The Effect of Hypoxia on Mesenchymal Stem Cell Biology

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

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Bone marrow cells regenerate infarcted myocardium

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Sox9 Modulates Proliferation and Expression of Osteogenic Markers of Adipose-Derived Stem Cells (ASC)

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Mesenchymal and haematopoietic stem cells form a unique bone marrow niche

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Comparative Analysis of Mesenchymal Stem Cells from Bone Marrow, Umbilical Cord Blood, or Adipose Tissue

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Cellular and developmental control of O ₂ homeostasis by hypoxia-inducible factor 1α

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Mesenchymal stem cells reside in virtually all post-natal organs and tissues

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Hypoxia-inducible factors and the response to hypoxic stress

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HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption

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HIF‐1α is required for solid tumor formation and embryonic vascularization

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Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy

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The impact of O2 availability on human cancer

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Identification of stromal cell precursors in human bone marrow by a novel monoclonal antibody, STRO-1

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Adult mesenchymal stem cells: characterization, differentiation, and application in cell and gene therapy

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Directed migration of neural stem cells to sites of CNS injury by the stromal cell-derived factor 1α/CXC chemokine receptor 4 pathway

Imitola, J., Raddassi, K., Park, K. I., Müeller, F.-J., Nieto, M., Teng, Y. D., Frenkel, D., Li, J., Sidman, R. L., Walsh, C. A., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408258102 · Cited by 1,056 · see citing works

Cell death by necrosis: towards a molecular definition

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Human Bone Marrow–Derived Mesenchymal Stem Cells in the Treatment of Gliomas

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Expansion of Human Adult Stem Cells from Bone Marrow Stroma: Conditions that Maximize the Yields of Early Progenitors and Evaluate Their Quality

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Searching for Alternative Sources of Postnatal Human Mesenchymal Stem Cells: Candidate MSC‐Like Cells from Umbilical Cord

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Distribution of hematopoietic stem cells in the bone marrow according to regional hypoxia

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Multiple myeloma: evolving genetic events and host interactions

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Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT

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Mesenchymal precursor cells in the blood of normal individuals

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Hypoxic Preconditioning Results in Increased Motility and Improved Therapeutic Potential of Human Mesenchymal Stem Cells

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Circulating Skeletal Stem Cells

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Human Placenta‐Derived Cells Have Mesenchymal Stem/Progenitor Cell Potential

Fukuchi, Y., Nakajima, H., Sugiyama, D., Hirose, I., Kitamura, T., & Tsuji, K. (2004) · Stem Cells · doi:10.1634/stemcells.22-5-649 · Cited by 646 · see citing works

Adult bone marrow is a rich source of human mesenchymal ‘stem’ cells but umbilical cord and mobilized adult blood are not

Wexler, S., Donaldson, C., Denning‐Kendall, P. A., Rice, C. M., Bradley, B. A., & Hows, J. (2003) · British Journal of Haematology · doi:10.1046/j.1365-2141.2003.04284.x · Cited by 643 · see citing works

Migration of Bone Marrow and Cord Blood Mesenchymal Stem Cells In Vitro Is Regulated by Stromal‐Derived Factor‐1‐CXCR4 and Hepatocyte Growth Factor‐c‐met Axes and Involves Matrix Metalloproteinases

Son, B., Marquez‐Curtis, L. A., Kucia, M., Wysoczynski, M., Turner, A. R., Ratajczak, J., Ratajczak, M. Z., & Janowska‐Wieczorek, A. (2006) · Stem Cells · doi:10.1634/stemcells.2005-0271 · Cited by 641 · see citing works

Hypoxia-Inducible mir-210 Regulates Normoxic Gene Expression Involved in Tumor Initiation

Huang, X., Ding, L., Bennewith, K. L., Tong, R. T., Welford, S. M., Ang, K. K., Story, M. D., Le, Q., & Giaccia, A. J. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.09.006 · Cited by 616 · see citing works

The microenvironment in mature B-cell malignancies: a target for new treatment strategies

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The Bone Marrow Vascular Niche: Home of HSC Differentiation and Mobilization

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Can stem cells cross lineage boundaries?

