20.2020 · Cited by 31

Constitutive formation of an RXFP1‐signalosome: a novel paradigm in GPCR function and regulation

Halls, M. L. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01470.x · Cited by 31

Epac1 and Epac2 are differentially involved in inflammatory and remodeling processes induced by cigarette smoke

Oldenburger, A., Timens, W., Bos, S. T., Smit, M., Smrcka, A. V., Laurent, A., Cao, J., Hylkema, M. N., Meurs, H., Maarsingh, H., et al. (2014) · The FASEB Journal · doi:10.1096/fj.13-248930 · Cited by 30

Functional and Neuroprotective Role of Striatal Adenosine A 2A Receptor Heterotetramers

Ferré, S., & Ciruela, F. (2019) · Journal of Caffeine and Adenosine Research · doi:10.1089/caff.2019.0008 · Cited by 35

Natural products as modulators of the cyclic-AMP pathway: evaluation and synthesis of lead compounds

Sengupta, S., & Mehta, G. (2018) · Organic & Biomolecular Chemistry · doi:10.1039/c8ob01388h · Cited by 30

Real‐time monitoring of cAMP levels in living endothelial cells: thrombin transiently inhibits adenylyl cyclase 6

Werthmann, R. C., von Hayn, K., Nikolaev, V. O., Lohse, M. J., & Bünemann, M. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.172957 · Cited by 30

Germline mutations in a G protein identify signaling cross-talk in T cells

Ham, H., Jing, H., Lamborn, I. T., Kober, M. M., Koval, A., Berchiche, Y. A., Anderson, D. E., Druey, K. M., Mandl, J. N., Isidor, B., et al. (2024) · Science · doi:10.1126/science.add8947 · Cited by 31

A Kinase–Anchoring Proteins and Adenylyl Cyclase in Cardiovascular Physiology and Pathology

Efendiev, R., & DESSAUER, C. W. (2011) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0b013e31821bc3f0 · Cited by 29

Characterization of a novel signal transducer element intrinsic to class IIIa/b adenylate cyclases and guanylate cyclases

Ziegler, M. M., Baßler, J., Beltz, S., Schultz, A. C. F., Lupas, A. N., & Schultz, J. E. (2017) · FEBS Journal · doi:10.1111/febs.14047 · Cited by 29

An experimental strategy to probe Gq contribution to signal transduction in living cells

Patt, J., Alenfelder, J., Pfeil, E. M., Voss, J. H., Merten, N., Eryilmaz, F., Heycke, N., Rick, U., Inoue, A., Kehraus, S., et al. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.100472 · Cited by 29

Acute morphine alters GABAergic transmission in the central amygdala during naloxone-precipitated morphine withdrawal: role of cyclic AMP

Bajo, M., Madamba, S. G., Roberto, M., & Siggins, G. R. (2014) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2014.00045 · Cited by 29

Loss of type 9 adenylyl cyclase triggers reduced phosphorylation of Hsp20 and diastolic dysfunction

Li, Y., Baldwin, T. A., Wang, Y., Subramaniam, J., Carbajal, A. G., Brand, C. S., Cunha, S. R., & DESSAUER, C. W. (2017) · Scientific Reports · doi:10.1038/s41598-017-05816-w · Cited by 28

The role of soluble adenylyl cyclase in neurite outgrowth

Stiles, T. L., Kapiloff, M. S., & Goldberg, J. L. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.07.012 · Cited by 27

cAMP/PKA enhances interleukin-1β-induced interleukin-6 synthesis through STAT3 in glial cells

Tanabe, K., Kozawa, O., & Iida, H. (2015) · Cellular Signalling · doi:10.1016/j.cellsig.2015.10.009 · Cited by 27

N Terminus of Type 5 Adenylyl Cyclase Scaffolds Gs Heterotrimer

Sadana, R., Dascal, N., & DESSAUER, C. W. (2009) · Molecular Pharmacology · doi:10.1124/mol.109.058370 · Cited by 27

Human Multisubunit E3 Ubiquitin Ligase Required for Heterotrimeric G-Protein β-Subunit Ubiquitination and Downstream Signaling

Young, B. D., Sha, J., Vashisht, A. A., & Wohlschlegel, J. A. (2021) · Journal of Proteome Research · doi:10.1021/acs.jproteome.1c00292 · Cited by 27

