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Cited by 326Electrolyte and hormonal disordersIon Transport and Channel RegulationUrinary Bladder and Prostate Research

The influence of age on the renal response to water deprivation in man

Rowe, John W., Shock, Nathan W., DeFronzo, Ralph A.·2008·Nephron
DOI 10.1159/000180731
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Abstract

Alterations in urine concentrating ability with age were examined in 98 active community-dwelling volunteers (aged 20-79 years) who were free from evidence of diseases known to adversely affect renal function. There was a significant decrease in urine osmolality reached after 12 h dehydration with advancing age, which could not be correlated with the age-related decline in creatinine clearance. A significant age-related diminution in the ability to conserve solute was also observed. This inability to conserve solute may result in diminished medullary tonicity and impaired urinary concentrating ability.

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Crossref · 10.1159/000180731

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  • Reduced thirst and reduced urine concentration by the kidney increase dehydration risk in older adults.

    “Among age-related physiological changes, reduced thirst and reduced urine concentration by the kidney increase dehydration risk (9,(243)(244)(245)(246).”

    From ESPEN practical guideline: Clinical nutrition and hydration in geriatrics (2022) · cites this paper as [246]

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Authors
Rowe, J. W., Shock, N. W., & DeFronzo, R. A.
Affiliations
National Institutes of Health (US)
ORCID
Venue
Nephron
Publisher
S. Karger AG
Published
2008-11-28
Volume
17
Issue
4
Pages
270-278
ISSN
  • 1660-8151 (ISSN-L)
  • 2235-3186
DOI
10.1159/000180731
OpenAlex
W1969365907
Cited by
326
References
0
Citations by year
2026: 2 · 2025: 3 · 2024: 7 · 2023: 3 · 2022: 2 · 2021: 3 · 2020: 4 · 2019: 8 · 2018: 10 · 2017: 8 · 2016: 4 · 2015: 7 · 2014: 14 · 2013: 12 · 2012: 7
FWCI
10.40
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • The Nephron journals/Nephron journals (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Electrolyte and hormonal disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
  • Health Sciences › Medicine › Urology › Urinary Bladder and Prostate Research
Keywords
aging, water deprivation, urine concentrating ability, urine osmolality, renal function, creatinine clearance, dehydration
MeSH terms
Adult, Aged, Aging, Creatinine, Glomerular Filtration Rate, Humans, Kidney, Kidney Concentrating Ability, Middle Aged, Osmolar Concentration, Urination, Water Deprivation

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