History of the treatment of chronic bronchitis
Abstract
Although chronic bronchitis was first named and described in 1808, the disease has been known since earliest time, and numerous drugs have been utilized in its therapy. The basic historic theories of human function have readily been applied to bronchitis; thus in Greek medicine, the disease was appreciated as one of excess phlegm. Early remedies included garlic, pepper, cinnamon, and turpentine, whereas later therapies of choice emphasized coffee, ipecac, and potassium nitrate. Most of the favored bronchodilator drugs of today are derived from the traditional folk remedies, ephedrine, atropine, and theophylline. The most interesting historical drugs, however, are those that have given rise to modern mucokinetic agents such as bromhexine and iodides.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Cited by
Sorted by citations
Revisiting an ancient spice with medicinal purposes: Cinnamon
Ribeiro‐Santos, R., Andrade, M. A., Madella, D. K. S. F., Martinazzo, A. P., Moura, L. D. A. G., de Melo, N. R., & Sanches-Silva, A. T. (2017) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2017.02.011 · Cited by 220 · see citing works
Therapeutic Uses of Inorganic Nitrite and Nitrate: From the Past to the Future
Butler, A. R., & Feelisch, M. (2008) · Circulation · doi:10.1161/circulationaha.107.753814 · Cited by 184 · see citing works
Inorganic nitrite therapy: historical perspective and future directions
Kevil, C. G., Kolluru, G. K., Pattillo, C. B., & Giordano, T. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.04.042 · Cited by 113 · see citing works
Hwa, J. S., Jin, Y. C., Lee, Y. S., et al. (2011) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2011.12.001 · Cited by 108 · see citing works
Hepatotoxicity of Herbal Supplements Mediated by Modulation of Cytochrome P450
Brewer, C., & Chen, T. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18112353 · Cited by 93 · see citing works
“White and black pepper are taken for GI distress, bronchitis, malaria, cholera, and cancer [137,138].”
BackgroundBarceloux, D. G. (2009) · Disease-a-Month · doi:10.1016/j.disamonth.2009.03.003 · Cited by 91 · see citing works
“Cinnamon was one of the early reatments for chronic bronchitis.(1) Other traditional uses include the reatment of impotence, frigidity, dyspnea, inflammation of the eye, eukorrhea, vaginitis, rheumatism, and neuralgia, as well as wounds and oothaches.”
BackgroundPlatelet Anti-Aggregation Activities of Compounds from Cinnamomum cassia
Kim, S. Y., Koo, Y. K., Koo, J. Y., et al. (2010) · Journal of Medicinal Food · doi:10.1089/jmf.2009.1365 · Cited by 66 · see citing works
“8,9 15 However, most of the pharmacological investigations of the chemical constituents of this plant have been limited to the effects of its essential oil and the oil’s major component cinnamaldehyde, which has shown bactericidal, 16 sedative, 17 hypotensive, 18 peripheral vasodilation, 18 and…”
InfluentialAnti‐fungal bandages containing cinnamon extract
Ahmed, J., Altun, E., Aydoğdu, M. O., Gündüz, O., Kerai-Varsani, L., Ren, G., & Edirisinghe, M. J. (2019) · International Wound Journal · doi:10.1111/iwj.13090 · Cited by 54 · see citing works
“Historically, cinnamon has been long used as a traditional medicine in the treatment of many conditions, such as bronchitis, rheumatism, and neuralgia.(4) Furthermore, many modern scientific articles report on the ability of cinnamon to be antidiabetic, antioxidant, anti-inflammatory, antifungal, anti-HIV, improve hea…”
BackgroundMucoactive drugs for asthma and COPD: any place in therapy?
