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Magnesium and Ascorbic Acid Supplementation in Diabetes mellitus
Abstract
The effect of magnesium (Mg) and ascorbic acid (AA) supplementation on metabolic control was assessed in 56 outpatient diabetics. A 90-day run-in period was followed by two 90-day treatment periods, during which Mg (600 mg/day) and AA (2 g/day) were administered in a randomized double-blind cross-over fashion. A decrease in systolic and diastolic blood pressure (132 +/- 3 vs. 138 +/- 4 and 77 +/- 2 vs. 82 +/- 2 mm Hg; p < 0.05) was observed in insulin-dependent diabetes mellitus subjects during Mg supplementation. No beneficial effect of Mg supplementation was observed on glycemic control, lipids or blood pressure in non-insulin-dependent diabetes mellitus (NIDDM) subjects. AA supplementation improved glycemic control among NIDDM subjects and both fasting blood glucose (9.1 +/- 0.5 vs. 10.1 +/- 0.6 mmol/l; p < 0.05) and HbA1c (8.5 +/- 0.3 vs. 9.3 +/- 0.3%; p < 0.05) improved. Beneficial effects of AA supplementation on cholesterol (5.9 +/- 0.2 vs. 6.2 +/- 0.2 mmol/l; p < 0.05) and triglycerides (2.2 +/- 0.2 vs. 2.5 +/- 0.2; p < 0.05) were also observed in NIDDM subjects. The results suggest that high-dose AA supplementation may have a beneficial effect in NIDDM subjects on both glycemic control and blood lipids.
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“Supplementation with vitamin C improved glycemic control in non-insulin-dependent diabetic patients as well as glycated hemoglobin (HA1c) and fasting blood glucose. In addition, supplementation with vitamin C improved the level of cholesterol and triglycerides showing the beneficial effect of vitamin C on glycemic control and lipids in non-insulin-dependent diabetic subjects.”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Eriksson and Kohvakka 1995
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Büyükbaş, S., Atalay, H., İnal, A., & Başaralı, K. (2015) · DergiPark (Istanbul University)
Nahas, R., & Goguen, J. (2013) · Canadian Journal of Diabetes · doi:10.1016/j.jcjd.2013.07.012
Lecturer, (. A. N., Singh, U., & Singh, S. (2011) · Indian Journal Of Applied Research · doi:10.15373/2249555x/may2013/168
Banu, J. (2020) · IntechOpen eBooks · doi:10.5772/intechopen.94645
(2004) · CRC series in modern nutrition science · doi:10.1201/9780203489673.ch2
Evaluation and analysis of the vitamin levels in the self-selected diets of senile diabetics
Huang, S.-X., Wang, Q., & Lin, X. (2002) · Journal of Zhejiang University. Science A · doi:10.1631/bf03396447
Shaker, S. A., Hanafi, M. Y., Mahmoud, S. A., et al. (2023) · Journal of the Medical Research Institute /Journal of Medical Research Institute · doi:10.21608/jmalexu.2023.337698
“27 This is in accordance to our data which indicated significant down-regulation of serum total cholesterol and LDL-cholesterol levels in the rats supplemented with vitamin C for 6 months while no significant change could be detected in the triglycerides level.”
BackgroundResultAntioxidants: An Introduction to Their Role in Prevention of Diabetic Neuropathy
Barche, S., Chandra, P., Rathee, P., Hooda, T., Lather, A., & Khatri, R. (2026) · Springer eBooks · doi:10.1007/978-981-95-9326-2_5
Waczulı́ková, I., Krahulec, B., Šikurová, L., et al. (2000) · Bratislavské lekárske listy/Bratislava medical journal · doi:10.1007/bf03656283
Ścibior, A., Aureliano, M., Romanowska, Z., Radko, L., & Męcik-Kronenberg, T. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27177620
“Similarly, Eriksson and Kohvakka [221], who performed a randomized, double-blinded, placebo-controlled study, reported no significant alterations in the FPG and HbA1c levels in Type 2 diabetic patients after a three-month treatment with Mg (unspecified Mg compound, 24.7 mmoL/d) (Tables 1 and 2).”
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Metadata
- Authors
- Eriksson, J., & Kohvakka, A.
- Affiliations
- City of Helsinki (FI)
- Venue
- Annals of Nutrition and Metabolism
- Publisher
- S. Karger AG
- Published
- 1995
- Volume
- 39
- Issue
- 4
- Pages
- 217-223
- ISSN
- 0250-6807 (ISSN-L)
- 1421-9697
- OpenAlex
- W2051475246
- Cited by
- 115
- References
- 0
- Citations by year
- 2026: 3 · 2024: 1 · 2023: 4 · 2022: 3 · 2021: 4 · 2020: 6 · 2019: 2 · 2018: 5 · 2017: 7 · 2016: 9 · 2015: 7 · 2014: 9 · 2013: 6 · 2012: 5
- FWCI
- 2.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of Nutrition and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Magnesium in Health and Disease
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Keywords
- magnesium supplementation, vitamin C supplementation, vitamin C, diabetes mellitus, type 1 diabetes, type 2 diabetes, glycemic control, HbA1c, blood pressure, serum lipids, cholesterol, triglycerides, fasting blood glucose
- MeSH terms
- Adult, Ascorbic Acid, Blood Glucose, Blood Pressure, Diabetes Mellitus, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Double-Blind Method, Humans, Lipids, Magnesium, Middle Aged, Cross-Over Studies
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