Anderson, D. J., Gage, F. H., & Weissman, I. L. (2001) · Nature Medicine · doi:10.1038/86439 · Cited by 489 · see citing works

The hematopoietic stem cell niche: Low in oxygen but a nice place to be

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SDF‐1 expression by mesenchymal stem cells results in trophic support of cardiac myocytes after myocardial infarction

Zhang, M., Mal, N., Kiedrowski, M. J., Chacko, M., Askari, A. T., Popović, Z., Koç, O. N., & Penn, M. S. (2007) · The FASEB Journal · doi:10.1096/fj.06-6558com · Cited by 456 · see citing works

Mesenchymal Stem Cells Derived from CD133‐Positive Cells in Mobilized Peripheral Blood and Cord Blood: Proliferation, Oct4 Expression, and Plasticity

Tondreau, T., Meuleman, N., Delforge, A., Dejeneffe, M., Leroy, R., Massy, M., Mortier, C., Bron, D., & Lagneaux, L. (2005) · Stem Cells · doi:10.1634/stemcells.2004-0330 · Cited by 438 · see citing works

Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation

Wong, C. C.-L., Gilkes, D. M., Zhang, H., Chen, J., Wei, H., Chaturvedi, P., Fraley, S. I., Wong, C.-M., Khoo, U.-S., Ng, I. O.-L., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1113483108 · Cited by 437 · see citing works

Cultivation of rat marrow‐derived mesenchymal stem cells in reduced oxygen tension: Effects on in vitro and in vivo osteochondrogenesis

Lennon, D. P., Edmison, J. M., & Caplan, A. I. (2001) · Journal of Cellular Physiology · doi:10.1002/jcp.1081 · Cited by 425 · see citing works

Directed migration of neural stem cells to sites of CNS injury by the stromal cell-derived factor 1 alpha/CXC chemokine receptor 4 pathway

Teng, Y. D., Frenkel, D., Nieto, M., Müeller, F.-J., Park, K. I., Raddassi, K., Imitola, J., Li, J., Sidman, R. L., Walsh, C. A., et al. (2004) · Cited by 421 · see citing works

Effects of hypoxia on human mesenchymal stem cell expansion and plasticity in 3D constructs

Grayson, W. L., Zhao, F., Izadpanah, R., Bunnell, B. A., & Ma, T. (2005) · Journal of Cellular Physiology · doi:10.1002/jcp.20571 · Cited by 409 · see citing works

Low oxygen concentration extends the lifespan of cultured human diploid cells

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Multilineage differentiation activity by cells isolated from umbilical cord blood: Expression of bone, fat, and neural markers

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The role of hypoxia in the maintenance of hematopoietic stem cells

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Hypoxia or in situ normoxia: The stem cell paradigm

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Histone Demethylases KDM4B and KDM6B Promotes Osteogenic Differentiation of Human MSCs

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Multipotential Mesenchymal Stem Cells Are Mobilized into Peripheral Blood by Hypoxia

Rochefort, G. Y., Delorme, B., López, A., Hérault, O., Bonnet, P., Charbord, P., Eder, V., & Domenech, J. (2006) · Stem Cells · doi:10.1634/stemcells.2006-0164 · Cited by 315 · see citing works

Low physiologic oxygen tensions reduce proliferation and differentiation of human multipotent mesenchymal stromal cells

Holzwarth, C., Vaegler, M., Gieseke, F., Pfister, S. M., Handgretinger, R., Kerst, G., & Müller, I. (2010) · BMC Cell Biology · doi:10.1186/1471-2121-11-11 · Cited by 314 · see citing works

Hypoxia Promotes Murine Bone‐Marrow‐Derived Stromal Cell Migration and Tube Formation

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Effect of reduced oxygen tension on chondrogenesis and osteogenesis in adipose-derived mesenchymal cells

Malladi, P., Xu, Y., Chiou, M., Giaccia, A. J., & Longaker, M. T. (2005) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00415.2005 · Cited by 301 · see citing works

The role of hypoxia in bone marrow-derived mesenchymal stem cells: considerations for regenerative medicine approaches

