The DOI matches its Crossref record; 120 of the 120 references it cites were found in a registry or an index.
Hepatocellular Carcinoma – Epidemiological Trends and Risk Factors
Abstract
Hepatocellular carcinoma (HCC) is the third most common cause of cancer-related deaths worldwide with about 600,000 patients dying from the disease annually. In 70–90%, HCC develops on the background of chronic liver cirrhosis or inflammation. Risk factors and etiologies vary among geographical regions. In regions with a high incidence the majority of cases are related to HBV and HCV hepatitis. In developed countries, in addition to virus-related HCC, high consumption of alcohol as well as non-alcoholic fatty liver disease often in the context of metabolic syndromes are the prevalent causes. Improvement in clinical management of patients with liver cirrhosis and the control of related complications are the key for the rising incidence of HCC. This review gives an overview on epidemiological trends and risk factors and their mechanisms involved in the hepatocarcinogenesis. Knowledge of these factors will help to improve current concepts for prevention, screening and treatment of this disease.
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Cited by
Fibrosis-dependent mechanisms of hepatocarcinogenesis
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Golgi protein 73 (GOLPH2) is a valuable serum marker for hepatocellular carcinoma
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NFκB1 is a suppressor of neutrophil-driven hepatocellular carcinoma
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Metadata
- Authors
- Schütte, K., Bornschein, J., & Malfertheiner, P.
- Venue
- Digestive Diseases
- Publisher
- S. Karger AG
- Published
- 2009
- Volume
- 27
- Issue
- 2
- Pages
- 80-92
- ISSN
- 0257-2753 (ISSN-L)
- 1421-9875
- OpenAlex
- W1983218872
- Cited by
- 441
- References
- 120
- FWCI
- 24.38
- Type
- journal article
- Language
- en
- Open access
- closed
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- Schütte, K., Bornschein, J., & Malfertheiner, P. (2009). Hepatocellular Carcinoma – Epidemiological Trends and Risk Factors. Digestive Diseases. https://doi.org/10.1159/000218339
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