Activation of orexin/hypocretin type 1 receptors stimulates cAMP synthesis in primary cultures of rat astrocytes

Woldan­-Tambor, A., Biegańska, K., Wiktorowska‐Owczarek, A., & Zawilska, J. B. (2011) · Pharmacological Reports · doi:10.1016/s1734-1140(11)70583-7 · Cited by 27

Inhibition of melanogenesis by 5,7-dihydroxyflavone (chrysin) via blocking adenylyl cyclase activity

Kim, D.-C., Rho, S., Shin, J.-C., Park, H. H., & Kim, D. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.06.108 · Cited by 27

Differential dopamine receptor subtype regulation of adenylyl cyclases in lipid rafts in human embryonic kidney and renal proximal tubule cells

Yu, P., Sun, M., Villar, V. A. M., Zhang, Y., Weinman, E. J., Felder, R. A., & José, P. A. (2014) · Cellular Signalling · doi:10.1016/j.cellsig.2014.07.003 · Cited by 27

Adenylyl cyclase 6 mediates the action of cyclic AMP‐dependent secretagogues in mouse pancreatic exocrine cells via protein kinase A pathway activation

Sabbatini, M. E., D’Alecy, L. G., Lentz, S. I., Tang, T., & Williams, J. A. (2013) · The Journal of Physiology · doi:10.1113/jphysiol.2012.249698 · Cited by 27

Regulation of IKs Potassium Current by Isoproterenol in Adult Cardiomyocytes Requires Type 9 Adenylyl Cyclase

Li, Y., Hof, T., Baldwin, T. A., Chen, L., Kass, R. S., & Dessauer, C. W. (2019) · Cells · doi:10.3390/cells8090981 · Cited by 27

Mechanisms and Regulation of Neuronal GABAB Receptor-Dependent Signaling

Rose, T. R., & Wickman, K. (2020) · Current topics in behavioral neurosciences · doi:10.1007/7854_2020_129 · Cited by 26

Continuous High Frequency Deep Brain Stimulation of the Rat Anterior Insula Attenuates the Relapse Post Withdrawal and Strengthens the Extinction of Morphine Seeking

Chang, H., Gao, C., Sun, K., Xiao, L., Li, X., Jiang, S., Zhu, C., Sun, T., Jin, Z., & Wang, F. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.577155 · Cited by 25

Regulation of Mg2+ Reabsorption and Transient Receptor Potential Melastatin Type 6 Activity by cAMP Signaling

Blanchard, M. G., Kittikulsuth, W., Nair, A. V., de Baaij, J. H. F., Latta, F., Genzen, J. R., Kohan, D. E., Bindels, R. J. M., & Hoenderop, J. G. J. (2015) · Journal of the American Society of Nephrology · doi:10.1681/asn.2014121228 · Cited by 26

Regulation of adenylyl cyclase 5 in striatal neurons confers the ability to detect coincident neuromodulatory signals

Bruce, N. J., Narzi, D., Trpevski, D., van Keulen, S. C., Nair, A. G., Röthlisberger, U., Wade, R. C., Carloni, P., & Kotaleski, J. H. (2019) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1007382 · Cited by 26

Cross-Talk Between the Adenylyl Cyclase/cAMP Pathway and Ca2+ Homeostasis

Sánchez-Collado, J., López, J. J., Jardín, I., Salido, G. M., & Rosado, J. A. (2020) · Reviews of physiology, biochemistry and pharmacology · doi:10.1007/112_2020_55 · Cited by 25

Dual Activation of Phosphodiesterase 3 and 4 Regulates Basal Cardiac Pacemaker Function and Beyond

Vinogradova, T. M., & Lakatta, E. G. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168414 · Cited by 25

Single-cell imaging of ERK and Akt activation dynamics and heterogeneity induced by G-protein-coupled receptors

Chavez-Abiega, S., Grönloh, M. L. B., Gadella, T. W. J., Bruggeman, F. J., & Goedhart, J. (2022) · Journal of Cell Science · doi:10.1242/jcs.259685 · Cited by 27

Constitutively Active μ-Opioid Receptors

Connor, M. A., & Traynor, J. R. (2010) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/b978-0-12-381298-8.00022-8 · Cited by 25

Compartmentalisation of cAMP-dependent signalling in blood platelets: The role of lipid rafts and actin polymerisation

