A Case of Nephrotic Syndrome with Glomerular Lipoprotein Deposition with Capillary Ballooning and Mesangiolysis
Abstract
A 33-year-old man with nephrotic syndrome and rapid deterioration of renal function showed curious glomerular morphological abnormalities. Ballooning of the glomerular capillaries due to a substance accumulated in the capillary lumina and mesangiolysis were prominent histological features. The deposits in the capillary lumen were positive for Sudan III staining, and also for β-lipoprotein, apoprotein B and apoprotein E by immunofluorescent technique. The staining of β-lipoprotein in a flower leaf pattern was a striking characteristic, while such staining was negative when studied in 20 patients with nephrotic syndrome who were used as controls. Based on these findings, the morphological abnormalities in this case were considered to be related to lipoprotein deposition in the glomeruli. This case is thought to be the first reported in a complete form in the literature which could be classified as a new kind of disease related to lipoprotein metabolism abnormalities.
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The APOE mutation NM_000041.4:c.494G>C (p.Arg165Pro) is in exon 4 of APOE and is known as APOE Chicago mutation.
“which is in the exon 4 of the APOE gene and also known as APOE Chicago mutation, a rare mutation of LPG.”
From A case report of youth-onset lipoprotein glomerulopathy with APOE Chicago mutation (2024) · cites this paper as [5]
The APOE Chicago mutation has only been reported in five patients/families so far.
“which has only been reported in five patients/families so far and their characteristics are summarized in Table 1.”
From A case report of youth-onset lipoprotein glomerulopathy with APOE Chicago mutation (2024) · cites this paper as [5]
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Oikawa, S., Matsunaga, A., Saito, T., Sato, H., Seki, T., Hoshi, K., Hayasaka, K., Kotake, H., Midorikawa, H., Sekikawa, A., et al. (1997) · Journal of the American Society of Nephrology · doi:10.1681/asn.v85820 · Cited by 103 · see citing works
Apolipoprotein E–related glomerular disorders
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Abnormal Lipoprotein and Apolipoprotein Pattern in Lipoprotein Glomerulopathy
Oikawa, S., Suzuki, N., Sakuma, E., Saito, T., Namai, K., Kotake, H., Fujii, Y., & Toyota, T. (1991) · American Journal of Kidney Diseases · doi:10.1016/s0272-6386(12)80649-4 · Cited by 60 · see citing works
A novel 18-amino acid deletion in apolipoprotein E associated with lipoprotein glomerulopathy
Ando, M., Sasaki, J., Hua, H., Matsunaga, A., Uchida, K., Jou, K., Oikawa, S., Saito, T., & Nihei, H. (1999) · Kidney International · doi:10.1046/j.1523-1755.1999.00677.x · Cited by 53 · see citing works
Arai, T., Yamashita, S., Yamane, M., Manabe, N., Matsuzaki, T., Kiriyama, K., Kanayama, Y., Himeno, S., & Matsuzawa, Y. (2003) · Atherosclerosis · doi:10.1016/s0021-9150(03)00194-1 · Cited by 43 · see citing works
A case report of youth-onset lipoprotein glomerulopathy with APOE Chicago mutation
Liu, Y., Cheng, Y., Wen, Y., Li, C., Chen, G., & Li, M. (2024) · BMC Nephrology · doi:10.1186/s12882-024-03515-z · Cited by 2 · see citing works
- Authors
- Watanabe, Y., Ozaki, I., Yoshida, F., Fukatsu, A., Itoh, Y., Matsuo, S., & Sakamoto, N.
- Affiliations
- Nagoya University Hospital (JP)
- Venue
- Nephron
- Publisher
- S. Karger AG
- Published
- 2008-12-09
- Volume
- 51
- Issue
- 2
- Pages
- 265-270
- ISSN
- 1660-8151 (ISSN-L)
- 2235-3186
- OpenAlex
- W2066612478
- Cited by
- 60
- References
- 0
- Citations by year
- 2024: 1 · 2019: 1 · 2017: 1 · 2016: 1 · 2014: 2 · 2013: 2 · 2012: 1
- FWCI
- 1.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Nephron journals/Nephron journals (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Nephrology › Renal Diseases and Glomerulopathies
- Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Keywords
- nephrotic syndrome, mesangiolysis, low-density lipoprotein, apolipoprotein B, apolipoprotein E, Sudan III staining, glomerular morphology, rapidly progressive renal failure
- MeSH terms
- Adult, Apoproteins, Fluorescent Antibody Technique, Glomerular Mesangium, Humans, Kidney Glomerulus, Lipoproteins, Male, Microscopy, Electron, Nephrotic Syndrome
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