Gastrin and Colon Cancer: A Unifying Hypothesis
Abstract
Recently, a variety of studies in vivo as well as in vitro have demonstrated that gastrointestinal hormones can influence the rate of proliferation of neoplastic cells. The widespread use of omeprazole, which increases serum gastrin, coupled with the findings that omeprazole causes gastric carcinoid tumors in rats and that a significant number of patients with adenocarcinoma of the colon have increased serum gastrin have focussed attention on the relationship between gastrin and colon cancer. In the present paper, we have reviewed the experimental findings in humans, experimental animals, and colon cancer cells in tissue culture that bear on the possible relationships between gastrin and colon cancer. Based on these findings, we have proposed two hypotheses that can account for the increased serum gastrin that occurs in some patients with colon cancer.
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Chronic hypergastrinemia, typically present during PPI use, can promote the growth of malignant colonic epithelial cells, facilitating the deleterious sequencing adenoma-carcinoma.
“Last, chronic hypergastrinemia, typically present during PPI use, can promote the growth of malignant colonic epithelial cells, facilitating the deleterious sequencing adenoma-carcinoma[151-153].”
From Proton pump inhibitors and dysbiosis: current knowledge and aspects to be clarified (2019) · cites this paper as [151]
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Proton pump inhibitors and dysbiosis: current knowledge and aspects to be clarified
Bruno, G., Zaccari, P., Rocco, G., Scalese, G., Panetta, C., Porowska, B., Pontone, S., & Severi, C. (2019) · World Journal of Gastroenterology · doi:10.3748/wjg.v25.i22.2706 · Cited by 258 · see citing works
Evenepoel, Claus, Geypens, et al. (1998) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.1998.00377.x · Cited by 91 · see citing works
Ligumsky, M., Lysy, J., Siguencia, G., & Friedlander, Y. (2001) · Journal of Clinical Gastroenterology · doi:10.1097/00004836-200107000-00008 · Cited by 62 · see citing works
“Studies with cell culture systems and animal models have reported gastrin-induced stimulation of gastric, pancreatic, and colonic growth, and increased serum gastrin and its intermediates were found in patients with colorectal neoplasia.(12,13,15,21,28) Recently, gastrin-Gly receptors that mediate the growthpromoting…”
BackgroundEffect of Proton Pump Inhibitors on Colorectal Cancer
Sasaki, T., Mori, S., Kishi, S., Fujiwara‐Tani, R., Ohmori, H., Nishiguchi, Y., Hojo, Y., Kawahara, I., Nakashima, C., Fujii, K., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21113877 · Cited by 49 · see citing works
“Long-term use of PPIs also increases the risk of CRC [10].”
BackgroundUse of Proton Pump Inhibitor and Risk of Colorectal Cancer: A Meta-analysis of Observational Studies
Ahn, J. S., Park, S. M., Eom, C.-S., Kim, S., & Myung, S. (2012) · Korean Journal of Family Medicine · doi:10.4082/kjfm.2012.33.5.272 · Cited by 44 · see citing works
Lessons from the gastrin knockout mice
Friis-Hansen, L. J. (2006) · Regulatory Peptides · doi:10.1016/j.regpep.2006.12.008 · Cited by 36 · see citing works
Alteration in digestion and absorption of nutrients during profound acid suppression
Evenepoel, P. (2001) · Best Practice & Research Clinical Gastroenterology · doi:10.1053/bega.2000.0197 · Cited by 35 · see citing works
Gastrointestinal Hormones and Neurotransmitters
Liddle, R. A. (2010) · Elsevier eBooks · doi:10.1016/b978-1-4160-6189-2.00001-9 · Cited by 24 · see citing works
Barak, L. S., Oakley, R. H., & Shetzline, M. A. (2003) · Assay and Drug Development Technologies · doi:10.1089/154065803322163722 · Cited by 18 · see citing works
Özer, B., & Sezerman, O. U. (2016) · Functional & Integrative Genomics · doi:10.1007/s10142-016-0533-9 · Cited by 15 · see citing works
“…the top 15 pathways that were found by our method, 14 were found as being linked to prostate cancer based on previous studies (Britten 2004; Jia et al. 2012; Jung-Hynes et al. 2010; Li et al. 1997; Priolo et al. 2014; Stewart et al. 2004; Swinnen et al. 2000; Tang et al. 2015; Tsouko et al. 2014).”
MethodCholecystokinin and gastrin receptors targeting in gastrointestinal cancer
Rai, R., Chandra, V., Tewari, M., Kumar, M., & Shukla, H. S. (2012) · Surgical Oncology · doi:10.1016/j.suronc.2012.06.004 · Cited by 16 · see citing works
“Patients with colon carcinoma were also found to have increased serum Gs level [157] and Gs may be considered as a suitable biomarker for colorectal cancer [158].”
BackgroundReflux disease management strategy: initial therapy
Dent, J., & Tytgat, G. N. (2003) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.17.s1.9_1.x · Cited by 4 · see citing works
10.1016/b978-84-9113-949-2.00004-4
(2000) · Time to knit · doi:10.1016/b978-84-9113-949-2.00004-4
- Authors
- Joshi, S. N., & Gardner, J. D.
- Affiliations
- Saint Louis University (US)
- ORCID
- Gardner, Jerry D.
- Venue
- Digestive Diseases
- Publisher
- S. Karger AG
- Published
- 2008-11-04
- Volume
- 14
- Issue
- 6
- Pages
- 334-344
- ISSN
- 0257-2753 (ISSN-L)
- 1421-9875
- OpenAlex
- W2094262088
- Cited by
- 13
- References
- 0
- Citations by year
- 2020: 1 · 2019: 1 · 2016: 1 · 2014: 1 · 2012: 2
- FWCI
- 0.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Digestive Diseases (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
- Health Sciences › Medicine › Oncology › Colorectal Cancer Treatments and Studies
- Health Sciences › Medicine › Epidemiology › Neuroendocrine Tumor Research Advances
- Keywords
- gastrin, colon cancer, serum gastrin, omeprazole, gastric carcinoid, gastrointestinal hormones, colon adenocarcinoma
- MeSH terms
- Animals, Colonic Neoplasms, Gastric Acid, Gastrins, Humans, Neoplasm Proteins, Receptors, Cholecystokinin, Zollinger-Ellison Syndrome
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