Raslan, Z., & Naseem, K. M. (2014) · Platelets · doi:10.3109/09537104.2014.916792 · Cited by 25

The Effects of Different Signaling Pathways in Adenylyl Cyclase Stimulation on Red Blood Cells Deformability

Семенов, А. Н., Shirshin, E. A., Muravyov, A. V., & Priezzhev, A. V. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00923 · Cited by 25

The Somatostatin Receptor-4 Agonist J-2156 Alleviates Mechanical Hypersensitivity in a Rat Model of Breast Cancer Induced Bone Pain

Shenoy, P. A., Kuo, A., Khan, N., Gorham, L., Nicholson, J. R., Corradini, L., Vetter, I., & Smith, M. T. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00495 · Cited by 24

Neuronal primary cilia integrate peripheral signals with metabolic drives

DeMars, K. M., Ross, M. R., Starr, A., & McIntyre, J. C. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1150232 · Cited by 21

The complex of TRIP-Br1 and XIAP ubiquitinates and degrades multiple adenylyl cyclase isoforms

Hu, W., Yu, X., Liu, Z., Sun, Y., Chen, X., Yang, X., Li, X., Lam, W. K., Duan, Y., Cao, X., et al. (2017) · eLife · doi:10.7554/elife.28021 · Cited by 24

Functional Heterogeneity of Protein Kinase A Activation in Multipotent Stromal Cells

Tyurin-Kuzmin, P., Karagyaur, M., Kulebyakin, K., Dyikanov, D., Chechekhin, V. I., Ivanova, A. M., Skryabina, M., Arbatskiy, M. S., Sysoeva, V., Kalinina, N., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21124442 · Cited by 23

Palladium-Catalyzed Regio- and Stereoselective γ-Arylation of Tertiary Allylic Amines: Identification of Potent Adenylyl Cyclase Inhibitors

Ye, Z., Brust, T. F., Watts, V. J., & Dai, M. (2015) · Organic Letters · doi:10.1021/ol503748t · Cited by 23

Targeting Metabolic Deregulation Landscapes in Breast Cancer Subtypes

Serrano-Carbajal, E. A., Enríquez, J. E., & Lemus, E. H. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00097 · Cited by 23

Terahertz photons promote neuron growth and synapse formation through cAMP signaling pathway

Zhong, Y., Yu, Y., Li, Y., Yin, J., Sun, Y., Jiang, R., & Chang, C. (2025) · PhotoniX · doi:10.1186/s43074-025-00165-8 · Cited by 23

Novel treatments for chronic pain: moving beyond opioids

O’Brien, J. B., & Roman, D. L. (2021) · Translational research · doi:10.1016/j.trsl.2021.03.008 · Cited by 22

Second messenger/signal transduction pathways in major mood disorders: moving from membrane to mechanism of action, part II: bipolar disorder

Niciu, M. J., Ionescu, D. F., Mathews, D. C., Richards, E. M., & Zarate, C. A. (2013) · CNS Spectrums · doi:10.1017/s1092852913000138 · Cited by 21

A molecular dynamics study of adenylyl cyclase: The impact of ATP and G-protein binding

Frezza, E., Martin, J., & Lavery, R. (2018) · PLoS ONE · doi:10.1371/journal.pone.0196207 · Cited by 22

Termination and activation of store‐operated cyclic AMP production

Maiellaro, I., Lefkimmiatis, K., Moyer, M. P., Curci, S., & Hofer, A. M. (2012) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2012.01592.x · Cited by 22

Different glycoforms of alpha-1-acid glycoprotein contribute to its functional alterations in platelets and neutrophils

Sumanth, M. S., Jacob, S. P., Abhilasha, K. V., Manne, B. K., Basrur, V., Lehoux, S. D., Campbell, R. A., Yost, C. C., McIntyre, T. M., Cummings, R. D., et al. (2020) · Journal of Leukocyte Biology · doi:10.1002/jlb.3a0720-422r · Cited by 21

Structural insights into membrane adenylyl cyclases, initiators of cAMP signaling

Schuster, D., Khanppnavar, B., Kantarci, I., Mehta, V., & Korkhov, V. M. (2023) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2023.12.002 · Cited by 21

Lidocaine‐induced apoptosis of gingival fibroblasts: participation of cAMP and PKC activity

