The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Strontium Promotes Osteogenic Differentiation of Mesenchymal Stem Cells Through the Ras/MAPK Signaling Pathway
Abstract
Strontium ralenate is a new anti-osteoporosis agent. The cellular and molecular mechanism underlying the anabolic effect of strontium on bone remains to be elucidated. Osteoblasts, the main bone forming cells are known to be derived from bone marrow mesenchymal stem cells (MSCs). The present study therefore aimed to investigate the possible effects of strontium on MSCs and signaling pathways possibly involved. It was firstly demonstrated that strontium treatment significantly increased osteoblast-related gene expression and alkaline phosphatase (ALP) of osteogenic-differentiating MSCs. Accompanying the enhanced osteogenic differentiation, the increased phosphorylation of mitogen-activated protein kinase (MAPK) ERK1/2 and p38 was detected in strontium-treated MSCs. PD98059 and SB203580, selective inhibitors of ERK1/2 kinase and p38, attenuated the effect of strontium on osteogenesis. Furthermore, it was demonstrated that Rat Sarcoma viral oncogene homolog (RAS), an upstream regulator of ERK1/2 and p38, was activated by strontium treatment and siRNA-mediated Ras knockdown inhibited strontium-stimulated expression of osteogenic markers. Finally, the transcriptional activity and phosphorylation level of Runx2 was significantly increased in response to strontium treatment in MSCs. PD98059 and Ras siRNA inhibited the effect of strontium on Runx2 activation. Taken together, these results indicated that strontium can promote osteogenic differentiation of MSCs through activating the Ras/MAPK signaling pathway and the downstream transcription factor Runx2.
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Komori, T., Yagi, H., Nomura, S., Yamaguchi, A., Sasaki, K., Deguchi, K., Shimizu, Y., Bronson, R. T., Gao, Y.-H., Inada, M., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80258-5 · Cited by 4,244
Meunier, P. J., Roux, C., Seeman, E., Ortolani, S., Badurski, J. E., Spector, T. D., Cannata, J., Balogh, A., Lemmel, E.-M., Pors-Nielsen, S., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa022436 · Cited by 1,638
Increasing complexity of Ras signaling
Campbell, S. L., Khosravi-Far, R., Rossman, K. L., Clark, G. J., & Der, C. J. (1998) · Oncogene · doi:10.1038/sj.onc.1202174 · Cited by 1,079
Reginster, J. Y., Seeman, E., De Vernejoul, M. C., Adami, S., Compston, J., Phenekos, C., Devogelaer, J. P., Curiel, M. D., Sawicki, A., Goemaere, S., et al. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1774 · Cited by 1,071
Bonnelye, E., Chabadel, A., Saltel, F., & Jurdic, P. (2008) · Bone · doi:10.1016/j.bone.2007.08.043 · Cited by 830
Jaiswal, R. K., Jaiswal, N., Bruder, S. P., Mbalaviele, G., Marshak, D. R., & Pittenger, M. F. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.13.9645 · Cited by 771
The biological role of strontium
Pors Nielsen, S. (2004) · Bone · doi:10.1016/j.bone.2004.04.026 · Cited by 733
MAPK Pathways Activate and Phosphorylate the Osteoblast-specific Transcription Factor, Cbfa1
Xiao, G., Jiang, D., Thomas, P., Benson, M. D., Guan, K., Karsenty, G., & Franceschi, R. T. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.6.4453 · Cited by 552
The divalent strontium salt S12911 enhances bone cell replication and bone formation in vitro
Canalis, E. (1996) · Bone · doi:10.1016/8756-3282(96)00080-4 · Cited by 498
Xiao, G., Gopalakrishnan, R., Jiang, D., Reith, E., Benson, M. D., & Franceschi, R. T. (2002) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2002.17.1.101 · Cited by 456
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The Effect of Hypoxia on Mesenchymal Stem Cell Biology
Ejtehadifar, M., Shamsasenjan, K., Movassaghpour, A., Akbarzadehlaleh, P., Dehdilani, N., Abbasi, P., Molaeipour, Z., & Saleh, M. (2015) · Advanced Pharmaceutical Bulletin · doi:10.15171/apb.2015.021 · Cited by 235
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Lu, F., Verleg, S. M. N. E., Groven, R. V. M., Poeze, M., van Griensven, M., & Blokhuis, T. J. (2024) · Bone · doi:10.1016/j.bone.2024.117021 · Cited by 25
Metadata
- Authors
- Peng, S., Zhou, G., Luk, K. D. K., Cheung, K. M. C., Li, Z., Lam, W. M., Zhou, Z., & Lu, W. W.
- Venue
- Cellular Physiology and Biochemistry
- Publisher
- S. Karger AG
- Published
- 2009
- Volume
- 23
- Issue
- 1-3
- Pages
- 165-174
- ISSN
- 1015-8987 (ISSN-L)
- 1421-9778
- OpenAlex
- W1967000850
- Cited by
- 276
- References
- 36
- FWCI
- 4.08
- Type
- journal article
- Language
- en
- Open access
- closed
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- Peng, S., Zhou, G., Luk, K. D. K., Cheung, K. M. C., Li, Z., Lam, W. M., Zhou, Z., & Lu, W. W. (2009). Strontium Promotes Osteogenic Differentiation of Mesenchymal Stem Cells Through the Ras/MAPK Signaling Pathway. Cellular Physiology and Biochemistry. https://doi.org/10.1159/000204105
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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