Rogers, D. F. (2002) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.11.1.15 · Cited by 50 · see citing works
Ulbricht, C. E., Seamon, E., Windsor, R. C., Armbruester, N., Bryan, J. K., Costa, D., Giese, N., Gruenwald, J., Iovin, R. C., Isaac, R., et al. (2011) · Journal of Dietary Supplements · doi:10.3109/19390211.2011.627783 · Cited by 48 · see citing works
“purification, bronchitis, chronic bronchitis [559], chronic diarrhea, cognitive func-”
BackgroundA Review of Antiplatelet Activity of Traditional Medicinal Herbs on Integrative Medicine Studies
Kim, K., & Park, K. (2019) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2019/7125162 · Cited by 44 · see citing works
Ahmed, J., Gültekinoğlu, M., Bayram, C., et al. (2021) · MedComm · doi:10.1002/mco2.71 · Cited by 25 · see citing works
Barceloux, D. G. (2008) · doi:10.1002/9780470330319.ch4 · Cited by 8 · see citing works
A Brief History of Bronchitis in England and Wales
Widdicombe, J. H. (2020) · Chronic Obstructive Pulmonary Diseases Journal of the COPD Foundation · doi:10.15326/jcopdf.7.4.2020.0135 · Cited by 7 · see citing works
Perineal ulcer: a rare cause of extensive subcutaneous emphysema
Sahu, K. K., Sherif, A. A., Mishra, A. K., et al. (2019) · BMJ Case Reports · doi:10.1136/bcr-2019-229918 · Cited by 6 · see citing works
Rogers, D. F., & Rubin, B. K. (2007) · doi:10.1002/9780470755976.ch62 · Cited by 5 · see citing works
Toxicology and Drug Interactions of Nutraceuticals
Cope, R. B. (2019) · Springer eBooks · doi:10.1007/978-3-030-04624-8_51 · Cited by 2 · see citing works
200 Jahre Bronchitis – 1808 bis 2008
Klippe, H. J., & Kirsten, D. (2009) · Pneumologie · doi:10.1055/s-0028-1119572 · Cited by 1 · see citing works
“Zur Therapie bleibt Badham konservativ, ganz den Pharmaka seiner Zeit verhaftet [6].”
“Alpha-1, are you in? (C)harlie (O)scar (P)appa (D)elta, over!”
Muntingh, G. L. (2016) · South African Family Practice · doi:10.4102/safp.v58i1.4437
Cinnamomum zeylanicum Nees (Lauraceae): Cannelle de Ceylan
Goetz, P. W., & Ghédira, K. (2012) · Phytothérapie pratique · doi:10.1007/978-2-8178-0058-5_14
Guerrero-Encinas, I., Burruel-Ibarra, S. E., Quihui‐Cota, L., et al. (2026) · Food Biophysics · doi:10.1007/s11483-025-10092-7
“Both the chemical and physical characteristics of CEO have garnered significant interest in the food, cosmetic, and pharmaceutical industries, as they have been associated with notable anti-bacterial, antifungal, antinematode, anti-inflammatory, and anticancer activities [ 8–10].”
- Authors
- Ziment, I.
- Corresponding author
- Ziment, Irwin
- Venue
- Respiration
- Publisher
- S. Karger AG
- Published
- 2009-01-20
- Volume
- 58 Suppl 1
- Pages
- 37-42
- ISSN
- 0025-7931 (ISSN-L)
- 1423-0356
- OpenAlex
- W2114804513
- Cited by
- 21
- References
- 0
- Citations by year
- 2026: 1 · 2021: 1 · 2020: 1 · 2019: 4 · 2017: 2 · 2016: 1 · 2012: 1
- FWCI
- 56.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Respiration (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Arts and Humanities › History › History of Medicine Studies
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Historical Medical Research and Treatments
- Social Sciences › Arts and Humanities › History and Philosophy of Science › History of Science and Medicine
- Keywords
- chronic bronchitis, bronchodilators, ephedrine, atropine, theophylline, bromhexine, iodide, sputum, traditional remedies, ipecac, potassium nitrate
- MeSH terms
- Bronchitis, Chronic Disease, Humans, History, 17th Century, History, 18th Century, History, 19th Century, History, 20th Century, History, Ancient, History, Medieval
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review