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Animal Model of Adenine-Induced Chronic Renal Failure in Rats
Abstract
Long-term feeding of adenine to rats produced metabolic abnormalities resembling chronic renal failure in humans. Among the disturbances produced were azotemia, accumulation of uremic toxins, metabolic imbalances of amino acids and electrolytes, and hormonal imbalances. The pathological findings in the kidneys of these experimental rats revealed lesions of proximal tubules, of some distal tubules and of glomeruli. Contracted kidneys were found in the rats with severe perturbations. Our results suggest that long-term adenine feeding provides a model which would be useful to study chronic renal failure.
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Cited by
Saito, H., Kusano, K., Kinosaki, M., Ito, H., Hirata, M., Segawa, H., Miyamoto, K.-I., & Fukushima, N. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m207872200 · Cited by 414
Trans-splicing vectors expand the utility of adeno-associated virus for gene therapy
Yan, Z., Zhang, Y., Duan, D., & Engelhardt, J. F. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.12.6716 · Cited by 305
Large animal models of cardiovascular disease
Tsang, H. G., Rashdan, N. A., Whitelaw, C. B. A., Corcoran, B. M., Summers, K. M., & MacRae, V. E. (2016) · Cell Biochemistry and Function · doi:10.1002/cbf.3173 · Cited by 154
Analysis of structural components of decellularized scaffolds in renal fibrosis
Zhang, R., Jiang, J., Yu, Y., Wang, F., Gao, N., Zhou, Y., Wan, X., Wang, Z., Wei, P., & Mei, J. (2021) · Bioactive Materials · doi:10.1016/j.bioactmat.2020.12.028 · Cited by 21
Nageeb, M. M., Talaat, A., Reda, S. M., & Elsammak, G. A. (2024) · Naunyn-Schmiedeberg's Archives of Pharmacology · doi:10.1007/s00210-023-02585-4 · Cited by 7
Metadata
- Authors
- Yokozawa, T., Zheng, P. D., Oura, H., & Koizumi, F.
- Venue
- Nephron
- Publisher
- S. Karger AG
- Published
- 1986
- Volume
- 44
- Issue
- 3
- Pages
- 230-234
- ISSN
- 1660-8151 (ISSN-L)
- 2235-3186
- OpenAlex
- W2031948766
- Cited by
- 355
- References
- 0
- FWCI
- 10.08
- Type
- journal article
- Language
- en
- Open access
- closed
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- Yokozawa, T., Zheng, P. D., Oura, H., & Koizumi, F. (1986). Animal Model of Adenine-Induced Chronic Renal Failure in Rats. Nephron. https://doi.org/10.1159/000183992
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
