Synthesis rates of albumin and fibrinogen during and after acute hepatitis
Abstract
Synthesis rates of albumin and fibrinogen were determined in six patients with acute virus hepatitis and in nine control patients using the 14C carbonate method of McFarlane. Five patients were restudied several weeks after complete recovery. The following results were obtained. (1) The mean albumin and fibrinogen synthesis rates in the control group were 238.8 and 23.5 mg/kg/day, respectively. (2) In two patients with mild courses of hepatitis and in one patient studied during the early phase of a rapid and fatal course the albumin synthesis rate during the acute disease did not differ from controls whereas fibrinogen synthesis rate was slightly increased. (3) Three patients with severe hepatitis showed a definite decrease in albumin and fibrinogen synthesis rates, the lowest value being 76 mg/kg/day for albumin and 6.3 mg/kg/day for fibrinogen. (4) The decrease in plasma protein synthesis correlated neither with serum transaminase or bilirubin levels nor with plasma albumin or fibrinogen concentrations during the acute phase. (5) The two patients with the lowest albumin and fibrinogen synthesis rates also showed a definite decrease of the prothrombin index during the acute phase. Both patients presented very prolonged courses of the disease. (6) In all patients studied twice, plasma protein synthesis rates were normal after recovery.
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In the Western world, the severity of inflammatory effects of comorbidity, obesity, lifestyle, organ failure, and aging leads to a proportional decrease in serum albumin levels.
“In the Western world, the severity of the inflammatory effects of comorbidity, obesity, lifestyle, organ failure, and aging lead to a proportional decrease in serum albumin levels.23, 76, 101, 102, 103, 104, 105, 106”
From Hypoalbuminemia: Pathogenesis and Clinical Significance (2019) · cites this paper as [101]
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Hypoalbuminemia: Pathogenesis and Clinical Significance
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Mezey, E. (1978) · Gastroenterology · doi:10.1016/0016-5085(78)90259-7 · Cited by 107 · see citing works
Die Regulation des Serumalbuminspiegels unter physiologischen und pathologischen Bedingungen
Weigand, K. (1977) · Journal of Molecular Medicine · doi:10.1007/bf01488107 · Cited by 19 · see citing works
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Briggs, M., & Briggs, M. (1979) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(79)90062-1 · Cited by 18 · see citing works
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ORAL CONTRACEPTIVES AND PLASMA PROTEIN METABOLISM
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Zusammenfassung der Diskussion zum Thema: „Grundlagen der Komponententherapie“
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Aktif Viral Hepatit B’li Hastalarda Serum Protein Düzeylerinin İncelenmesi
Bayraktar, N., Gönel, A., Koyuncu, İ., & Bayraktar, M. (2019) · Harran Üniversitesi Tıp Fakültesi Dergisi · doi:10.35440/hutfd.589266
Frydman, G. H., Pate, K. A. M., & Vitsky, A. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-95488-4.00135-2
- Authors
- Mayer, G., & Schomerus, H.
- Affiliations
- Philipps University of Marburg (DE)
- Corresponding author
- Mayer, G.
- ORCID
- Mayer, G.
- Venue
- Digestion
- Publisher
- S. Karger AG
- Published
- 2009-01-23
- Volume
- 13
- Issue
- 5
- Pages
- 261-271
- ISSN
- 0012-2823 (ISSN-L)
- 1421-9867
- OpenAlex
- W2001736281
- Cited by
- 15
- References
- 0
- Citations by year
- 2024: 1 · 2021: 1 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 1
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Digestion (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
- Keywords
- acute hepatitis, albumin synthesis, fibrinogen synthesis, plasma protein synthesis, liver function, prothrombin index, transaminases, bilirubin, viral hepatitis
- MeSH terms
- Acute Disease, Adult, Transaminases, Bilirubin, Female, Fibrinogen, Hepatitis A, Humans, Liver, Middle Aged, Prothrombin, Serum Albumin, Urea
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