Reproductive Endocrine Functions in Men with Primary Hypothyroidism: Effect of Thyroxine Replacement
Abstract
Reproductive endocrine functions were studied in men with primary hypothyroidism during the hypothyroid phase and after achieving euthyroid status with thyroxine substitution therapy. Hypergonadotropism [luteinising hormone (LH), 18.7 ± 7.3 IU/1; follicle-stimulating hormone (FSH), 6.3 ± 2.0 IU/1], low serum testosterone (6.1 ± 2.8 nmol/l), low serum sex-hormone-binding globulin (SHBG; 13.2 ± 2.0 nmol/l) and subnormal testosterone response to human chorionic gonadotropin hCG; (30% increase in serum testosterone following hCG) observed during the hypothyroid phase were restored to normal (LH, 7.2 ± 2.0 IU/1; FSH, 2.7 ± 0.9 IU/1; testosterone, 12.9 ± 2.7 nmol/l; SHBG, 26.5 ± 8.4 nmol/l, and 2-fold increase in serum testosterone following hCG) with thyroxine substitution therapy. Some improvement in sperm count and motility was also observed.
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Hypothyroidism is accompanied by a decrease in both SHBG and total T, which is reversible with adequate treatment.
“Hypothyroidism on the other hand is accompanied by a decrease in both SHBG and total T [98], which is reversible with adequate treatment [99].”
From Role of sex hormone-binding globulin in the free hormone hypothesis and the relevance of free testosterone in androgen physiology (2022) · cites this paper as [98]
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Krassas, G. E., Poppe, K., & Glinoer, D. (2010) · Endocrine Reviews · doi:10.1210/er.2009-0041 · Cited by 1,223 · see citing works
Narinx, N., David, K., Walravens, J., Vermeersch, P., Claessens, F., Fiers, T., Lapauw, B., Antonio, L., & Vanderschueren, D. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04562-1 · Cited by 96 · see citing works
Prevalence and predictors of hyperprolactinemia in subclinical hypothyroidism
Sharma, L. K., Sharma, N., Gadpayle, A. K., & Dutta, D. (2016) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2016.07.012 · Cited by 58 · see citing works
Secretion of testicular steroids and gonadotrophins in hypothyroidism
Kumar, A., Mohanty, B. P., & Rani, L. (2007) · Andrologia · doi:10.1111/j.1439-0272.2007.00798.x · Cited by 18 · see citing works
- Authors
- Kumar, J., Khurana, M. L., Ammini, A. C., Karmarkar, M. G., & Ahuja, M. M. S.
- Affiliations
- All India Institute of Medical Sciences (IN)
- Venue
- Hormone Research
- Publisher
- S. Karger AG
- Published
- 2008-12-02
- Volume
- 34
- Issue
- 5-6
- Pages
- 215-218
- ISSN
- 0301-0163 (ISSN-L)
- 1423-0046
- OpenAlex
- W2000457923
- Cited by
- 89
- References
- 0
- Citations by year
- 2025: 3 · 2024: 3 · 2023: 4 · 2022: 3 · 2021: 3 · 2020: 2 · 2019: 4 · 2018: 2 · 2017: 4 · 2016: 3 · 2015: 2 · 2014: 2 · 2013: 1 · 2012: 1
- FWCI
- 4.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Hormone Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- primary hypothyroidism, male hypogonadism, thyroxine replacement, reproductive endocrine function, luteinizing hormone, follicle-stimulating hormone, serum testosterone, sex hormone-binding globulin, human chorionic gonadotropin stimulation test, sperm count, sperm motility, euthyroidism
- MeSH terms
- Adult, Endocrine Glands, Gonadotropins, Chorionic Gonadotropin, Humans, Hypothyroidism, Male, Middle Aged, Semen, Sex Hormone-Binding Globulin, Testosterone, Thyroxine
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