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Cited by 18Thyroid Disorders and TreatmentsHormonal and reproductive studiesSperm and Testicular Function

Secretion of testicular steroids and gonadotrophins in hypothyroidism

Kumar, A., Mohanty, B. P., Rani, L.·2007·Andrologia
DOI 10.1111/j.1439-0272.2007.00798.x
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Abstract

Inconsistent alterations in gonadal steroidogenesis and pituitary functions have been reported in hypothyroid males. We have compared the lipid and endocrine profiles of the euthyroid and hypothyroid [thyroid-stimulating hormone (TSH) >100 mIU l(-1)] males. Hypothyroidism was found to be associated with an increase in the circulating level of total cholesterol and LDL-cholesterol (LDL-C) and a reduction in the levels of progesterone and testosterone, without any change in the serum levels of oestradiol and gonadotrophins. The failure of gonadotrophins to rise could be accounted by a normal level of serum oestradiol in the hypothyroid male. A mild hyperprolactinaemia was also noted in the hypothyroid patients. The reduction in serum testosterone level could be explained by (i) a reduced uptake of LDL-C by the Leydig cells and thereby a reduction in the synthesis of progesterone and consequentially testosterone, (ii) a further reduction in the rate of conversion of progesterone to testosterone, (iii) a higher rate of conversion of testosterone to oestradiol, (iv) a decrease in serum triiodothyronine and (v) hyperprolactinaemia. Rise in TSH needs to be investigated as a cause of the suppression of gonadal steroidogenesis.

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Authors
Kumar, A., Mohanty, B. P., & Rani, L.
Affiliations
All India Institute of Medical Sciences (IN)
Corresponding author
Kumar, A.
ORCID
Kumar, A.
Venue
Andrologia
Publisher
Hindawi Limited
Published
2007-12
Volume
39
Issue
6
Pages
253-260
ISSN
  • 0303-4569 (ISSN-L)
  • 1439-0272
DOI
10.1111/j.1439-0272.2007.00798.x
OpenAlex
W2055635642
Cited by
18
References
45
Citations by year
2025: 1 · 2022: 1 · 2020: 3 · 2019: 1 · 2017: 2 · 2015: 2 · 2014: 2 · 2013: 1 · 2012: 3
FWCI
0.49
Type
journal article
Language
en
Open access
closed
Licence
doi.wiley.com/10.1002/tdm_license_1.1 (tdm, 2831 d)
Locations
  • Andrologia (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
Keywords
hypothyroidism, testicular steroidogenesis, gonadotropins, testosterone, progesterone, estradiol, hyperprolactinemia, thyroid-stimulating hormone, LDL cholesterol, Leydig cells, triiodothyronine, male hypogonadism
MeSH terms
Adult, Cholesterol, Estradiol, Follicle Stimulating Hormone, Gonadotropins, Humans, Hypothyroidism, Luteinizing Hormone, Cholesterol, LDL, Male, Middle Aged, Progesterone, Prolactin, Testosterone, Thyrotropin, Thyroxine, Triiodothyronine, Case-Control Studies

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