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Strontium Promotes Osteogenic Differentiation of Mesenchymal Stem Cells Through the Ras/MAPK Signaling Pathway

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Definitive Hematopoiesis Requires the Mixed-Lineage Leukemia Gene

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Homing of in vitro expanded Stro-1- or Stro-1+ human mesenchymal stem cells into the NOD/SCID mouse and their role in supporting human CD34 cell engraftment

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Long term culture of mesenchymal stem cells in hypoxia promotes a genetic program maintaining their undifferentiated and multipotent status

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Effects of hypoxic culture conditions on umbilical cord-derived human mesenchymal stem cells

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Hypoxia-inducible Factor-1 Deficiency Results in Dysregulated Erythropoiesis Signaling and Iron Homeostasis in Mouse Development

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Effect of Hypoxia on Gene Expression of Bone Marrow-Derived Mesenchymal Stem Cells and Mononuclear Cells

Ohnishi, S., Yasuda, T., Kitamura, S., & Nagaya, N. (2007) · Stem Cells · doi:10.1634/stemcells.2006-0347 · Cited by 222 · see citing works

Transient Changes in Oxygen Tension Inhibit Osteogenic Differentiation and Runx2 Expression in Osteoblasts

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Mesenchymal stem cells attenuate cardiac fibroblast proliferation and collagen synthesis through paracrine actions

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Critical role for lysyl oxidase in mesenchymal stem cell-driven breast cancer malignancy

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Molecular mechanisms mediating metastasis of hypoxic breast cancer cells

Semenza, G. L. (2012) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2012.08.001 · Cited by 217 · see citing works

Different Facets of Aging in Human Mesenchymal Stem Cells

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Cellular responses to reactive oxygen species-induced DNA damage and aging

Bertram, C., & Hass, R. (2008) · Biological Chemistry · doi:10.1515/bc.2008.031 · Cited by 208 · see citing works

Inhibition of Rho-Kinase Attenuates Hypoxia-Induced Angiogenesis in the Pulmonary Circulation

Hyvelin, J.-M., Howell, K., Nichol, A., Costello, C. M., Preston, R. J., & McLoughlin, P. (2005) · Circulation Research · doi:10.1161/01.res.0000174287.17953.83 · Cited by 207 · see citing works

Disparate Mesenchyme-Lineage Tendencies in Mesenchymal Stem Cells from Human Bone Marrow and Umbilical Cord Blood

Chang, Y.-J., Shih, D. T.-B., Tseng, C., Hsieh, T., Lee, D.-C., & Hwang, S. (2005) · Stem Cells · doi:10.1634/stemcells.2004-0308 · Cited by 198 · see citing works

Hypoxia Promotes Osteogenesis but Suppresses Adipogenesis of Human Mesenchymal Stromal Cells in a Hypoxia-Inducible Factor-1 Dependent Manner

Wagegg, M., Gaber, T., Lohanatha, F. L., Hahne, M., Strehl, C., Fangradt, M., Tran, C. L., Schönbeck, K., Hoff, P., Ode, A., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046483 · Cited by 194 · see citing works

MicroRNA-34a Inhibits Osteoblast Differentiation and In Vivo Bone Formation of Human Stromal Stem Cells

Chen, L., Holmstrøm, K., Qiu, W., Ditzel, N., Shi, K., Hokland, L. B., & Kassem, M. S. (2013) · Stem Cells · doi:10.1002/stem.1615 · Cited by 182 · see citing works

Hypoxia-inducible MicroRNA-210 augments the metastatic potential of tumor cells by targeting vacuole membrane protein 1 in hepatocellular carcinoma

Qiao, Y., Liang, L., Guo, W., Zha, R., Tian, Q., Huang, S., Yao, J., Ding, J., Bao, M., Ge, C., et al. (2010) · Hepatology · doi:10.1002/hep.24614 · Cited by 175 · see citing works

Migration of mesenchymal stem cells to heart allografts during chronic rejection

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Regulation of Endothelial Matrix Metalloproteinase-2 by Hypoxia/Reoxygenation