Villarruel, E. Q., Borda, E., Sterin‐Borda, L., & Orman, B. E. (2010) · Cell Biology International · doi:10.1042/cbi20100200 · Cited by 20

Effect of N-Terminal Myristoylation on the Active Conformation of Gαi1–GTP

van Keulen, S. C., & Röthlisberger, U. (2016) · Biochemistry · doi:10.1021/acs.biochem.6b00388 · Cited by 20

Similarly Potent Inhibition of Adenylyl Cyclase by P-Site Inhibitors in Hearts from Wild Type and AC5 Knockout Mice

Braeunig, J. H., Schweda, F., Han, P.-L., & Seifert, R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0068009 · Cited by 19

Structure–activity relationships for the interactions of 2′- and 3′-(O)-(N-methyl)anthraniloyl-substituted purine and pyrimidine nucleotides with mammalian adenylyl cyclases

Pinto, C., Lushington, G. H., Richter, M., Gille, A., Geduhn, J., König, B., Mou, T.-C., Sprang, S. R., & Seifert, R. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.05.010 · Cited by 19

Inhibitors of Bacillus anthracis edema factor

Seifert, R., & Dove, S. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.07.002 · Cited by 19

Synthesis of the Mechanisms of Opioid Tolerance: Do We Still Say NO?

Gledhill, L. J., & Babey, A. (2021) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-021-01065-8 · Cited by 19

The Unfolded Protein Response and Its Implications for Novel Therapeutic Strategies in Inflammatory Bowel Disease

Garcia, N. V., Hong, K. U., & Matoba, N. (2023) · Biomedicines · doi:10.3390/biomedicines11072066 · Cited by 18

Regulation of nephron water and electrolyte transport by adenylyl cyclases

Rieg, T., & Kohan, D. E. (2014) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00656.2013 · Cited by 19

Identification and characterization of a potent and biologically-active PDE4/7 inhibitor via fission yeast-based assays

de Medeiros, A. S., Wyman, A. R., Alaamery, M. A., Allain, C. J., Ivey, F. D., Wang, L., Le, H., Morken, J. P., Habara, A. H., Le, C., et al. (2017) · Cellular Signalling · doi:10.1016/j.cellsig.2017.08.011 · Cited by 19

Versatility of the BID Domain: Conserved Function as Type-IV-Secretion-Signal and Secondarily Evolved Effector Functions Within Bartonella-Infected Host Cells

Wagner, A., Tittes, C., & Dehio, C. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.00921 · Cited by 19

Effects of 39 Compounds on Calmodulin-Regulated Adenylyl Cyclases AC1 and Bacillus anthracis Edema Factor

Lübker, C., & Seifert, R. (2015) · PLOS ONE · doi:10.1371/journal.pone.0124017 · Cited by 18

A biochemical and genetic discovery pipeline identifies PLCδ4b as a nonreceptor activator of heterotrimeric G-proteins

Maziarz, M., Broselid, S., DiGiacomo, V., Park, J., Luebbers, A., Garcia-Navarrete, L., Blanco‐Canosa, J. B., Baillie, G. S., & Garcia‐Marcos, M. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.003580 · Cited by 18

cAMP at Perinuclear mAKAPα Signalosomes Is Regulated by Local Ca2+ Signaling in Primary Hippocampal Neurons

Boczek, T., Yu, Q., Zhu, Y., Dodge‐Kafka, K. L., Goldberg, J. L., & Kapiloff, M. S. (2021) · eNeuro · doi:10.1523/eneuro.0298-20.2021 · Cited by 18

Bicarbonate-sensitive soluble and transmembrane adenylyl cyclases in peripheral chemoreceptors

Nunes, A. R., Holmes, A. P., Sample, V., Kumar, P., Cann, M. J., Monteiro, E. C., Zhang, J., & Gauda, E. B. (2013) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2013.05.013 · Cited by 18

Exploring the inhibition mechanism of adenylyl cyclase type 5 by n-terminal myristoylated Gαi1

van Keulen, S. C., & Röthlisberger, U. (2017) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1005673 · Cited by 18

Stimulus-secretion Coupling in Pancreatic Acinar Cells

Williams, J. A., & Yule, D. I. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-382026-6.00050-6 · Cited by 18

Integration and Spatial Organization of Signaling by G Protein-Coupled Receptor Homo- and Heterodimers

