Cited by 368Phosphodiesterase function and regulationReceptor Mechanisms and SignalingProtein Kinase Regulation and GTPase Signaling

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Physiological Roles for G Protein-Regulated Adenylyl Cyclase Isoforms: Insights from Knockout and Overexpression Studies

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Sadana, Rachna, Dessauer, Carmen W.·2009·Neurosignals

DOI 10.1159/000166277PMC PMC2790773

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Abstract

Cyclic AMP is a universal second messenger, produced by a family of adenylyl cyclase (AC) enzymes. The last three decades have brought a wealth of new information about the regulation of cyclic AMP production by ACs. Nine hormone-sensitive, membrane-bound AC isoforms have been identified in addition to a tenth isoform that lacks membrane spans and more closely resembles the cyanobacterial AC enzymes. New model systems for purifying and characterizing the catalytic domains of AC have led to the crystal structure of these domains and the mapping of numerous interaction sites. However, big hurdles remain in unraveling the roles of individual AC isoforms and their regulation in physiological systems. In this review we explore the latest on AC knockout and overexpression studies to better understand the roles of G protein regulation of ACs in the brain, olfactory bulb, and heart.

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Authors: Sadana, R., & Dessauer, C. W.
Affiliations: The University of Texas Health Science Center at Houston (US)
ORCID: Sadana, Rachna
Dessauer, Carmen W.
Venue: Neurosignals
Publisher: S. Karger AG
Published: 2009
Volume: 17
Issue: 1
Pages: 5-22
ISSN: 1424-862X (ISSN-L)
1424-8638
DOI: 10.1159/000166277
PMC: PMC2790773
OpenAlex: W2055802786
Cited by: 361
References: 203
Citations by year: 2026: 10 · 2025: 20 · 2024: 20 · 2023: 16 · 2022: 23 · 2021: 32 · 2020: 21 · 2019: 17 · 2018: 22 · 2017: 21 · 2016: 15 · 2015: 18 · 2014: 24 · 2013: 28 · 2012: 25
FWCI: 1.26
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Neurosignals (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of General Medical Sciences (GM 60419, R01GM060419)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Phosphodiesterase function and regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Keywords: adenylyl cyclase isoforms, G protein regulation, cyclic AMP, second messenger signaling, brain, olfactory bulb, heart
MeSH terms: Adenylyl Cyclases, Animals, Brain, Calcium, Isoenzymes, Memory, Myocardium, Nerve Degeneration, Neuronal Plasticity, Olfactory Bulb, Pain, Protein Conformation, Apoptosis, Substance-Related Disorders, Heterotrimeric GTP-Binding Proteins

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Physiological Roles for G Protein-Regulated Adenylyl Cyclase Isoforms: Insights from Knockout and Overexpression Studies

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