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Hypoxia-Induced Down-Regulation of microRNA-34a Promotes EMT by Targeting the Notch Signaling Pathway in Tubular Epithelial Cells

Du, R., Sun, W., Xia, L., Zhao, A., Yu, Y., Zhao, L., Wang, H., Huang, C., & Sun, S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030771 · Cited by 171 · see citing works

Transcriptional Profiling of Human Cord Blood CD133+ and Cultured Bone Marrow Mesenchymal Stem Cells in Response to Hypoxia

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Human Bone Marrow-Derived Mesenchymal (Stromal) Progenitor Cells (MPCs) Cannot Be Recovered from Peripheral Blood Progenitor Cell Collections

Lazarus, H. M., Haynesworth, S. E., Gerson, S. L., & Caplan, A. I. (1997) · Journal of Hematotherapy · doi:10.1089/scd.1.1997.6.447 · Cited by 165 · see citing works

Enrichment for STRO‐1 expression enhances the cardiovascular paracrine activity of human bone marrow‐derived mesenchymal cell populations

Psaltis, P. J., Paton, S., See, F., Arthur, A., Martin, S. K., Itescu, S., Worthley, S. G., Gronthos, S., & Zannettino, A. C. W. (2010) · Journal of Cellular Physiology · doi:10.1002/jcp.22081 · Cited by 164 · see citing works

O2 sensing at the mammalian carotid body: why multiple O2 sensors and multiple transmitters?

Prabhakar, N. R. (2005) · Experimental Physiology · doi:10.1113/expphysiol.2005.031922 · Cited by 156 · see citing works

Optimization of mesenchymal stem cell expansion procedures by cell separation and culture conditions modification

Carrancio, S., López-Holgado, N., Sanchez-Guijo, F. M., Villarón, E. M., Barbado, M. V., Tabera, S., Díez‐Campelo, M., Blanco, J. F., Miguel, J. F. S., & del Cañizo, M. C. (2008) · Experimental Hematology · doi:10.1016/j.exphem.2008.03.012 · Cited by 153 · see citing works

Matrix Metalloproteinase 1 Is Necessary for the Migration of Human Bone Marrow-Derived Mesenchymal Stem Cells Toward Human Glioma

Ho, I. A. W., Chan, K. Y. W., Ng, W.-H., Guo, C. M., Hui, K. M., Cheang, P., & Lam, P. Y. P. (2009) · Stem Cells · doi:10.1002/stem.50 · Cited by 147 · see citing works

Inhibition of TGF‐β/Smad Signaling by BAMBI Blocks Differentiation of Human Mesenchymal Stem Cells to Carcinoma‐Associated Fibroblasts and Abolishes their Protumor Effects

Shangguan, L., Ti, X., Krause, U., Hai, B., Zhao, Y., Yang, Z., & Liu, F. (2012) · Stem Cells · doi:10.1002/stem.1251 · Cited by 146 · see citing works

Identification of subpopulations in mesenchymal stem cell-like cultures from human umbilical cord

Majore, I., Moretti, P., Hass, R., & Kasper, C. (2009) · Cell Communication and Signaling · doi:10.1186/1478-811x-7-6 · Cited by 142 · see citing works

Hypoxia-induced mixed-lineage leukemia 1 regulates glioma stem cell tumorigenic potential

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Isolation and Characterization of Resident Mesenchymal Stem Cells in Human Glomeruli

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The Novel SPARC Family Member SMOC-2 Potentiates Angiogenic Growth Factor Activity

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The Oncogenic Potential of Mesenchymal Stem Cells in the Treatment of Cancer: Directions for Future Research

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Regulation of hematopoietic stem cell fate

Krause, D. S. (2002) · Oncogene · doi:10.1038/sj.onc.1205316 · Cited by 101 · see citing works

Leptin Functions Peripherally to Regulate Differentiation of Mesenchymal Progenitor Cells

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The prototype endothelial marker PAL-E is a leukocyte trafficking molecule

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Hypoxia and RAS-signaling pathways converge on, and cooperatively downregulate, the RECK tumor-suppressor protein through microRNAs

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