Maggio, R., Fasciani, I., Carli, M., Petragnano, F., Marampon, F., Rossi, M., & Scarselli, M. (2021) · Biomolecules · doi:10.3390/biom11121828 · Cited by 18

The Impact of Bartonella VirB/VirD4 Type IV Secretion System Effectors on Eukaryotic Host Cells

Fromm, K., & Dehio, C. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.762582 · Cited by 17

Role of Phosphodiesterase 4-Mediated Cyclic AMP Signaling in Pharmacotherapy for Substance Dependence

Wen, R.-T., Feng, W., Liang, J.-H., & Zhang, H. (2014) · Current Pharmaceutical Design · doi:10.2174/1381612820666140826114412 · Cited by 17

Complementary biosensors reveal different G-protein signaling modes triggered by GPCRs and non-receptor activators

Garcia‐Marcos, M. (2021) · eLife · doi:10.7554/elife.65620 · Cited by 17

Adenylyl cyclases in the digestive system

Sabbatini, M. E., Gorelick, F. S., & Glaser, S. S. (2014) · Cellular Signalling · doi:10.1016/j.cellsig.2014.01.033 · Cited by 17

Role of Epac proteins in mechanisms of cAMP-dependent immunoregulation

Ширшев, С. В. (2011) · Biochemistry (Moscow) · doi:10.1134/s000629791109001x · Cited by 19

ENaC contribution to epithelial wound healing is independent of the healing mode and of any increased expression in the channel

Justet, C., Evans, F., Vasilskis, E., Hernández, J. A., & Chifflet, S. (2013) · Cell and Tissue Research · doi:10.1007/s00441-013-1635-5 · Cited by 16

Towards selective inhibitors of adenylyl cyclase toxin from Bordetella pertussis

Seifert, R., & Dove, S. (2012) · Trends in Microbiology · doi:10.1016/j.tim.2012.04.002 · Cited by 16

The type VI adenylyl cyclase protects cardiomyocytes from β-adrenergic stress by a PKA/STAT3-dependent pathway

Wu, Y., Chen, C., Chien, C., Lai, H., Jiang, S., Chen, Y.-C., Lai, L., Hsiao, W.-F., Chen, W., & Chern, Y. (2017) · Journal of Biomedical Science · doi:10.1186/s12929-017-0367-3 · Cited by 16

Adenylyl cyclase 7 and neuropsychiatric disorders: A new target for depression?

Price, T., & Brust, T. F. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.03.015 · Cited by 18

AKAP79 Orchestrates a Cyclic AMP Signalosome Adjacent to Orai1 Ca2+ Channels

Kar, P., Barak, P., Zerio, A., Lin, Y.-P., Parekh, A. J., Watts, V. J., Cooper, D. M. F., Zaccolo, M., Kramer, H., & Parekh, A. B. (2021) · Function · doi:10.1093/function/zqab036 · Cited by 16

Vidarabine is neither a potent nor a selective AC5 inhibitor

Seifert, R. (2014) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.12.025 · Cited by 16

Serum Amyloid A3 Secreted by Preosteoclasts Inhibits Parathyroid Hormone-stimulated cAMP Signaling in Murine Osteoblasts

Choudhary, S., Goetjen, A., Estus, T., Jacome-Galarza, C. E., Aguila, H. L., Lorenzo, J. A., & Pilbeam, C. C. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.686576 · Cited by 16

Structural re-positioning,in silicomolecular modelling, oxidative degradation, and biological screening of linagliptin as adenosine 3 receptor (ADORA3) modulators targeting hepatocellular carcinoma

Ayoub, B. M., Attia, Y. M., & Ahmed, M. S. (2018) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756366.2018.1462801 · Cited by 16

Bradykinin signaling regulates solute permeability and cellular junction organization in lymphatic endothelial cells

Kempe, S., Fois, G., Brunner, C., Hoffmann, T. K., Hahn, J., & Greve, J. (2019) · Microcirculation · doi:10.1111/micc.12592 · Cited by 16

Impairment of adenylyl cyclase 2 function and expression in hypoxanthine phosphoribosyltransferase-deficient rat B103 neuroblastoma cells as model for Lesch–Nyhan disease: BODIPY–forskolin as pharmacological tool

