Cited by 60Renal Diseases and GlomerulopathiesLipid metabolism and disordersChronic Kidney Disease and Diabetes

Abnormal Lipoprotein and Apolipoprotein Pattern in Lipoprotein Glomerulopathy

Oikawa, Shinichi, Suzuki, Norihiro, Sakuma, Eriko, Saito, Takao, Namai, Kazuyuki, Kotake, Hidetoshi, Fujii, Yutaka, Toyota, Takayoshi·1991·American Journal of Kidney Diseases

Abstract

Recently, two cases of renal disease were observed in which there was an abnormal accumulation of lipids, "lipoprotein thrombi," in the glomerular capillary lumen. This disease has been designated as lipoprotein glomerulopathy. Four other cases have been diagnosed independently by renal histology in other clinical laboratories. All six patients showed proteinuria (1.6 to 10 g/d), normal lecithin-cholesterol acyltransferase (LCAT) activity, type III hyperlipoproteinemia-like lipoprotein profiles, and significantly (P less than 0.01) higher levels of plasma apolipoprotein (apo) E (greater than 10 mg/dL) compared with the control patients with hyperlipidemic nephrotic syndrome without lipoprotein thrombi and type IIb hyperlipoproteinemia without renal disease. Lipoprotein glomerulopathy is not familial type III hyperlipoproteinemia (dysbetalipoproteinemia), because apolipoprotein E3 is present. Apo E isoforms were all rare: five cases of E2/3 and one case of E4/4. These results suggest that excessive apo E is associated with apo E isoform and lipoprotein metabolic derangement in such a renal disease. Further studies are needed on the relationship between the apo E hyperlipoproteinemia and the formation of lipoprotein thrombi.

Integrity signals

Registry

Crossref · 10.1016/s0272-6386(12)80649-4

Cites

35 of 35 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Oikawa, S., Suzuki, N., Sakuma, E., Saito, T., Namai, K., Kotake, H., Fujii, Y., & Toyota, T.
Affiliations
Tohoku University (JP)
Corresponding author
Oikawa, Shinichi
Venue
American Journal of Kidney Diseases
Publisher
Elsevier BV
Published
1991-11
Volume
18
Issue
5
Pages
553-558
ISSN
0272-6386 (ISSN-L)
OpenAlex
W1991397623
Cited by
60
References
35
Citations by year
2026: 1 · 2025: 2 · 2024: 1 · 2022: 2 · 2019: 2 · 2017: 1 · 2013: 3
FWCI
1.22
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Kidney Diseases (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Nephrology › Renal Diseases and Glomerulopathies
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
  • Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
Keywords
lipoprotein glomerulopathy, apolipoprotein E, type III hyperlipoproteinemia, dysbetalipoproteinemia, apolipoprotein E isoforms, proteinuria, type IIb hyperlipoproteinemia, lecithin:cholesterol acyltransferase
MeSH terms
Adult, Apolipoproteins, Apolipoproteins E, Female, Humans, Hyperlipoproteinemias, Hyperlipoproteinemia Type III, Kidney Diseases, Kidney Glomerulus, Phosphatidylcholine-Sterol O-Acyltransferase, Lipoproteins, Male, Middle Aged, Proteinuria

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review