Kinast, L., von der Ohe, J., Burhenne, H., & Seifert, R. (2012) · Naunyn-Schmiedeberg's Archives of Pharmacology · doi:10.1007/s00210-012-0759-6 · Cited by 15

Protein kinase A accelerates the rate of early stage differentiation of pluripotent stem cells

Minakawa, T., Kanki, Y., Nakamura, K., & Yamashita, J. K. (2020) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.12.098 · Cited by 15

Prostaglandin E Receptor EP1 Forms a Complex with Dopamine D1 Receptor and Directs D1-Induced cAMP Production to Adenylyl Cyclase 7 through Mobilizing G Subunits in Human Embryonic Kidney 293T Cells

Ehrlich, A. T., Furuyashiki, T., Kitaoka, S., Kakizuka, A., & Narumiya, S. (2013) · Molecular Pharmacology · doi:10.1124/mol.113.087288 · Cited by 15

Bacillus anthracis Edema Factor Substrate Specificity: Evidence for New Modes of Action

Göttle, M., Dove, S., & Seifert, R. (2012) · Toxins · doi:10.3390/toxins4070505 · Cited by 15

High constitutive Akt2 activity in U937 promonocytes: effective reduction of Akt2 phosphorylation by the histamine H2-receptor and the β2-adrenergic receptor

Werner, K., Neumann, D., & Seifert, R. (2015) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-015-1179-1 · Cited by 15

Coordinate Down-regulation of Adenylyl Cyclase Isoforms and the Stimulatory G Protein (Gs) in Intestinal Epithelial Cell Differentiation

Choi, L. J., Jeníková, G., Hanson, E. M., Spehlmann, M. E., Boehling, N. S., Kirstein, S. L., Bundey, R. A., Smith, J. R., Insel, P. A., & Eckmann, L. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.059741 · Cited by 15

Encephalopathy-causing mutations in Gβ1 (GNB1) alter regulation of neuronal GIRK channels

Reddy, H. P., Yakubovich, D., Raifman, T. K., Tabak, G., Tsemakhovich, V., Pedersen, M. H., Shalomov, B., Colombo, S., Goldstein, D. B., Javitch, J. A., et al. (2021) · iScience · doi:10.1016/j.isci.2021.103018 · Cited by 15

Transcranial Direct Current Stimulation (tDCS) Ameliorates Stress-Induced Sleep Disruption via Activating Infralimbic-Ventrolateral Preoptic Projections

Su, Y.-J., Yi, P.-L., & Chang, F. (2024) · Brain Sciences · doi:10.3390/brainsci14010105 · Cited by 14

Adenylyl cyclase 2 expression and function in neurological diseases

Gray, M., Nash, K. R., & Yao, Y. (2024) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14880 · Cited by 14

Peripheral ablation of type III adenylyl cyclase induces hyperalgesia and eliminates KOR-mediated analgesia in mice

Zhang, W., Cao, H., Li, Y., Fu, X., & Zhang, Y. (2021) · JCI Insight · doi:10.1172/jci.insight.153191 · Cited by 13

The N Terminus of Phosphodiesterase TbrPDEB1 of Trypanosoma brucei Contains the Signal for Integration into the Flagellar Skeleton

Luginbuehl, E., Ryter, D., Schranz-Zumkehr, J., Oberholzer, M., Kunz, S., & Seebeck, T. (2010) · Eukaryotic Cell · doi:10.1128/ec.00112-10 · Cited by 14

Annexin A4 N‐terminal peptide inhibits adenylyl cyclase 5 and limits β‐adrenoceptor‐mediated prolongation of cardiac action potential

Heinick, A., Pluteanu, F., Hermes, C., Klemme, A., Domnik, M., Husser, X., Gerke, V., Schmitz, W. L., & Müller, F. U. (2020) · The FASEB Journal · doi:10.1096/fj.201902094rr · Cited by 14

Presynaptic nigral GPR55 receptors stimulate [ 3 H]‐GABA release through [ 3 H]‐cAMP production and PKA activation and promote motor behavior

Sánchez‐Zavaleta, R., Ávalos‐Fuentes, J. A., González‐Hernández, A. V., Recillas‐Morales, S., Paz‐Bermúdez, F. J., Leyva‐Gómez, G., Cortés, H., & Florán, B. (2022) · Synapse · doi:10.1002/syn.22246 · Cited by 13

Gα Protein Signaling Bias at Serotonin 1A Receptor

Alabdali, R., Franchini, L., & Orlandi, C. (2023) · Molecular Pharmacology · doi:10.1124/molpharm.123.000722 · Cited by 11

Adenylyl cyclase isoforms 5 and 6 in the cardiovascular system: complex regulation and divergent roles

Maghsoudi, S., Shuaib, R., Bastelaere, B. V., & Dakshinamurti, S. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1370506 · Cited by 13

Functional characterization of transmembrane adenylyl cyclases from the honeybee brain

Balfanz, S., Ehling, P., Wachten, S., Jordan, N., Erber, J., Mujagić, S., & Baumann, A. (2012) · Insect Biochemistry and Molecular Biology · doi:10.1016/j.ibmb.2012.02.005 · Cited by 13

Real-Time Monitoring of Intracellular cAMP During Acute Ethanol Exposure

Gupta, R., Qualls‐Creekmore, E., & Yoshimura, M. (2013) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.12133 · Cited by 13

Bacillus bombysepticus α-Toxin Binding to G Protein-Coupled Receptor Kinase 2 Regulates cAMP/PKA Signaling Pathway to Induce Host Death

Lin, P., Cheng, T., Ma, S., Gao, J., Jin, S., Jiang, L., & Xia, Q. (2016) · PLoS Pathogens · doi:10.1371/journal.ppat.1005527 · Cited by 14

Unanticipated signaling events associated with cardiac adenylyl cyclase gene transfer

Gao, M. H., & Hammond, H. K. (2011) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2011.02.009 · Cited by 12

The evolutionary conservation of eukaryotic membrane-bound adenylyl cyclase isoforms

Schultz, J. E. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1009797 · Cited by 12

Regions on Adenylyl Cyclase VII Required for Selective Regulation by the G13 Pathway

Jiang, L. I., Wang, J. E., & Sternweis, P. C. (2012) · Molecular Pharmacology · doi:10.1124/mol.112.082446 · Cited by 12

Unique Pharmacological Properties of the Kappa Opioid Receptor Signaling Through Gαz as Shown with Bioluminescence Resonance Energy Transfer

Barnett, M. E., Knapp, B. I., & Bidlack, J. M. (2020) · Molecular Pharmacology · doi:10.1124/mol.120.119404 · Cited by 12

Oxytocin stimulates lipolysis, prostaglandin E2 synthesis, and leptin secretion in 3T3-L1 adipocytes

Assinder, S. J., & Boumelhem, B. B. (2021) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2021.111381 · Cited by 12

Adenylyl cyclase 1 as a major isoform to generate cAMP signaling for apoA-1-mediated cholesterol efflux pathway

Tang, W., Ma, W., Ding, H., Lin, M., Xiang, L., Lin, G., & Zhang, Z. (2018) · Journal of Lipid Research · doi:10.1194/jlr.m082297 · Cited by 11

Eukaryotic ADCY7 catalyzes the production of c-di-AMP to activate the NLRP3 inflammasome

Liu, Q., Tang, Z., Qian, Y., Wang, C., Kong, C., Li, M., Geng, X., Zhang, Y., Cheng, X., Ren, C., et al. (2025) · Nature Chemical Biology · doi:10.1038/s41589-025-01919-y · Cited by 11

Physiological roles of mammalian transmembrane adenylyl cyclase isoforms

Ostrom, K. F., LaVigne, J. E., Brust, T. F., Seifert, R., Dessauer, C. W., Watts, V. J., & Ostrom, R. S. (2022) · Physiological Reviews · doi:10.1152/physrev.00013.2021 · Cited by 131

Regulation and Role of Adenylyl Cyclase Isoforms

Hanoune, J., & Defer, N. (2001) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.41.1.145 · Cited by 690

Tissue specificity and physiological relevance of various isoforms of adenylyl cyclase

Defer, N., Best‐Belpomme, M., & Hanoune, J. (2000) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.2000.279.3.f400 · Cited by 389

Isoform Selective Regulation of Adenylyl Cyclase by Small Molecule Inhibitors and Gbetagamma Protein

Brand, C. S. (2015) · Digital Commons-TMC (Texas Medical Center) · Cited by 1

Research progress of adenylyl cyclase isoforms in mammals

Min, S. S. (2011) · International Journal of Pathology and Clinical Medicine